| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 60,379,366 | 60,379,366 | 0 | 1.60 | 1.43 | -0.17 | hold |
| BlackRock, Inc. | 49,075,309 | 50,023,485 | +948,176 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 38,176,251 | 43,000,000 | +4,823,749 | 1.97 | 1.95 | -0.02 | buy |
| VANGUARD GROUP INC | 34,146,851 | 35,614,200 | +1,467,349 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 27,225,292 | 27,225,292 | 0 | 5.73 | 3.93 | -1.80 | hold |
| Vestal Point Capital, LP | 22,005,340 | 23,775,000 | +1,769,660 | 2.50 | 1.76 | -0.73 | buy |
| STATE STREET CORP | 23,911,792 | 23,631,876 | -279,916 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 2,400,000 | 16,140,000 | +13,740,000 | 0.30 | 1.57 | +1.27 | buy |
| Clearbridge Investments, LLC | 8,687,142 | 14,376,311 | +5,689,169 | 0.01 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,567,594 | 14,152,038 | +584,444 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 11,534,238 | 13,295,442 | +1,761,204 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 6,663,314 | 12,035,901 | +5,372,587 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 5,211,433 | 11,745,012 | +6,533,579 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 8,136,200 | 9,815,660 | +1,679,460 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 7,126,818 | 9,606,217 | +2,479,399 | 0.03 | 0.03 | +0.00 | buy |
| Woodline Partners LP | 7,728,745 | 7,998,188 | +269,443 | 0.08 | 0.06 | -0.02 | buy |
| Eversept Partners, LP | 0 | 7,320,174 | +7,320,174 | 0.00 | 1.04 | +1.04 | buy |
| SEGALL BRYANT & HAMILL, LLC | 7,426,854 | 7,192,184 | -234,670 | 0.18 | 0.14 | -0.04 | sell |
| Aberdeen Group plc | 3,692,753 | 6,985,932 | +3,293,179 | 0.01 | 0.02 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 960,307 | 6,649,244 | +5,688,937 | 0.49 | 3.02 | +2.53 | buy |
| BANK OF AMERICA CORP /DE/ | 9,692,359 | 6,389,739 | -3,302,620 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 10,806,625 | 6,047,354 | -4,759,271 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 5,256,963 | 5,254,214 | -2,749 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 5,601,100 | 4,999,100 | -602,000 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 4,795,555 | 4,981,598 | +186,043 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 12,365,344 | 4,837,625 | -7,527,719 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,451,031 | 4,689,314 | +238,283 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 3,260,934 | 4,448,600 | +1,187,666 | 0.13 | 0.13 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 3,794,565 | 3,718,003 | -76,562 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 1,399,808 | 3,599,221 | +2,199,413 | 0.01 | 0.01 | +0.01 | buy |
| Kynam Capital Management, LP | 3,659,526 | 3,456,318 | -203,208 | 0.50 | 0.52 | +0.03 | sell |
| Exome Asset Management LLC | 3,215,457 | 3,414,377 | +198,920 | 4.58 | 3.97 | -0.61 | buy |
| Ally Bridge Group (NY) LLC | 2,056,637 | 3,251,475 | +1,194,838 | 2.95 | 3.81 | +0.87 | buy |
| 683 Capital Management, LLC | 2,850,000 | 3,100,000 | +250,000 | 0.46 | 0.44 | -0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,130,000 | 2,330,000 | +200,000 | 0.06 | 0.05 | -0.01 | buy |
| BARCLAYS PLC | 1,154,923 | 2,152,825 | +997,902 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 2,850,769 | 2,114,479 | -736,290 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,372,016 | 2,078,625 | +706,609 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 1,896,010 | 1,895,892 | -118 | 0.02 | 0.02 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,639,814 | 1,634,410 | -5,404 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,872,500 | 1,603,685 | -268,815 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 150,000 | 1,600,000 | +1,450,000 | 0.08 | 0.75 | +0.67 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,509,920 | 1,554,849 | -1,955,071 | 0.01 | 0.00 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,500,000 | 0 | 0.37 | 0.31 | -0.06 | hold |
| NAN FUNG TRINITY (HK) Ltd | 0 | 1,373,550 | +1,373,550 | 0.00 | 0.23 | +0.23 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 895,025 | 1,085,427 | +190,402 | 0.14 | 0.15 | +0.01 | buy |
| World Investment Advisors | 1,029,553 | 1,032,403 | +2,850 | 0.04 | 0.03 | -0.01 | buy |
| Stonepine Capital Management, LLC | 500,000 | 1,000,000 | +500,000 | 0.77 | 1.39 | +0.62 | buy |
