| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 18,769,493 | 20,306,596 | +1,537,103 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 12,570,000 | 11,865,000 | -705,000 | 1.03 | 1.31 | +0.28 | sell |
| Kynam Capital Management, LP | 8,826,710 | 9,085,368 | +258,658 | 5.71 | 5.35 | -0.36 | buy |
| STATE STREET CORP | 9,346,799 | 8,849,588 | -497,211 | 0.00 | 0.00 | +0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,135,804 | 8,135,804 | 0 | 0.84 | 0.92 | +0.09 | hold |
| ALKEON CAPITAL MANAGEMENT LLC | 7,099,484 | 7,093,822 | -5,662 | 0.22 | 0.30 | +0.07 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 4,710,277 | 4,837,985 | +127,708 | 0.00 | 0.00 | +0.00 | buy |
| RP Management, LLC | 3,846,154 | 3,846,154 | 0 | 13.29 | 12.84 | -0.46 | hold |
| Rock Springs Capital Management LP | 3,619,258 | 3,622,358 | +3,100 | 0.67 | 0.90 | +0.22 | buy |
| Fisher Asset Management, LLC | 2,856,703 | 3,338,062 | +481,359 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 3,404,700 | 3,277,600 | -127,100 | 0.19 | 0.21 | +0.02 | sell |
| Caligan Partners LP | 4,598,737 | 2,583,585 | -2,015,152 | 6.64 | 6.22 | -0.42 | sell |
| GOLDMAN SACHS GROUP INC | 2,530,259 | 2,320,529 | -209,730 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,948,984 | 2,252,749 | +303,765 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,919,512 | 2,181,012 | +261,500 | 0.03 | 0.04 | +0.01 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,079,641 | 2,163,743 | +84,102 | 0.77 | 0.89 | +0.12 | buy |
| FMR LLC | 1,942,279 | 1,988,389 | +46,110 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,785,134 | 1,887,994 | +102,860 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,754,763 | 1,860,925 | +106,162 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 1,843,652 | 1,843,289 | -363 | 0.01 | 0.01 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,590,861 | 1,792,908 | -797,953 | 0.06 | 0.05 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 1,865,623 | 1,772,501 | -93,122 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,674,391 | 1,760,808 | +86,417 | 0.02 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 1,577,949 | 1,739,080 | +161,131 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 1,526,481 | 1,490,376 | -36,105 | 0.17 | 0.15 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,751,561 | 1,322,900 | -428,661 | 0.01 | 0.01 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 2,135,263 | 1,194,059 | -941,204 | 0.40 | 0.27 | -0.13 | sell |
| BANK OF AMERICA CORP /DE/ | 1,300,338 | 1,160,965 | -139,373 | 0.00 | 0.00 | +0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 0 | 1,069,899 | +1,069,899 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 101,923 | 1,005,108 | +903,185 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 16,225 | 892,430 | +876,205 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 846,844 | 883,817 | +36,973 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 1,037,171 | 880,991 | -156,180 | 0.10 | 0.08 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.50 | 0.43 | -0.07 | hold |
| Cutter Capital Management, LP | 1,975,298 | 798,137 | -1,177,161 | 3.72 | 1.79 | -1.93 | sell |
| AQR CAPITAL MANAGEMENT LLC | 543,241 | 787,227 | +243,986 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 839,508 | 711,425 | -128,083 | 0.01 | 0.01 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 782,664 | 682,324 | -100,340 | 0.02 | 0.03 | +0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 650,318 | 676,292 | +25,974 | 0.02 | 0.02 | +0.00 | buy |
| DAFNA Capital Management LLC | 704,500 | 667,000 | -37,500 | 1.04 | 1.20 | +0.16 | sell |
| NORGES BANK | 651,635 | 611,900 | -39,735 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 775,957 | 596,838 | -179,119 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 593,466 | +593,466 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 960,180 | 589,080 | -371,100 | 0.01 | 0.01 | -0.00 | sell |
| JPMORGAN CHASE & CO | 747,531 | 577,129 | -170,402 | 0.00 | 0.00 | -0.00 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 535,558 | 535,558 | 0 | 3.55 | 3.25 | -0.30 | hold |
| Eversept Partners, LP | 1,152,573 | 535,405 | -617,168 | 0.55 | 0.31 | -0.23 | sell |
| PDT Partners, LLC | 366,770 | 522,280 | +155,510 | 0.21 | 0.35 | +0.14 | buy |
