| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 485,000 | 12,893,611 | +12,408,611 | 0.02 | 0.78 | +0.76 | buy |
| Logos Global Management LP | 0 | 9,000,000 | +9,000,000 | 0.00 | 3.13 | +3.13 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 7,495,000 | +7,495,000 | 0.00 | 0.15 | +0.15 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 7,200,000 | +7,200,000 | 0.00 | 0.04 | +0.04 | buy |
| Fairmount Funds Management LLC | 0 | 6,666,667 | +6,666,667 | 0.00 | 2.40 | +2.40 | buy |
| STATE STREET CORP | 25,625,606 | 31,604,392 | +5,978,786 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,032,352 | 12,760,298 | +5,727,946 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,138,567 | +3,138,567 | 0.00 | 0.03 | +0.03 | buy |
| SAMLYN CAPITAL, LLC | 0 | 3,114,924 | +3,114,924 | 0.00 | 0.18 | +0.18 | buy |
| Vivo Capital, LLC | 24,143,681 | 27,225,292 | +3,081,611 | 4.17 | 7.06 | +2.89 | buy |
| Affinity Asset Advisors, LLC | 0 | 2,500,000 | +2,500,000 | 0.00 | 1.34 | +1.34 | buy |
| Vestal Point Capital, LP | 0 | 2,200,000 | +2,200,000 | 0.00 | 0.60 | +0.60 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 187,779 | 2,064,963 | +1,877,184 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 1,666,666 | +1,666,666 | 0.00 | 0.15 | +0.15 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 9,484,971 | 10,942,584 | +1,457,613 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 711,949 | 2,150,971 | +1,439,022 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGER MANAGEMENT, LLC | 0 | 1,338,084 | +1,338,084 | 0.00 | 1.99 | +1.99 | buy |
| VANGUARD GROUP INC | 28,564,574 | 29,869,287 | +1,304,713 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 1,281,194 | +1,281,194 | 0.00 | 0.11 | +0.11 | buy |
| Woodline Partners LP | 0 | 1,214,570 | +1,214,570 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 3,180,403 | 4,390,682 | +1,210,279 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 1,192,200 | +1,192,200 | 0.00 | 0.14 | +0.14 | buy |
| Saturn V Capital Management LP | 0 | 1,123,995 | +1,123,995 | 0.00 | 1.49 | +1.49 | buy |
| Invesco Ltd. | 4,360,330 | 5,469,131 | +1,108,801 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 29,583,449 | 30,505,929 | +922,480 | 2.19 | 2.89 | +0.71 | buy |
| Rafferty Asset Management, LLC | 1,669,087 | 2,411,211 | +742,124 | 0.01 | 0.03 | +0.01 | buy |
| PATHWAY CAPITAL MANAGEMENT, LP | 0 | 636,838 | +636,838 | 0.00 | 1.96 | +1.96 | buy |
| Lion Point Capital, LP | 0 | 600,000 | +600,000 | 0.00 | 3.79 | +3.79 | buy |
| Russell Investments Group, Ltd. | 1,237,234 | 1,750,599 | +513,365 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,943,649 | 11,425,985 | +482,336 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 546,796 | 963,293 | +416,497 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 913,550 | 1,324,550 | +411,000 | 1.20 | 4.05 | +2.85 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 384,356 | +384,356 | 0.00 | 0.21 | +0.21 | buy |
| UBS Group AG | 1,441,603 | 1,807,311 | +365,708 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 350,376 | +350,376 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 643,164 | 986,109 | +342,945 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 293,396 | +293,396 | 0.00 | 0.01 | +0.01 | buy |
| State of Tennessee, Department of Treasury | 0 | 279,929 | +279,929 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 607,500 | 886,800 | +279,300 | 1.27 | 2.51 | +1.24 | buy |
| J. Goldman & Co LP | 0 | 261,397 | +261,397 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 1,738,574 | 1,999,718 | +261,144 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.23 | +0.23 | buy |
| TD ASSET MANAGEMENT INC | 0 | 238,800 | +238,800 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 194,346 | +194,346 | 0.00 | 0.03 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 177,124 | +177,124 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 144,800 | 314,460 | +169,660 | 0.03 | 0.07 | +0.04 | buy |
| Temasek Holdings (Private) Ltd | 0 | 139,964 | +139,964 | 0.00 | 0.00 | +0.00 | buy |
