| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 11,020,968 | +11,020,968 | 0.00 | 3.00 | +3.00 | buy |
| Vestal Point Capital, LP | 2,250,000 | 7,025,000 | +4,775,000 | 0.64 | 1.87 | +1.23 | buy |
| PERCEPTIVE ADVISORS LLC | 3,162,529 | 7,434,033 | +4,271,504 | 0.45 | 1.40 | +0.95 | buy |
| Aberdeen Group plc | 913,593 | 5,040,670 | +4,127,077 | 0.01 | 0.08 | +0.07 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 4,009,240 | +4,009,240 | 0.00 | 0.98 | +0.98 | buy |
| BANK OF AMERICA CORP /DE/ | 1,535,557 | 5,091,765 | +3,556,208 | 0.00 | 0.00 | +0.00 | buy |
| RFG Advisory, LLC | 0 | 2,870,700 | +2,870,700 | 0.00 | 0.50 | +0.50 | buy |
| Candriam S.C.A. | 0 | 2,286,841 | +2,286,841 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 671,693 | 2,815,304 | +2,143,611 | 0.01 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,515,317 | 6,392,628 | +1,877,311 | 0.05 | 0.05 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 1,563,040 | +1,563,040 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 21,137,791 | 22,650,988 | +1,513,197 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 7,404,386 | 8,908,506 | +1,504,120 | 0.03 | 0.04 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,228,852 | 2,690,651 | +1,461,799 | 0.00 | 0.01 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 1,227,040 | +1,227,040 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 210,999 | 1,411,199 | +1,200,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 141,449 | 1,337,693 | +1,196,244 | 0.01 | 0.10 | +0.10 | buy |
| STATE STREET CORP | 11,073,211 | 12,208,360 | +1,135,149 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 0 | 923,057 | +923,057 | 0.00 | 3.60 | +3.60 | buy |
| Man Group plc | 407,850 | 1,293,300 | +885,450 | 0.01 | 0.03 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 900,057 | 1,708,099 | +808,042 | 0.67 | 1.69 | +1.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,053,786 | 5,782,776 | +728,990 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 843,370 | 1,541,978 | +698,608 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 14,341,000 | 15,038,000 | +697,000 | 1.43 | 1.69 | +0.25 | buy |
| IMC-Chicago, LLC | 0 | 631,290 | +631,290 | 0.00 | 0.09 | +0.09 | buy |
| Nantahala Capital Management, LLC | 1,356,377 | 1,987,397 | +631,020 | 0.63 | 1.18 | +0.55 | buy |
| FIRST TRUST ADVISORS LP | 374,961 | 800,900 | +425,939 | 0.00 | 0.01 | +0.00 | buy |
| Bridgewater Associates, LP | 235,572 | 638,054 | +402,482 | 0.01 | 0.03 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,004,939 | 2,350,405 | +345,466 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 491,086 | 821,367 | +330,281 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,904,146 | 2,230,105 | +325,959 | 0.82 | 1.18 | +0.36 | buy |
| MORGAN STANLEY | 1,745,563 | 2,022,988 | +277,425 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 2,467,567 | 2,733,253 | +265,686 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,856,903 | 2,104,725 | +247,822 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 246,477 | +246,477 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 3,612,366 | 3,819,263 | +206,897 | 0.01 | 0.01 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 202,900 | +202,900 | 0.00 | 0.30 | +0.30 | buy |
| ExodusPoint Capital Management, LP | 0 | 190,058 | +190,058 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 186,125 | +186,125 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 57,351 | 208,903 | +151,552 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 26,133 | 163,266 | +137,133 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 123,961 | +123,961 | 0.00 | 0.01 | +0.01 | buy |
| DOLIVER ADVISORS, LP | 274,328 | 374,328 | +100,000 | 0.54 | 0.81 | +0.27 | buy |
| Gotham Asset Management, LLC | 216,946 | 312,961 | +96,015 | 0.01 | 0.01 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 85,300 | 180,010 | +94,710 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 150,728 | 243,416 | +92,688 | 0.00 | 0.00 | +0.00 | buy |
| Weiss Asset Management LP | 0 | 82,100 | +82,100 | 0.00 | 0.01 | +0.01 | buy |
| Hillsdale Investment Management Inc. | 559,100 | 639,100 | +80,000 | 0.12 | 0.17 | +0.05 | buy |
