| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 20,915,971 | 22,095,163 | +1,179,192 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 20,306,596 | 21,890,422 | +1,583,826 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 11,865,000 | 11,865,000 | 0 | 1.31 | 1.26 | -0.05 | hold |
| Kynam Capital Management, LP | 9,085,368 | 9,085,368 | 0 | 5.35 | 4.51 | -0.84 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 8,135,804 | 8,144,442 | +8,638 | 0.92 | 1.17 | +0.24 | buy |
| STATE STREET CORP | 8,849,588 | 7,498,967 | -1,350,621 | 0.00 | 0.00 | -0.00 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 7,093,822 | 7,093,822 | 0 | 0.30 | 0.31 | +0.01 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 4,837,985 | 4,823,735 | -14,250 | 0.00 | 0.00 | -0.00 | sell |
| RP Management, LLC | 3,846,154 | 3,846,154 | 0 | 12.84 | 12.84 | 0.00 | hold |
| Fisher Asset Management, LLC | 3,338,062 | 3,182,617 | -155,445 | 0.01 | 0.01 | -0.00 | sell |
| Caligan Partners LP | 2,583,585 | 2,995,932 | +412,347 | 6.22 | 5.71 | -0.52 | buy |
| GW&K Investment Management, LLC | 3,277,600 | 2,941,396 | -336,204 | 0.21 | 0.19 | -0.03 | sell |
| Rock Springs Capital Management LP | 3,622,358 | 2,677,996 | -944,362 | 0.90 | 0.77 | -0.13 | sell |
| TWO SIGMA ADVISERS, LP | 2,181,012 | 2,499,812 | +318,800 | 0.04 | 0.04 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 2,163,743 | 2,081,316 | -82,427 | 0.89 | 0.86 | -0.03 | sell |
| NORTHERN TRUST CORP | 1,860,925 | 2,004,911 | +143,986 | 0.00 | 0.00 | -0.00 | buy |
| Eversept Partners, LP | 535,405 | 1,980,312 | +1,444,907 | 0.31 | 1.54 | +1.22 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,887,994 | 1,979,992 | +91,998 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 1,843,289 | 1,842,986 | -303 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,760,808 | 1,774,214 | +13,406 | 0.03 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,772,501 | 1,720,581 | -51,920 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,739,080 | 1,665,732 | -73,348 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,792,908 | 1,579,960 | -212,948 | 0.05 | 0.04 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 1,490,376 | 1,422,196 | -68,180 | 0.15 | 0.15 | -0.01 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,194,059 | 1,384,633 | +190,574 | 0.27 | 0.31 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 2,320,529 | 1,291,230 | -1,029,299 | 0.00 | 0.00 | -0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 1,069,899 | 1,177,929 | +108,030 | 0.07 | 0.09 | +0.02 | buy |
| Invesco Ltd. | 1,005,108 | 1,072,600 | +67,492 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 892,430 | 983,033 | +90,603 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,160,965 | 899,838 | -261,127 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 787,227 | 839,274 | +52,047 | 0.01 | 0.01 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 676,292 | 835,972 | +159,680 | 0.02 | 0.03 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.43 | 0.40 | -0.04 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,322,900 | 790,105 | -532,795 | 0.01 | 0.01 | -0.00 | sell |
| FMR LLC | 1,988,389 | 777,268 | -1,211,121 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 516,209 | 725,305 | +209,096 | 0.11 | 0.13 | +0.02 | buy |
| DAFNA Capital Management LLC | 667,000 | 667,000 | 0 | 1.20 | 1.27 | +0.08 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 682,324 | 633,864 | -48,460 | 0.03 | 0.02 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 883,817 | 625,905 | -257,912 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 596,838 | 596,938 | +100 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 711,425 | 572,346 | -139,079 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 593,466 | 565,215 | -28,251 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 589,080 | 545,021 | -44,059 | 0.01 | 0.01 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 830 | 542,100 | +541,270 | 0.00 | 0.21 | +0.21 | buy |
| ORACLE INVESTMENT MANAGEMENT INC | 535,558 | 535,558 | 0 | 3.25 | 2.70 | -0.55 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 529,653 | +529,653 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 611,900 | 524,804 | -87,096 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 83,770 | 522,657 | +438,887 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 522,280 | 522,290 | +10 | 0.35 | 0.35 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 460,530 | 519,217 | +58,687 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 880,991 | 494,356 | -386,635 | 0.08 | 0.04 | -0.04 | sell |
| JPMORGAN CHASE & CO | 577,129 | 474,376 | -102,753 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 476,672 | 464,246 | -12,426 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 0 | 450,199 | +450,199 | 0.00 | 0.02 | +0.02 | buy |
| Knott David M Jr | 382,000 | 440,000 | +58,000 | 1.02 | 1.20 | +0.18 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 183,928 | 427,282 | +243,354 | 0.00 | 0.01 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 431,230 | 403,412 | -27,818 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 389,530 | 401,111 | +11,581 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 363,968 | 386,568 | +22,600 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 14,152 | 359,881 | +345,729 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 259,382 | 359,522 | +100,140 | 0.02 | 0.03 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 229,090 | 315,263 | +86,173 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 303,517 | 309,132 | +5,615 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 152,923 | 276,702 | +123,779 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 275,790 | 275,390 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 249,745 | 275,083 | +25,338 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 253,901 | 272,844 | +18,943 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 271,739 | 263,338 | -8,401 | 0.04 | 0.04 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 263,748 | 262,382 | -1,366 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 279,143 | 258,545 | -20,598 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 367,514 | 247,795 | -119,719 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 425,019 | 240,352 | -184,667 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 371,034 | 234,836 | -136,198 | 0.01 | 0.01 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 234,866 | 225,700 | -9,166 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 171,090 | 217,740 | +46,650 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 464,048 | 216,881 | -247,167 | 0.45 | 0.22 | -0.23 | sell |
| Semanteon Capital Management, LP | 149,576 | 197,760 | +48,184 | 0.77 | 0.80 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 496,784 | 196,225 | -300,559 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 11,325 | 194,797 | +183,472 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 273,959 | 194,386 | -79,573 | 0.12 | 0.08 | -0.04 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 177,253 | 184,485 | +7,232 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 111,027 | 167,957 | +56,930 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 158,110 | 167,492 | +9,382 | 0.01 | 0.01 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 285,588 | 164,484 | -121,104 | 0.16 | 0.09 | -0.07 | sell |
| LAZARD ASSET MANAGEMENT LLC | 96,096 | 161,516 | +65,420 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 155,375 | 155,045 | -330 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 142,699 | 139,132 | -3,567 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 119,750 | 126,949 | +7,199 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,252,749 | 126,806 | -2,125,943 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 127,726 | 126,797 | -929 | 0.00 | 0.00 | -0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 114,063 | 114,063 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 67,997 | 104,163 | +36,166 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 299,152 | 103,531 | -195,621 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 110,486 | 102,731 | -7,755 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 86,533 | 101,188 | +14,655 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 99,450 | +99,450 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 54,237 | 97,793 | +43,556 | 0.00 | 0.01 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 97,257 | +97,257 | 0.00 | 0.02 | +0.02 | buy |
| Counterweight Ventures, LLC | 93,384 | 93,384 | 0 | 0.50 | 0.50 | -0.01 | hold |
| HSBC HOLDINGS PLC | 67,247 | 90,061 | +22,814 | 0.00 | 0.00 | +0.00 | buy |