| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 63,771,366 | 63,771,366 | 0 | 0.86 | 1.01 | +0.14 | hold |
| BlackRock, Inc. | 45,913,344 | 47,319,779 | +1,406,435 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 23,290,000 | 41,508,659 | +18,218,659 | 1.30 | 2.50 | +1.20 | buy |
| Deep Track Capital, LP | 32,511,271 | 31,720,278 | -790,993 | 0.98 | 0.98 | -0.00 | sell |
| STATE STREET CORP | 26,867,322 | 30,497,183 | +3,629,861 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 9,925,786 | 21,576,569 | +11,650,783 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 0 | 20,457,134 | +20,457,134 | 0.00 | 0.05 | +0.05 | buy |
| Clearbridge Investments, LLC | 14,242,953 | 19,620,320 | +5,377,367 | 0.02 | 0.03 | +0.01 | buy |
| Eversept Partners, LP | 17,659,983 | 18,834,883 | +1,174,900 | 1.31 | 1.85 | +0.54 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,027,335 | 13,670,785 | +643,450 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 12,603,418 | 12,665,119 | +61,701 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 9,025,000 | 11,225,000 | +2,200,000 | 0.71 | 1.04 | +0.33 | buy |
| GOLDMAN SACHS GROUP INC | 16,174,398 | 11,176,591 | -4,997,807 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 27,225,292 | 8,671,797 | -18,553,495 | 2.32 | 1.07 | -1.25 | sell |
| MILLENNIUM MANAGEMENT LLC | 4,603,876 | 7,321,522 | +2,717,646 | 0.00 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 3,456,318 | 6,836,318 | +3,380,000 | 0.30 | 0.65 | +0.35 | buy |
| FMR LLC | 8,076,965 | 6,597,156 | -1,479,809 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 5,140,809 | 5,203,516 | +62,707 | 0.00 | 0.00 | +0.00 | buy |
| Pale Fire Capital SE | 4,788,594 | 4,888,304 | +99,710 | 0.81 | 0.64 | -0.17 | buy |
| NORTHERN TRUST CORP | 4,726,605 | 4,862,264 | +135,659 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 5,048,936 | 4,740,048 | -308,888 | 0.09 | 0.07 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 2,698,010 | 4,556,278 | +1,858,268 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,514,063 | 4,483,376 | -30,687 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 2,839,484 | 3,921,476 | +1,081,992 | 0.02 | 0.03 | +0.01 | buy |
| UBS Group AG | 3,273,705 | 3,693,333 | +419,628 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 2,960,047 | +2,960,047 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 1,999,843 | 2,931,489 | +931,646 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 11,320,000 | 2,540,000 | -8,780,000 | 0.55 | 0.11 | -0.44 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,330,000 | 2,330,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| JANUS HENDERSON GROUP PLC | 239,357 | 2,218,196 | +1,978,839 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,801,468 | 1,889,468 | -912,000 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 737,166 | 1,799,521 | +1,062,355 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 1,573,836 | 1,540,236 | -33,600 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 3,107,529 | 1,445,859 | -1,661,670 | 0.01 | 0.00 | -0.00 | sell |
| NAN FUNG TRINITY (HK) Ltd | 1,373,550 | 1,373,550 | 0 | 0.14 | 0.22 | +0.08 | hold |
| Invesco Ltd. | 1,225,658 | 1,304,458 | +78,800 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,232,288 | 1,271,014 | +38,726 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,296,163 | 1,250,017 | -46,146 | 0.00 | 0.00 | +0.00 | sell |
| HRT FINANCIAL LP | 1,200,225 | 1,214,752 | +14,527 | 0.00 | 0.00 | -0.00 | buy |
| World Investment Advisors | 1,033,779 | 1,033,779 | 0 | 0.02 | 0.02 | +0.00 | hold |
| XTX Topco Ltd | 258,397 | 961,159 | +702,762 | 0.01 | 0.02 | +0.02 | buy |
| Swiss National Bank | 926,100 | 947,500 | +21,400 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 821,890 | 883,595 | +61,705 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 1,013,003 | 771,971 | -241,032 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 475,257 | 737,143 | +261,886 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 727,512 | 700,101 | -27,411 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 651,571 | 651,185 | -386 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 139,391 | 633,501 | +494,110 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 502,509 | 620,795 | +118,286 | 0.18 | 0.26 | +0.07 | buy |
