| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 46,202,425 | 46,202,425 | 0 | 1.94 | 2.59 | +0.65 | hold |
| VANGUARD GROUP INC | 29,869,287 | 31,933,299 | +2,064,012 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 27,225,292 | 27,225,292 | 0 | 7.06 | 10.66 | +3.60 | hold |
| Darwin Global Management, Ltd. | 0 | 23,915,480 | +23,915,480 | 0.00 | 12.35 | +12.35 | buy |
| STATE STREET CORP | 31,604,392 | 22,548,467 | -9,055,925 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 183,391 | 20,030,000 | +19,846,609 | 0.01 | 1.67 | +1.66 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,200,000 | 19,725,000 | +12,525,000 | 0.04 | 0.15 | +0.11 | buy |
| Woodline Partners LP | 1,214,570 | 16,951,016 | +15,736,446 | 0.04 | 0.69 | +0.65 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 7,495,000 | 16,837,000 | +9,342,000 | 0.15 | 0.42 | +0.28 | buy |
| FMR LLC | 12,760,298 | 15,355,776 | +2,595,478 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 30,505,929 | 13,000,000 | -17,505,929 | 2.89 | 1.65 | -1.25 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 11,425,985 | 12,836,821 | +1,410,836 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 10,942,584 | 12,091,824 | +1,149,240 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 4,390,682 | 11,297,679 | +6,906,997 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,064,963 | 11,277,923 | +9,212,960 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 181,037 | 9,401,957 | +9,220,920 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 12,893,611 | 8,930,252 | -3,963,359 | 0.78 | 0.75 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 7,302,296 | 7,650,414 | +348,118 | 0.02 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 6,356,182 | +6,356,182 | 0.00 | 0.46 | +0.46 | buy |
| NORTHERN TRUST CORP | 5,028,567 | 4,740,272 | -288,295 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,889,756 | 4,339,021 | +449,265 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 4,448,896 | 4,117,336 | -331,560 | 0.28 | 0.31 | +0.03 | sell |
| Invesco Ltd. | 5,469,131 | 3,625,709 | -1,843,422 | 0.00 | 0.00 | -0.00 | sell |
| HHLR ADVISORS, LTD. | 0 | 2,990,500 | +2,990,500 | 0.00 | 0.31 | +0.31 | buy |
| NEA Management Company, LLC | 12,776,409 | 2,776,409 | -10,000,000 | 2.62 | 0.89 | -1.73 | sell |
| Ally Bridge Group (NY) LLC | 2,760,497 | 2,736,663 | -23,834 | 5.06 | 6.91 | +1.85 | sell |
| UBS Group AG | 1,807,311 | 2,317,361 | +510,050 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 963,293 | 2,278,262 | +1,314,969 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 986,109 | 2,266,903 | +1,280,794 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,138,567 | 2,176,159 | -962,408 | 0.03 | 0.02 | -0.00 | sell |
| Russell Investments Group, Ltd. | 1,750,599 | 2,142,919 | +392,320 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 1,600,739 | 2,016,622 | +415,883 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 666,013 | 1,743,472 | +1,077,459 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 3,354,140 | 1,593,168 | -1,760,972 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 2,500,000 | 1,500,000 | -1,000,000 | 1.34 | 1.00 | -0.34 | sell |
| JANE STREET GROUP, LLC | 488,505 | 1,483,880 | +995,375 | 0.00 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 1,324,550 | 1,373,550 | +49,000 | 4.05 | 6.21 | +2.16 | buy |
| DEUTSCHE BANK AG\ | 1,352,053 | 1,344,128 | -7,925 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGER MANAGEMENT, LLC | 1,338,084 | 1,338,084 | 0 | 1.99 | 2.92 | +0.93 | hold |
| TD ASSET MANAGEMENT INC | 238,800 | 1,201,200 | +962,400 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 250,000 | 999,270 | +749,270 | 0.23 | 1.05 | +0.81 | buy |
| Rafferty Asset Management, LLC | 2,411,211 | 967,446 | -1,443,765 | 0.03 | 0.02 | -0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 362,868 | 915,949 | +553,081 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 393,846 | 902,055 | +508,209 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,999,718 | 866,690 | -1,133,028 | 0.00 | 0.00 | -0.00 | sell |
| MML INVESTORS SERVICES, LLC | 1,053,428 | 851,228 | -202,200 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 727,218 | 846,768 | +119,550 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 804,300 | 810,800 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 781,723 | +781,723 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 744,270 | +744,270 | 0.00 | 0.51 | +0.51 | buy |