| GW&K Investment Management, LLC | 3,160,924 | 3,240,462 | +79,538 | 0.21 | 0.27 | +0.06 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 78,103 | +78,103 | 0.00 | 0.07 | +0.07 | buy |
| GROUP ONE TRADING LLC | 60,524 | 136,282 | +75,758 | 0.01 | 0.04 | +0.03 | buy |
| Cresset Asset Management, LLC | 0 | 74,814 | +74,814 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 560,182 | 633,132 | +72,950 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 70,830 | +70,830 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 70,800 | +70,800 | 0.00 | 0.04 | +0.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 191,847 | 258,345 | +66,498 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 0 | 65,365 | +65,365 | 0.00 | 0.11 | +0.11 | buy |
| Legato Capital Management LLC | 23,949 | 87,010 | +63,061 | 0.02 | 0.08 | +0.06 | buy |
| ALPS ADVISORS INC | 0 | 60,250 | +60,250 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 45,000 | 105,000 | +60,000 | 0.03 | 0.06 | +0.03 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 57,138 | +57,138 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 23,152 | 80,061 | +56,909 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 56,529 | +56,529 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 376,568 | 430,558 | +53,990 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 53,965 | +53,965 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 177,392 | 230,996 | +53,604 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 51,893 | 103,862 | +51,969 | 0.04 | 0.12 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 137,626 | 187,721 | +50,095 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 103,157 | 150,264 | +47,107 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 2,992,895 | 3,039,820 | +46,925 | 1.31 | 1.91 | +0.60 | buy |
| Russell Investments Group, Ltd. | 229,226 | 271,668 | +42,442 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 41,165 | +41,165 | 0.00 | 0.01 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 12,790 | 53,776 | +40,986 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 40,889 | +40,889 | 0.00 | 0.10 | +0.10 | buy |
| AXQ CAPITAL, LP | 0 | 38,952 | +38,952 | 0.00 | 0.05 | +0.05 | buy |
| WINTON GROUP Ltd | 15,600 | 53,216 | +37,616 | 0.00 | 0.02 | +0.01 | buy |
| Cetera Investment Advisers | 12,330 | 48,413 | +36,083 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 607,992 | 637,658 | +29,666 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 29,554 | +29,554 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 131,103 | 160,531 | +29,428 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 837,889 | 866,464 | +28,575 | 1.37 | 1.42 | +0.05 | buy |
| Vontobel Holding Ltd. | 0 | 27,000 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 26,600 | +26,600 | 0.00 | 0.61 | +0.61 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 64,507 | 90,977 | +26,470 | 0.07 | 0.13 | +0.05 | buy |
| Corient Private Wealth LLC | 70,378 | 95,467 | +25,089 | 0.00 | 0.00 | +0.00 | buy |
| BENDER ROBERT & ASSOCIATES | 0 | 23,710 | +23,710 | 0.00 | 0.05 | +0.05 | buy |
| NAVELLIER & ASSOCIATES INC | 21,903 | 45,286 | +23,383 | 0.02 | 0.04 | +0.03 | buy |
| Tower Research Capital LLC (TRC) | 1,524 | 23,887 | +22,363 | 0.00 | 0.01 | +0.01 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 22,167 | +22,167 | 0.00 | 0.00 | +0.00 | buy |
| Vinva Investment Management Ltd | 18,733 | 40,321 | +21,588 | 0.00 | 0.01 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 0 | 21,353 | +21,353 | 0.00 | 0.03 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 90,278 | 111,529 | +21,251 | 0.19 | 0.29 | +0.10 | buy |
| nVerses Capital, LLC | 0 | 20,422 | +20,422 | 0.00 | 0.18 | +0.18 | buy |
| Entropy Technologies, LP | 56,517 | 75,908 | +19,391 | 0.02 | 0.03 | +0.01 | buy |
| DnB Asset Management AS | 0 | 19,285 | +19,285 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 19,271 | +19,271 | 0.00 | 0.07 | +0.07 | buy |
| Brevan Howard Capital Management LP | 0 | 18,888 | +18,888 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 141,985 | 158,462 | +16,477 | 0.03 | 0.06 | +0.02 | buy |
| AVIVA PLC | 0 | 15,695 | +15,695 | 0.00 | 0.00 | +0.00 | buy |
| BHK Investment Advisors, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.05 | +0.05 | buy |