| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 12,208,289 | 16,073,106 | +3,864,817 | 0.05 | 0.05 | 0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 3,444,788 | 4,990,499 | +1,545,711 | 0.12 | 0.12 | +0.01 | buy |
| Deep Track Capital, LP | 24,170,966 | 25,700,000 | +1,529,034 | 3.62 | 2.11 | -1.51 | buy |
| MPM BioImpact LLC | 9,191,290 | 10,712,481 | +1,521,191 | 5.94 | 6.06 | +0.12 | buy |
| NEA Management Company, LLC | 21,347,838 | 22,776,409 | +1,428,571 | 5.23 | 3.73 | -1.50 | buy |
| Rafferty Asset Management, LLC | 1,324,844 | 1,902,266 | +577,422 | 0.02 | 0.02 | -0.00 | buy |
| Logos Global Management LP | 2,200,000 | 2,750,000 | +550,000 | 0.98 | 0.83 | -0.14 | buy |
| Nan Fung Group Holdings Ltd | 388,000 | 753,550 | +365,550 | 0.80 | 1.29 | +0.50 | buy |
| Ally Bridge Group (NY) LLC | 2,123,162 | 2,221,639 | +98,477 | 8.25 | 5.53 | -2.73 | buy |
| Crestline Management, LP | 490,151 | 585,151 | +95,000 | 0.17 | 0.15 | -0.02 | buy |
| HighVista Strategies LLC | 122,704 | 200,893 | +78,189 | 0.18 | 0.20 | +0.02 | buy |
| PROFUND ADVISORS LLC | 245,162 | 322,857 | +77,695 | 0.04 | 0.04 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 59,958 | 126,974 | +67,016 | 0.01 | 0.02 | +0.00 | buy |
| WEDBUSH SECURITIES INC | 33,500 | 91,555 | +58,055 | 0.01 | 0.01 | 0.00 | buy |
| E Fund Management Co., Ltd. | 71,235 | 97,708 | +26,473 | 0.02 | 0.02 | -0.00 | buy |
| Forefront Analytics, LLC | 14,891 | 29,116 | +14,225 | 0.03 | 0.04 | +0.01 | buy |
| ALPS ADVISORS INC | 373,971 | 386,300 | +12,329 | 0.01 | 0.01 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 21,309 | 29,866 | +8,557 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,669 | 13,426 | +6,757 | 0.01 | 0.01 | +0.00 | buy |
| HighMark Wealth Management LLC | 350 | 2,000 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 20,123 | 20,623 | +500 | 0.01 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 35,190 | 32,005 | -3,185 | 0.07 | 0.04 | -0.03 | sell |
| Summit X, LLC | 362,254 | 358,458 | -3,796 | 0.28 | 0.24 | -0.04 | sell |
| Douglas Lane & Associates, LLC | 75,900 | 70,900 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 42,190 | 25,973 | -16,217 | 0.02 | 0.01 | -0.01 | sell |
| LAZARI CAPITAL MANAGEMENT, INC. | 153,924 | 127,924 | -26,000 | 0.28 | 0.16 | -0.12 | sell |
| Laurion Capital Management LP | 205,973 | 44,027 | -161,946 | 0.03 | 0.00 | -0.03 | sell |
| TCG Crossover Management, LLC | 23,589,779 | 23,375,839 | -213,940 | 12.42 | 7.30 | -5.12 | sell |
| Opaleye Management Inc. | 2,350,000 | 1,915,000 | -435,000 | 1.80 | 1.32 | -0.48 | sell |
| ADVISORY RESEARCH INC | 921,335 | 236,682 | -684,653 | 0.38 | 0.07 | -0.31 | sell |
| ARMISTICE CAPITAL, LLC | 4,500,000 | 3,624,000 | -876,000 | 0.36 | 0.23 | -0.13 | sell |
| Sofinnova Investments, Inc. | 5,429,155 | 3,702,546 | -1,726,609 | 1.15 | 0.55 | -0.61 | sell |