| ALGERT GLOBAL LLC | 353,133 | 516,209 | +163,076 | 0.07 | 0.11 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 86,846 | 496,784 | +409,938 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 226,586 | 476,672 | +250,086 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 400,448 | 464,048 | +63,600 | 0.34 | 0.45 | +0.11 | buy |
| DEUTSCHE BANK AG\ | 431,994 | 460,530 | +28,536 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 431,230 | +431,230 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 391,485 | 425,019 | +33,534 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 35,524 | 411,414 | +375,890 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 432,903 | 389,530 | -43,373 | 0.00 | 0.00 | -0.00 | sell |
| Knott David M Jr | 314,307 | 382,000 | +67,693 | 0.77 | 1.02 | +0.25 | buy |
| Rafferty Asset Management, LLC | 465,731 | 371,034 | -94,697 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 739,599 | 367,514 | -372,085 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 363,968 | 363,968 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAPITAL FUND MANAGEMENT S.A. | 247,540 | 357,615 | +110,075 | 0.02 | 0.03 | +0.01 | buy |
| RHUMBLINE ADVISERS | 318,665 | 303,517 | -15,148 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 240,600 | 302,724 | +62,124 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 212,581 | 299,152 | +86,571 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 363,838 | 285,588 | -78,250 | 0.16 | 0.16 | +0.01 | sell |
| CITADEL ADVISORS LLC | 317,979 | 279,143 | -38,836 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 275,790 | 275,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cinctive Capital Management LP | 0 | 273,959 | +273,959 | 0.00 | 0.12 | +0.12 | buy |
| Jump Financial, LLC | 200,200 | 271,739 | +71,539 | 0.02 | 0.04 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 94,958 | 263,748 | +168,790 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 208,825 | 259,382 | +50,557 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 253,901 | +253,901 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 266,273 | 249,745 | -16,528 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 249,495 | +249,495 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 276,351 | 234,866 | -41,485 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 350,800 | 229,090 | -121,710 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 0 | 196,500 | +196,500 | 0.00 | 1.01 | +1.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 233,547 | 183,928 | -49,619 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 182,868 | 177,253 | -5,615 | 0.00 | 0.00 | +0.00 | sell |
| Schonfeld Strategic Advisors LLC | 452,603 | 171,090 | -281,513 | 0.02 | 0.01 | -0.01 | sell |
| SG Americas Securities, LLC | 0 | 158,921 | +158,921 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 161,003 | 158,110 | -2,893 | 0.01 | 0.01 | +0.00 | sell |
| Inspire Investing, LLC | 57,550 | 158,008 | +100,458 | 0.04 | 0.12 | +0.08 | buy |
| AMERICAN CENTURY COMPANIES INC | 148,490 | 155,375 | +6,885 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 116,945 | 152,923 | +35,978 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 149,785 | +149,785 | 0.00 | 0.06 | +0.06 | buy |
| Semanteon Capital Management, LP | 0 | 149,576 | +149,576 | 0.00 | 0.77 | +0.77 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 143,874 | 142,699 | -1,175 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 13,700 | 136,100 | +122,400 | 0.00 | 0.03 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 113,527 | 127,726 | +14,199 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 119,750 | 119,750 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Skandinaviska Enskilda Banken AB (publ) | 114,063 | 114,063 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capula Management Ltd | 161,296 | 113,186 | -48,110 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 0 | 111,027 | +111,027 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 111,167 | 110,486 | -681 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 107,820 | +107,820 | 0.00 | 0.00 | +0.00 | buy |
| AMH Equity Ltd | 0 | 100,000 | +100,000 | 0.00 | 1.00 | +1.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 96,096 | +96,096 | 0.00 | 0.00 | +0.00 | buy |
| Counterweight Ventures, LLC | 13,500 | 93,384 | +79,884 | 0.06 | 0.50 | +0.44 | buy |