| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 20,224,825 | 21,318,582 | +1,093,757 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 16,035,870 | 15,293,121 | -742,749 | 0.01 | 0.01 | +0.01 | sell |
| Avoro Capital Advisors LLC | 10,900,000 | 10,625,000 | -275,000 | 4.86 | 6.93 | +2.07 | sell |
| FMR LLC | 5,759,830 | 6,520,408 | +760,578 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 6,397,364 | 6,403,830 | +6,466 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,131,042 | 3,264,963 | +133,921 | 0.01 | 0.01 | +0.01 | buy |
| Slate Path Capital LP | 4,982,000 | 2,523,500 | -2,458,500 | 2.66 | 2.26 | -0.40 | sell |
| BAKER BROS. ADVISORS LP | 1,670,762 | 2,175,645 | +504,883 | 0.42 | 0.85 | +0.43 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,081,689 | 2,087,953 | +6,264 | 0.05 | 0.08 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 306,833 | 1,832,997 | +1,526,164 | 0.04 | 0.48 | +0.44 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 993,000 | 1,832,946 | +839,946 | 0.52 | 1.56 | +1.04 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,099,398 | 1,769,340 | -330,058 | 0.52 | 0.80 | +0.28 | sell |
| NORGES BANK | 0 | 1,704,464 | +1,704,464 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,773,878 | 1,677,522 | -96,356 | 0.01 | 0.02 | +0.01 | sell |
| Siren, L.L.C. | 2,669,880 | 1,500,476 | -1,169,404 | 3.60 | 2.97 | -0.63 | sell |
| MORGAN STANLEY | 1,702,674 | 1,476,005 | -226,669 | 0.00 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,345,860 | 1,353,719 | +7,859 | 0.01 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 1,311,590 | 1,346,257 | +34,667 | 0.01 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 1,053,794 | 1,311,727 | +257,933 | 0.01 | 0.03 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 973,567 | 1,280,446 | +306,879 | 0.02 | 0.04 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,759,489 | 1,260,380 | -499,109 | 0.01 | 0.02 | +0.00 | sell |
| Pictet Asset Management Holding SA | 291,023 | 1,028,736 | +737,713 | 0.01 | 0.07 | +0.06 | buy |
| UBS Group AG | 918,183 | 987,287 | +69,104 | 0.01 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 900,000 | +900,000 | 0.00 | 2.19 | +2.19 | buy |
| Bank of New York Mellon Corp | 814,548 | 887,848 | +73,300 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 110,245 | 838,818 | +728,573 | 0.00 | 0.01 | +0.01 | buy |
| Western Financial Corp/CA | 820,239 | 820,239 | 0 | 12.31 | 21.60 | +9.29 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 780,132 | 715,539 | -64,593 | 0.01 | 0.02 | +0.01 | sell |
| Assenagon Asset Management S.A. | 380,625 | 684,889 | +304,264 | 0.02 | 0.07 | +0.05 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 124,529 | 663,262 | +538,733 | 0.01 | 0.12 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 760,687 | 622,029 | -138,658 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 775,717 | 611,910 | -163,807 | 0.00 | 0.00 | +0.00 | sell |
| RTW INVESTMENTS, LP | 0 | 584,716 | +584,716 | 0.00 | 0.39 | +0.39 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 550,000 | +550,000 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 502,892 | 547,758 | +44,866 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 539,336 | 478,514 | -60,822 | 0.07 | 0.11 | +0.04 | sell |
| CITADEL ADVISORS LLC | 317,614 | 474,259 | +156,645 | 0.01 | 0.02 | +0.01 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 470,000 | +470,000 | 0.00 | 0.88 | +0.88 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 137,516 | 422,731 | +285,215 | 0.00 | 0.03 | +0.02 | buy |
| Woodline Partners LP | 1,000,158 | 400,184 | -599,974 | 0.16 | 0.10 | -0.06 | sell |
| Privium Fund Management B.V. | 473,951 | 398,204 | -75,747 | 2.94 | 4.87 | +1.93 | sell |
| Legal & General Group Plc | 386,374 | 395,311 | +8,937 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 792,966 | 376,216 | -416,750 | 0.06 | 0.05 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 0 | 375,371 | +375,371 | 0.00 | 0.07 | +0.07 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 370,000 | +370,000 | 0.00 | 0.38 | +0.38 | buy |
| RHUMBLINE ADVISERS | 371,112 | 352,395 | -18,717 | 0.01 | 0.02 | +0.01 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 372,282 | 324,251 | -48,031 | 0.01 | 0.02 | +0.01 | sell |
| BARCLAYS PLC | 350,239 | 321,833 | -28,406 | 0.00 | 0.01 | +0.00 | sell |
| Nuveen, LLC | 278,336 | 288,578 | +10,242 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 402,659 | 288,511 | -114,148 | 0.05 | 0.07 | +0.02 | sell |
