| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 1,214,570 | 16,951,016 | +15,736,446 | 0.04 | 0.69 | +0.65 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 7,200,000 | 19,725,000 | +12,525,000 | 0.04 | 0.15 | +0.11 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,138,567 | 2,176,159 | +962,408 | 0.03 | 0.03 | 0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 250,000 | 999,270 | +749,270 | 0.23 | 1.05 | +0.81 | buy |
| PROFUND ADVISORS LLC | 376,360 | 183,256 | +193,104 | 0.05 | 0.03 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 1,295 | 90,000 | +88,705 | 0.00 | 0.08 | +0.08 | buy |
| ALPS ADVISORS INC | 385,154 | 462,671 | +77,517 | 0.01 | 0.01 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 1,324,550 | 1,373,550 | +49,000 | 4.05 | 6.21 | +2.16 | buy |
| Global Retirement Partners, LLC | 100,000 | 60,000 | +40,000 | 0.01 | 0.01 | 0.00 | sell |
| Lion Point Capital, LP | 600,000 | 630,000 | +30,000 | 1.11 | 4.87 | +3.76 | buy |
| VIRTUS ADVISERS, LLC | 39,205 | 67,490 | +28,285 | 0.07 | 0.14 | +0.07 | buy |
| Summit X, LLC | 381,670 | 405,638 | +23,968 | 0.32 | 0.39 | +0.07 | buy |
| Polar Asset Management Partners Inc. | 350,376 | 370,311 | +19,935 | 0.02 | 0.03 | +0.01 | buy |
| WEDBUSH SECURITIES INC | 104,054 | 90,120 | +13,934 | 0.01 | 0.01 | 0.00 | sell |
| Alternative Investment Advisors, LLC. | 10,302 | 19,597 | +9,295 | 0.02 | 0.05 | +0.03 | buy |
| Forefront Analytics, LLC | 17,876 | 19,906 | +2,030 | 0.03 | 0.04 | +0.01 | buy |
| HighMark Wealth Management LLC | 4,600 | 5,325 | +725 | 0.01 | 0.01 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 26,203 | 26,824 | +621 | 0.01 | 0.01 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 34,703 | 23,101 | -11,602 | 0.01 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 2,760,497 | 2,736,663 | -23,834 | 5.06 | 6.91 | +1.85 | sell |
| LAZARI CAPITAL MANAGEMENT, INC. | 93,424 | 69,424 | -24,000 | 0.17 | 0.13 | -0.03 | sell |
| Inspire Investing, LLC | 107,919 | 82,660 | -25,259 | 0.04 | 0.04 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 104,929 | 69,683 | -35,246 | 0.04 | 0.04 | -0.00 | sell |
| E Fund Management Co., Ltd. | 113,941 | 58,754 | -55,187 | 0.02 | 0.01 | -0.01 | sell |
| HighVista Strategies LLC | 240,234 | 179,799 | -60,435 | 0.28 | 0.28 | -0.00 | sell |
| Arnhold LLC | 142,400 | 68,400 | -74,000 | 0.05 | 0.03 | -0.02 | sell |
| J. Goldman & Co LP | 261,397 | 40,500 | -220,897 | 0.03 | 0.00 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 314,460 | 82,862 | -231,598 | 0.07 | 0.03 | -0.04 | sell |
| SEGALL BRYANT & HAMILL, LLC | 4,448,896 | 4,117,336 | -331,560 | 0.28 | 0.31 | +0.03 | sell |
| Affinity Asset Advisors, LLC | 2,500,000 | 1,500,000 | -1,000,000 | 1.34 | 1.00 | -0.34 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,125,280 | 58,700 | -1,066,580 | 0.08 | 0.01 | -0.07 | sell |
| Rafferty Asset Management, LLC | 2,411,211 | 967,446 | -1,443,765 | 0.03 | 0.02 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 12,893,611 | 8,930,252 | -3,963,359 | 0.78 | 0.75 | -0.03 | sell |
| NEA Management Company, LLC | 12,776,409 | 2,776,409 | -10,000,000 | 2.62 | 0.89 | -1.73 | sell |
| Deep Track Capital, LP | 30,505,929 | 13,000,000 | -17,505,929 | 2.89 | 1.65 | -1.25 | sell |