| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 21,137,791 | 22,650,988 | +1,513,197 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 15,827,186 | 15,827,186 | 0 | 1.26 | 1.60 | +0.33 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 14,341,000 | 15,038,000 | +697,000 | 1.43 | 1.69 | +0.25 | buy |
| STATE STREET CORP | 11,073,211 | 12,208,360 | +1,135,149 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 11,020,968 | +11,020,968 | 0.00 | 3.00 | +3.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,404,386 | 8,908,506 | +1,504,120 | 0.03 | 0.04 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 3,162,529 | 7,434,033 | +4,271,504 | 0.45 | 1.40 | +0.95 | buy |
| Vestal Point Capital, LP | 2,250,000 | 7,025,000 | +4,775,000 | 0.64 | 1.87 | +1.23 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,515,317 | 6,392,628 | +1,877,311 | 0.05 | 0.05 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,053,786 | 5,782,776 | +728,990 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 9,366,526 | 5,680,795 | -3,685,731 | 4.76 | 3.43 | -1.32 | sell |
| BANK OF AMERICA CORP /DE/ | 1,535,557 | 5,091,765 | +3,556,208 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 913,593 | 5,040,670 | +4,127,077 | 0.01 | 0.08 | +0.07 | buy |
| UBS Group AG | 5,263,914 | 4,943,994 | -319,920 | 0.01 | 0.01 | +0.00 | sell |
| Frazier Life Sciences Management, L.P. | 0 | 4,009,240 | +4,009,240 | 0.00 | 0.98 | +0.98 | buy |
| Nuveen, LLC | 3,612,366 | 3,819,263 | +206,897 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 3,160,924 | 3,240,462 | +79,538 | 0.21 | 0.27 | +0.06 | buy |
| Eversept Partners, LP | 2,992,895 | 3,039,820 | +46,925 | 1.31 | 1.91 | +0.60 | buy |
| RFG Advisory, LLC | 0 | 2,870,700 | +2,870,700 | 0.00 | 0.50 | +0.50 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 671,693 | 2,815,304 | +2,143,611 | 0.01 | 0.03 | +0.03 | buy |
| Fisher Asset Management, LLC | 2,467,567 | 2,733,253 | +265,686 | 0.01 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,228,852 | 2,690,651 | +1,461,799 | 0.00 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,004,939 | 2,350,405 | +345,466 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 3,212,785 | 2,347,443 | -865,342 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 0 | 2,286,841 | +2,286,841 | 0.00 | 0.11 | +0.11 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,904,146 | 2,230,105 | +325,959 | 0.82 | 1.18 | +0.36 | buy |
| NORTHERN TRUST CORP | 1,856,903 | 2,104,725 | +247,822 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,745,563 | 2,022,988 | +277,425 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,356,377 | 1,987,397 | +631,020 | 0.63 | 1.18 | +0.55 | buy |
| STIFEL FINANCIAL CORP | 1,824,517 | 1,825,184 | +667 | 0.01 | 0.02 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 900,057 | 1,708,099 | +808,042 | 0.67 | 1.69 | +1.02 | buy |
| Pacer Advisors, Inc. | 0 | 1,563,040 | +1,563,040 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 843,370 | 1,541,978 | +698,608 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,741,800 | 1,425,200 | -316,600 | 0.28 | 0.30 | +0.02 | sell |
| Legal & General Group Plc | 210,999 | 1,411,199 | +1,200,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 141,449 | 1,337,693 | +1,196,244 | 0.01 | 0.10 | +0.10 | buy |
| Invesco Ltd. | 1,354,897 | 1,308,813 | -46,084 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,542,714 | 1,302,257 | -1,240,457 | 0.01 | 0.01 | -0.00 | sell |
| Man Group plc | 407,850 | 1,293,300 | +885,450 | 0.01 | 0.03 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 1,227,040 | +1,227,040 | 0.00 | 0.02 | +0.02 | buy |
| JUPITER ASSET MANAGEMENT LTD | 1,197,619 | 1,196,371 | -1,248 | 0.07 | 0.06 | -0.01 | sell |
| CITADEL ADVISORS LLC | 1,298,902 | 1,018,743 | -280,159 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,031,488 | 1,004,373 | -27,115 | 0.03 | 0.04 | +0.01 | sell |
| Rosalind Advisors, Inc. | 0 | 923,057 | +923,057 | 0.00 | 3.60 | +3.60 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 837,889 | 866,464 | +28,575 | 1.37 | 1.42 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 491,086 | 821,367 | +330,281 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 374,961 | 800,900 | +425,939 | 0.00 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,128,821 | 776,990 | -1,351,831 | 0.03 | 0.01 | -0.01 | sell |
