| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 17,676,767 | 18,769,493 | +1,092,726 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 13,050,000 | 12,570,000 | -480,000 | 0.77 | 1.03 | +0.26 | sell |
| STATE STREET CORP | 17,477,344 | 9,346,799 | -8,130,545 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 6,527,491 | 8,826,710 | +2,299,219 | 3.69 | 5.71 | +2.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,995,000 | 8,135,804 | +3,140,804 | 0.44 | 0.84 | +0.40 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 4,099,484 | 7,099,484 | +3,000,000 | 0.11 | 0.22 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,400,271 | 4,710,277 | +310,006 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 758,502 | 4,598,737 | +3,840,235 | 1.02 | 6.64 | +5.62 | buy |
| RP Management, LLC | 3,846,154 | 3,846,154 | 0 | 10.85 | 13.29 | +2.45 | hold |
| Rock Springs Capital Management LP | 3,496,256 | 3,619,258 | +123,002 | 0.45 | 0.67 | +0.22 | buy |
| GW&K Investment Management, LLC | 3,453,908 | 3,404,700 | -49,208 | 0.15 | 0.19 | +0.04 | sell |
| Fisher Asset Management, LLC | 2,884,619 | 2,856,703 | -27,916 | 0.01 | 0.01 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 967,722 | 2,590,861 | +1,623,139 | 0.02 | 0.06 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 1,925,365 | 2,530,259 | +604,894 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 462,334 | 2,135,263 | +1,672,929 | 0.06 | 0.40 | +0.34 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,151,545 | 2,079,641 | -71,904 | 0.62 | 0.77 | +0.15 | sell |
| Cutter Capital Management, LP | 2,105,459 | 1,975,298 | -130,161 | 4.12 | 3.72 | -0.40 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 130,775 | 1,948,984 | +1,818,209 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,835,076 | 1,942,279 | +107,203 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 2,473,412 | 1,919,512 | -553,900 | 0.03 | 0.03 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 2,335,191 | 1,865,623 | -469,568 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 1,843,936 | 1,843,652 | -284 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,731,803 | 1,785,134 | +53,331 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,805,175 | 1,754,763 | -50,412 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,830,169 | 1,751,561 | -78,608 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,574,641 | 1,674,391 | +99,750 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 2,008,045 | 1,577,949 | -430,096 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,749,448 | 1,526,481 | -222,967 | 0.17 | 0.17 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,366,167 | 1,300,338 | -65,829 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 1,432,427 | 1,152,573 | -279,854 | 0.54 | 0.55 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 177,100 | 1,112,232 | +935,132 | 0.01 | 0.12 | +0.11 | buy |
| Sarissa Capital Management LP | 1,094,168 | 1,094,168 | 0 | 0.97 | 1.14 | +0.17 | hold |
| Trexquant Investment LP | 116,933 | 1,037,171 | +920,238 | 0.01 | 0.10 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,590,380 | 960,180 | -630,200 | 0.01 | 0.01 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 999,316 | 846,844 | -152,472 | 0.00 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 1,116,678 | 839,508 | -277,170 | 0.01 | 0.01 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.42 | 0.50 | +0.08 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 719,442 | 782,664 | +63,222 | 0.02 | 0.02 | +0.00 | buy |
| Bank of New York Mellon Corp | 689,708 | 775,957 | +86,249 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 269,076 | 747,531 | +478,455 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 156,119 | 739,599 | +583,480 | 0.00 | 0.02 | +0.02 | buy |
| DAFNA Capital Management LLC | 709,500 | 704,500 | -5,000 | 0.82 | 1.04 | +0.22 | sell |
| NORGES BANK | 1,006,029 | 651,635 | -354,394 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 632,559 | 650,318 | +17,759 | 0.02 | 0.02 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 457,370 | 543,241 | +85,871 | 0.00 | 0.01 | +0.00 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 535,558 | 535,558 | 0 | 2.19 | 3.55 | +1.36 | hold |
| Rafferty Asset Management, LLC | 1,569,782 | 465,731 | -1,104,051 | 0.03 | 0.01 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 452,603 | +452,603 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 246,974 | 432,903 | +185,929 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 748,794 | 431,994 | -316,800 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 0 | 400,448 | +400,448 | 0.00 | 0.34 | +0.34 | buy |
| Prosight Management, LP | 1,400,000 | 398,700 | -1,001,300 | 1.98 | 0.74 | -1.24 | sell |
| UBS Group AG | 996,555 | 391,485 | -605,070 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 380,523 | 366,770 | -13,753 | 0.18 | 0.21 | +0.03 | sell |
| Swiss National Bank | 363,968 | 363,968 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GSA CAPITAL PARTNERS LLP | 0 | 363,838 | +363,838 | 0.00 | 0.16 | +0.16 | buy |
| ALGERT GLOBAL LLC | 297,822 | 353,133 | +55,311 | 0.06 | 0.07 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 33,876 | 350,800 | +316,924 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 299,749 | 318,665 | +18,916 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 160,085 | 317,979 | +157,894 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 314,307 | +314,307 | 0.00 | 0.77 | +0.77 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,116,957 | 276,351 | -840,606 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 236,220 | 275,790 | +39,570 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 267,649 | +267,649 | 0.00 | 0.14 | +0.14 | buy |
| Legal & General Group Plc | 276,691 | 266,273 | -10,418 | 0.00 | 0.00 | +0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 211,531 | 247,540 | +36,009 | 0.01 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 240,600 | +240,600 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 136,849 | 233,547 | +96,698 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 276,258 | 226,586 | -49,672 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 99,429 | 212,581 | +113,152 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 63,752 | 208,825 | +145,073 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 200,200 | +200,200 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 184,788 | 182,868 | -1,920 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 300,000 | 180,000 | -120,000 | 0.01 | 0.01 | -0.00 | sell |
| Capula Management Ltd | 0 | 161,296 | +161,296 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 145,406 | 161,003 | +15,597 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 39,339 | 156,946 | +117,607 | 0.03 | 0.08 | +0.06 | buy |
| Laurion Capital Management LP | 122,437 | 148,655 | +26,218 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 14,899 | 148,490 | +133,591 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 145,324 | 143,874 | -1,450 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 0 | 142,359 | +142,359 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 94,216 | 125,004 | +30,788 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 88,970 | 119,750 | +30,780 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,274,775 | 116,945 | -2,157,830 | 0.01 | 0.00 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 114,063 | 114,063 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 113,800 | 113,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 103,002 | +103,002 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 99,411 | 101,923 | +2,512 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 89,614 | 97,577 | +7,963 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 76,927 | 94,958 | +18,031 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 12,499 | 94,467 | +81,968 | 0.01 | 0.04 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 89,352 | +89,352 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 88,400 | 88,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 167,782 | 86,846 | -80,936 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 241,872 | 86,815 | -155,057 | 0.05 | 0.02 | -0.03 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 63,478 | 85,298 | +21,820 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 58,725 | 83,253 | +24,528 | 0.00 | 0.00 | +0.00 | buy |
| DOLIVER ADVISORS, LP | 81,000 | 81,000 | 0 | 0.12 | 0.14 | +0.02 | hold |
| JANUS HENDERSON GROUP PLC | 80,385 | 79,332 | -1,053 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 120,262 | 76,822 | -43,440 | 0.00 | 0.00 | -0.00 | sell |