| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 22,650,988 | 23,893,036 | +1,242,048 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 15,827,186 | 15,827,186 | 0 | 1.60 | 1.38 | -0.22 | hold |
| STATE STREET CORP | 12,208,360 | 15,191,098 | +2,982,738 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,038,000 | 15,096,403 | +58,403 | 1.69 | 1.57 | -0.11 | buy |
| TCG Crossover Management, LLC | 11,020,968 | 11,020,968 | 0 | 3.00 | 2.65 | -0.35 | hold |
| PERCEPTIVE ADVISORS LLC | 7,434,033 | 10,308,888 | +2,874,855 | 1.40 | 1.60 | +0.20 | buy |
| Vestal Point Capital, LP | 7,025,000 | 8,300,000 | +1,275,000 | 1.87 | 1.94 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 6,392,628 | 6,775,349 | +382,721 | 0.05 | 0.05 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,782,776 | 6,248,046 | +465,270 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 5,040,670 | 5,310,871 | +270,201 | 0.08 | 0.07 | -0.00 | buy |
| UBS Group AG | 4,943,994 | 5,078,280 | +134,286 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 5,091,765 | 4,801,284 | -290,481 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,347,443 | 4,481,874 | +2,134,431 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 4,009,240 | 4,009,240 | 0 | 0.98 | 0.87 | -0.11 | hold |
| Nuveen, LLC | 3,819,263 | 4,007,237 | +187,974 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 187,721 | 3,394,729 | +3,207,008 | 0.00 | 0.02 | +0.02 | buy |
| GW&K Investment Management, LLC | 3,240,462 | 3,171,113 | -69,349 | 0.27 | 0.25 | -0.02 | sell |
| JANE STREET GROUP, LLC | 622,607 | 2,762,683 | +2,140,076 | 0.01 | 0.02 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 2,690,651 | 2,718,781 | +28,130 | 0.01 | 0.00 | -0.00 | buy |
| Fisher Asset Management, LLC | 2,733,253 | 2,604,027 | -129,226 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 776,990 | 2,530,290 | +1,753,300 | 0.01 | 0.03 | +0.02 | buy |
| Kynam Capital Management, LP | 5,680,795 | 2,522,660 | -3,158,135 | 3.43 | 1.39 | -2.04 | sell |
| Candriam S.C.A. | 2,286,841 | 2,514,949 | +228,108 | 0.11 | 0.11 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 2,353,291 | +2,353,291 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,350,405 | 2,353,291 | +2,886 | 0.00 | 0.00 | -0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,230,105 | 2,332,043 | +101,938 | 1.18 | 1.13 | -0.05 | buy |
| NORTHERN TRUST CORP | 2,104,725 | 2,255,731 | +151,006 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 440,141 | 2,214,302 | +1,774,161 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,022,988 | 1,999,684 | -23,304 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 1,987,397 | 1,901,160 | -86,237 | 1.18 | 1.15 | -0.03 | sell |
| Eversept Partners, LP | 3,039,820 | 1,865,653 | -1,174,167 | 1.91 | 1.02 | -0.89 | sell |
| ORBIMED ADVISORS LLC | 1,425,200 | 1,852,000 | +426,800 | 0.30 | 0.35 | +0.05 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,227,040 | 1,844,912 | +617,872 | 0.02 | 0.03 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 1,825,184 | 1,826,234 | +1,050 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,018,743 | 1,759,160 | +740,417 | 0.01 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 1,196,371 | 1,642,874 | +446,503 | 0.06 | 0.08 | +0.02 | buy |
| IMC-Chicago, LLC | 631,290 | 1,634,336 | +1,003,046 | 0.09 | 0.15 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 1,708,099 | 1,624,279 | -83,820 | 1.69 | 1.67 | -0.02 | sell |
| Legal & General Group Plc | 1,411,199 | 1,455,514 | +44,315 | 0.00 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 471,573 | 1,249,771 | +778,198 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 1,308,813 | 1,233,783 | -75,030 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,815,304 | 1,195,651 | -1,619,653 | 0.03 | 0.01 | -0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,302,257 | 1,174,052 | -128,205 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 800,900 | 1,120,469 | +319,569 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 1,081,523 | +1,081,523 | 0.00 | 0.02 | +0.02 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 848,336 | +848,336 | 0.00 | 0.19 | +0.19 | buy |
| FMR LLC | 633,132 | 808,903 | +175,771 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 190,058 | 744,917 | +554,859 | 0.02 | 0.07 | +0.05 | buy |
| Man Group plc | 1,293,300 | 732,867 | -560,433 | 0.03 | 0.01 | -0.01 | sell |
