| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 15,827,186 | +15,827,186 | 0.00 | 1.26 | +1.26 | buy |
| JANUS HENDERSON GROUP PLC | 93,641 | 7,404,386 | +7,310,745 | 0.00 | 0.03 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 3,162,529 | +3,162,529 | 0.00 | 0.45 | +0.45 | buy |
| BAKER BROS. ADVISORS LP | 0 | 2,822,727 | +2,822,727 | 0.00 | 0.13 | +0.13 | buy |
| Vestal Point Capital, LP | 0 | 2,250,000 | +2,250,000 | 0.00 | 0.64 | +0.64 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 12,169,000 | 14,341,000 | +2,172,000 | 1.42 | 1.43 | +0.02 | buy |
| Eversept Partners, LP | 1,373,625 | 2,992,895 | +1,619,270 | 0.80 | 1.31 | +0.51 | buy |
| Nantahala Capital Management, LLC | 0 | 1,356,377 | +1,356,377 | 0.00 | 0.63 | +0.63 | buy |
| STATE STREET CORP | 9,807,438 | 11,073,211 | +1,265,773 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 1,228,852 | +1,228,852 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 1,017,374 | +1,017,374 | 0.00 | 0.05 | +0.05 | buy |
| Point72 Asset Management, L.P. | 238,187 | 1,213,576 | +975,389 | 0.00 | 0.01 | +0.01 | buy |
| GW&K Investment Management, LLC | 2,197,765 | 3,160,924 | +963,159 | 0.15 | 0.21 | +0.07 | buy |
| Aberdeen Group plc | 0 | 913,593 | +913,593 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 901,500 | 1,741,800 | +840,300 | 0.16 | 0.28 | +0.11 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 837,889 | +837,889 | 0.00 | 1.37 | +1.37 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 778,521 | +778,521 | 0.00 | 0.09 | +0.09 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 370,463 | 1,031,488 | +661,025 | 0.01 | 0.03 | +0.02 | buy |
| HRT FINANCIAL LP | 57,906 | 716,826 | +658,920 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 1,108,660 | 1,659,192 | +550,532 | 0.02 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 2,711,806 | 3,212,785 | +500,979 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 21,790,881 | 22,273,375 | +482,494 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,094,278 | 2,542,714 | +448,436 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 245,761 | 671,693 | +425,932 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 962,376 | 1,354,897 | +392,521 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 59,487 | 325,051 | +265,564 | 0.00 | 0.00 | +0.00 | buy |
| Phocas Financial Corp. | 0 | 250,797 | +250,797 | 0.00 | 0.25 | +0.25 | buy |
| DAFNA Capital Management LLC | 218,255 | 418,255 | +200,000 | 0.41 | 0.76 | +0.35 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.08 | +0.08 | buy |
| DIADEMA PARTNERS LP | 0 | 190,928 | +190,928 | 0.00 | 0.89 | +0.89 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 455,591 | 625,490 | +169,899 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 244,409 | 376,568 | +132,159 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 113,004 | 233,354 | +120,350 | 0.01 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 465,338 | 570,189 | +104,851 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 133,036 | 233,639 | +100,603 | 0.00 | 0.00 | +0.00 | buy |
| Empire Financial Management Company, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.17 | +0.17 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 230,341 | 327,941 | +97,600 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 4,419,629 | 4,515,317 | +95,688 | 0.05 | 0.05 | +0.00 | buy |
| Jain Global LLC | 0 | 74,455 | +74,455 | 0.00 | 0.01 | +0.01 | buy |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 0 | 64,507 | +64,507 | 0.00 | 0.07 | +0.07 | buy |
| PROFUND ADVISORS LLC | 80,019 | 141,985 | +61,966 | 0.02 | 0.03 | +0.01 | buy |
| Man Group plc | 354,484 | 407,850 | +53,366 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 51,701 | +51,701 | 0.00 | 0.19 | +0.19 | buy |
