| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 20,544,248 | 21,790,881 | +1,246,633 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 21,425,849 | 21,245,876 | -179,973 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,692,000 | 12,169,000 | +7,477,000 | 0.76 | 1.42 | +0.65 | buy |
| STATE STREET CORP | 8,505,392 | 9,807,438 | +1,302,046 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 8,463,742 | 9,390,270 | +926,528 | 8.16 | 5.31 | -2.86 | buy |
| UBS Group AG | 5,614,651 | 5,967,737 | +353,086 | 0.01 | 0.01 | -0.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 5,714,021 | 5,464,021 | -250,000 | 0.25 | 0.19 | -0.06 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 4,278,555 | 5,225,986 | +947,431 | 0.03 | 0.03 | -0.00 | buy |
| MORGAN STANLEY | 5,329,679 | 5,202,959 | -126,720 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 5,054,610 | 5,052,307 | -2,303 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 4,288,223 | 4,419,629 | +131,406 | 0.07 | 0.05 | -0.02 | buy |
| TWO SIGMA ADVISERS, LP | 4,228,412 | 4,240,712 | +12,300 | 0.08 | 0.06 | -0.01 | buy |
| Hood River Capital Management LLC | 1,243,934 | 3,620,261 | +2,376,327 | 0.16 | 0.32 | +0.17 | buy |
| Nuveen, LLC | 3,534,454 | 3,617,882 | +83,428 | 0.01 | 0.01 | -0.00 | buy |
| Assenagon Asset Management S.A. | 3,620,637 | 3,092,592 | -528,045 | 0.05 | 0.03 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 3,523,917 | 2,711,806 | -812,111 | 0.01 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 2,782,489 | 2,632,696 | -149,793 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 2,373,489 | 2,410,362 | +36,873 | 0.03 | 0.03 | -0.00 | buy |
| GW&K Investment Management, LLC | 2,623,537 | 2,197,765 | -425,772 | 0.21 | 0.15 | -0.06 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,526,734 | 2,140,534 | -386,200 | 0.03 | 0.02 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,456,857 | 2,094,278 | +637,421 | 0.01 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 2,077,966 | 2,055,915 | -22,051 | 0.16 | 0.13 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,969,875 | 1,994,404 | +24,529 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,841,155 | 1,902,819 | -938,336 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 1,913,729 | 1,892,043 | -21,686 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,060,280 | 1,880,389 | -179,891 | 0.99 | 0.78 | -0.22 | sell |
| JANE STREET GROUP, LLC | 278,498 | 1,848,346 | +1,569,848 | 0.00 | 0.02 | +0.01 | buy |
| STIFEL FINANCIAL CORP | 1,823,288 | 1,822,992 | -296 | 0.02 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 4,389,477 | 1,709,336 | -2,680,141 | 0.04 | 0.01 | -0.03 | sell |
| Eversept Partners, LP | 1,207,638 | 1,373,625 | +165,987 | 1.09 | 0.80 | -0.29 | buy |
| CITADEL ADVISORS LLC | 2,557,432 | 1,359,882 | -1,197,550 | 0.02 | 0.01 | -0.01 | sell |
| Avoro Capital Advisors LLC | 4,500,000 | 1,250,000 | -3,250,000 | 0.71 | 0.12 | -0.58 | sell |
| Cubist Systematic Strategies, LLC | 0 | 1,246,696 | +1,246,696 | 0.00 | 0.13 | +0.13 | buy |
| Pictet Asset Management Holding SA | 969,041 | 1,196,319 | +227,278 | 0.01 | 0.01 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 1,220,077 | 1,134,813 | -85,264 | 0.15 | 0.11 | -0.04 | sell |
| JPMORGAN CHASE & CO | 1,584,206 | 1,132,377 | -451,829 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 723,321 | 1,108,660 | +385,339 | 0.01 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 465,831 | 1,069,015 | +603,184 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 1,007,992 | 1,012,664 | +4,672 | 1.04 | 0.84 | -0.20 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,148,794 | 999,785 | -149,009 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 993,117 | 962,376 | -30,741 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 2,474,075 | 957,021 | -1,517,054 | 0.08 | 0.02 | -0.06 | sell |
| Jump Financial, LLC | 1,347,112 | 924,776 | -422,336 | 0.16 | 0.11 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 0 | 901,500 | +901,500 | 0.00 | 0.16 | +0.16 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,257,691 | 848,562 | -409,129 | 0.04 | 0.02 | -0.02 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 371,772 | 839,403 | +467,631 | 0.01 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.36 | 0.23 | -0.13 | hold |
