| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 758,502 | 4,598,737 | +3,840,235 | 1.02 | 6.64 | +5.62 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,995,000 | 8,135,804 | +3,140,804 | 0.44 | 0.84 | +0.40 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 4,099,484 | 7,099,484 | +3,000,000 | 0.04 | 0.07 | +0.04 | buy |
| Kynam Capital Management, LP | 6,527,491 | 8,826,710 | +2,299,219 | 3.69 | 5.71 | +2.02 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 156,119 | 739,599 | +583,480 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 241,872 | 86,815 | +155,057 | 0.05 | 0.02 | 0.00 | sell |
| Rock Springs Capital Management LP | 3,496,256 | 3,619,258 | +123,002 | 0.45 | 0.67 | +0.22 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,574,641 | 1,674,391 | +99,750 | 0.02 | 0.03 | 0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 719,442 | 782,664 | +63,222 | 0.02 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 297,822 | 353,133 | +55,311 | 0.06 | 0.08 | 0.00 | buy |
| Laurion Capital Management LP | 122,437 | 148,655 | +26,218 | 0.01 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 20,000 | 40,000 | +20,000 | 0.08 | 0.23 | +0.15 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 18,518 | 36,112 | +17,594 | 0.02 | 0.04 | +0.02 | buy |
| Teza Capital Management LLC | 45,035 | 61,675 | +16,640 | 0.03 | 0.05 | +0.02 | buy |
| ALPS ADVISORS INC | 145,406 | 161,003 | +15,597 | 0.01 | 0.01 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 44,503 | 54,055 | +9,552 | 0.00 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 89,614 | 97,577 | +7,963 | 0.00 | 0.00 | 0.00 | buy |
| Northeast Financial Consultants Inc | 60,633 | 65,633 | +5,000 | 0.02 | 0.02 | +0.00 | buy |
| GRIMES & COMPANY, INC. | 71,439 | 75,275 | +3,836 | 0.01 | 0.01 | +0.00 | buy |
| Diversified Trust Co | 20,978 | 24,752 | +3,774 | 0.00 | 0.00 | +0.00 | buy |
| Waverly Advisors, LLC | 17,429 | 19,713 | +2,284 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 23,225 | 23,593 | +368 | 0.01 | 0.02 | +0.01 | buy |
| Rehmann Capital Advisory Group | 12,074 | 11,999 | -75 | 0.00 | 0.01 | +0.00 | sell |
| Visionary Wealth Advisors | 28,540 | 28,240 | -300 | 0.01 | 0.01 | +0.00 | sell |
| GREAT VALLEY ADVISOR GROUP, INC. | 17,400 | 16,400 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| PERSONAL CFO SOLUTIONS, LLC | 66,731 | 61,731 | -5,000 | 0.05 | 0.06 | +0.01 | sell |
| DAFNA Capital Management LLC | 709,500 | 704,500 | -5,000 | 0.82 | 1.04 | +0.22 | sell |
| ELCO Management Co., LLC | 36,021 | 30,792 | -5,229 | 0.11 | 0.11 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 59,257 | 52,865 | -6,392 | 0.16 | 0.16 | +0.00 | sell |
| NATIXIS | 11,684 | 2,334 | -9,350 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 69,466 | 57,550 | -11,916 | 0.04 | 0.04 | +0.00 | sell |
| PDT Partners, LLC | 380,523 | 366,770 | -13,753 | 0.18 | 0.21 | +0.03 | sell |
| China Universal Asset Management Co., Ltd. | 39,639 | 24,247 | -15,392 | 0.03 | 0.02 | -0.00 | sell |
| Empire Financial Management Company, LLC | 79,000 | 59,000 | -20,000 | 0.13 | 0.12 | -0.01 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 41,101 | 16,381 | -24,720 | 0.05 | 0.02 | -0.03 | sell |
| Fisher Asset Management, LLC | 2,884,619 | 2,856,703 | -27,916 | 0.01 | 0.01 | +0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 64,365 | 30,176 | -34,189 | 0.02 | 0.00 | -0.01 | sell |
| E Fund Management Co., Ltd. | 74,180 | 28,285 | -45,895 | 0.02 | 0.01 | -0.01 | sell |
| GW&K Investment Management, LLC | 3,453,908 | 3,404,700 | -49,208 | 0.15 | 0.19 | +0.04 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,151,545 | 2,079,641 | -71,904 | 0.62 | 0.77 | +0.15 | sell |
| Hudson Bay Capital Management LP | 300,000 | 180,000 | -120,000 | 0.01 | 0.01 | -0.00 | sell |
| Cutter Capital Management, LP | 2,105,459 | 1,975,298 | -130,161 | 4.12 | 3.72 | -0.40 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,749,448 | 1,526,481 | -222,967 | 0.17 | 0.17 | +0.00 | sell |
| Eversept Partners, LP | 1,432,427 | 1,152,573 | -279,854 | 0.49 | 0.49 | +0.00 | sell |
| Avoro Capital Advisors LLC | 13,050,000 | 12,570,000 | -480,000 | 0.77 | 1.03 | +0.26 | sell |
| Prosight Management, LP | 1,400,000 | 398,700 | -1,001,300 | 1.98 | 0.74 | -1.24 | sell |
| Rafferty Asset Management, LLC | 1,569,782 | 465,731 | -1,104,051 | 0.03 | 0.01 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 10,126,176 | 75,778 | -10,050,398 | 0.65 | 0.01 | -0.64 | sell |