| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 22,769,246 | 21,425,849 | -1,343,397 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 21,659,765 | 20,544,248 | -1,115,517 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 7,813,404 | 8,505,392 | +691,988 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 8,928,523 | 8,463,742 | -464,781 | 5.73 | 8.16 | +2.43 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 7,214,021 | 5,714,021 | -1,500,000 | 0.32 | 0.25 | -0.07 | sell |
| UBS Group AG | 2,403,186 | 5,614,651 | +3,211,465 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,297,674 | 5,329,679 | +3,032,005 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,960,637 | 5,054,610 | +93,973 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,189,665 | 4,692,000 | -497,665 | 0.77 | 0.76 | -0.01 | sell |
| Avoro Capital Advisors LLC | 8,700,000 | 4,500,000 | -4,200,000 | 1.02 | 0.71 | -0.31 | sell |
| D. E. Shaw & Co., Inc. | 1,589,112 | 4,389,477 | +2,800,365 | 0.01 | 0.04 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,045,535 | 4,288,223 | +2,242,688 | 0.03 | 0.07 | +0.04 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 194,152 | 4,278,555 | +4,084,403 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA ADVISERS, LP | 3,220,712 | 4,228,412 | +1,007,700 | 0.05 | 0.08 | +0.02 | buy |
| Assenagon Asset Management S.A. | 14,071 | 3,620,637 | +3,606,566 | 0.00 | 0.05 | +0.05 | buy |
| Nuveen, LLC | 27,775 | 3,534,454 | +3,506,679 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,931,934 | 3,523,917 | +1,591,983 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,435,657 | 2,841,155 | +1,405,498 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 3,052,137 | 2,782,489 | -269,648 | 0.01 | 0.01 | -0.00 | sell |
| GW&K Investment Management, LLC | 2,884,680 | 2,623,537 | -261,143 | 0.20 | 0.21 | +0.01 | sell |
| CITADEL ADVISORS LLC | 574,189 | 2,557,432 | +1,983,243 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 605,218 | 2,526,734 | +1,921,516 | 0.01 | 0.03 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,033,783 | 2,474,075 | +440,292 | 0.06 | 0.08 | +0.03 | buy |
| Qube Research & Technologies Ltd | 940,665 | 2,373,489 | +1,432,824 | 0.01 | 0.03 | +0.02 | buy |
| Walleye Capital LLC | 154,692 | 2,300,628 | +2,145,936 | 0.01 | 0.19 | +0.18 | buy |
| JUPITER ASSET MANAGEMENT LTD | 2,148,969 | 2,077,966 | -71,003 | 0.15 | 0.16 | +0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,027,568 | 2,060,280 | +32,712 | 0.89 | 0.99 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,922,038 | 1,969,875 | +47,837 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,955,258 | 1,913,729 | -41,529 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,812,874 | 1,906,667 | -1,906,207 | 0.03 | 0.02 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 1,836,979 | 1,823,288 | -13,691 | 0.01 | 0.02 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,065,583 | 1,584,206 | +518,623 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 125,627 | 1,456,857 | +1,331,230 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 148,849 | 1,347,112 | +1,198,263 | 0.02 | 0.16 | +0.14 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,042,424 | 1,257,691 | +215,267 | 0.03 | 0.04 | +0.01 | buy |
| Hood River Capital Management LLC | 0 | 1,243,934 | +1,243,934 | 0.00 | 0.16 | +0.16 | buy |
| SEGALL BRYANT & HAMILL, LLC | 1,330,314 | 1,220,077 | -110,237 | 0.15 | 0.15 | +0.00 | sell |
| Eversept Partners, LP | 2,172,436 | 1,207,638 | -964,798 | 1.84 | 1.09 | -0.75 | sell |
| Legal & General Group Plc | 981,218 | 1,204,483 | +223,265 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,201,449 | 1,148,794 | -52,655 | 0.01 | 0.01 | -0.00 | sell |
| M&G Plc | 0 | 1,046,016 | +1,046,016 | 0.00 | 0.05 | +0.05 | buy |
| Parkman Healthcare Partners LLC | 1,000,562 | 1,007,992 | +7,430 | 0.89 | 1.04 | +0.15 | buy |
| ALGERT GLOBAL LLC | 960,057 | 1,002,810 | +42,753 | 0.18 | 0.19 | +0.01 | buy |
| Invesco Ltd. | 968,155 | 993,117 | +24,962 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 612,324 | 969,041 | +356,717 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 402,600 | 804,112 | +401,512 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.33 | 0.36 | +0.03 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 766,899 | +766,899 | 0.00 | 0.05 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 612,219 | 752,984 | +140,765 | 0.03 | 0.05 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 485,482 | 727,470 | +241,988 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 764,898 | 723,321 | -41,577 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 448,466 | 691,969 | +243,503 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 778,729 | 683,416 | -95,313 | 0.41 | 0.35 | -0.07 | sell |
