| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 2,400,000 | 16,140,000 | +13,740,000 | 0.30 | 1.57 | +1.27 | buy |
| Clearbridge Investments, LLC | 8,687,142 | 14,376,311 | +5,689,169 | 0.01 | 0.02 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 960,307 | 6,649,244 | +5,688,937 | 0.49 | 3.02 | +2.53 | buy |
| Deep Track Capital, LP | 38,176,251 | 43,000,000 | +4,823,749 | 1.97 | 1.95 | -0.02 | buy |
| Aberdeen Group plc | 3,692,753 | 6,985,932 | +3,293,179 | 0.01 | 0.02 | +0.01 | buy |
| Vestal Point Capital, LP | 22,005,340 | 23,775,000 | +1,769,660 | 2.50 | 1.76 | -0.73 | buy |
| Ikarian Capital, LLC | 150,000 | 1,600,000 | +1,450,000 | 0.08 | 0.75 | +0.67 | buy |
| Ally Bridge Group (NY) LLC | 2,056,637 | 3,251,475 | +1,194,838 | 2.95 | 3.81 | +0.87 | buy |
| ALGERT GLOBAL LLC | 3,260,934 | 4,448,600 | +1,187,666 | 0.13 | 0.13 | 0.00 | buy |
| Stonepine Capital Management, LLC | 500,000 | 1,000,000 | +500,000 | 0.77 | 1.38 | +0.61 | buy |
| GSA CAPITAL PARTNERS LLP | 234,606 | 679,331 | +444,725 | 0.04 | 0.08 | 0.00 | buy |
| Woodline Partners LP | 7,728,745 | 7,998,188 | +269,443 | 0.08 | 0.06 | -0.02 | buy |
| 683 Capital Management, LLC | 2,850,000 | 3,100,000 | +250,000 | 0.31 | 0.29 | -0.03 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,130,000 | 2,330,000 | +200,000 | 0.06 | 0.05 | -0.01 | buy |
| Exome Asset Management LLC | 3,215,457 | 3,414,377 | +198,920 | 4.58 | 3.97 | -0.61 | buy |
| Virtus Investment Advisers, LLC | 91,587 | 284,868 | +193,281 | 0.04 | 0.14 | +0.10 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 895,025 | 1,085,427 | +190,402 | 0.11 | 0.15 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 266,176 | 441,176 | +175,000 | 0.08 | 0.10 | +0.02 | buy |
| Nvest Financial, LLC | 199,241 | 322,125 | +122,884 | 0.17 | 0.24 | +0.07 | buy |
| Polymer Capital Management (US) LLC | 13,676 | 111,354 | +97,678 | 0.01 | 0.03 | +0.02 | buy |
| Quadrature Capital Ltd | 80,756 | 150,706 | +69,950 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 220,935 | 284,724 | +63,789 | 0.04 | 0.04 | +0.00 | buy |
| DnB Asset Management AS | 136,581 | 190,763 | +54,182 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 526,436 | 576,436 | +50,000 | 0.02 | 0.01 | -0.00 | buy |
| FIFTH LANE CAPITAL, LP | 20,000 | 30,000 | +10,000 | 0.14 | 0.05 | -0.09 | buy |
| E Fund Management Co., Ltd. | 82,389 | 92,238 | +9,849 | 0.01 | 0.01 | -0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 95,524 | 101,924 | +6,400 | 0.06 | 0.05 | -0.01 | buy |
| HighVista Strategies LLC | 127,284 | 132,711 | +5,427 | 0.08 | 0.07 | -0.01 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 295,425 | 299,819 | +4,394 | 0.05 | 0.04 | -0.01 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 29,670 | 32,210 | +2,540 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 127,752 | 127,922 | +170 | 0.02 | 0.02 | -0.00 | buy |
| Crewe Advisors LLC | 7,900 | 7,950 | +50 | 0.00 | 0.00 | -0.00 | buy |
| TIAA TRUST, NATIONAL ASSOCIATION | 58,310 | 58,250 | -60 | 0.00 | 0.00 | -0.00 | sell |
| Elmwood Wealth Management, Inc. | 28,285 | 28,200 | -85 | 0.02 | 0.02 | -0.00 | sell |
| Candriam S.C.A. | 1,896,010 | 1,895,892 | -118 | 0.02 | 0.02 | -0.00 | sell |
| Csenge Advisory Group | 15,792 | 15,474 | -318 | 0.00 | 0.00 | +0.00 | sell |
| PINNACLE ASSOCIATES LTD | 52,505 | 50,505 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| INCEPTIONR LLC | 17,258 | 15,078 | -2,180 | 0.01 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 185,493 | 175,931 | -9,562 | 0.01 | 0.01 | -0.00 | sell |
| Zuckerman Investment Group, LLC | 103,000 | 88,000 | -15,000 | 0.02 | 0.01 | -0.01 | sell |
| Farringdon Capital, Ltd. | 31,652 | 14,903 | -16,749 | 0.03 | 0.01 | -0.02 | sell |
| Hennion & Walsh Asset Management, Inc. | 388,176 | 371,035 | -17,141 | 0.03 | 0.02 | -0.01 | sell |
| Forefront Analytics, LLC | 62,973 | 35,181 | -27,792 | 0.11 | 0.06 | -0.06 | sell |
| Rafferty Asset Management, LLC | 881,607 | 828,509 | -53,098 | 0.01 | 0.00 | -0.00 | sell |
| Summit X, LLC | 547,899 | 494,789 | -53,110 | 0.18 | 0.13 | -0.05 | sell |
| Kynam Capital Management, LP | 3,659,526 | 3,456,318 | -203,208 | 0.50 | 0.52 | +0.03 | sell |
| SEGALL BRYANT & HAMILL, LLC | 7,426,854 | 7,192,184 | -234,670 | 0.18 | 0.14 | -0.04 | sell |
| Velan Capital Investment Management LP | 655,000 | 70,000 | -585,000 | 1.07 | 0.10 | -0.97 | sell |