| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 15,392,319 | 17,763,720 | +2,371,401 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 10,466,378 | 12,777,003 | +2,310,625 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 408,297 | 1,971,586 | +1,563,289 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 201,845 | 1,754,980 | +1,553,135 | 0.00 | 0.02 | +0.01 | buy |
| Avoro Capital Advisors LLC | 11,550,000 | 13,050,000 | +1,500,000 | 1.28 | 1.08 | -0.20 | buy |
| Kynam Capital Management, LP | 3,133,193 | 4,600,000 | +1,466,807 | 3.69 | 3.12 | -0.57 | buy |
| NORGES BANK | 846,612 | 2,216,612 | +1,370,000 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,825,824 | 3,136,688 | +1,310,864 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,286,000 | 4,539,525 | +1,253,525 | 0.51 | 0.50 | -0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 1,028,503 | +1,028,503 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 99,711 | 1,026,042 | +926,331 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 371,872 | 1,193,964 | +822,092 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 343,848 | 1,081,646 | +737,798 | 0.01 | 0.03 | +0.01 | buy |
| Rock Springs Capital Management LP | 2,551,226 | 3,270,381 | +719,155 | 0.48 | 0.48 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,756,145 | 2,351,720 | +595,575 | 0.03 | 0.03 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 649,913 | 1,212,979 | +563,066 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 0 | 504,528 | +504,528 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 650,240 | 1,042,912 | +392,672 | 0.06 | 0.08 | +0.02 | buy |
| UBS Group AG | 305,951 | 684,988 | +379,037 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 5,362,980 | 5,718,477 | +355,497 | 1.20 | 1.26 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,911,077 | 4,260,638 | +349,561 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,091,518 | 1,420,294 | +328,776 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 73,517 | 373,944 | +300,427 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 542,968 | 790,163 | +247,195 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,542,711 | 1,774,754 | +232,043 | 0.00 | 0.00 | -0.00 | buy |
| Sarissa Capital Management LP | 775,000 | 1,000,000 | +225,000 | 0.74 | 0.92 | +0.18 | buy |
| JANE STREET GROUP, LLC | 618,606 | 822,940 | +204,334 | 0.01 | 0.01 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 160,724 | +160,724 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 547,328 | 704,529 | +157,201 | 0.00 | 0.00 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 542,776 | 691,698 | +148,922 | 0.02 | 0.02 | -0.00 | buy |
| Rafferty Asset Management, LLC | 807,888 | 955,587 | +147,699 | 0.03 | 0.02 | -0.01 | buy |
| Laurion Capital Management LP | 0 | 133,775 | +133,775 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,460,807 | 1,594,436 | +133,629 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 207,095 | 336,765 | +129,670 | 0.07 | 0.08 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 94,435 | 209,905 | +115,470 | 0.01 | 0.02 | +0.01 | buy |
| Maven Securities LTD | 0 | 90,000 | +90,000 | 0.00 | 0.06 | +0.06 | buy |
| HRT FINANCIAL LP | 212,698 | 292,412 | +79,714 | 0.01 | 0.01 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 70,091 | +70,091 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 0 | 66,223 | +66,223 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 65,000 | 130,000 | +65,000 | 0.00 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 652,000 | 709,500 | +57,500 | 1.44 | 1.02 | -0.42 | buy |
| ROYAL BANK OF CANADA | 57,641 | 113,523 | +55,882 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 9,956 | 55,761 | +45,805 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 649,318 | 693,029 | +43,711 | 0.01 | 0.01 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 42,673 | +42,673 | 0.00 | 0.02 | +0.02 | buy |
| PDT Partners, LLC | 270,709 | 311,198 | +40,489 | 0.24 | 0.21 | -0.04 | buy |
| D. E. Shaw & Co., Inc. | 0 | 30,631 | +30,631 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 37,526 | 64,856 | +27,330 | 0.01 | 0.01 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 27,022 | +27,022 | 0.00 | 0.02 | +0.02 | buy |
