| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,758,883 | 2,560,833 | +801,950 | 0.03 | 0.04 | +0.01 | buy |
| Avoro Capital Advisors LLC | 8,555,555 | 8,888,888 | +333,333 | 2.85 | 3.08 | +0.22 | buy |
| Woodline Partners LP | 555,628 | 821,518 | +265,890 | 0.15 | 0.20 | +0.06 | buy |
| Artal Group S.A. | 3,036,668 | 3,189,389 | +152,721 | 2.21 | 2.11 | -0.10 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 313,289 | 463,894 | +150,605 | 0.14 | 0.21 | +0.07 | buy |
| E. Ohman J:or Asset Management AB | 640,160 | 714,206 | +74,046 | 0.47 | 0.46 | -0.01 | buy |
| Hudson Bay Capital Management LP | 135,000 | 180,000 | +45,000 | 0.02 | 0.02 | +0.00 | buy |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 72,299 | 102,262 | +29,963 | 0.41 | 0.50 | +0.09 | buy |
| NEOS Investment Management LLC | 34,560 | 60,439 | +25,879 | 0.06 | 0.06 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 27,745 | 51,828 | +24,083 | 0.14 | 0.23 | +0.10 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 28,098 | 44,989 | +16,891 | 0.17 | 0.22 | +0.05 | buy |
| Privium Fund Management B.V. | 273,936 | 286,936 | +13,000 | 2.09 | 1.85 | -0.25 | buy |
| World Investment Advisors | 7,752 | 18,432 | +10,680 | 0.03 | 0.03 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 600 | 5,900 | +5,300 | 0.00 | 0.03 | +0.03 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 225,583 | 229,261 | +3,678 | 0.02 | 0.01 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 72 | 3,405 | +3,333 | 0.00 | 0.01 | +0.01 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 150,198 | 152,259 | +2,061 | 0.03 | 0.03 | -0.00 | buy |
| Resona Asset Management Co.,Ltd. | 21,162 | 22,691 | +1,529 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 3,031 | 3,416 | +385 | 0.05 | 0.04 | -0.00 | buy |
| NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC | 27,635 | 27,720 | +85 | 0.02 | 0.02 | -0.00 | buy |
| EP Wealth Advisors, LLC | 8,819 | 8,844 | +25 | 0.00 | 0.00 | -0.00 | buy |
| Hanson & Doremus Investment Management | 320 | 200 | -120 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 7,682 | 7,522 | -160 | 0.09 | 0.08 | -0.01 | sell |
| NVWM, LLC | 27,581 | 27,416 | -165 | 0.22 | 0.19 | -0.03 | sell |
| SECURIAN ASSET MANAGEMENT, INC | 10,100 | 9,905 | -195 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 30,470 | 29,870 | -600 | 0.00 | 0.00 | -0.00 | sell |
| HIGHLINE WEALTH PARTNERS LLC | 652 | 1 | -651 | 0.01 | 0.00 | -0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 53,039 | 49,879 | -3,160 | 0.26 | 0.25 | -0.01 | sell |
| BANQUE PICTET & CIE SA | 108,053 | 104,792 | -3,261 | 0.03 | 0.02 | -0.00 | sell |
| E Fund Management Co., Ltd. | 12,956 | 8,900 | -4,056 | 0.02 | 0.01 | -0.01 | sell |
| WEALTH EFFECTS LLC | 164,460 | 159,600 | -4,860 | 1.73 | 1.50 | -0.23 | sell |
| OAK RIDGE INVESTMENTS LLC | 41,932 | 36,600 | -5,332 | 0.12 | 0.09 | -0.03 | sell |
| Scientech Research LLC | 15,230 | 7,842 | -7,388 | 0.23 | 0.04 | -0.19 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 97,168 | 88,425 | -8,743 | 0.11 | 0.09 | -0.02 | sell |
| China Universal Asset Management Co., Ltd. | 23,838 | 14,592 | -9,246 | 0.09 | 0.05 | -0.03 | sell |
| Hennion & Walsh Asset Management, Inc. | 45,734 | 24,880 | -20,854 | 0.07 | 0.03 | -0.04 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 153,357 | 129,669 | -23,688 | 0.01 | 0.00 | -0.00 | sell |
| ONTARIO TEACHERS PENSION PLAN BOARD | 87,883 | 37,553 | -50,330 | 0.02 | 0.01 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 120,000 | 50,000 | -70,000 | 0.56 | 0.20 | -0.35 | sell |
| Retirement Systems of Alabama | 348,784 | 153,292 | -195,492 | 0.04 | 0.02 | -0.02 | sell |
| Capital International Investors | 479,106 | 255,871 | -223,235 | 0.00 | 0.00 | -0.00 | sell |
| Rokos Capital Management LLP | 1,229,148 | 939,984 | -289,164 | 0.19 | 0.15 | -0.03 | sell |