| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 21,790,881 | 22,273,375 | +482,494 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 21,245,876 | 21,137,791 | -108,085 | 0.00 | 0.00 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 15,827,186 | +15,827,186 | 0.00 | 1.26 | +1.26 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 12,169,000 | 14,341,000 | +2,172,000 | 1.42 | 1.43 | +0.02 | buy |
| STATE STREET CORP | 9,807,438 | 11,073,211 | +1,265,773 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 9,390,270 | 9,366,526 | -23,744 | 5.31 | 4.76 | -0.55 | sell |
| JANUS HENDERSON GROUP PLC | 93,641 | 7,404,386 | +7,310,745 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 5,967,737 | 5,263,914 | -703,823 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 5,052,307 | 5,053,786 | +1,479 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,419,629 | 4,515,317 | +95,688 | 0.05 | 0.05 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 4,240,712 | 4,089,112 | -151,600 | 0.06 | 0.06 | -0.00 | sell |
| Nuveen, LLC | 3,617,882 | 3,612,366 | -5,516 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,711,806 | 3,212,785 | +500,979 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 3,162,529 | +3,162,529 | 0.00 | 0.45 | +0.45 | buy |
| GW&K Investment Management, LLC | 2,197,765 | 3,160,924 | +963,159 | 0.15 | 0.21 | +0.07 | buy |
| Eversept Partners, LP | 1,373,625 | 2,992,895 | +1,619,270 | 0.80 | 1.31 | +0.51 | buy |
| BAKER BROS. ADVISORS LP | 0 | 2,822,727 | +2,822,727 | 0.00 | 0.13 | +0.13 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,094,278 | 2,542,714 | +448,436 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 2,632,696 | 2,467,567 | -165,129 | 0.01 | 0.01 | -0.00 | sell |
| Vestal Point Capital, LP | 0 | 2,250,000 | +2,250,000 | 0.00 | 0.64 | +0.64 | buy |
| Qube Research & Technologies Ltd | 2,410,362 | 2,164,162 | -246,200 | 0.03 | 0.02 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,140,534 | 2,128,821 | -11,713 | 0.02 | 0.03 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,994,404 | 2,004,939 | +10,535 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,880,389 | 1,904,146 | +23,757 | 0.78 | 0.82 | +0.04 | buy |
| NORTHERN TRUST CORP | 1,892,043 | 1,856,903 | -35,140 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 1,822,992 | 1,824,517 | +1,525 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 5,202,959 | 1,745,563 | -3,457,396 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 901,500 | 1,741,800 | +840,300 | 0.16 | 0.28 | +0.11 | buy |
| Squarepoint Ops LLC | 1,108,660 | 1,659,192 | +550,532 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,902,819 | 1,535,557 | -367,262 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 0 | 1,356,377 | +1,356,377 | 0.00 | 0.63 | +0.63 | buy |
| Invesco Ltd. | 962,376 | 1,354,897 | +392,521 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,359,882 | 1,298,902 | -60,980 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 1,709,336 | 1,247,466 | -461,870 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 1,228,852 | +1,228,852 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 238,187 | 1,213,576 | +975,389 | 0.00 | 0.01 | +0.01 | buy |
| JUPITER ASSET MANAGEMENT LTD | 2,055,915 | 1,197,619 | -858,296 | 0.13 | 0.07 | -0.06 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 370,463 | 1,031,488 | +661,025 | 0.01 | 0.03 | +0.02 | buy |
| Hudson Bay Capital Management LP | 0 | 1,017,374 | +1,017,374 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 0 | 913,593 | +913,593 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 924,776 | 910,930 | -13,846 | 0.11 | 0.09 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 1,012,664 | 900,057 | -112,607 | 0.84 | 0.67 | -0.18 | sell |
| JPMORGAN CHASE & CO | 1,132,377 | 843,370 | -289,007 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 837,889 | +837,889 | 0.00 | 1.37 | +1.37 | buy |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | 800,000 | 0 | 0.23 | 0.31 | +0.07 | hold |
| Susquehanna Portfolio Strategies, LLC | 0 | 778,521 | +778,521 | 0.00 | 0.09 | +0.09 | buy |