| Hillsdale Investment Management Inc. | 559,100 | 639,100 | +80,000 | 0.12 | 0.17 | +0.05 | buy |
| Bridgewater Associates, LP | 235,572 | 638,054 | +402,482 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 607,992 | 637,658 | +29,666 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 560,182 | 633,132 | +72,950 | 0.00 | 0.00 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 631,290 | +631,290 | 0.00 | 0.09 | +0.09 | buy |
| JANE STREET GROUP, LLC | 649,357 | 622,607 | -26,750 | 0.01 | 0.01 | +0.00 | sell |
| PDT Partners, LLC | 683,416 | 563,440 | -119,976 | 0.35 | 0.32 | -0.03 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 625,490 | 536,304 | -89,186 | 0.00 | 0.01 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 570,189 | 523,281 | -46,908 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 1,017,374 | 490,369 | -527,005 | 0.05 | 0.03 | -0.02 | sell |
| Pictet Asset Management Holding SA | 740,510 | 471,573 | -268,937 | 0.01 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 704,291 | 440,141 | -264,150 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 376,568 | 430,558 | +53,990 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 418,255 | 430,248 | +11,993 | 0.76 | 0.93 | +0.17 | buy |
| Swiss National Bank | 394,368 | 408,668 | +14,300 | 0.00 | 0.00 | +0.00 | buy |
| DOLIVER ADVISORS, LP | 274,328 | 374,328 | +100,000 | 0.54 | 0.81 | +0.27 | buy |
| Susquehanna Portfolio Strategies, LLC | 778,521 | 374,016 | -404,505 | 0.09 | 0.05 | -0.04 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 378,853 | 368,978 | -9,875 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 382,556 | 354,260 | -28,296 | 0.01 | 0.01 | +0.00 | sell |
| Gotham Asset Management, LLC | 216,946 | 312,961 | +96,015 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 292,850 | 306,464 | +13,614 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,247,466 | 302,101 | -945,365 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 347,190 | 279,064 | -68,126 | 0.01 | 0.01 | +0.00 | sell |
| Russell Investments Group, Ltd. | 229,226 | 271,668 | +42,442 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 266,562 | 266,137 | -425 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 278,190 | 263,669 | -14,521 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 191,847 | 258,345 | +66,498 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 246,477 | +246,477 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 150,728 | 243,416 | +92,688 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 233,639 | 236,941 | +3,302 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 359,580 | 232,947 | -126,633 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 177,392 | 230,996 | +53,604 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 233,354 | 213,254 | -20,100 | 0.01 | 0.02 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 57,351 | 208,903 | +151,552 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 202,900 | +202,900 | 0.00 | 0.30 | +0.30 | buy |
| Phocas Financial Corp. | 250,797 | 195,540 | -55,257 | 0.25 | 0.29 | +0.04 | sell |
| Engineers Gate Manager LP | 224,543 | 194,475 | -30,068 | 0.02 | 0.02 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 190,058 | +190,058 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 137,626 | 187,721 | +50,095 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 186,125 | +186,125 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 85,300 | 180,010 | +94,710 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 26,133 | 163,266 | +137,133 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 131,103 | 160,531 | +29,428 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 141,985 | 158,462 | +16,477 | 0.03 | 0.06 | +0.02 | buy |
| QTR Family Wealth, LLC | 154,062 | 157,062 | +3,000 | 0.44 | 0.63 | +0.19 | buy |
| SEI INVESTMENTS CO | 103,157 | 150,264 | +47,107 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 60,524 | 136,282 | +75,758 | 0.01 | 0.04 | +0.03 | buy |
| BARCLAYS PLC | 726,367 | 133,597 | -592,770 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 119,567 | 131,160 | +11,593 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 117,853 | 130,171 | +12,318 | 0.00 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 123,961 | +123,961 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 327,941 | 118,005 | -209,936 | 0.00 | 0.00 | -0.00 | sell |