| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 4,011,287 | 38,176,251 | +34,164,964 | 0.53 | 1.97 | +1.43 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 30,009,536 | 60,379,366 | +30,369,830 | 1.41 | 1.60 | +0.19 | buy |
| Vestal Point Capital, LP | 11,000,000 | 22,005,340 | +11,005,340 | 2.31 | 2.50 | +0.19 | buy |
| Clearbridge Investments, LLC | 0 | 8,687,142 | +8,687,142 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 2,000,000 | 8,000,000 | +6,000,000 | 0.83 | 2.26 | +1.43 | buy |
| BANK OF AMERICA CORP /DE/ | 3,900,627 | 9,692,359 | +5,791,732 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,488,892 | 7,126,818 | +5,637,926 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,452,700 | 5,601,100 | +4,148,400 | 0.01 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 7,034,632 | 10,806,625 | +3,771,993 | 0.02 | 0.02 | -0.00 | buy |
| Kynam Capital Management, LP | 0 | 3,659,526 | +3,659,526 | 0.00 | 0.50 | +0.50 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,509,920 | +3,509,920 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 1,529,298 | 4,795,555 | +3,266,257 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,202,995 | 5,140,464 | +2,937,469 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 892,910 | 3,794,565 | +2,901,655 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 2,850,000 | +2,850,000 | 0.00 | 0.46 | +0.46 | buy |
| ALGERT GLOBAL LLC | 528,686 | 3,260,934 | +2,732,248 | 0.04 | 0.13 | +0.08 | buy |
| CITADEL ADVISORS LLC | 4,184,145 | 6,663,314 | +2,479,169 | 0.01 | 0.01 | -0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 2,400,000 | +2,400,000 | 0.00 | 0.30 | +0.30 | buy |
| Candriam S.C.A. | 0 | 1,896,010 | +1,896,010 | 0.00 | 0.02 | +0.02 | buy |
| Aberdeen Group plc | 1,847,285 | 3,692,753 | +1,845,468 | 0.01 | 0.01 | -0.00 | buy |
| Exome Asset Management LLC | 1,561,152 | 3,215,457 | +1,654,305 | 4.23 | 4.58 | +0.35 | buy |
| Invesco Ltd. | 2,077,602 | 3,618,607 | +1,541,005 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 57,022 | 1,399,808 | +1,342,786 | 0.00 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 166,650 | 1,409,274 | +1,242,624 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 787,667 | 1,872,500 | +1,084,833 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 1,074,824 | 2,056,637 | +981,813 | 3.26 | 2.95 | -0.31 | buy |
| STEMPOINT CAPITAL LP | 0 | 960,307 | +960,307 | 0.00 | 0.49 | +0.49 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 822,700 | +822,700 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 800,001 | +800,001 | 0.00 | 0.07 | +0.07 | buy |
| VANGUARD GROUP INC | 33,538,822 | 34,146,851 | +608,029 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 49,000 | 655,000 | +606,000 | 0.15 | 1.07 | +0.92 | buy |
| WELLS FARGO & COMPANY/MN | 392,696 | 962,773 | +570,077 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 526,436 | +526,436 | 0.00 | 0.03 | +0.03 | buy |
| Stonepine Capital Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.77 | +0.77 | buy |
| GROUP ONE TRADING LLC | 0 | 443,864 | +443,864 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,141,514 | 13,567,594 | +426,080 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 476,994 | 895,025 | +418,031 | 0.14 | 0.14 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 376,760 | +376,760 | 0.00 | 0.02 | +0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 1,850,000 | 2,130,000 | +280,000 | 0.11 | 0.06 | -0.05 | buy |
| Point72 (DIFC) Ltd | 31,133 | 259,053 | +227,920 | 0.01 | 0.04 | +0.03 | buy |
| JANE STREET GROUP, LLC | 399,434 | 602,087 | +202,653 | 0.00 | 0.00 | -0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 195,682 | +195,682 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 351,724 | 535,975 | +184,251 | 0.01 | 0.01 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 105,800 | 285,606 | +179,806 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 167,148 | 338,597 | +171,449 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 168,042 | +168,042 | 0.00 | 0.00 | +0.00 | buy |
| Summit X, LLC | 382,972 | 547,899 | +164,927 | 0.30 | 0.18 | -0.12 | buy |
| Ikarian Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.08 | +0.08 | buy |
