| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,765,000 | 1,322,000 | +1,443,000 | 0.51 | 0.20 | 0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 4,437,329 | 5,302,020 | +864,691 | 0.06 | 0.05 | 0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,600,000 | 2,450,000 | +850,000 | 1.99 | 2.54 | 0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 1,268,852 | 1,672,313 | +403,461 | 0.07 | 0.07 | 0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 1,837,854 | 2,037,688 | +199,834 | 0.17 | 0.15 | 0.00 | buy |
| Rock Springs Capital Management LP | 2,334,085 | 2,497,193 | +163,108 | 0.46 | 0.42 | -0.05 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 94,440 | 190,541 | +96,101 | 0.01 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 153,718 | 71,532 | +82,186 | 0.14 | 0.06 | 0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 15,700 | 80,600 | +64,900 | 0.00 | 0.01 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 347,611 | 401,209 | +53,598 | 0.02 | 0.01 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 42,523 | 78,295 | +35,772 | 0.05 | 0.08 | 0.00 | buy |
| ALGERT GLOBAL LLC | 260,986 | 291,556 | +30,570 | 0.10 | 0.09 | 0.00 | buy |
| PROFUND ADVISORS LLC | 152,754 | 176,892 | +24,138 | 0.08 | 0.07 | 0.00 | buy |
| ALPS ADVISORS INC | 122,818 | 138,878 | +16,060 | 0.01 | 0.01 | 0.00 | buy |
| ExodusPoint Capital Management, LP | 1,221,681 | 1,212,547 | +9,134 | 0.12 | 0.10 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,340,318 | 1,331,488 | +8,830 | 0.04 | 0.03 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 225,764 | 232,463 | +6,699 | 0.08 | 0.06 | 0.00 | buy |
| GW&K Investment Management, LLC | 2,603,931 | 2,598,242 | +5,689 | 0.21 | 0.17 | -0.04 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 37,588 | 42,481 | +4,893 | 0.03 | 0.02 | -0.01 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 10,300 | 12,100 | +1,800 | 0.00 | 0.00 | 0.00 | buy |
| NATIXIS | 2,927 | 2,334 | +593 | 0.00 | 0.00 | 0.00 | sell |
| Itau Unibanco Holding S.A. | 428 | 377 | +51 | 0.00 | 0.00 | 0.00 | sell |