| Pictet Asset Management Holding SA | 1,196,319 | 740,510 | -455,809 | 0.01 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 782,232 | 726,367 | -55,865 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 57,906 | 716,826 | +658,920 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 999,785 | 704,291 | -295,494 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 683,416 | 683,416 | 0 | 0.33 | 0.35 | +0.02 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 245,761 | 671,693 | +425,932 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 1,848,346 | 649,357 | -1,198,989 | 0.02 | 0.01 | -0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 455,591 | 625,490 | +169,899 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 619,988 | 607,992 | -11,996 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 465,338 | 570,189 | +104,851 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 653,814 | 560,182 | -93,632 | 0.00 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 561,600 | 559,100 | -2,500 | 0.13 | 0.12 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 1,069,015 | 491,086 | -577,929 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 957,021 | 449,743 | -507,278 | 0.02 | 0.01 | -0.01 | sell |
| DAFNA Capital Management LLC | 218,255 | 418,255 | +200,000 | 0.41 | 0.76 | +0.35 | buy |
| Man Group plc | 354,484 | 407,850 | +53,366 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 385,368 | 394,368 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 369,322 | 382,556 | +13,234 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 394,740 | 378,853 | -15,887 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 244,409 | 376,568 | +132,159 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 734,987 | 374,961 | -360,026 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 3,092,592 | 359,580 | -2,733,012 | 0.03 | 0.00 | -0.03 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 848,562 | 357,086 | -491,476 | 0.02 | 0.01 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 309,110 | 355,055 | +45,945 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 375,851 | 347,190 | -28,661 | 0.01 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 230,341 | 327,941 | +97,600 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 59,487 | 325,051 | +265,564 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 265,505 | 292,850 | +27,345 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 278,333 | 278,190 | -143 | 0.00 | 0.00 | +0.00 | sell |
| DOLIVER ADVISORS, LP | 274,328 | 274,328 | 0 | 0.54 | 0.54 | -0.00 | hold |
| RHUMBLINE ADVISERS | 326,835 | 266,562 | -60,273 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 210,000 | 252,000 | +42,000 | 0.35 | 0.48 | +0.13 | buy |
| Walleye Capital LLC | 227,064 | 251,670 | +24,606 | 0.01 | 0.01 | -0.00 | buy |
| Phocas Financial Corp. | 0 | 250,797 | +250,797 | 0.00 | 0.25 | +0.25 | buy |
| Bridgewater Associates, LP | 411,503 | 235,572 | -175,931 | 0.01 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 133,036 | 233,639 | +100,603 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 113,004 | 233,354 | +120,350 | 0.01 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 314,493 | 229,226 | -85,267 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 442,847 | 224,543 | -218,304 | 0.04 | 0.02 | -0.02 | sell |
| Gotham Asset Management, LLC | 343,771 | 216,946 | -126,825 | 0.01 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 226,165 | 210,999 | -15,166 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.08 | +0.08 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 182,466 | 191,847 | +9,381 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 190,928 | +190,928 | 0.00 | 0.89 | +0.89 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 161,348 | 177,392 | +16,044 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 185,415 | 161,456 | -23,959 | 0.00 | 0.00 | -0.00 | sell |
| QTR Family Wealth, LLC | 157,137 | 154,062 | -3,075 | 0.57 | 0.44 | -0.12 | sell |
| MACKENZIE FINANCIAL CORP | 129,317 | 150,728 | +21,411 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 80,019 | 141,985 | +61,966 | 0.02 | 0.03 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 166,841 | 141,449 | -25,392 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 460,947 | 137,626 | -323,321 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 105,102 | 131,103 | +26,001 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 228,895 | 126,685 | -102,210 | 0.01 | 0.00 | -0.01 | sell |
| Elo Mutual Pension Insurance Co | 127,504 | 123,539 | -3,965 | 0.02 | 0.01 | -0.00 | sell |