| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 47,319,779 | 49,115,571 | +1,795,792 | 0.00 | 0.00 | -0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 63,771,366 | 42,809,751 | -20,961,615 | 1.01 | 0.48 | -0.53 | sell |
| Soleus Capital Management, L.P. | 41,508,659 | 42,808,659 | +1,300,000 | 2.50 | 1.89 | -0.62 | buy |
| STATE STREET CORP | 30,497,183 | 35,856,671 | +5,359,488 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 21,576,569 | 29,038,928 | +7,462,359 | 0.02 | 0.02 | -0.00 | buy |
| Clearbridge Investments, LLC | 19,620,320 | 19,648,853 | +28,533 | 0.03 | 0.02 | -0.00 | buy |
| Eversept Partners, LP | 18,834,883 | 18,717,422 | -117,461 | 1.85 | 1.31 | -0.54 | sell |
| GOLDMAN SACHS GROUP INC | 11,176,591 | 16,633,368 | +5,456,777 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,670,785 | 14,555,954 | +885,169 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 12,665,119 | 12,945,431 | +280,312 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 11,225,000 | 12,225,000 | +1,000,000 | 1.04 | 0.95 | -0.10 | buy |
| Vivo Capital, LLC | 8,671,797 | 8,671,797 | 0 | 1.07 | 1.01 | -0.06 | hold |
| MILLENNIUM MANAGEMENT LLC | 7,321,522 | 8,112,267 | +790,745 | 0.01 | 0.01 | -0.00 | buy |
| Kynam Capital Management, LP | 6,836,318 | 6,836,318 | 0 | 0.65 | 0.48 | -0.16 | hold |
| Candriam S.C.A. | 3,921,476 | 5,589,182 | +1,667,706 | 0.03 | 0.03 | +0.00 | buy |
| FMR LLC | 6,597,156 | 5,502,807 | -1,094,349 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 4,888,304 | 5,307,204 | +418,900 | 0.64 | 0.48 | -0.16 | buy |
| NORTHERN TRUST CORP | 4,862,264 | 5,032,212 | +169,948 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 3,693,333 | 4,896,096 | +1,202,763 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,799,521 | 4,579,000 | +2,779,479 | 0.00 | 0.01 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 4,740,048 | 4,485,554 | -254,494 | 0.07 | 0.07 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,889,468 | 4,308,013 | +2,418,545 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 4,284,662 | +4,284,662 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,483,376 | 4,284,662 | -198,714 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 127,711 | 4,235,000 | +4,107,289 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 20,457,134 | 4,045,201 | -16,411,933 | 0.05 | 0.01 | -0.05 | sell |
| BANK OF AMERICA CORP /DE/ | 4,556,278 | 3,534,234 | -1,022,044 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 5,203,516 | 3,439,976 | -1,763,540 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 1,445,859 | 3,361,584 | +1,915,725 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 360,845 | 2,939,469 | +2,578,624 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 11,987 | 2,526,145 | +2,514,158 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 426,698 | 2,416,441 | +1,989,743 | 0.00 | 0.00 | +0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,330,000 | 2,330,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| NAN FUNG TRINITY (HK) Ltd | 1,373,550 | 2,223,550 | +850,000 | 0.22 | 0.28 | +0.06 | buy |
| Bank of New York Mellon Corp | 1,540,236 | 1,618,246 | +78,010 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,250,017 | 1,547,239 | +297,222 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 2,931,489 | 1,546,476 | -1,385,013 | 0.00 | 0.00 | -0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 1,191,941 | +1,191,941 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 1,304,458 | 1,175,208 | -129,250 | 0.00 | 0.00 | -0.00 | sell |
| World Investment Advisors | 1,033,779 | 1,033,779 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 620,795 | 1,011,201 | +390,406 | 0.26 | 0.30 | +0.05 | buy |
| Voleon Capital Management LP | 122,612 | 1,004,988 | +882,376 | 0.00 | 0.02 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 396,632 | 1,000,910 | +604,278 | 0.02 | 0.04 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,271,014 | 983,698 | -287,316 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 947,500 | 964,000 | +16,500 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 633,501 | 826,216 | +192,715 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 700,101 | 732,065 | +31,964 | 0.00 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 610,659 | 712,124 | +101,465 | 0.04 | 0.03 | -0.01 | buy |