| FMR LLC | 583,614 | 655,893 | +72,279 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 3,107,669 | 638,908 | -2,468,761 | 4.86 | 1.11 | -3.75 | sell |
| Bank of New York Mellon Corp | 589,877 | 612,658 | +22,781 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 389,392 | 559,184 | +169,792 | 0.03 | 0.06 | +0.02 | buy |
| Hillsdale Investment Management Inc. | 522,300 | 536,000 | +13,700 | 0.20 | 0.18 | -0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 532,350 | +532,350 | 0.00 | 0.02 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 512,200 | +512,200 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,641 | 510,341 | +499,700 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 496,812 | 480,801 | -16,011 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 496,042 | 465,831 | -30,211 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 103,329 | 440,249 | +336,920 | 0.00 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 589,310 | 429,335 | -159,975 | 0.01 | 0.00 | -0.00 | sell |
| Man Group plc | 232,363 | 421,770 | +189,407 | 0.01 | 0.01 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 21,684 | 412,518 | +390,834 | 0.01 | 0.23 | +0.22 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 396,862 | 404,531 | +7,669 | 0.00 | 0.01 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 529,570 | 394,034 | -135,536 | 0.02 | 0.02 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 324,395 | 393,885 | +69,490 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 276,859 | 381,480 | +104,621 | 0.01 | 0.01 | +0.01 | buy |
| Swiss National Bank | 381,268 | 379,268 | -2,000 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 528,246 | 375,249 | -152,997 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 670,361 | 371,772 | -298,589 | 0.01 | 0.01 | -0.01 | sell |
| RHUMBLINE ADVISERS | 321,154 | 336,939 | +15,785 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 141,865 | 336,095 | +194,230 | 0.07 | 0.07 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 334,347 | +334,347 | 0.00 | 0.45 | +0.45 | buy |
| Knott David M Jr | 460,000 | 332,625 | -127,375 | 1.63 | 1.35 | -0.28 | sell |
| Hudson Bay Capital Management LP | 498,679 | 304,772 | -193,907 | 0.02 | 0.02 | -0.01 | sell |
| Rafferty Asset Management, LLC | 253,325 | 300,951 | +47,626 | 0.01 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 184,904 | 298,201 | +113,297 | 0.00 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 286,509 | +286,509 | 0.00 | 0.22 | +0.22 | buy |
| WELLS FARGO & COMPANY/MN | 218,084 | 284,931 | +66,847 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 485,809 | 278,498 | -207,311 | 0.01 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 275,390 | 275,390 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DOLIVER ADVISORS, LP | 74,328 | 274,328 | +200,000 | 0.16 | 0.67 | +0.52 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,324,221 | 274,127 | -1,050,094 | 0.34 | 0.07 | -0.27 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 586,206 | 252,414 | -333,792 | 0.01 | 0.01 | -0.01 | sell |
| Jain Global LLC | 0 | 240,693 | +240,693 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 43,496 | 235,532 | +192,036 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 109,467 | 223,243 | +113,776 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 63,463 | 222,590 | +159,127 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 136,103 | 219,084 | +82,981 | 0.03 | 0.06 | +0.03 | buy |
| DAFNA Capital Management LLC | 558,255 | 218,255 | -340,000 | 1.19 | 0.54 | -0.65 | sell |
| ExodusPoint Capital Management, LP | 60,933 | 210,840 | +149,907 | 0.01 | 0.02 | +0.02 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 315,000 | 210,000 | -105,000 | 0.57 | 0.43 | -0.14 | sell |
| Aquatic Capital Management LLC | 0 | 207,774 | +207,774 | 0.00 | 0.04 | +0.04 | buy |
| Gotham Asset Management, LLC | 44,064 | 201,813 | +157,749 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 16,495 | 188,196 | +171,701 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 179,143 | 182,456 | +3,313 | 0.00 | 0.00 | +0.00 | buy |