| Brevan Howard Capital Management LP | 0 | 125,399 | +125,399 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 1,000,601 | 1,120,328 | +119,727 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 0 | 106,635 | +106,635 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,267,176 | 1,372,016 | +104,840 | 0.00 | 0.00 | -0.00 | buy |
| Inspire Investing, LLC | 116,860 | 220,935 | +104,075 | 0.05 | 0.04 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 138,891 | 234,606 | +95,715 | 0.04 | 0.03 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 91,587 | +91,587 | 0.00 | 0.04 | +0.04 | buy |
| Quantbot Technologies LP | 0 | 81,642 | +81,642 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 80,756 | +80,756 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 55,351 | 131,234 | +75,883 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 69,705 | 142,716 | +73,011 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 43,529 | 102,064 | +58,535 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 53,917 | +53,917 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 50,988 | 103,521 | +52,533 | 0.02 | 0.01 | -0.00 | buy |
| Kazazian Asset Management, LLC | 0 | 47,500 | +47,500 | 0.00 | 0.06 | +0.06 | buy |
| SIMPLEX TRADING, LLC | 142,582 | 190,021 | +47,439 | 0.01 | 0.01 | -0.00 | buy |
| DnB Asset Management AS | 92,243 | 136,581 | +44,338 | 0.00 | 0.00 | -0.00 | buy |
| Forefront Analytics, LLC | 19,023 | 62,973 | +43,950 | 0.03 | 0.11 | +0.08 | buy |
| JPMORGAN CHASE & CO | 498,730 | 540,799 | +42,069 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 66,661 | 106,675 | +40,014 | 0.00 | 0.00 | -0.00 | buy |
| SIH Partners, LLLP | 0 | 39,868 | +39,868 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 39,643 | +39,643 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 27,829 | 67,441 | +39,612 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 38,321 | 73,211 | +34,890 | 0.00 | 0.00 | -0.00 | buy |
| Farringdon Capital, Ltd. | 0 | 31,652 | +31,652 | 0.00 | 0.03 | +0.03 | buy |
| Quantinno Capital Management LP | 0 | 29,515 | +29,515 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 25,148 | 53,053 | +27,905 | 0.00 | 0.00 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 267,629 | 295,425 | +27,796 | 0.10 | 0.05 | -0.05 | buy |
| Sowell Financial Services LLC | 0 | 27,000 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 24,699 | +24,699 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 17,059 | 41,448 | +24,389 | 0.00 | 0.00 | -0.00 | buy |
| Focus Partners Advisor Solutions, LLC | 0 | 24,370 | +24,370 | 0.00 | 0.00 | +0.00 | buy |
| Zuckerman Investment Group, LLC | 80,000 | 103,000 | +23,000 | 0.02 | 0.02 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 150,308 | 170,441 | +20,133 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 58,863 | 78,289 | +19,426 | 0.20 | 0.09 | -0.11 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 76,424 | 95,524 | +19,100 | 0.11 | 0.06 | -0.05 | buy |
| INCEPTIONR LLC | 0 | 17,258 | +17,258 | 0.00 | 0.01 | +0.01 | buy |
| J.W. COLE ADVISORS, INC. | 0 | 16,230 | +16,230 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 14,708 | +14,708 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 59,623 | 71,528 | +11,905 | 0.00 | 0.00 | -0.00 | buy |
| Bernardo Wealth Planning LLC | 0 | 11,650 | +11,650 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 11,245 | +11,245 | 0.00 | 0.00 | +0.00 | buy |
| Waverly Advisors, LLC | 0 | 10,555 | +10,555 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 61,658 | 71,680 | +10,022 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 10 | 9,644 | +9,634 | 0.00 | 0.00 | +0.00 | buy |
| Frisch Financial Group, Inc. | 10,325 | 19,025 | +8,700 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 384,411 | 392,534 | +8,123 | 0.00 | 0.00 | -0.00 | buy |
| Alternative Investment Advisors, LLC. | 32,578 | 39,278 | +6,700 | 0.06 | 0.03 | -0.03 | buy |
| IHT Wealth Management, LLC | 27,350 | 33,750 | +6,400 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 143,998 | 150,298 | +6,300 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 4,309 | 10,162 | +5,853 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH LANE CAPITAL, LP | 15,000 | 20,000 | +5,000 | 0.16 | 0.14 | -0.02 | buy |