| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 46,202,425 | 46,202,425 | 0 | 1.52 | 1.94 | +0.42 | hold |
| STATE STREET CORP | 25,625,606 | 31,604,392 | +5,978,786 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 29,583,449 | 30,505,929 | +922,480 | 2.19 | 2.89 | +0.71 | buy |
| VANGUARD GROUP INC | 28,564,574 | 29,869,287 | +1,304,713 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 24,143,681 | 27,225,292 | +3,081,611 | 4.17 | 7.06 | +2.89 | buy |
| TCG Crossover Management, LLC | 23,375,839 | 17,391,639 | -5,984,200 | 5.47 | 4.54 | -0.93 | sell |
| ORBIMED ADVISORS LLC | 485,000 | 12,893,611 | +12,408,611 | 0.02 | 0.78 | +0.76 | buy |
| NEA Management Company, LLC | 22,776,409 | 12,776,409 | -10,000,000 | 3.20 | 2.62 | -0.59 | sell |
| FMR LLC | 7,032,352 | 12,760,298 | +5,727,946 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,943,649 | 11,425,985 | +482,336 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 9,484,971 | 10,942,584 | +1,457,613 | 0.00 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 10,715,620 | 10,475,675 | -239,945 | 5.29 | 5.56 | +0.27 | sell |
| Logos Global Management LP | 0 | 9,000,000 | +9,000,000 | 0.00 | 3.13 | +3.13 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 7,495,000 | +7,495,000 | 0.00 | 0.15 | +0.15 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,730,986 | 7,302,296 | -7,428,690 | 0.03 | 0.02 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 7,200,000 | +7,200,000 | 0.00 | 0.04 | +0.04 | buy |
| Fairmount Funds Management LLC | 0 | 6,666,667 | +6,666,667 | 0.00 | 2.40 | +2.40 | buy |
| Invesco Ltd. | 4,360,330 | 5,469,131 | +1,108,801 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 5,117,735 | 5,028,567 | -89,168 | 0.00 | 0.00 | +0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 4,419,820 | 4,448,896 | +29,076 | 0.18 | 0.28 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 3,180,403 | 4,390,682 | +1,210,279 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,842,500 | 3,889,756 | +47,256 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 10,564,267 | 3,354,140 | -7,210,127 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,138,567 | +3,138,567 | 0.00 | 0.03 | +0.03 | buy |
| SAMLYN CAPITAL, LLC | 0 | 3,114,924 | +3,114,924 | 0.00 | 0.18 | +0.18 | buy |
| Ally Bridge Group (NY) LLC | 2,971,639 | 2,760,497 | -211,142 | 3.74 | 5.06 | +1.33 | sell |
| Affinity Asset Advisors, LLC | 0 | 2,500,000 | +2,500,000 | 0.00 | 1.34 | +1.34 | buy |
| Rafferty Asset Management, LLC | 1,669,087 | 2,411,211 | +742,124 | 0.01 | 0.03 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 2,200,000 | +2,200,000 | 0.00 | 0.60 | +0.60 | buy |
| CITIGROUP INC | 711,949 | 2,150,971 | +1,439,022 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 187,779 | 2,064,963 | +1,877,184 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,738,574 | 1,999,718 | +261,144 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 1,441,603 | 1,807,311 | +365,708 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,237,234 | 1,750,599 | +513,365 | 0.00 | 0.01 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 1,666,666 | +1,666,666 | 0.00 | 0.15 | +0.15 | buy |
| Bank of New York Mellon Corp | 1,771,145 | 1,600,739 | -170,406 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 7,068,004 | 1,352,053 | -5,715,951 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGER MANAGEMENT, LLC | 0 | 1,338,084 | +1,338,084 | 0.00 | 1.99 | +1.99 | buy |
| Nan Fung Group Holdings Ltd | 913,550 | 1,324,550 | +411,000 | 1.20 | 4.05 | +2.85 | buy |
| Artal Group S.A. | 0 | 1,281,194 | +1,281,194 | 0.00 | 0.11 | +0.11 | buy |
| Woodline Partners LP | 0 | 1,214,570 | +1,214,570 | 0.00 | 0.04 | +0.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 1,192,200 | +1,192,200 | 0.00 | 0.14 | +0.14 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,135,195 | 1,125,280 | -9,915 | 0.05 | 0.08 | +0.02 | sell |
| Saturn V Capital Management LP | 0 | 1,123,995 | +1,123,995 | 0.00 | 1.49 | +1.49 | buy |
| MML INVESTORS SERVICES, LLC | 1,295,228 | 1,053,428 | -241,800 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 643,164 | 986,109 | +342,945 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 546,796 | 963,293 | +416,497 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 607,500 | 886,800 | +279,300 | 1.27 | 2.51 | +1.24 | buy |