| Partners Group Holding AG | 0 | 120,090 | +120,090 | 0.00 | 0.04 | +0.04 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 260,827 | 362,868 | +102,041 | 0.00 | 0.00 | +0.00 | buy |
| TOKIO MARINE ASSET MANAGEMENT CO LTD | 0 | 100,774 | +100,774 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 275,823 | 376,360 | +100,537 | 0.02 | 0.05 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 63,437 | 162,820 | +99,383 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 121,561 | 195,761 | +74,200 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 246,560 | 305,347 | +58,787 | 0.00 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 53,576 | +53,576 | 0.00 | 0.00 | +0.00 | buy |
| FISHMAN JAY A LTD/MI | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 617,363 | 666,013 | +48,650 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,842,500 | 3,889,756 | +47,256 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 62,820 | 104,929 | +42,109 | 0.03 | 0.04 | +0.02 | buy |
| OSAIC HOLDINGS, INC. | 227,206 | 268,202 | +40,996 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 0 | 32,472 | +32,472 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 0 | 31,148 | +31,148 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 773,600 | 804,300 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 179,807 | 209,373 | +29,566 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 4,419,820 | 4,448,896 | +29,076 | 0.18 | 0.28 | +0.10 | buy |
| Dai-ichi Life Insurance Company, Ltd | 0 | 27,993 | +27,993 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 358,782 | 385,154 | +26,372 | 0.01 | 0.01 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 0 | 26,200 | +26,200 | 0.00 | 0.04 | +0.04 | buy |
| E Fund Management Co., Ltd. | 89,633 | 113,941 | +24,308 | 0.01 | 0.02 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 230,264 | 251,716 | +21,452 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 20,013 | +20,013 | 0.00 | 0.00 | +0.00 | buy |
| Summit X, LLC | 361,961 | 381,670 | +19,709 | 0.22 | 0.32 | +0.11 | buy |
| Mirae Asset Global Investments Co., Ltd. | 70,392 | 89,059 | +18,667 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 709,143 | 727,218 | +18,075 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 16,668 | 32,977 | +16,309 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 15,151 | +15,151 | 0.00 | 0.00 | +0.00 | buy |
| Poehling Capital Management, INC. | 60,500 | 75,501 | +15,001 | 0.04 | 0.07 | +0.03 | buy |
| Verition Fund Management LLC | 0 | 14,695 | +14,695 | 0.00 | 0.00 | +0.00 | buy |
| American Trust | 0 | 11,377 | +11,377 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 11,223 | +11,223 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 11,194 | +11,194 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 119,503 | 130,316 | +10,813 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 10,393 | +10,393 | 0.00 | 0.01 | +0.01 | buy |
| Alternative Investment Advisors, LLC. | 0 | 10,302 | +10,302 | 0.00 | 0.02 | +0.02 | buy |
| Kingsview Wealth Management, LLC | 0 | 10,250 | +10,250 | 0.00 | 0.00 | +0.00 | buy |
| IFG Advisory, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 262,662 | 271,574 | +8,912 | 0.00 | 0.01 | +0.00 | buy |
| Crewe Advisors LLC | 1,000 | 9,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 57,404 | 64,438 | +7,034 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 514 | 7,128 | +6,614 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 28,817 | 35,028 | +6,211 | 0.00 | 0.00 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 99,557 | 104,054 | +4,497 | 0.01 | 0.01 | +0.00 | buy |
| Vishria Bird Financial Group, LLC | 20,615 | 24,265 | +3,650 | 0.02 | 0.03 | +0.01 | buy |
| Cresset Asset Management, LLC | 160,634 | 164,040 | +3,406 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 23,093 | 26,203 | +3,110 | 0.00 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 2,000 | 4,600 | +2,600 | 0.00 | 0.01 | +0.01 | buy |
| Arizona State Retirement System | 109,729 | 111,935 | +2,206 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4,000 | 4,706 | +706 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 129,639 | 130,249 | +610 | 0.00 | 0.00 | +0.00 | buy |