| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 5,440 | 1,028,255 | +1,022,815 | 0.01 | 1.05 | +1.04 | buy |
| Avoro Capital Advisors LLC | 565,000 | 1,130,000 | +565,000 | 0.24 | 0.48 | +0.24 | buy |
| Woodline Partners LP | 468,497 | 927,187 | +458,690 | 0.15 | 0.31 | +0.16 | buy |
| Capital International Investors | 822,929 | 1,277,560 | +454,631 | 0.01 | 0.01 | +0.00 | buy |
| E. Ohman J:or Asset Management AB | 490,917 | 641,869 | +150,952 | 0.50 | 0.72 | +0.22 | buy |
| Hudson Bay Capital Management LP | 160,000 | 241,807 | +81,807 | 0.03 | 0.05 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 58,000 | 95,000 | +37,000 | 0.01 | 0.01 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 152,230 | 172,865 | +20,635 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 259,036 | 273,936 | +14,900 | 2.07 | 2.37 | +0.30 | buy |
| China Universal Asset Management Co., Ltd. | 2,753 | 12,429 | +9,676 | 0.02 | 0.07 | +0.05 | buy |
| Edgestream Partners, L.P. | 41,287 | 49,489 | +8,202 | 0.09 | 0.11 | +0.02 | buy |
| E Fund Management Co., Ltd. | 15,293 | 19,531 | +4,238 | 0.03 | 0.04 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 39,159 | 41,211 | +2,052 | 0.07 | 0.07 | +0.00 | buy |
| World Investment Advisors | 14,757 | 16,707 | +1,950 | 0.08 | 0.07 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 20,135 | 21,574 | +1,439 | 0.12 | 0.13 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,799 | 3,243 | +444 | 0.05 | 0.06 | +0.02 | buy |
| Evolutionary Tree Capital Management, LLC | 51,266 | 51,687 | +421 | 1.78 | 1.75 | -0.03 | buy |
| Retirement Systems of Alabama | 327,043 | 327,453 | +410 | 0.04 | 0.04 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 175 | 143 | -32 | 0.00 | 0.00 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 100,279 | 100,226 | -53 | 0.02 | 0.02 | +0.00 | sell |
| Wealth Architects, LLC | 12,199 | 12,110 | -89 | 0.06 | 0.05 | -0.00 | sell |
| SECURIAN ASSET MANAGEMENT, INC | 9,079 | 8,979 | -100 | 0.01 | 0.01 | +0.00 | sell |
| Bank Pictet & Cie (Europe) AG | 8,885 | 8,559 | -326 | 0.01 | 0.01 | -0.00 | sell |
| Beaumont Financial Advisors, LLC | 10,622 | 10,175 | -447 | 0.03 | 0.03 | -0.00 | sell |
| Fiera Capital Corp | 59,058 | 58,036 | -1,022 | 0.01 | 0.01 | +0.00 | sell |
| Headlands Technologies LLC | 1,883 | 31 | -1,852 | 0.02 | 0.00 | -0.02 | sell |
| WEALTH EFFECTS LLC | 164,750 | 161,850 | -2,900 | 2.19 | 1.86 | -0.32 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 159,989 | 156,152 | -3,837 | 0.01 | 0.01 | +0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 47,671 | 43,644 | -4,027 | 0.16 | 0.15 | -0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 59,669 | 54,094 | -5,575 | 0.30 | 0.30 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 46,419 | 38,636 | -7,783 | 0.01 | 0.01 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 131,699 | 118,313 | -13,386 | 0.04 | 0.03 | -0.01 | sell |
| Candriam S.C.A. | 220,054 | 185,054 | -35,000 | 0.04 | 0.04 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 433,651 | 319,651 | -114,000 | 0.25 | 0.20 | -0.05 | sell |
| SECTORAL ASSET MANAGEMENT INC | 157,552 | 8,182 | -149,370 | 0.82 | 0.11 | -0.72 | sell |
| Avidity Partners Management LP | 1,063,897 | 714,000 | -349,897 | 1.15 | 0.84 | -0.32 | sell |
| Rokos Capital Management LLP | 1,675,921 | 1,229,148 | -446,773 | 0.33 | 0.33 | +0.00 | sell |