| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 0 | 1,704,464 | +1,704,464 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 306,833 | 1,832,997 | +1,526,164 | 0.04 | 0.48 | +0.44 | buy |
| BlackRock, Inc. | 20,224,825 | 21,318,582 | +1,093,757 | 0.01 | 0.02 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 900,000 | +900,000 | 0.00 | 2.19 | +2.19 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 993,000 | 1,832,946 | +839,946 | 0.52 | 1.56 | +1.04 | buy |
| FMR LLC | 5,759,830 | 6,520,408 | +760,578 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 291,023 | 1,028,736 | +737,713 | 0.01 | 0.07 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 110,245 | 838,818 | +728,573 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 584,716 | +584,716 | 0.00 | 0.39 | +0.39 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 550,000 | +550,000 | 0.00 | 0.06 | +0.06 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 124,529 | 663,262 | +538,733 | 0.01 | 0.12 | +0.10 | buy |
| BAKER BROS. ADVISORS LP | 1,670,762 | 2,175,645 | +504,883 | 0.42 | 0.85 | +0.43 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 470,000 | +470,000 | 0.00 | 0.88 | +0.88 | buy |
| Alyeska Investment Group, L.P. | 0 | 375,371 | +375,371 | 0.00 | 0.07 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 370,000 | +370,000 | 0.00 | 0.38 | +0.38 | buy |
| JANUS HENDERSON GROUP PLC | 973,567 | 1,280,446 | +306,879 | 0.02 | 0.04 | +0.02 | buy |
| Assenagon Asset Management S.A. | 380,625 | 684,889 | +304,264 | 0.02 | 0.07 | +0.05 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 137,516 | 422,731 | +285,215 | 0.00 | 0.03 | +0.02 | buy |
| FengHe Fund Management Pte. Ltd. | 0 | 266,700 | +266,700 | 0.00 | 1.00 | +1.00 | buy |
| Fisher Asset Management, LLC | 1,053,794 | 1,311,727 | +257,933 | 0.01 | 0.03 | +0.02 | buy |
| Trexquant Investment LP | 0 | 250,944 | +250,944 | 0.00 | 0.15 | +0.15 | buy |
| Hillsdale Investment Management Inc. | 0 | 193,850 | +193,850 | 0.00 | 0.36 | +0.36 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 159,532 | +159,532 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 317,614 | 474,259 | +156,645 | 0.01 | 0.02 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 144,500 | +144,500 | 0.00 | 0.90 | +0.90 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 138,905 | +138,905 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,131,042 | 3,264,963 | +133,921 | 0.01 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 20,301 | 146,064 | +125,763 | 0.00 | 0.01 | +0.01 | buy |
| Weiss Asset Management LP | 0 | 111,375 | +111,375 | 0.00 | 0.10 | +0.10 | buy |
| Russell Investments Group, Ltd. | 12,884 | 122,115 | +109,231 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 13,616 | 112,279 | +98,663 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 13,385 | 100,385 | +87,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 814,548 | 887,848 | +73,300 | 0.01 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 80,235 | 152,507 | +72,272 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 70,000 | +70,000 | 0.00 | 0.33 | +0.33 | buy |
| UBS Group AG | 918,183 | 987,287 | +69,104 | 0.01 | 0.01 | +0.01 | buy |
| Bridgewater Associates, LP | 0 | 59,966 | +59,966 | 0.00 | 0.01 | +0.01 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 57,900 | +57,900 | 0.00 | 0.35 | +0.35 | buy |
| TD ASSET MANAGEMENT INC | 0 | 55,800 | +55,800 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 25,671 | 80,958 | +55,287 | 0.02 | 0.15 | +0.14 | buy |
| BESSEMER GROUP INC | 1,068 | 51,795 | +50,727 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 50,164 | 100,277 | +50,113 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 45,169 | 92,623 | +47,454 | 0.00 | 0.00 | +0.00 | buy |
| Orion Investment Co | 0 | 46,370 | +46,370 | 0.00 | 0.94 | +0.94 | buy |
| Caption Management, LLC | 0 | 44,900 | +44,900 | 0.00 | 0.13 | +0.13 | buy |
| Invesco Ltd. | 502,892 | 547,758 | +44,866 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 42,523 | +42,523 | 0.00 | 0.06 | +0.06 | buy |
| State of New Jersey Common Pension Fund D | 0 | 42,471 | +42,471 | 0.00 | 0.01 | +0.01 | buy |
| Magnetar Financial LLC | 0 | 39,901 | +39,901 | 0.00 | 0.03 | +0.03 | buy |
