| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 18,161,519 | 14,830,553 | -3,330,966 | 0.02 | 0.02 | -0.00 | sell |
| Avoro Capital Advisors LLC | 10,699,999 | 11,355,555 | +655,556 | 6.61 | 8.31 | +1.70 | buy |
| FMR LLC | 7,266,652 | 8,039,804 | +773,152 | 0.02 | 0.03 | +0.00 | buy |
| STATE STREET CORP | 6,496,130 | 5,694,640 | -801,490 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 4,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 0 | 3,896,536 | +3,896,536 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 3,280,647 | 3,883,976 | +603,329 | 0.03 | 0.03 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,278,828 | 3,530,612 | -748,216 | 0.02 | 0.02 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 3,342,493 | 3,301,919 | -40,574 | 0.92 | 0.90 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 1,992,783 | 1,992,783 | 0 | 0.72 | 0.81 | +0.10 | hold |
| Siren, L.L.C. | 1,615,476 | 1,715,476 | +100,000 | 2.81 | 2.84 | +0.03 | buy |
| Vestal Point Capital, LP | 2,275,000 | 1,575,000 | -700,000 | 3.99 | 3.00 | -0.99 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,573,297 | 1,389,055 | -184,242 | 1.16 | 1.18 | +0.02 | sell |
| FIRST TRUST ADVISORS LP | 149,148 | 1,352,918 | +1,203,770 | 0.01 | 0.06 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,190,335 | 1,350,556 | +160,221 | 0.55 | 0.64 | +0.09 | buy |
| NORTHERN TRUST CORP | 1,655,837 | 1,192,868 | -462,969 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 608,531 | 1,181,608 | +573,077 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,739,923 | 1,150,007 | -589,916 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,064,455 | 1,139,810 | +75,355 | 0.00 | 0.01 | +0.00 | buy |
| Hood River Capital Management LLC | 1,056,534 | 1,120,747 | +64,213 | 0.66 | 0.66 | -0.00 | buy |
| Bank of New York Mellon Corp | 1,215,000 | 1,115,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| Holocene Advisors, LP | 0 | 1,106,177 | +1,106,177 | 0.00 | 0.21 | +0.21 | buy |
| MORGAN STANLEY | 960,507 | 1,084,835 | +124,328 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,330,996 | 964,479 | -366,517 | 0.02 | 0.01 | -0.00 | sell |
| Fisher Asset Management, LLC | 1,113,568 | 957,691 | -155,877 | 0.02 | 0.02 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 923,927 | +923,927 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,192,085 | 923,927 | -268,158 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 1,336,271 | 861,520 | -474,751 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 960,144 | 859,538 | -100,606 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,043,732 | 853,360 | -190,372 | 0.01 | 0.01 | -0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 540,144 | 830,247 | +290,103 | 1.57 | 1.76 | +0.19 | buy |
| Western Financial Corp/CA | 820,239 | 820,239 | 0 | 20.13 | 19.58 | -0.55 | hold |
| JPMORGAN CHASE & CO | 683,068 | 637,399 | -45,669 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 836,981 | 625,569 | -211,412 | 0.12 | 0.10 | -0.02 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 378,833 | 596,573 | +217,740 | 0.03 | 0.04 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 35,800 | 580,609 | +544,809 | 0.00 | 0.04 | +0.03 | buy |
| Pictet Asset Management Holding SA | 1,273,266 | 573,419 | -699,847 | 0.08 | 0.04 | -0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 650,599 | 558,643 | -91,956 | 0.03 | 0.02 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 312,824 | 540,466 | +227,642 | 0.06 | 0.13 | +0.06 | buy |
| 1832 Asset Management L.P. | 0 | 538,500 | +538,500 | 0.00 | 0.05 | +0.05 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 490,122 | 514,658 | +24,536 | 0.02 | 0.02 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 498,655 | +498,655 | 0.00 | 0.07 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 656,129 | 483,495 | -172,634 | 0.04 | 0.03 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 206,412 | 470,754 | +264,342 | 0.03 | 0.07 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,036,495 | 468,921 | -567,574 | 0.10 | 0.05 | -0.05 | sell |
| FRANKLIN RESOURCES INC | 462,707 | 462,133 | -574 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,183,838 | 431,560 | -752,278 | 0.06 | 0.02 | -0.04 | sell |
| Nuveen, LLC | 499,837 | 415,883 | -83,954 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 404,436 | 374,897 | -29,539 | 0.02 | 0.02 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 370,000 | 370,000 | 0 | 0.38 | 0.40 | +0.02 | hold |