| Swiss National Bank | 773,600 | 804,300 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 709,143 | 727,218 | +18,075 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 617,363 | 666,013 | +48,650 | 0.00 | 0.00 | +0.00 | buy |
| PATHWAY CAPITAL MANAGEMENT, LP | 0 | 636,838 | +636,838 | 0.00 | 1.96 | +1.96 | buy |
| Lion Point Capital, LP | 0 | 600,000 | +600,000 | 0.00 | 3.79 | +3.79 | buy |
| BARCLAYS PLC | 1,575,585 | 567,263 | -1,008,322 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 512,741 | 512,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 778,500 | 500,000 | -278,500 | 1.16 | 0.89 | -0.27 | sell |
| JANE STREET GROUP, LLC | 613,415 | 488,505 | -124,910 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 699,443 | 481,712 | -217,731 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 433,890 | 417,682 | -16,208 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 410,422 | 396,052 | -14,370 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 393,846 | 393,846 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALPS ADVISORS INC | 358,782 | 385,154 | +26,372 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 384,356 | +384,356 | 0.00 | 0.21 | +0.21 | buy |
| Summit X, LLC | 361,961 | 381,670 | +19,709 | 0.22 | 0.32 | +0.11 | buy |
| PROFUND ADVISORS LLC | 275,823 | 376,360 | +100,537 | 0.02 | 0.05 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 260,827 | 362,868 | +102,041 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 350,376 | +350,376 | 0.00 | 0.03 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 351,022 | 344,060 | -6,962 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 372,643 | 331,808 | -40,835 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 144,800 | 314,460 | +169,660 | 0.03 | 0.07 | +0.04 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 246,560 | 305,347 | +58,787 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 714,012 | 295,551 | -418,461 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 293,396 | +293,396 | 0.00 | 0.01 | +0.01 | buy |
| State of Tennessee, Department of Treasury | 0 | 279,929 | +279,929 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 262,662 | 271,574 | +8,912 | 0.00 | 0.01 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 227,206 | 268,202 | +40,996 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 261,397 | +261,397 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 254,663 | 252,495 | -2,168 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 230,264 | 251,716 | +21,452 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 250,000 | +250,000 | 0.00 | 0.23 | +0.23 | buy |
| HighVista Strategies LLC | 240,234 | 240,234 | 0 | 0.18 | 0.28 | +0.10 | hold |
| TD ASSET MANAGEMENT INC | 0 | 238,800 | +238,800 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 179,807 | 209,373 | +29,566 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 200,000 | 200,000 | 0 | 0.35 | 0.62 | +0.26 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 210,890 | 197,771 | -13,119 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 121,561 | 195,761 | +74,200 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 194,346 | +194,346 | 0.00 | 0.03 | +0.03 | buy |
| Cambridge Investment Research Advisors, Inc. | 225,373 | 193,175 | -32,198 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 183,391 | 183,391 | 0 | 0.01 | 0.01 | +0.01 | hold |
| Private Advisor Group, LLC | 351,144 | 181,551 | -169,593 | 0.01 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 181,018 | 181,037 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 177,124 | +177,124 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 204,125 | 171,947 | -32,178 | 0.00 | 0.00 | +0.00 | sell |
| Cresset Asset Management, LLC | 160,634 | 164,040 | +3,406 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 63,437 | 162,820 | +99,383 | 0.00 | 0.01 | +0.01 | buy |
| Arnhold LLC | 142,400 | 142,400 | 0 | 0.03 | 0.05 | +0.02 | hold |
| Temasek Holdings (Private) Ltd | 0 | 139,964 | +139,964 | 0.00 | 0.00 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 132,053 | 131,045 | -1,008 | 0.02 | 0.03 | +0.01 | sell |
| ProShare Advisors LLC | 119,503 | 130,316 | +10,813 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 129,639 | 130,249 | +610 | 0.00 | 0.00 | +0.00 | buy |