| Aberdeen Group plc | 520,644 | 286,146 | -234,498 | 0.03 | 0.03 | +0.00 | sell |
| FengHe Fund Management Pte. Ltd. | 0 | 266,700 | +266,700 | 0.00 | 1.00 | +1.00 | buy |
| AMERIPRISE FINANCIAL INC | 274,163 | 257,477 | -16,686 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 250,944 | +250,944 | 0.00 | 0.15 | +0.15 | buy |
| Swiss National Bank | 214,100 | 245,400 | +31,300 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 246,072 | 242,074 | -3,998 | 0.00 | 0.01 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 207,955 | 237,730 | +29,775 | 0.01 | 0.01 | +0.01 | buy |
| Clearbridge Investments, LLC | 391,155 | 208,062 | -183,093 | 0.01 | 0.01 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 227,269 | 198,387 | -28,882 | 0.00 | 0.00 | +0.00 | sell |
| Hillsdale Investment Management Inc. | 0 | 193,850 | +193,850 | 0.00 | 0.36 | +0.36 | buy |
| PINNACLE ASSOCIATES LTD | 203,314 | 191,669 | -11,645 | 0.09 | 0.16 | +0.07 | sell |
| ALLIANCEBERNSTEIN L.P. | 155,894 | 172,666 | +16,772 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 160,985 | 159,538 | -1,447 | 0.01 | 0.02 | +0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 159,532 | +159,532 | 0.00 | 0.04 | +0.04 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 272,974 | 158,622 | -114,352 | 0.06 | 0.07 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 80,235 | 152,507 | +72,272 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 136,645 | 152,225 | +15,580 | 0.01 | 0.01 | +0.01 | buy |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 148,476 | 149,776 | +1,300 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 474,462 | 147,412 | -327,050 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 142,825 | 147,353 | +4,528 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 20,301 | 146,064 | +125,763 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 144,500 | +144,500 | 0.00 | 0.90 | +0.90 | buy |
| WEALTH EFFECTS LLC | 168,450 | 143,300 | -25,150 | 1.87 | 2.98 | +1.11 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 138,905 | +138,905 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 138,020 | 133,875 | -4,145 | 0.01 | 0.01 | +0.01 | sell |
| HighTower Advisors, LLC | 132,889 | 133,229 | +340 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,436,840 | 123,855 | -1,312,985 | 0.05 | 0.01 | -0.05 | sell |
| Russell Investments Group, Ltd. | 12,884 | 122,115 | +109,231 | 0.00 | 0.01 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 129,958 | 118,750 | -11,208 | 0.01 | 0.01 | +0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,982 | 118,372 | +14,390 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 13,616 | 112,279 | +98,663 | 0.00 | 0.01 | +0.01 | buy |
| Weiss Asset Management LP | 0 | 111,375 | +111,375 | 0.00 | 0.10 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 116,504 | 107,366 | -9,138 | 0.00 | 0.00 | +0.00 | sell |
| Neuberger Berman Group LLC | 13,385 | 100,385 | +87,000 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 50,164 | 100,277 | +50,113 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 225,000 | 100,000 | -125,000 | 0.57 | 0.34 | -0.23 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,000 | 98,151 | +35,151 | 0.00 | 0.01 | +0.00 | buy |
| TFG Asset Management GP Ltd | 81,841 | 96,935 | +15,094 | 0.41 | 1.36 | +0.95 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 99,744 | 95,001 | -4,743 | 0.01 | 0.01 | +0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 45,169 | 92,623 | +47,454 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 111,022 | 89,484 | -21,538 | 0.25 | 1.37 | +1.13 | sell |
| Rafferty Asset Management, LLC | 114,379 | 84,469 | -29,910 | 0.01 | 0.02 | +0.01 | sell |
| Aquatic Capital Management LLC | 25,671 | 80,958 | +55,287 | 0.02 | 0.15 | +0.14 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,875 | 79,214 | +14,339 | 0.01 | 0.01 | +0.01 | buy |
| Pinion Investment Advisors, LLC | 75,000 | 75,000 | 0 | 0.78 | 1.21 | +0.44 | hold |
| Creative Planning | 52,006 | 74,421 | +22,415 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 71,963 | 73,040 | +1,077 | 0.01 | 0.02 | +0.01 | buy |
| Erste Asset Management GmbH | 73,000 | 73,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| State of Alaska, Department of Revenue | 69,568 | 70,399 | +831 | 0.02 | 0.05 | +0.03 | buy |
| PDT Partners, LLC | 90,819 | 70,048 | -20,771 | 0.20 | 0.30 | +0.10 | sell |