| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 485,000 | 12,893,611 | +12,408,611 | 0.02 | 0.78 | +0.76 | buy |
| Vivo Capital, LLC | 24,143,681 | 27,225,292 | +3,081,611 | 4.17 | 7.06 | +2.89 | buy |
| Deep Track Capital, LP | 29,583,449 | 30,505,929 | +922,480 | 2.19 | 2.89 | +0.71 | buy |
| Rafferty Asset Management, LLC | 1,669,087 | 2,411,211 | +742,124 | 0.01 | 0.03 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 913,550 | 1,324,550 | +411,000 | 1.20 | 4.05 | +2.85 | buy |
| Exome Asset Management LLC | 607,500 | 886,800 | +279,300 | 1.27 | 2.51 | +1.24 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 144,800 | 314,460 | +169,660 | 0.03 | 0.07 | +0.05 | buy |
| PROFUND ADVISORS LLC | 275,823 | 376,360 | +100,537 | 0.03 | 0.05 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 62,820 | 104,929 | +42,109 | 0.03 | 0.04 | +0.02 | buy |
| SEGALL BRYANT & HAMILL, LLC | 4,419,820 | 4,448,896 | +29,076 | 0.18 | 0.28 | +0.10 | buy |
| ALPS ADVISORS INC | 358,782 | 385,154 | +26,372 | 0.01 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 89,633 | 113,941 | +24,308 | 0.01 | 0.02 | +0.01 | buy |
| Summit X, LLC | 361,961 | 381,670 | +19,709 | 0.22 | 0.32 | +0.11 | buy |
| Poehling Capital Management, INC. | 60,500 | 75,501 | +15,001 | 0.04 | 0.07 | +0.03 | buy |
| Crewe Advisors LLC | 1,000 | 9,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 99,557 | 104,054 | +4,497 | 0.01 | 0.01 | 0.00 | buy |
| Vishria Bird Financial Group, LLC | 20,615 | 24,265 | +3,650 | 0.02 | 0.03 | +0.01 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 23,093 | 26,203 | +3,110 | 0.00 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 2,000 | 4,600 | +2,600 | 0.00 | 0.01 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 34,118 | 34,703 | +585 | 0.00 | 0.01 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 132,053 | 131,045 | -1,008 | 0.02 | 0.03 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 41,892 | 39,205 | -2,687 | 0.06 | 0.07 | +0.01 | sell |
| MGO ONE SEVEN LLC | 26,260 | 19,060 | -7,200 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,135,195 | 1,125,280 | -9,915 | 0.05 | 0.08 | +0.02 | sell |
| World Investment Advisors | 20,000 | 10,043 | -9,957 | 0.01 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 28,316 | 17,876 | -10,440 | 0.03 | 0.03 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 17,295 | 1,295 | -16,000 | 0.02 | 0.00 | -0.02 | sell |
| LAZARI CAPITAL MANAGEMENT, INC. | 114,424 | 93,424 | -21,000 | 0.14 | 0.17 | +0.03 | sell |
| Inspire Investing, LLC | 181,369 | 107,919 | -73,450 | 0.04 | 0.04 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 2,971,639 | 2,760,497 | -211,142 | 3.74 | 5.06 | +1.33 | sell |
| MPM BioImpact LLC | 10,715,620 | 10,475,675 | -239,945 | 5.29 | 5.56 | +0.27 | sell |
| Velan Capital Investment Management LP | 778,500 | 500,000 | -278,500 | 1.16 | 0.89 | -0.27 | sell |
| TCG Crossover Management, LLC | 23,375,839 | 17,391,639 | -5,984,200 | 5.47 | 4.54 | -0.93 | sell |
| NEA Management Company, LLC | 22,776,409 | 12,776,409 | -10,000,000 | 3.20 | 2.62 | -0.59 | sell |