| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 1,130,000 | 8,555,555 | +7,425,555 | 0.48 | 2.85 | +2.38 | buy |
| Slate Path Capital LP | 1,329,000 | 4,139,000 | +2,810,000 | 0.90 | 2.35 | +1.44 | buy |
| Artal Group S.A. | 1,028,255 | 3,036,668 | +2,008,413 | 1.05 | 2.21 | +1.17 | buy |
| ORBIMED ADVISORS LLC | 319,651 | 739,651 | +420,000 | 0.20 | 0.39 | +0.19 | buy |
| ONTARIO TEACHERS PENSION PLAN BOARD | 6,562 | 87,883 | +81,321 | 0.00 | 0.02 | +0.02 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 172,865 | 225,583 | +52,718 | 0.01 | 0.02 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 100,226 | 150,198 | +49,972 | 0.02 | 0.03 | +0.01 | buy |
| Candriam S.C.A. | 185,054 | 228,054 | +43,000 | 0.04 | 0.04 | +0.00 | buy |
| NEOS Investment Management LLC | 11,712 | 34,560 | +22,848 | 0.03 | 0.06 | +0.03 | buy |
| Retirement Systems of Alabama | 327,453 | 348,784 | +21,331 | 0.04 | 0.04 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,429 | 23,838 | +11,409 | 0.07 | 0.09 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,574 | 26,832 | +5,258 | 0.13 | 0.10 | -0.03 | buy |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 25,670 | 30,470 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 41,211 | 45,734 | +4,523 | 0.07 | 0.07 | -0.00 | buy |
| WEALTH EFFECTS LLC | 161,850 | 164,460 | +2,610 | 1.86 | 1.73 | -0.13 | buy |
| SECURIAN ASSET MANAGEMENT, INC | 8,979 | 10,100 | +1,121 | 0.01 | 0.01 | +0.00 | buy |
| EP Wealth Advisors, LLC | 8,500 | 8,819 | +319 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 300 | 600 | +300 | 0.00 | 0.00 | +0.00 | buy |
| HIGHLINE WEALTH PARTNERS LLC | 681 | 652 | -29 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,243 | 3,031 | -212 | 0.06 | 0.05 | -0.02 | sell |
| Bank Pictet & Cie (Europe) AG | 8,559 | 8,125 | -434 | 0.01 | 0.01 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 8,182 | 7,682 | -500 | 0.11 | 0.09 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 54,094 | 53,039 | -1,055 | 0.30 | 0.26 | -0.04 | sell |
| E. Ohman J:or Asset Management AB | 641,869 | 640,160 | -1,709 | 0.72 | 0.47 | -0.25 | sell |
| OAK RIDGE INVESTMENTS LLC | 43,644 | 41,932 | -1,712 | 0.15 | 0.12 | -0.03 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 156,152 | 153,357 | -2,795 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 19,531 | 12,956 | -6,575 | 0.04 | 0.02 | -0.01 | sell |
| Evolutionary Tree Capital Management, LLC | 51,687 | 44,896 | -6,791 | 1.75 | 1.29 | -0.45 | sell |
| World Investment Advisors | 16,707 | 7,752 | -8,955 | 0.07 | 0.03 | -0.03 | sell |
| BANQUE PICTET & CIE SA | 118,313 | 108,053 | -10,260 | 0.03 | 0.03 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 38,636 | 1,543 | -37,093 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 241,807 | 135,000 | -106,807 | 0.05 | 0.02 | -0.03 | sell |
| Woodline Partners LP | 927,187 | 555,628 | -371,559 | 0.31 | 0.15 | -0.16 | sell |
| Capital International Investors | 1,277,560 | 479,106 | -798,454 | 0.01 | 0.00 | -0.01 | sell |