| Empire Financial Management Company, LLC | 47,500 | 73,500 | +26,000 | 0.15 | 0.17 | +0.03 | buy |
| XTX Topco Ltd | 31,833 | 56,404 | +24,571 | 0.04 | 0.07 | +0.04 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 20,702 | +20,702 | 0.00 | 0.01 | +0.01 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 20,561 | +20,561 | 0.00 | 0.02 | +0.02 | buy |
| Inspire Investing, LLC | 43,070 | 63,325 | +20,255 | 0.04 | 0.04 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33,128 | 53,330 | +20,202 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 11,891 | 31,428 | +19,537 | 0.00 | 0.01 | +0.00 | buy |
| Teza Capital Management LLC | 18,452 | 37,420 | +18,968 | 0.02 | 0.04 | +0.02 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 8,881 | 27,713 | +18,832 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 4,865 | 23,692 | +18,827 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 136,652 | 155,389 | +18,737 | 0.05 | 0.04 | -0.01 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 18,650 | +18,650 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 16,364 | +16,364 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 16,037 | +16,037 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 319,617 | 334,867 | +15,250 | 0.00 | 0.00 | -0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 14,143 | +14,143 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 13,612 | +13,612 | 0.00 | 0.00 | +0.00 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 12,763 | +12,763 | 0.00 | 0.04 | +0.04 | buy |
| MA Private Wealth | 0 | 12,700 | +12,700 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 38,321 | 50,731 | +12,410 | 0.16 | 0.19 | +0.03 | buy |
| Point72 Hong Kong Ltd | 0 | 11,428 | +11,428 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 23,037 | 34,013 | +10,976 | 0.00 | 0.00 | +0.00 | buy |
| JGP Global Gestao de Recursos Ltda. | 0 | 10,650 | +10,650 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 236,561 | 246,974 | +10,413 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 35,500 | 45,900 | +10,400 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 37,273 | 47,359 | +10,086 | 0.00 | 0.00 | -0.00 | buy |
| MACKENZIE FINANCIAL CORP | 13,413 | 23,439 | +10,026 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 41,497 | 51,317 | +9,820 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 104,315 | 113,684 | +9,369 | 0.00 | 0.00 | -0.00 | buy |
| Quarry LP | 0 | 9,000 | +9,000 | 0.00 | 0.03 | +0.03 | buy |
| ProShare Advisors LLC | 37,012 | 44,462 | +7,450 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 114,960 | 122,180 | +7,220 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 20,408 | 26,842 | +6,434 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,508 | 10,420 | +5,912 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 710,651 | 714,458 | +3,807 | 0.08 | 0.06 | -0.02 | buy |
| Advisory Services Network, LLC | 0 | 3,740 | +3,740 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 18,875 | 21,035 | +2,160 | 0.00 | 0.00 | -0.00 | buy |
| FAIRFIELD, BUSH & CO. | 0 | 1,565 | +1,565 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 38,006 | 39,162 | +1,156 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 773 | 1,683 | +910 | 0.00 | 0.00 | +0.00 | buy |
| Golden State Equity Partners | 10,925 | 11,430 | +505 | 0.02 | 0.02 | -0.00 | buy |
| Geneos Wealth Management Inc. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 3,358 | 3,839 | +481 | 0.01 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 14,005 | 14,465 | +460 | 0.00 | 0.00 | -0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 333 | 663 | +330 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 499 | 743 | +244 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 47 | 274 | +227 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 17,949 | 18,150 | +201 | 0.00 | 0.00 | -0.00 | buy |
| J.W. COLE ADVISORS, INC. | 19,900 | 20,100 | +200 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,003 | 98,194 | +191 | 0.00 | 0.00 | -0.00 | buy |
| XPONANCE, INC. | 11,199 | 11,381 | +182 | 0.00 | 0.00 | -0.00 | buy |