| Man Group plc | 396,908 | 696,669 | +299,761 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 657,024 | +657,024 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 521,439 | 651,079 | +129,640 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 624,046 | +624,046 | 0.00 | 0.49 | +0.49 | buy |
| FRANKLIN RESOURCES INC | 30,761 | 618,891 | +588,130 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 883,595 | 606,440 | -277,155 | 0.01 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 111,428 | 605,298 | +493,870 | 0.00 | 0.01 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 258,414 | 588,165 | +329,751 | 0.02 | 0.05 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 651,185 | 578,321 | -72,864 | 0.00 | 0.00 | -0.00 | sell |
| Lion Point Capital, LP | 578,000 | 578,000 | 0 | 5.15 | 3.54 | -1.61 | hold |
| ALLIANCEBERNSTEIN L.P. | 555,701 | 571,821 | +16,120 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 460,729 | 558,500 | +97,771 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 737,143 | 542,133 | -195,010 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 534,461 | +534,461 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 349,627 | 525,963 | +176,336 | 0.05 | 0.03 | -0.02 | buy |
| Quadrature Capital Ltd | 232,332 | 524,064 | +291,732 | 0.00 | 0.01 | +0.00 | buy |
| Nvest Financial, LLC | 508,474 | 517,150 | +8,676 | 0.28 | 0.21 | -0.07 | buy |
| ADAR1 Capital Management, LLC | 200,000 | 505,817 | +305,817 | 0.02 | 0.03 | +0.01 | buy |
| Private Advisor Group, LLC | 423,328 | 502,878 | +79,550 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 961,159 | 463,897 | -497,262 | 0.02 | 0.01 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 390,016 | 459,584 | +69,568 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 279,083 | 381,115 | +102,032 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 290,780 | 340,638 | +49,858 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 318,809 | 328,089 | +9,280 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 250,662 | 327,983 | +77,321 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 296,841 | 309,547 | +12,706 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 394,909 | 306,586 | -88,323 | 0.02 | 0.01 | -0.01 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 295,425 | 297,204 | +1,779 | 0.04 | 0.03 | -0.01 | buy |
| JPMORGAN CHASE & CO | 291,838 | 289,524 | -2,314 | 0.00 | 0.00 | -0.00 | sell |
| MML INVESTORS SERVICES, LLC | 0 | 247,906 | +247,906 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 0 | 225,592 | +225,592 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 218,530 | +218,530 | 0.00 | 0.00 | +0.00 | buy |
| ALLSTATE CORP | 0 | 210,185 | +210,185 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 203,526 | 209,593 | +6,067 | 0.00 | 0.00 | -0.00 | buy |
| Mason & Associates Inc | 120,700 | 200,312 | +79,612 | 0.03 | 0.04 | +0.01 | buy |
| Cresset Asset Management, LLC | 194,464 | 199,707 | +5,243 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 107,731 | 188,592 | +80,861 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 173,689 | +173,689 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | 171,453 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 220,604 | 166,015 | -54,589 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 18,795 | 159,533 | +140,738 | 0.00 | 0.02 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 163,622 | 155,336 | -8,286 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 154,450 | +154,450 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 153,371 | 153,371 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 148,669 | 148,907 | +238 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 49,047 | 148,042 | +98,995 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 142,122 | 142,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 99,074 | 137,644 | +38,570 | 0.04 | 0.04 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 143,513 | 136,872 | -6,641 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 24,102 | 135,350 | +111,248 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 131,507 | 132,559 | +1,052 | 0.00 | 0.00 | -0.00 | buy |
| Amundi | 132,367 | 132,367 | 0 | 0.00 | 0.00 | -0.00 | hold |