| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 11,550,000 | 13,050,000 | +1,500,000 | 1.28 | 1.08 | -0.20 | buy |
| Kynam Capital Management, LP | 3,133,193 | 4,600,000 | +1,466,807 | 3.69 | 3.12 | -0.57 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,286,000 | 4,539,525 | +1,253,525 | 0.51 | 0.50 | -0.01 | buy |
| Rock Springs Capital Management LP | 2,551,226 | 3,270,381 | +719,155 | 0.48 | 0.48 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,756,145 | 2,351,720 | +595,575 | 0.04 | 0.04 | 0.00 | buy |
| ExodusPoint Capital Management, LP | 750,053 | 192,202 | +557,851 | 0.07 | 0.01 | 0.00 | sell |
| BRAIDWELL LP | 5,362,980 | 5,718,477 | +355,497 | 1.20 | 1.26 | +0.06 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,872,964 | 2,197,261 | +324,297 | 0.75 | 0.76 | 0.00 | buy |
| Sarissa Capital Management LP | 775,000 | 1,000,000 | +225,000 | 0.74 | 0.92 | +0.18 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 241,820 | 60,159 | +181,661 | 0.04 | 0.03 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 542,776 | 691,698 | +148,922 | 0.02 | 0.02 | -0.00 | buy |
| Rafferty Asset Management, LLC | 807,888 | 955,587 | +147,699 | 0.03 | 0.02 | -0.01 | buy |
| ALGERT GLOBAL LLC | 207,095 | 336,765 | +129,670 | 0.07 | 0.08 | 0.00 | buy |
| Hudson Bay Capital Management LP | 65,000 | 130,000 | +65,000 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 652,000 | 709,500 | +57,500 | 1.44 | 1.02 | -0.42 | buy |
| PDT Partners, LLC | 270,709 | 311,198 | +40,489 | 0.24 | 0.21 | -0.04 | buy |
| Graham Capital Management, L.P. | 37,526 | 64,856 | +27,330 | 0.01 | 0.01 | +0.00 | buy |
| Empire Financial Management Company, LLC | 47,500 | 73,500 | +26,000 | 0.15 | 0.17 | +0.03 | buy |
| Inspire Investing, LLC | 43,070 | 63,325 | +20,255 | 0.04 | 0.04 | +0.00 | buy |
| Teza Capital Management LLC | 18,452 | 37,420 | +18,968 | 0.02 | 0.04 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 4,865 | 23,692 | +18,827 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 136,652 | 155,389 | +18,737 | 0.05 | 0.04 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 191,527 | 178,769 | +12,758 | 0.13 | 0.10 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 38,321 | 50,731 | +12,410 | 0.16 | 0.19 | +0.03 | buy |
| E Fund Management Co., Ltd. | 41,497 | 51,317 | +9,820 | 0.02 | 0.02 | -0.00 | buy |
| Golden State Equity Partners | 10,925 | 11,430 | +505 | 0.02 | 0.02 | -0.00 | buy |
| J.W. COLE ADVISORS, INC. | 19,900 | 20,100 | +200 | 0.01 | 0.01 | -0.00 | buy |
| Rehmann Capital Advisory Group | 12,141 | 12,074 | -67 | 0.01 | 0.01 | -0.00 | sell |
| Oakworth Capital, Inc. | 1,120 | 1,020 | -100 | 0.00 | 0.00 | -0.00 | sell |
| PERSONAL CFO SOLUTIONS, LLC | 66,756 | 66,303 | -453 | 0.09 | 0.07 | -0.02 | sell |
| Arete Wealth Advisors, LLC | 23,300 | 22,550 | -750 | 0.03 | 0.01 | -0.02 | sell |
| ELCO Management Co., LLC | 31,811 | 30,653 | -1,158 | 0.16 | 0.12 | -0.04 | sell |
| GRIMES & COMPANY, INC. | 73,575 | 72,355 | -1,220 | 0.02 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 139,850 | 138,101 | -1,749 | 0.01 | 0.01 | -0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 1,672,313 | 1,669,484 | -2,829 | 0.02 | 0.02 | +0.00 | sell |
| Visionary Wealth Advisors | 33,540 | 28,540 | -5,000 | 0.02 | 0.01 | -0.01 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 25,476 | 19,041 | -6,435 | 0.05 | 0.03 | -0.02 | sell |
| Bayesian Capital Management, LP | 78,700 | 60,600 | -18,100 | 0.06 | 0.04 | -0.03 | sell |
| ORACLE INVESTMENT MANAGEMENT INC | 555,522 | 535,558 | -19,964 | 1.21 | 1.95 | +0.74 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,275,638 | 2,197,261 | -78,377 | 1.02 | 0.76 | -0.26 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 153,474 | 12,670 | -140,804 | 0.20 | 0.01 | -0.19 | sell |
| Prosight Management, LP | 2,408,135 | 2,232,242 | -175,893 | 5.40 | 5.37 | -0.04 | sell |
| GW&K Investment Management, LLC | 2,570,863 | 2,337,683 | -233,180 | 0.18 | 0.13 | -0.05 | sell |
| SEGALL BRYANT & HAMILL, LLC | 2,017,986 | 1,739,317 | -278,669 | 0.17 | 0.20 | +0.04 | sell |
| Fisher Asset Management, LLC | 3,185,199 | 2,884,569 | -300,630 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 470,137 | 96,397 | -373,740 | 0.02 | 0.00 | -0.02 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 791,671 | 248,728 | -542,943 | 2.09 | 0.46 | -1.63 | sell |
| Eversept Partners, LP | 2,479,103 | 1,529,047 | -950,056 | 1.49 | 0.80 | -0.68 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,800,000 | 800,000 | -1,000,000 | 1.80 | 0.44 | -1.36 | sell |
| BAKER BROS. ADVISORS LP | 12,710,818 | 10,126,176 | -2,584,642 | 0.52 | 0.69 | +0.17 | sell |