| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 21,318,582 | 18,161,519 | -3,157,063 | 0.02 | 0.02 | -0.00 | sell |
| Avoro Capital Advisors LLC | 10,625,000 | 10,699,999 | +74,999 | 6.93 | 6.61 | -0.32 | buy |
| FMR LLC | 6,520,408 | 7,266,652 | +746,244 | 0.02 | 0.02 | +0.00 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 6,587,000 | +6,587,000 | 0.00 | 0.47 | +0.47 | buy |
| STATE STREET CORP | 6,403,830 | 6,496,130 | +92,300 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,264,963 | 4,278,828 | +1,013,865 | 0.01 | 0.02 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,832,997 | 3,342,493 | +1,509,496 | 0.48 | 0.92 | +0.44 | buy |
| Invesco Ltd. | 547,758 | 3,280,647 | +2,732,889 | 0.00 | 0.03 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 900,000 | 2,275,000 | +1,375,000 | 2.19 | 3.99 | +1.80 | buy |
| BAKER BROS. ADVISORS LP | 2,175,645 | 1,992,783 | -182,862 | 0.85 | 0.72 | -0.13 | sell |
| GOLDMAN SACHS GROUP INC | 1,677,522 | 1,739,923 | +62,401 | 0.02 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,346,257 | 1,655,837 | +309,580 | 0.01 | 0.01 | +0.00 | buy |
| Siren, L.L.C. | 1,500,476 | 1,615,476 | +115,000 | 2.97 | 2.81 | -0.16 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,832,946 | 1,573,297 | -259,649 | 1.56 | 1.16 | -0.40 | sell |
| JANUS HENDERSON GROUP PLC | 1,280,446 | 1,436,990 | +156,544 | 0.04 | 0.04 | +0.00 | buy |
| UBS Group AG | 987,287 | 1,336,271 | +348,984 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,260,380 | 1,330,996 | +70,616 | 0.02 | 0.02 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,028,736 | 1,273,266 | +244,530 | 0.07 | 0.08 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 1,215,000 | +1,215,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,353,719 | 1,192,085 | -161,634 | 0.01 | 0.01 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,769,340 | 1,190,335 | -579,005 | 0.80 | 0.55 | -0.25 | sell |
| D. E. Shaw & Co., Inc. | 146,064 | 1,183,838 | +1,037,774 | 0.01 | 0.06 | +0.05 | buy |
| Fisher Asset Management, LLC | 1,311,727 | 1,113,568 | -198,159 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 622,029 | 1,064,455 | +442,426 | 0.00 | 0.00 | +0.00 | buy |
| Hood River Capital Management LLC | 0 | 1,056,534 | +1,056,534 | 0.00 | 0.66 | +0.66 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 838,818 | 1,043,732 | +204,914 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 1,036,495 | +1,036,495 | 0.00 | 0.10 | +0.10 | buy |
| MORGAN STANLEY | 1,476,005 | 960,507 | -515,498 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 887,848 | 960,144 | +72,296 | 0.01 | 0.01 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 663,262 | 836,981 | +173,719 | 0.12 | 0.12 | +0.01 | buy |
| Western Financial Corp/CA | 820,239 | 820,239 | 0 | 21.60 | 20.13 | -1.47 | hold |
| JPMORGAN CHASE & CO | 611,910 | 683,068 | +71,158 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 422,731 | 656,129 | +233,398 | 0.03 | 0.04 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 7,742 | 651,544 | +643,802 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 40,398 | 650,599 | +610,201 | 0.00 | 0.03 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 147,412 | 608,531 | +461,119 | 0.00 | 0.01 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,087,953 | 587,125 | -1,500,828 | 0.08 | 0.02 | -0.06 | sell |
| RTW INVESTMENTS, LP | 584,716 | 585,682 | +966 | 0.39 | 0.37 | -0.02 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 470,000 | 540,144 | +70,144 | 0.88 | 1.57 | +0.69 | buy |
| Nuveen, LLC | 288,578 | 499,837 | +211,259 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 715,539 | 490,122 | -225,417 | 0.02 | 0.02 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 375,371 | 472,870 | +97,499 | 0.07 | 0.08 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 107,366 | 462,707 | +355,341 | 0.00 | 0.01 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 35,955 | 461,193 | +425,238 | 0.01 | 0.11 | +0.10 | buy |
| RHUMBLINE ADVISERS | 352,395 | 404,436 | +52,041 | 0.02 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,911 | 378,833 | +349,922 | 0.00 | 0.03 | +0.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 370,000 | 370,000 | 0 | 0.38 | 0.38 | -0.00 | hold |
| Privium Fund Management B.V. | 398,204 | 366,936 | -31,268 | 4.87 | 4.79 | -0.08 | sell |