| J. Goldman & Co LP | 0 | 610,659 | +610,659 | 0.00 | 0.04 | +0.04 | buy |
| Lion Point Capital, LP | 578,000 | 578,000 | 0 | 3.95 | 5.15 | +1.20 | hold |
| ALLIANCEBERNSTEIN L.P. | 386,341 | 555,701 | +169,360 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 524,159 | 521,439 | -2,720 | 0.00 | 0.00 | -0.00 | sell |
| Nvest Financial, LLC | 228,791 | 508,474 | +279,683 | 0.13 | 0.28 | +0.16 | buy |
| WELLS FARGO & COMPANY/MN | 855,141 | 460,729 | -394,412 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 71,628 | 426,698 | +355,070 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 420,332 | 423,328 | +2,996 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 123,848 | 396,908 | +273,060 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 421,458 | 396,632 | -24,826 | 0.02 | 0.02 | +0.00 | sell |
| PROFUND ADVISORS LLC | 306,913 | 394,909 | +87,996 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 312,027 | 390,016 | +77,989 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 360,845 | +360,845 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 354,150 | 349,627 | -4,523 | 0.04 | 0.05 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 301,593 | 318,809 | +17,216 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 443,328 | 296,841 | -146,487 | 0.00 | 0.00 | -0.00 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 295,425 | 295,425 | 0 | 0.04 | 0.04 | +0.00 | hold |
| JPMORGAN CHASE & CO | 264,478 | 291,838 | +27,360 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 183,366 | 290,780 | +107,414 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 158,787 | 279,083 | +120,296 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 26,879 | 258,414 | +231,535 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 0 | 255,927 | +255,927 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 297,062 | 250,662 | -46,400 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 178,497 | 232,332 | +53,835 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 203,847 | 220,604 | +16,757 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 205,691 | 207,981 | +2,290 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 1,575,429 | 205,967 | -1,369,462 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 202,520 | 203,526 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 336,176 | 200,000 | -136,176 | 0.03 | 0.02 | -0.02 | sell |
| Cresset Asset Management, LLC | 188,546 | 194,464 | +5,918 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | 171,453 | 0 | 0.00 | 0.00 | +0.00 | hold |
| State of New Jersey Common Pension Fund D | 0 | 163,622 | +163,622 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 153,371 | 153,371 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 166,844 | 148,669 | -18,175 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 233,992 | 143,513 | -90,479 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 142,122 | 142,122 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Scientech Research LLC | 227,472 | 133,846 | -93,626 | 0.19 | 0.17 | -0.02 | sell |
| Amundi | 28,423 | 132,367 | +103,944 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 134,936 | 131,507 | -3,429 | 0.00 | 0.00 | +0.00 | sell |
| TORONTO DOMINION BANK | 0 | 127,711 | +127,711 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 29,590 | 122,612 | +93,022 | 0.00 | 0.00 | +0.00 | buy |
| Mason & Associates Inc | 120,700 | 120,700 | 0 | 0.03 | 0.03 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 34,599 | 119,000 | +84,401 | 0.00 | 0.01 | +0.00 | buy |
| HighTower Advisors, LLC | 117,204 | 117,329 | +125 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 104,020 | 113,281 | +9,261 | 0.01 | 0.01 | +0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 93,924 | 112,424 | +18,500 | 0.04 | 0.06 | +0.02 | buy |
| Arax Advisory Partners | 627,297 | 111,428 | -515,869 | 0.02 | 0.00 | -0.02 | sell |
| DRW Securities, LLC | 103,202 | 111,075 | +7,873 | 0.01 | 0.01 | -0.00 | buy |
| E Fund Management Co., Ltd. | 92,238 | 111,070 | +18,832 | 0.01 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 90,283 | 109,753 | +19,470 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 65,807 | 108,172 | +42,365 | 0.00 | 0.00 | +0.00 | buy |