| BARCLAYS PLC | 804,112 | 782,232 | -21,880 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 727,470 | 734,987 | +7,517 | 0.01 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 143,312 | 731,411 | +588,099 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 1,002,810 | 713,088 | -289,722 | 0.19 | 0.09 | -0.10 | sell |
| PDT Partners, LLC | 683,416 | 683,416 | 0 | 0.35 | 0.33 | -0.02 | hold |
| FMR LLC | 655,893 | 653,814 | -2,079 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 612,658 | 619,988 | +7,330 | 0.00 | 0.00 | -0.00 | buy |
| Hillsdale Investment Management Inc. | 536,000 | 561,600 | +25,600 | 0.18 | 0.13 | -0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 535,968 | +535,968 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 393,885 | 465,338 | +71,453 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,906,667 | 460,947 | -1,445,720 | 0.02 | 0.00 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 480,801 | 455,591 | -25,210 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 141,506 | 442,847 | +301,341 | 0.02 | 0.04 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 336,095 | 434,531 | +98,436 | 0.07 | 0.08 | +0.01 | buy |
| Bridgewater Associates, LP | 0 | 411,503 | +411,503 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 691,969 | 394,740 | -297,229 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 429,335 | 394,565 | -34,770 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 379,268 | 385,368 | +6,100 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 375,249 | 375,851 | +602 | 0.01 | 0.01 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 381,480 | 370,463 | -11,017 | 0.01 | 0.01 | -0.00 | sell |
| Rafferty Asset Management, LLC | 300,951 | 369,322 | +68,371 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 210,840 | 364,457 | +153,617 | 0.02 | 0.04 | +0.02 | buy |
| SEI INVESTMENTS CO | 223,243 | 362,216 | +138,973 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 421,770 | 354,484 | -67,286 | 0.01 | 0.01 | -0.00 | sell |
| Gotham Asset Management, LLC | 201,813 | 343,771 | +141,958 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 336,939 | 326,835 | -10,104 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 138,304 | 325,795 | +187,491 | 0.01 | 0.04 | +0.02 | buy |
| Russell Investments Group, Ltd. | 440,249 | 314,493 | -125,756 | 0.01 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 99,046 | 309,110 | +210,064 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 275,390 | 278,333 | +2,943 | 0.00 | 0.00 | -0.00 | buy |
| DOLIVER ADVISORS, LP | 274,328 | 274,328 | 0 | 0.67 | 0.54 | -0.13 | hold |
| Graham Capital Management, L.P. | 219,084 | 267,730 | +48,646 | 0.06 | 0.08 | +0.02 | buy |
| FEDERATED HERMES, INC. | 298,201 | 265,505 | -32,696 | 0.01 | 0.00 | -0.00 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 264,800 | +264,800 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 166,577 | 262,465 | +95,888 | 0.02 | 0.02 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 404,531 | 245,761 | -158,770 | 0.01 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 188,196 | 244,409 | +56,213 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 238,187 | +238,187 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 510,341 | 230,341 | -280,000 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 235,532 | 228,895 | -6,637 | 0.01 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 2,300,628 | 227,064 | -2,073,564 | 0.19 | 0.01 | -0.18 | sell |
| Legal & General Group Plc | 1,204,483 | 226,165 | -978,318 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 218,255 | 218,255 | 0 | 0.54 | 0.41 | -0.13 | hold |
| HUSSMAN STRATEGIC ADVISORS, INC. | 210,000 | 210,000 | 0 | 0.43 | 0.35 | -0.08 | hold |
| TWINBEECH CAPITAL LP | 0 | 195,737 | +195,737 | 0.00 | 0.06 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 111,467 | 190,294 | +78,827 | 0.07 | 0.12 | +0.05 | buy |
| ROYAL BANK OF CANADA | 222,590 | 185,415 | -37,175 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 182,456 | 182,466 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 752,984 | 166,841 | -586,143 | 0.05 | 0.01 | -0.04 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 146,639 | 161,348 | +14,709 | 0.00 | 0.00 | -0.00 | buy |
| QTR Family Wealth, LLC | 151,986 | 157,137 | +5,151 | 0.84 | 0.57 | -0.28 | buy |
| WELLS FARGO & COMPANY/MN | 284,931 | 133,036 | -151,895 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 123,048 | 131,711 | +8,663 | 0.00 | 0.00 | -0.00 | buy |