| Edgestream Partners, L.P. | 0 | 36,481 | +36,481 | 0.00 | 0.07 | +0.07 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 35,955 | +35,955 | 0.00 | 0.01 | +0.01 | buy |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 0 | 35,780 | +35,780 | 0.00 | 0.05 | +0.05 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,000 | 98,151 | +35,151 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,311,590 | 1,346,257 | +34,667 | 0.01 | 0.01 | +0.01 | buy |
| Fieldview Capital Management, LLC | 0 | 31,665 | +31,665 | 0.00 | 0.36 | +0.36 | buy |
| Swiss National Bank | 214,100 | 245,400 | +31,300 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 207,955 | 237,730 | +29,775 | 0.01 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 28,600 | +28,600 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 31,863 | 56,273 | +24,410 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 52,006 | 74,421 | +22,415 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 7,128 | 28,911 | +21,783 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 21,285 | +21,285 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 10,300 | 31,500 | +21,200 | 0.00 | 0.01 | +0.01 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 20,695 | +20,695 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 19,772 | +19,772 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF HAWAII | 0 | 19,218 | +19,218 | 0.00 | 0.06 | +0.06 | buy |
| ALLIANCEBERNSTEIN L.P. | 155,894 | 172,666 | +16,772 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 10,473 | 27,139 | +16,666 | 0.03 | 0.10 | +0.07 | buy |
| GUGGENHEIM CAPITAL LLC | 40,361 | 56,644 | +16,283 | 0.01 | 0.03 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 16,110 | +16,110 | 0.00 | 0.06 | +0.06 | buy |
| PRUDENTIAL FINANCIAL INC | 136,645 | 152,225 | +15,580 | 0.01 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 15,306 | +15,306 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 81,841 | 96,935 | +15,094 | 0.41 | 1.36 | +0.95 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,982 | 118,372 | +14,390 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,875 | 79,214 | +14,339 | 0.01 | 0.01 | +0.01 | buy |
| Baader Bank Aktiengesellschaft | 0 | 14,194 | +14,194 | 0.00 | 0.08 | +0.08 | buy |
| VestGen Advisors, LLC | 0 | 12,312 | +12,312 | 0.00 | 0.03 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 14,828 | 26,874 | +12,046 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 12,043 | +12,043 | 0.00 | 0.16 | +0.16 | buy |
| O'Neil Global Advisors, Inc. | 0 | 12,037 | +12,037 | 0.00 | 0.27 | +0.27 | buy |
| STIFEL FINANCIAL CORP | 0 | 11,811 | +11,811 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 11,552 | +11,552 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 11,550 | +11,550 | 0.00 | 0.01 | +0.01 | buy |
| Farther Finance Advisors, LLC | 395 | 11,941 | +11,546 | 0.00 | 0.01 | +0.01 | buy |
| Cypress Point Wealth Management, LLC | 0 | 11,200 | +11,200 | 0.00 | 0.16 | +0.16 | buy |
| FORA Capital, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.09 | +0.09 | buy |
| Horizon Investments, LLC | 0 | 10,698 | +10,698 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 40,682 | 51,196 | +10,514 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 278,336 | 288,578 | +10,242 | 0.00 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 386,374 | 395,311 | +8,937 | 0.00 | 0.01 | +0.00 | buy |
| Abel Hall, LLC | 0 | 8,819 | +8,819 | 0.00 | 0.14 | +0.14 | buy |
| Allianz Asset Management GmbH | 10,300 | 18,900 | +8,600 | 0.00 | 0.00 | +0.00 | buy |
| MOODY LYNN & LIEBERSON, LLC | 13,500 | 22,000 | +8,500 | 0.03 | 0.08 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 49,800 | 58,200 | +8,400 | 0.17 | 0.29 | +0.12 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,345,860 | 1,353,719 | +7,859 | 0.01 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 7,742 | +7,742 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 7,277 | +7,277 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 13,901 | 21,140 | +7,239 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 29,434 | 36,542 | +7,108 | 0.03 | 0.07 | +0.04 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 7,046 | +7,046 | 0.00 | 0.00 | +0.00 | buy |