| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 2,791,880 | 5,362,980 | +2,571,100 | 0.64 | 1.20 | +0.56 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,322,000 | 3,286,000 | +1,964,000 | 0.20 | 0.51 | +0.31 | buy |
| ExodusPoint Capital Management, LP | 1,212,547 | 750,053 | +462,494 | 0.10 | 0.07 | 0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,331,488 | 1,756,145 | +424,657 | 0.03 | 0.04 | 0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,872,964 | 2,275,638 | +402,674 | 0.75 | 1.02 | +0.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 5,302,020 | 4,983,207 | +318,813 | 0.05 | 0.05 | 0.00 | sell |
| Kynam Capital Management, LP | 2,848,197 | 3,133,193 | +284,996 | 3.07 | 3.69 | +0.61 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 401,209 | 542,776 | +141,567 | 0.01 | 0.02 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 71,532 | 191,527 | +119,995 | 0.06 | 0.13 | 0.00 | buy |
| Eversept Partners, LP | 2,372,113 | 2,479,103 | +106,990 | 1.76 | 1.95 | +0.19 | buy |
| ALGERT GLOBAL LLC | 291,556 | 207,095 | +84,461 | 0.09 | 0.07 | 0.00 | sell |
| DAFNA Capital Management LLC | 569,000 | 652,000 | +83,000 | 1.10 | 1.44 | +0.34 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 78,295 | 153,474 | +75,179 | 0.08 | 0.20 | +0.12 | buy |
| PDT Partners, LLC | 199,079 | 270,709 | +71,630 | 0.19 | 0.24 | +0.05 | buy |
| Bayesian Capital Management, LP | 15,000 | 78,700 | +63,700 | 0.01 | 0.06 | +0.05 | buy |
| Rock Springs Capital Management LP | 2,497,193 | 2,551,226 | +54,033 | 0.42 | 0.48 | +0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 760,904 | 791,671 | +30,767 | 1.81 | 2.09 | +0.28 | buy |
| Saturn V Capital Management LP | 954,856 | 982,458 | +27,602 | 3.73 | 2.91 | -0.82 | buy |
| ELCO Management Co., LLC | 13,542 | 31,811 | +18,269 | 0.07 | 0.16 | +0.09 | buy |
| FRANKLIN STREET ADVISORS INC /NC | 50,000 | 60,000 | +10,000 | 0.03 | 0.04 | +0.01 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 42,481 | 52,046 | +9,565 | 0.02 | 0.02 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 232,463 | 241,820 | +9,357 | 0.06 | 0.04 | 0.00 | buy |
| Arete Wealth Advisors, LLC | 14,150 | 23,300 | +9,150 | 0.01 | 0.03 | +0.02 | buy |
| AXQ CAPITAL, LP | 17,534 | 23,134 | +5,600 | 0.15 | 0.06 | -0.09 | buy |
| Empire Financial Management Company, LLC | 42,500 | 47,500 | +5,000 | 0.12 | 0.15 | +0.03 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 12,100 | 16,300 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,477 | 4,865 | +2,388 | 0.01 | 0.01 | +0.00 | buy |
| Teza Capital Management LLC | 16,362 | 18,452 | +2,090 | 0.02 | 0.02 | +0.00 | buy |
| Diversified Trust Co | 18,974 | 20,978 | +2,004 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 138,878 | 139,850 | +972 | 0.01 | 0.01 | -0.00 | buy |
| GRIMES & COMPANY, INC. | 72,672 | 73,575 | +903 | 0.02 | 0.02 | +0.00 | buy |
| Hudson Bay Capital Management LP | 64,700 | 65,000 | +300 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 37,637 | 37,526 | -111 | 0.01 | 0.01 | -0.00 | sell |
| CarsonAllaria Wealth Management, Ltd. | 355 | 230 | -125 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 44,583 | 43,070 | -1,513 | 0.04 | 0.04 | +0.00 | sell |
| J.W. COLE ADVISORS, INC. | 22,200 | 19,900 | -2,300 | 0.01 | 0.01 | -0.00 | sell |
| Bridgefront Capital, LLC | 20,302 | 16,323 | -3,979 | 0.08 | 0.08 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 43,278 | 38,321 | -4,957 | 0.18 | 0.16 | -0.02 | sell |
| Visionary Wealth Advisors | 38,540 | 33,540 | -5,000 | 0.02 | 0.02 | -0.00 | sell |
| E Fund Management Co., Ltd. | 52,423 | 41,497 | -10,926 | 0.03 | 0.02 | -0.01 | sell |
| BENDER ROBERT & ASSOCIATES | 68,600 | 56,600 | -12,000 | 0.13 | 0.12 | -0.02 | sell |
| Dynamic Technology Lab Private Ltd | 38,825 | 22,609 | -16,216 | 0.03 | 0.02 | -0.02 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,410,190 | 2,390,948 | -19,242 | 0.05 | 0.05 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 2,037,688 | 2,017,986 | -19,702 | 0.15 | 0.17 | +0.02 | sell |
| GW&K Investment Management, LLC | 2,598,242 | 2,570,863 | -27,379 | 0.17 | 0.18 | +0.01 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 80,600 | 47,100 | -33,500 | 0.01 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 176,892 | 136,652 | -40,240 | 0.07 | 0.05 | -0.01 | sell |
| Prosight Management, LP | 2,500,000 | 2,408,135 | -91,865 | 5.15 | 5.40 | +0.25 | sell |
| Rafferty Asset Management, LLC | 974,963 | 807,888 | -167,075 | 0.04 | 0.03 | -0.01 | sell |
| Avoro Capital Advisors LLC | 12,055,000 | 11,550,000 | -505,000 | 1.15 | 1.28 | +0.12 | sell |
| TANG CAPITAL MANAGEMENT LLC | 2,450,000 | 1,800,000 | -650,000 | 2.54 | 1.80 | -0.74 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,155,723 | 470,137 | -685,586 | 0.05 | 0.02 | -0.03 | sell |