| AMERICAN CENTURY COMPANIES INC | 651,544 | 364,211 | -287,333 | 0.02 | 0.01 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 329,337 | +329,337 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 129,499 | 310,761 | +181,262 | 0.00 | 0.01 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 310,706 | +310,706 | 0.00 | 0.04 | +0.04 | buy |
| MARSHALL WACE, LLP | 179,573 | 305,031 | +125,458 | 0.01 | 0.02 | +0.01 | buy |
| SEI INVESTMENTS CO | 203,220 | 300,619 | +97,399 | 0.01 | 0.02 | +0.01 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 306,439 | 284,175 | -22,264 | 0.02 | 0.02 | +0.00 | sell |
| Russell Investments Group, Ltd. | 173,995 | 283,555 | +109,560 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 251,568 | 264,678 | +13,110 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 257,133 | 256,314 | -819 | 0.01 | 0.01 | +0.00 | sell |
| Squarepoint Ops LLC | 0 | 255,907 | +255,907 | 0.00 | 0.04 | +0.04 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 66,750 | 254,228 | +187,478 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 363,972 | 251,968 | -112,004 | 0.04 | 0.03 | -0.01 | sell |
| Swiss National Bank | 242,000 | 238,900 | -3,100 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 229,097 | 237,216 | +8,119 | 0.00 | 0.00 | +0.00 | buy |
| Privium Fund Management B.V. | 366,936 | 234,222 | -132,714 | 4.79 | 3.51 | -1.28 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 587,125 | 218,133 | -368,992 | 0.02 | 0.01 | -0.01 | sell |
| HSBC HOLDINGS PLC | 151,046 | 203,800 | +52,754 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 58,735 | 201,927 | +143,192 | 0.01 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 200,184 | 200,184 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Integral Health Asset Management, LLC | 300,000 | 200,000 | -100,000 | 1.00 | 0.67 | -0.33 | sell |
| SEI INVESTMENTS CO | 32,000 | 200,000 | +168,000 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 167,210 | 198,842 | +31,632 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 15,775 | 196,205 | +180,430 | 0.00 | 0.01 | +0.01 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 184,304 | 191,432 | +7,128 | 0.13 | 0.15 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 280,394 | 173,265 | -107,129 | 0.01 | 0.00 | -0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 171,575 | 171,232 | -343 | 0.02 | 0.02 | +0.00 | sell |
| PINNACLE ASSOCIATES LTD | 175,456 | 170,131 | -5,325 | 0.14 | 0.15 | +0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 182,555 | 169,913 | -12,642 | 0.00 | 0.00 | +0.00 | sell |
| Clearbridge Investments, LLC | 202,347 | 157,110 | -45,237 | 0.01 | 0.01 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 191,054 | 155,908 | -35,146 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 200,000 | 150,000 | -50,000 | 0.74 | 0.60 | -0.14 | sell |
| DEUTSCHE BANK AG\ | 259,963 | 149,240 | -110,723 | 0.01 | 0.00 | -0.00 | sell |
| WEALTH EFFECTS LLC | 143,300 | 147,300 | +4,000 | 3.18 | 3.24 | +0.06 | buy |
| Retirement Systems of Alabama | 171,672 | 145,687 | -25,985 | 0.04 | 0.04 | -0.00 | sell |
| TORONTO DOMINION BANK | 150,278 | 144,928 | -5,350 | 0.02 | 0.02 | +0.00 | sell |
| HighTower Advisors, LLC | 146,462 | 140,394 | -6,068 | 0.01 | 0.01 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 144,313 | 139,826 | -4,487 | 0.01 | 0.01 | +0.00 | sell |
| Weiss Asset Management LP | 0 | 134,014 | +134,014 | 0.00 | 0.12 | +0.12 | buy |
| BANK OF NOVA SCOTIA | 135,960 | 133,805 | -2,155 | 0.01 | 0.02 | +0.00 | sell |
| PFM Health Sciences, LP | 64,279 | 131,667 | +67,388 | 0.42 | 0.93 | +0.51 | buy |
| TFG Asset Management GP Ltd | 127,198 | 130,484 | +3,286 | 1.57 | 1.73 | +0.16 | buy |
| WELLS FARGO & COMPANY/MN | 158,398 | 128,789 | -29,609 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 144,500 | 128,000 | -16,500 | 1.12 | 0.98 | -0.13 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 117,600 | +117,600 | 0.00 | 0.54 | +0.54 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 124,853 | 116,948 | -7,905 | 0.02 | 0.02 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 120,238 | 116,393 | -3,845 | 0.01 | 0.01 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 160,422 | 111,955 | -48,467 | 0.01 | 0.01 | -0.00 | sell |
| VAN ECK ASSOCIATES CORP | 18,890 | 111,500 | +92,610 | 0.00 | 0.01 | +0.00 | buy |
| Empowered Funds, LLC | 137,220 | 108,041 | -29,179 | 0.05 | 0.05 | -0.01 | sell |