| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JUPITER ASSET MANAGEMENT LTD | 1,177,929 | 2,148,969 | +971,040 | 0.09 | 0.15 | +0.07 | buy |
| Parkman Healthcare Partners LLC | 216,881 | 1,000,562 | +783,681 | 0.22 | 0.89 | +0.67 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 633,864 | 1,042,424 | +408,560 | 0.02 | 0.03 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 983,033 | 589,310 | +393,723 | 0.01 | 0.01 | 0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 839,274 | 1,201,449 | +362,175 | 0.01 | 0.01 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,774,214 | 2,045,535 | +271,321 | 0.03 | 0.04 | 0.00 | buy |
| PDT Partners, LLC | 522,290 | 778,729 | +256,439 | 0.35 | 0.41 | +0.07 | buy |
| ALGERT GLOBAL LLC | 725,305 | 960,057 | +234,752 | 0.13 | 0.18 | 0.00 | buy |
| Eversept Partners, LP | 1,980,312 | 2,172,436 | +192,124 | 1.32 | 1.65 | +0.33 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 7,093,822 | 7,214,021 | +120,199 | 0.11 | 0.11 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 164,484 | 278,552 | +114,068 | 0.10 | 0.21 | 0.00 | buy |
| Caligan Partners LP | 2,995,932 | 3,107,669 | +111,737 | 5.71 | 4.86 | -0.84 | buy |
| Y-Intercept (Hong Kong) Ltd | 68,623 | 141,865 | +73,242 | 0.03 | 0.07 | 0.00 | buy |
| GW&K Investment Management, LLC | 2,941,396 | 2,884,680 | +56,716 | 0.19 | 0.20 | +0.01 | sell |
| AlphaQuest LLC | 28,442 | 62,646 | +34,204 | 0.03 | 0.06 | 0.00 | buy |
| Knott David M Jr | 440,000 | 460,000 | +20,000 | 1.20 | 1.63 | +0.43 | buy |
| Rafferty Asset Management, LLC | 234,836 | 253,325 | +18,489 | 0.01 | 0.01 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 47,100 | 56,704 | +9,604 | 0.00 | 0.00 | 0.00 | buy |
| E Fund Management Co., Ltd. | 16,612 | 23,674 | +7,062 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 47,750 | 53,981 | +6,231 | 0.01 | 0.02 | +0.00 | buy |
| R Squared Ltd | 6,335 | 11,670 | +5,335 | 0.05 | 0.09 | +0.05 | buy |
| GF FUND MANAGEMENT CO. LTD. | 4,349 | 5,303 | +954 | 0.00 | 0.00 | +0.00 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 61,516 | 62,188 | +672 | 0.09 | 0.09 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 19,434 | 19,114 | +320 | 0.01 | 0.01 | 0.00 | sell |
| Pinnacle Wealth Planning Services, Inc. | 12,710 | 12,914 | +204 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 101,188 | 101,378 | +190 | 0.00 | 0.00 | 0.00 | buy |
| SYON CAPITAL LLC | 13,149 | 12,105 | -1,044 | 0.01 | 0.01 | -0.00 | sell |
| Legato Capital Management LLC | 23,593 | 22,122 | -1,471 | 0.02 | 0.02 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 43,920 | 41,914 | -2,006 | 0.03 | 0.03 | -0.00 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 60,370 | 58,152 | -2,218 | 0.05 | 0.05 | -0.00 | sell |
| SkyView Investment Advisors, LLC | 13,000 | 10,500 | -2,500 | 0.02 | 0.01 | -0.00 | sell |
| GRIMES & COMPANY, INC. | 75,275 | 72,707 | -2,568 | 0.02 | 0.02 | +0.00 | sell |
| Inspire Investing, LLC | 53,479 | 45,901 | -7,578 | 0.05 | 0.04 | -0.00 | sell |
| Semanteon Capital Management, LP | 197,760 | 189,706 | -8,054 | 0.80 | 0.77 | -0.03 | sell |
| Teza Capital Management LLC | 47,874 | 35,579 | -12,295 | 0.05 | 0.12 | +0.07 | sell |
| ALPS ADVISORS INC | 167,492 | 152,985 | -14,507 | 0.01 | 0.01 | -0.00 | sell |
| Freestone Grove Partners LP | 30,313 | 14,735 | -15,578 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 32,337 | 16,269 | -16,068 | 0.14 | 0.40 | +0.26 | sell |
| Hillsdale Investment Management Inc. | 542,100 | 522,300 | -19,800 | 0.21 | 0.20 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 35,000 | 10,000 | -25,000 | 0.05 | 0.01 | -0.04 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 68,040 | 29,425 | -38,615 | 0.09 | 0.03 | -0.06 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,081,316 | 2,027,568 | -53,748 | 0.86 | 0.89 | +0.03 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,422,196 | 1,330,314 | -91,882 | 0.15 | 0.15 | +0.01 | sell |
| DAFNA Capital Management LLC | 667,000 | 558,255 | -108,745 | 1.27 | 1.19 | -0.09 | sell |
| Fisher Asset Management, LLC | 3,182,617 | 3,052,137 | -130,480 | 0.01 | 0.01 | +0.00 | sell |
| Kynam Capital Management, LP | 9,085,368 | 8,928,523 | -156,845 | 4.51 | 5.73 | +1.22 | sell |
| Rock Springs Capital Management LP | 2,677,996 | 222,011 | -2,455,985 | 0.77 | 0.10 | -0.67 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,144,442 | 5,189,665 | -2,954,777 | 1.16 | 0.77 | -0.39 | sell |
| Avoro Capital Advisors LLC | 11,865,000 | 8,700,000 | -3,165,000 | 1.26 | 1.02 | -0.24 | sell |