| Aberdeen Group plc | 286,146 | 363,972 | +77,826 | 0.03 | 0.04 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 28,600 | 325,700 | +297,100 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 312,824 | +312,824 | 0.00 | 0.06 | +0.06 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 324,251 | 306,439 | -17,812 | 0.02 | 0.02 | -0.00 | sell |
| Integral Health Asset Management, LLC | 100,000 | 300,000 | +200,000 | 0.34 | 1.00 | +0.66 | buy |
| ALLIANCEBERNSTEIN L.P. | 172,666 | 280,394 | +107,728 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 250,944 | 277,114 | +26,170 | 0.15 | 0.13 | -0.02 | buy |
| DEUTSCHE BANK AG\ | 242,074 | 259,963 | +17,889 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 0 | 257,133 | +257,133 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 42,743 | 251,568 | +208,825 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 245,400 | 242,000 | -3,400 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 395,311 | 229,097 | -166,214 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 376,216 | 206,412 | -169,804 | 0.05 | 0.03 | -0.02 | sell |
| Neuberger Berman Group LLC | 100,385 | 203,914 | +103,529 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 112,279 | 203,220 | +90,941 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 208,062 | 202,347 | -5,715 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 400,184 | 200,184 | -200,000 | 0.10 | 0.05 | -0.06 | sell |
| Affinity Asset Advisors, LLC | 70,000 | 200,000 | +130,000 | 0.33 | 0.74 | +0.40 | buy |
| Longaeva Partners L.P. | 0 | 194,589 | +194,589 | 0.00 | 0.59 | +0.59 | buy |
| AMERIPRISE FINANCIAL INC | 257,477 | 191,054 | -66,423 | 0.00 | 0.00 | -0.00 | sell |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 15,802 | 184,304 | +168,502 | 0.01 | 0.13 | +0.12 | buy |
| RAYMOND JAMES FINANCIAL INC | 198,387 | 182,555 | -15,832 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 123,855 | 179,573 | +55,718 | 0.01 | 0.01 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 191,669 | 175,456 | -16,213 | 0.16 | 0.14 | -0.02 | sell |
| Russell Investments Group, Ltd. | 122,115 | 173,995 | +51,880 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 172,174 | +172,174 | 0.00 | 0.01 | +0.01 | buy |
| Retirement Systems of Alabama | 0 | 171,672 | +171,672 | 0.00 | 0.04 | +0.04 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 138,905 | 171,575 | +32,670 | 0.02 | 0.02 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 147,353 | 167,210 | +19,857 | 0.01 | 0.00 | -0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 162,005 | +162,005 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,151 | 160,422 | +62,271 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 152,507 | 158,398 | +5,891 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 151,046 | +151,046 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 0 | 150,278 | +150,278 | 0.00 | 0.02 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 237,730 | 149,148 | -88,582 | 0.01 | 0.01 | -0.00 | sell |
| HighTower Advisors, LLC | 133,229 | 146,462 | +13,233 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 144,500 | 144,500 | 0 | 0.90 | 1.12 | +0.22 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 118,372 | 144,313 | +25,941 | 0.01 | 0.01 | +0.00 | buy |
| WEALTH EFFECTS LLC | 143,300 | 143,300 | 0 | 2.98 | 3.18 | +0.20 | hold |
| MetLife Investment Management, LLC | 73,040 | 140,404 | +67,364 | 0.02 | 0.04 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 133,875 | 139,598 | +5,723 | 0.01 | 0.01 | -0.00 | buy |
| Empowered Funds, LLC | 18,018 | 137,220 | +119,202 | 0.01 | 0.05 | +0.05 | buy |
| BANK OF NOVA SCOTIA | 0 | 135,960 | +135,960 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 100,277 | 129,499 | +29,222 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 96,935 | 127,198 | +30,263 | 1.36 | 1.57 | +0.21 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 149,776 | 124,853 | -24,923 | 0.02 | 0.02 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 159,538 | 120,238 | -39,300 | 0.02 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 321,833 | 115,343 | -206,490 | 0.01 | 0.00 | -0.01 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 158,622 | 108,413 | -50,209 | 0.07 | 0.05 | -0.02 | sell |
| Cormorant Asset Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.32 | +0.32 | buy |
| CITADEL ADVISORS LLC | 474,259 | 98,194 | -376,065 | 0.02 | 0.00 | -0.02 | sell |