| Rosalind Advisors, Inc. | 923,057 | 721,504 | -201,553 | 3.60 | 2.71 | -0.89 | sell |
| Schonfeld Strategic Advisors LLC | 1,337,693 | 710,816 | -626,877 | 0.10 | 0.04 | -0.07 | sell |
| Bank of New York Mellon Corp | 637,658 | 680,481 | +42,823 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 109,409 | 569,956 | +460,547 | 0.02 | 0.05 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 821,367 | 563,361 | -258,006 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 536,304 | 538,813 | +2,509 | 0.01 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,541,978 | 525,449 | -1,016,529 | 0.00 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 638,054 | 491,057 | -146,997 | 0.03 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 523,281 | 480,364 | -42,917 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 430,558 | 468,785 | +38,227 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 450,000 | +450,000 | 0.00 | 0.44 | +0.44 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 866,464 | 422,051 | -444,413 | 1.42 | 0.60 | -0.81 | sell |
| Swiss National Bank | 408,668 | 415,268 | +6,600 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 302,101 | 408,529 | +106,428 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 374,016 | 404,704 | +30,688 | 0.05 | 0.06 | +0.01 | buy |
| DAFNA Capital Management LLC | 430,248 | 400,248 | -30,000 | 0.93 | 0.76 | -0.17 | sell |
| Hudson Bay Capital Management LP | 490,369 | 400,000 | -90,369 | 0.03 | 0.02 | -0.01 | sell |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 0 | 380,801 | +380,801 | 0.00 | 0.06 | +0.06 | buy |
| DOLIVER ADVISORS, LP | 374,328 | 374,328 | 0 | 0.81 | 0.85 | +0.04 | hold |
| Aquatic Capital Management LLC | 0 | 362,895 | +362,895 | 0.00 | 0.12 | +0.12 | buy |
| CITIGROUP INC | 71,164 | 360,189 | +289,025 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 232,947 | 353,044 | +120,097 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 243,416 | 347,299 | +103,883 | 0.00 | 0.00 | +0.00 | buy |
| Phocas Financial Corp. | 195,540 | 340,541 | +145,001 | 0.29 | 0.47 | +0.18 | buy |
| ALLIANCEBERNSTEIN L.P. | 263,669 | 327,909 | +64,240 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 368,978 | 320,566 | -48,412 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 60,250 | 317,960 | +257,710 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 230,996 | 305,897 | +74,901 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 98,883 | 293,925 | +195,042 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 266,137 | 279,839 | +13,702 | 0.00 | 0.00 | -0.00 | buy |
| NFJ INVESTMENT GROUP, LLC | 0 | 278,792 | +278,792 | 0.00 | 0.09 | +0.09 | buy |
| Rafferty Asset Management, LLC | 354,260 | 265,618 | -88,642 | 0.01 | 0.01 | -0.01 | sell |
| Point72 Asset Management, L.P. | 0 | 260,917 | +260,917 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 53,216 | 255,600 | +202,384 | 0.02 | 0.08 | +0.07 | buy |
| MARSHALL WACE, LLP | 246,477 | 252,764 | +6,287 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 258,345 | 251,230 | -7,115 | 0.00 | 0.00 | -0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 56,529 | 242,508 | +185,979 | 0.01 | 0.06 | +0.04 | buy |
| IEQ CAPITAL, LLC | 0 | 227,421 | +227,421 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 236,941 | 222,894 | -14,047 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 210,000 | +210,000 | 0.00 | 0.48 | +0.48 | buy |
| PFM Health Sciences, LP | 0 | 207,357 | +207,357 | 0.00 | 0.18 | +0.18 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 195,128 | +195,128 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 194,475 | 175,002 | -19,473 | 0.02 | 0.02 | -0.00 | sell |
| Squarepoint Ops LLC | 39,765 | 174,714 | +134,949 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 163,266 | 163,267 | +1 | 0.00 | 0.00 | -0.00 | buy |
| QTR Family Wealth, LLC | 157,062 | 161,082 | +4,020 | 0.63 | 0.56 | -0.07 | buy |
| Gotham Asset Management, LLC | 312,961 | 156,421 | -156,540 | 0.01 | 0.00 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 160,531 | 155,544 | -4,987 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 95,467 | 150,447 | +54,980 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 150,264 | 145,683 | -4,581 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 113,763 | 138,657 | +24,894 | 0.00 | 0.00 | +0.00 | buy |