| Swiss National Bank | 995,500 | 973,500 | -22,000 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 5,140,464 | 944,790 | -4,195,674 | 0.01 | 0.00 | -0.01 | sell |
| RHUMBLINE ADVISERS | 839,456 | 873,893 | +34,437 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 881,607 | 828,509 | -53,098 | 0.01 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 800,001 | 800,001 | 0 | 0.07 | 0.07 | +0.00 | hold |
| Invesco Ltd. | 3,618,607 | 790,447 | -2,828,160 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 0 | 716,000 | +716,000 | 0.00 | 0.36 | +0.36 | buy |
| AMERIPRISE FINANCIAL INC | 751,706 | 696,781 | -54,925 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 234,606 | 679,331 | +444,725 | 0.03 | 0.07 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 625,291 | 625,291 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 962,773 | 581,942 | -380,831 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 526,436 | 576,436 | +50,000 | 0.03 | 0.02 | -0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 53,917 | 572,002 | +518,085 | 0.00 | 0.02 | +0.02 | buy |
| MML INVESTORS SERVICES, LLC | 551,115 | 551,915 | +800 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 508,526 | 550,871 | +42,345 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 540,799 | 540,088 | -711 | 0.00 | 0.00 | -0.00 | sell |
| Lion Point Capital, LP | 500,000 | 500,000 | 0 | 5.07 | 4.79 | -0.28 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 433,407 | 498,445 | +65,038 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 1,409,274 | 497,407 | -911,867 | 0.01 | 0.00 | -0.01 | sell |
| Summit X, LLC | 547,899 | 494,789 | -53,110 | 0.18 | 0.13 | -0.05 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 484,962 | 479,503 | -5,459 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 266,176 | 441,176 | +175,000 | 0.08 | 0.10 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 285,606 | 437,795 | +152,189 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,120,328 | 398,775 | -721,553 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 376,760 | 393,990 | +17,230 | 0.02 | 0.02 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 392,534 | 372,513 | -20,021 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 388,176 | 371,035 | -17,141 | 0.03 | 0.02 | -0.01 | sell |
| MetLife Investment Management, LLC | 305,308 | 363,137 | +57,829 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 106,675 | 357,427 | +250,752 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 535,975 | 354,715 | -181,260 | 0.01 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 443,864 | 352,342 | -91,522 | 0.03 | 0.02 | -0.01 | sell |
| Private Advisor Group, LLC | 338,597 | 347,488 | +8,891 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 343,560 | +343,560 | 0.00 | 0.00 | +0.00 | buy |
| Nvest Financial, LLC | 199,241 | 322,125 | +122,884 | 0.17 | 0.24 | +0.07 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 298,131 | 316,622 | +18,491 | 0.00 | 0.00 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 295,425 | 299,819 | +4,394 | 0.05 | 0.04 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 91,587 | 284,868 | +193,281 | 0.04 | 0.14 | +0.10 | buy |
| Inspire Investing, LLC | 220,935 | 284,724 | +63,789 | 0.04 | 0.04 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,984,299 | 249,489 | -2,734,810 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 18,892,975 | 239,357 | -18,653,618 | 0.02 | 0.00 | -0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 324,063 | 227,282 | -96,781 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 226,579 | +226,579 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 219,046 | 224,100 | +5,054 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 142,716 | 214,771 | +72,055 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 47,318 | 207,992 | +160,674 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 136,581 | 190,763 | +54,182 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 172,884 | 177,304 | +4,420 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 212,699 | 176,450 | -36,249 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 185,493 | 175,931 | -9,562 | 0.01 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | 171,453 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 163,990 | 169,025 | +5,035 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 159,525 | 166,862 | +7,337 | 0.00 | 0.00 | -0.00 | buy |