| NewEdge Advisors, LLC | 0 | 50,041 | +50,041 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 42,730 | 90,278 | +47,548 | 0.09 | 0.19 | +0.10 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 309,110 | 355,055 | +45,945 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.03 | +0.03 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 210,000 | 252,000 | +42,000 | 0.35 | 0.48 | +0.13 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 66,298 | 100,690 | +34,392 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 30,000 | +30,000 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 28,347 | 58,269 | +29,922 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 265,505 | 292,850 | +27,345 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 85,745 | 112,539 | +26,794 | 0.02 | 0.03 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 105,102 | 131,103 | +26,001 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 24,898 | +24,898 | 0.00 | 0.05 | +0.05 | buy |
| Walleye Capital LLC | 227,064 | 251,670 | +24,606 | 0.01 | 0.01 | -0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 29,713 | 54,065 | +24,352 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 23,777 | +23,777 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,880,389 | 1,904,146 | +23,757 | 0.78 | 0.82 | +0.04 | buy |
| CAXTON ASSOCIATES LLP | 15,712 | 38,144 | +22,432 | 0.00 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 5,325 | 26,797 | +21,472 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 129,317 | 150,728 | +21,411 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 61,755 | 82,766 | +21,011 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 39,527 | 60,524 | +20,997 | 0.01 | 0.01 | +0.01 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 0 | 19,249 | +19,249 | 0.00 | 0.00 | +0.00 | buy |
| Brooklyn Investment Group | 0 | 18,708 | +18,708 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 17,111 | +17,111 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 98,175 | 114,541 | +16,366 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 53,308 | 69,598 | +16,290 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 161,348 | 177,392 | +16,044 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 15,600 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 37,083 | 51,893 | +14,810 | 0.03 | 0.04 | +0.01 | buy |
| Stratos Wealth Partners, LTD. | 0 | 14,700 | +14,700 | 0.00 | 0.00 | +0.00 | buy |
| SteelPeak Wealth, LLC | 0 | 13,690 | +13,690 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 369,322 | 382,556 | +13,234 | 0.01 | 0.01 | +0.00 | buy |
| Quantessence Capital LLC | 0 | 13,200 | +13,200 | 0.00 | 1.19 | +1.19 | buy |
| AlphaQuest LLC | 64,103 | 76,405 | +12,302 | 0.03 | 0.03 | +0.00 | buy |
| Mariner, LLC | 19,688 | 31,495 | +11,807 | 0.00 | 0.00 | +0.00 | buy |
| FIDUCIARY TRUST CO | 26,019 | 37,253 | +11,234 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,994,404 | 2,004,939 | +10,535 | 0.00 | 0.00 | +0.00 | buy |
| Envestnet Portfolio Solutions, Inc. | 0 | 10,430 | +10,430 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 182,466 | 191,847 | +9,381 | 0.00 | 0.00 | +0.00 | buy |
| COMMERCE BANK | 29,715 | 39,065 | +9,350 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 385,368 | 394,368 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 24,436 | 32,910 | +8,474 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 43,297 | 47,604 | +4,307 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 114,339 | 118,473 | +4,134 | 0.07 | 0.08 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 116,201 | 119,567 | +3,366 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 275 | 3,542 | +3,267 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 39,800 | 42,900 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| INCEPTIONR LLC | 11,314 | 13,631 | +2,317 | 0.02 | 0.03 | +0.01 | buy |
| Legato Capital Management LLC | 21,777 | 23,949 | +2,172 | 0.02 | 0.02 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 8,116 | 10,231 | +2,115 | 0.00 | 0.00 | +0.00 | buy |
| Counterweight Ventures, LLC | 93,384 | 95,384 | +2,000 | 0.41 | 0.42 | +0.00 | buy |
| Atria Investments, Inc | 12,229 | 14,092 | +1,863 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 1,822,992 | 1,824,517 | +1,525 | 0.01 | 0.01 | +0.00 | buy |
| Cetera Investment Advisers | 10,836 | 12,330 | +1,494 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 5,052,307 | 5,053,786 | +1,479 | 0.00 | 0.00 | -0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 10,728 | 12,123 | +1,395 | 0.00 | 0.00 | -0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 10,728 | 12,123 | +1,395 | 0.01 | 0.00 | -0.00 | buy |