| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 17,763,720 | 17,676,767 | -86,953 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 12,777,003 | 17,477,344 | +4,700,341 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 13,050,000 | 13,050,000 | 0 | 1.08 | 0.77 | -0.31 | hold |
| BAKER BROS. ADVISORS LP | 10,126,176 | 10,126,176 | 0 | 0.69 | 0.65 | -0.04 | hold |
| Kynam Capital Management, LP | 4,600,000 | 6,527,491 | +1,927,491 | 3.12 | 3.69 | +0.57 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,539,525 | 4,995,000 | +455,475 | 0.50 | 0.44 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,260,638 | 4,400,271 | +139,633 | 0.00 | 0.00 | -0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,669,484 | 4,099,484 | +2,430,000 | 0.07 | 0.11 | +0.05 | buy |
| RP Management, LLC | 3,846,154 | 3,846,154 | 0 | 15.49 | 10.85 | -4.64 | hold |
| Rock Springs Capital Management LP | 3,270,381 | 3,496,256 | +225,875 | 0.48 | 0.45 | -0.03 | buy |
| GW&K Investment Management, LLC | 2,337,683 | 3,453,908 | +1,116,225 | 0.13 | 0.15 | +0.02 | buy |
| BRAIDWELL LP | 5,718,477 | 3,379,577 | -2,338,900 | 1.26 | 0.55 | -0.70 | sell |
| Fisher Asset Management, LLC | 2,884,569 | 2,884,619 | +50 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 2,268,012 | 2,473,412 | +205,400 | 0.03 | 0.03 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,212,979 | 2,335,191 | +1,122,212 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,193,964 | 2,274,775 | +1,080,811 | 0.01 | 0.01 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,197,261 | 2,151,545 | -45,716 | 0.76 | 0.62 | -0.14 | sell |
| Cutter Capital Management, LP | 1,521,812 | 2,105,459 | +583,647 | 4.36 | 4.12 | -0.23 | buy |
| MORGAN STANLEY | 3,136,688 | 2,008,045 | -1,128,643 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,774,754 | 1,925,365 | +150,611 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 1,844,055 | 1,843,936 | -119 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 2,715,894 | 1,835,076 | -880,818 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,676,182 | 1,830,169 | +153,987 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 1,846,766 | 1,805,175 | -41,591 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,739,317 | 1,749,448 | +10,131 | 0.20 | 0.17 | -0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,594,436 | 1,731,803 | +137,367 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 1,616,244 | +1,616,244 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,754,980 | 1,590,380 | -164,600 | 0.02 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 2,351,720 | 1,574,641 | -777,079 | 0.03 | 0.02 | -0.01 | sell |
| Rafferty Asset Management, LLC | 955,587 | 1,569,782 | +614,195 | 0.02 | 0.03 | +0.01 | buy |
| Eversept Partners, LP | 1,529,047 | 1,432,427 | -96,620 | 0.90 | 0.54 | -0.35 | sell |
| Prosight Management, LP | 2,232,242 | 1,400,000 | -832,242 | 5.37 | 1.98 | -3.39 | sell |
| BANK OF AMERICA CORP /DE/ | 1,420,294 | 1,366,167 | -54,127 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 334,867 | 1,116,957 | +782,090 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 822,940 | 1,116,678 | +293,738 | 0.01 | 0.01 | +0.00 | buy |
| Sarissa Capital Management LP | 1,000,000 | 1,094,168 | +94,168 | 0.92 | 0.97 | +0.05 | buy |
| NORGES BANK | 2,216,612 | 1,006,029 | -1,210,583 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 826,617 | 999,316 | +172,699 | 0.01 | 0.00 | -0.00 | buy |
| UBS Group AG | 684,988 | 996,555 | +311,567 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,081,646 | 967,722 | -113,924 | 0.03 | 0.02 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.44 | 0.42 | -0.02 | hold |
| Caligan Partners LP | 0 | 758,502 | +758,502 | 0.00 | 1.02 | +1.02 | buy |
| OSAIC HOLDINGS, INC. | 693,029 | 750,694 | +57,665 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,026,042 | 748,794 | -277,248 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 691,698 | 719,442 | +27,744 | 0.02 | 0.02 | -0.00 | buy |
| DAFNA Capital Management LLC | 709,500 | 709,500 | 0 | 1.02 | 0.82 | -0.20 | hold |
