| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FRED ALGER MANAGEMENT, LLC | 306,833 | 1,832,997 | +1,526,164 | 0.04 | 0.48 | +0.44 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 993,000 | 1,832,946 | +839,946 | 0.52 | 1.55 | +1.03 | buy |
| BAKER BROS. ADVISORS LP | 1,670,762 | 2,175,645 | +504,883 | 0.42 | 0.85 | +0.43 | buy |
| Entropy Technologies, LP | 10,473 | 27,139 | +16,666 | 0.03 | 0.10 | +0.07 | buy |
| TFG Asset Management GP Ltd | 81,841 | 96,935 | +15,094 | 0.38 | 1.36 | +0.98 | buy |
| MOODY LYNN & LIEBERSON, LLC | 13,500 | 22,000 | +8,500 | 0.03 | 0.08 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 49,800 | 58,200 | +8,400 | 0.17 | 0.29 | +0.12 | buy |
| Summit Global Investments | 9,934 | 14,287 | +4,353 | 0.02 | 0.06 | +0.04 | buy |
| Virtus Investment Advisers, LLC | 7,015 | 9,749 | +2,734 | 0.07 | 0.18 | +0.11 | buy |
| Empowered Funds, LLC | 17,239 | 18,018 | +779 | 0.01 | 0.02 | +0.01 | buy |
| Wealth Architects, LLC | 12,149 | 12,268 | +119 | 0.04 | 0.07 | +0.03 | buy |
| Beaumont Financial Advisors, LLC | 10,323 | 10,388 | +65 | 0.02 | 0.05 | +0.02 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 15,000 | 15,050 | +50 | 0.00 | 0.01 | +0.00 | buy |
| Retirement Wealth Solutions LLC | 39 | 41 | +2 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 75 | 71 | -4 | 0.00 | 0.00 | +0.00 | sell |
| Clearstead Trust, LLC | 152 | 74 | -78 | 0.00 | 0.00 | -0.00 | sell |
| Tradewinds Capital Management, LLC | 185 | 90 | -95 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 820 | 545 | -275 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 2,975 | 2,668 | -307 | 0.00 | 0.00 | +0.00 | sell |
| Costello Asset Management, INC | 940 | 400 | -540 | 0.01 | 0.01 | -0.00 | sell |
| OAK RIDGE INVESTMENTS LLC | 31,536 | 30,687 | -849 | 0.07 | 0.12 | +0.05 | sell |
| Atlantic Private Wealth, LLC | 4,000 | 2,600 | -1,400 | 0.09 | 0.11 | +0.02 | sell |
| Vanguard Capital Wealth Advisors | 11,285 | 9,444 | -1,841 | 0.31 | 0.50 | +0.19 | sell |
| IvyRock Asset Management (HK) Ltd | 10,500 | 8,500 | -2,000 | 0.16 | 0.30 | +0.14 | sell |
| EDGEWOOD MANAGEMENT LLC | 30,000 | 25,000 | -5,000 | 0.00 | 0.01 | +0.00 | sell |
| Bayforest Capital Ltd | 5,644 | 54 | -5,590 | 0.09 | 0.00 | -0.09 | sell |
| PINNACLE ASSOCIATES LTD | 203,314 | 191,669 | -11,645 | 0.09 | 0.16 | +0.07 | sell |
| China Universal Asset Management Co., Ltd. | 42,234 | 30,130 | -12,104 | 0.12 | 0.15 | +0.03 | sell |
| JOHNSON INVESTMENT COUNSEL INC | 22,635 | 6,000 | -16,635 | 0.01 | 0.00 | -0.00 | sell |
| KING LUTHER CAPITAL MANAGEMENT CORP | 80,640 | 60,475 | -20,165 | 0.01 | 0.02 | +0.00 | sell |
| NEOS Investment Management LLC | 31,795 | 11,542 | -20,253 | 0.01 | 0.00 | -0.00 | sell |
| TEMA ETFS LLC | 31,795 | 11,542 | -20,253 | 0.09 | 0.06 | -0.03 | sell |
| PDT Partners, LLC | 90,819 | 70,048 | -20,771 | 0.20 | 0.30 | +0.10 | sell |
| WINTON GROUP Ltd | 28,945 | 7,891 | -21,054 | 0.04 | 0.02 | -0.02 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111,022 | 89,484 | -21,538 | 0.25 | 1.37 | +1.13 | sell |
| WEALTH EFFECTS LLC | 168,450 | 143,300 | -25,150 | 1.87 | 2.98 | +1.11 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 372,282 | 324,251 | -48,031 | 0.01 | 0.02 | +0.01 | sell |
| Exome Asset Management LLC | 104,507 | 49,758 | -54,749 | 2.38 | 1.63 | -0.75 | sell |
| MACQUARIE GROUP LTD | 72,440 | 4,182 | -68,258 | 0.00 | 0.00 | -0.00 | sell |
| Privium Fund Management B.V. | 473,951 | 398,204 | -75,747 | 2.94 | 4.87 | +1.93 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 272,974 | 158,622 | -114,352 | 0.06 | 0.07 | +0.01 | sell |
| Integral Health Asset Management, LLC | 225,000 | 100,000 | -125,000 | 0.57 | 0.34 | -0.23 | sell |
| Clearbridge Investments, LLC | 391,155 | 208,062 | -183,093 | 0.01 | 0.01 | +0.00 | sell |
| Aberdeen Group plc | 520,644 | 286,146 | -234,498 | 0.03 | 0.03 | +0.00 | sell |
| Avoro Capital Advisors LLC | 10,900,000 | 10,625,000 | -275,000 | 4.86 | 6.93 | +2.07 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,099,398 | 1,769,340 | -330,058 | 0.52 | 0.80 | +0.28 | sell |
| Siren, L.L.C. | 2,669,880 | 1,500,476 | -1,169,404 | 3.60 | 2.97 | -0.63 | sell |
| Slate Path Capital LP | 4,982,000 | 2,523,500 | -2,458,500 | 2.66 | 2.26 | -0.40 | sell |