| FIRST TRUST ADVISORS LP | 0 | 692,863 | +692,863 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 600,000 | 630,000 | +30,000 | 3.79 | 8.36 | +4.58 | buy |
| BARCLAYS PLC | 567,263 | 604,981 | +37,718 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 512,741 | 599,291 | +86,550 | 0.00 | 0.00 | +0.00 | buy |
| Matrix Capital Management Company, LP | 0 | 571,500 | +571,500 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 385,154 | 462,671 | +77,517 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 417,682 | 414,472 | -3,210 | 0.00 | 0.00 | +0.00 | sell |
| Legal & General Group Plc | 396,052 | 406,655 | +10,603 | 0.00 | 0.00 | +0.00 | buy |
| Summit X, LLC | 381,670 | 405,638 | +23,968 | 0.32 | 0.39 | +0.07 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 404,621 | +404,621 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 383,732 | +383,732 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 375,395 | +375,395 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 350,376 | 370,311 | +19,935 | 0.03 | 0.04 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 331,808 | 363,157 | +31,349 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 54,809 | 361,485 | +306,676 | 0.00 | 0.01 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 0 | 351,850 | +351,850 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 271,574 | 332,762 | +61,188 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 305,347 | 305,347 | 0 | 0.01 | 0.01 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 209,373 | 289,394 | +80,021 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 251,716 | 262,324 | +10,608 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 253,857 | +253,857 | 0.00 | 0.06 | +0.06 | buy |
| LPL Financial LLC | 195,761 | 250,327 | +54,566 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 197,771 | 240,453 | +42,682 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,150,971 | 229,020 | -1,921,951 | 0.01 | 0.00 | -0.01 | sell |
| Rosalind Advisors, Inc. | 200,000 | 200,000 | 0 | 0.62 | 0.67 | +0.05 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 171,947 | 192,213 | +20,266 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 268,202 | 189,548 | -78,654 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 193,175 | 189,225 | -3,950 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 481,712 | 185,406 | -296,306 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 376,360 | 183,256 | -193,104 | 0.05 | 0.03 | -0.02 | sell |
| Caption Management, LLC | 0 | 180,000 | +180,000 | 0.00 | 0.08 | +0.08 | buy |
| HighVista Strategies LLC | 240,234 | 179,799 | -60,435 | 0.28 | 0.28 | -0.00 | sell |
| Private Advisor Group, LLC | 181,551 | 179,168 | -2,383 | 0.00 | 0.01 | +0.00 | sell |
| Cresset Asset Management, LLC | 164,040 | 166,502 | +2,462 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 293,396 | 155,432 | -137,964 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 99,069 | 153,678 | +54,609 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 152,700 | +152,700 | 0.00 | 0.01 | +0.01 | buy |
| CANADA LIFE ASSURANCE Co | 64,438 | 147,280 | +82,842 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 127,922 | 142,122 | +14,200 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 139,964 | 139,964 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 58,934 | 138,555 | +79,621 | 0.00 | 0.00 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 131,045 | 131,045 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Tower Research Capital LLC (TRC) | 6,372 | 127,564 | +121,192 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 127,071 | +127,071 | 0.00 | 0.02 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 162,820 | 124,182 | -38,638 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 28,312 | 118,637 | +90,325 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 111,935 | 115,400 | +3,465 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 130,316 | 105,240 | -25,076 | 0.00 | 0.00 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 97,809 | 104,924 | +7,115 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 130,249 | 91,134 | -39,115 | 0.00 | 0.00 | -0.00 | sell |