| Bank of New York Mellon Corp | 751,985 | 689,708 | -62,277 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,028,503 | 667,394 | -361,109 | 0.01 | 0.01 | -0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 669,067 | 632,559 | -36,508 | 0.02 | 0.02 | -0.01 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 535,558 | 535,558 | 0 | 3.50 | 2.19 | -1.31 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 462,334 | +462,334 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 373,944 | 457,370 | +83,426 | 0.00 | 0.00 | -0.00 | buy |
| Assenagon Asset Management S.A. | 529,419 | 386,885 | -142,534 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 311,198 | 380,523 | +69,325 | 0.21 | 0.18 | -0.02 | buy |
| Swiss National Bank | 373,468 | 363,968 | -9,500 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 130,000 | 300,000 | +170,000 | 0.01 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 294,651 | 299,749 | +5,098 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 336,765 | 297,822 | -38,943 | 0.08 | 0.06 | -0.02 | sell |
| Legal & General Group Plc | 309,053 | 276,691 | -32,362 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 704,529 | 276,258 | -428,271 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 547,537 | 269,076 | -278,461 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 246,974 | 246,974 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PROFUND ADVISORS LLC | 155,389 | 241,872 | +86,483 | 0.04 | 0.05 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 236,220 | 236,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 221,552 | 212,781 | -8,771 | 0.02 | 0.01 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 211,531 | +211,531 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 199,961 | 184,788 | -15,173 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 1,042,912 | 177,100 | -865,812 | 0.08 | 0.01 | -0.07 | sell |
| ExodusPoint Capital Management, LP | 192,202 | 172,961 | -19,241 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 790,163 | 167,782 | -622,381 | 0.01 | 0.00 | -0.01 | sell |
| CITADEL ADVISORS LLC | 369,636 | 160,085 | -209,551 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 96,397 | 156,119 | +59,722 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 138,101 | 145,406 | +7,305 | 0.01 | 0.01 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 145,444 | 145,324 | -120 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 160,724 | 141,387 | -19,337 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 122,180 | 138,074 | +15,894 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 154,761 | 136,849 | -17,912 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 113,684 | 130,775 | +17,091 | 0.00 | 0.00 | -0.00 | buy |
| Laurion Capital Management LP | 133,775 | 122,437 | -11,338 | 0.03 | 0.02 | -0.01 | sell |
| Redwood Investment Management, LLC | 0 | 122,270 | +122,270 | 0.00 | 0.06 | +0.06 | buy |
| ROYAL BANK OF CANADA | 113,523 | 120,262 | +6,739 | 0.00 | 0.00 | -0.00 | buy |
| Trexquant Investment LP | 421,516 | 116,933 | -304,583 | 0.06 | 0.01 | -0.04 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 190,541 | 114,063 | -76,478 | 0.01 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 113,800 | 113,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,194 | 99,429 | +1,235 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 97,438 | 99,411 | +1,973 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 320,674 | 97,614 | -223,060 | 0.01 | 0.00 | -0.01 | sell |
| HSBC HOLDINGS PLC | 21,035 | 94,216 | +73,181 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 94,217 | 93,415 | -802 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 53,330 | 89,614 | +36,284 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 97,361 | 88,970 | -8,391 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 92,860 | 88,400 | -4,460 | 0.00 | 0.00 | -0.00 | sell |
| DOLIVER ADVISORS, LP | 81,000 | 81,000 | 0 | 0.15 | 0.12 | -0.03 | hold |
| JANUS HENDERSON GROUP PLC | 80,287 | 80,385 | +98 | 0.00 | 0.00 | -0.00 | buy |
| Empire Financial Management Company, LLC | 73,500 | 79,000 | +5,500 | 0.17 | 0.13 | -0.04 | buy |
| SHERBROOKE PARK ADVISERS LLC | 12,763 | 78,814 | +66,051 | 0.04 | 0.08 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 0 | 76,927 | +76,927 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 51,317 | 74,180 | +22,863 | 0.02 | 0.02 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 73,765 | 73,765 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GRIMES & COMPANY, INC. | 72,355 | 71,439 | -916 | 0.01 | 0.01 | -0.00 | sell |