| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 9,401,957 | 22,565,846 | +13,163,889 | 0.02 | 0.05 | 0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 19,725,000 | 28,875,000 | +9,150,000 | 0.15 | 0.23 | +0.08 | buy |
| World Investment Advisors | 10,043 | 1,029,553 | +1,019,510 | 0.00 | 0.15 | +0.14 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 999,270 | 1,801,561 | +802,291 | 1.05 | 1.84 | +0.80 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 6,356,182 | 7,072,000 | +715,818 | 0.46 | 0.55 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 90,000 | 557,159 | +467,159 | 0.08 | 0.42 | +0.35 | buy |
| Rafferty Asset Management, LLC | 967,446 | 1,424,004 | +456,558 | 0.02 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 383,732 | 775,219 | +391,487 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 127,071 | 395,071 | +268,000 | 0.02 | 0.05 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,862 | 348,062 | +265,200 | 0.03 | 0.12 | +0.09 | buy |
| J. Goldman & Co LP | 40,500 | 176,239 | +135,739 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 183,256 | 281,519 | +98,263 | 0.03 | 0.05 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 253,857 | 341,884 | +88,027 | 0.06 | 0.07 | +0.02 | buy |
| Inspire Investing, LLC | 82,660 | 159,754 | +77,094 | 0.04 | 0.07 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 69,683 | 115,937 | +46,254 | 0.04 | 0.06 | +0.02 | buy |
| E Fund Management Co., Ltd. | 58,754 | 91,488 | +32,734 | 0.01 | 0.02 | +0.01 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 131,045 | 151,555 | +20,510 | 0.04 | 0.07 | +0.03 | buy |
| WEDBUSH SECURITIES INC | 90,120 | 94,771 | +4,651 | 0.01 | 0.02 | 0.00 | buy |
| Values First Advisors, Inc. | 27,006 | 30,674 | +3,668 | 0.07 | 0.08 | +0.01 | buy |
| Alternative Investment Advisors, LLC. | 19,597 | 22,209 | +2,612 | 0.05 | 0.05 | +0.01 | buy |
| Chicago Partners Investment Group LLC | 23,101 | 24,815 | +1,714 | 0.00 | 0.00 | -0.00 | buy |
| Informed Momentum Co LLC | 744,270 | 745,614 | +1,344 | 0.51 | 0.51 | -0.01 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 26,824 | 27,122 | +298 | 0.01 | 0.01 | -0.00 | buy |
| NorthCrest Asset Manangement, LLC | 31,500 | 31,575 | +75 | 0.00 | 0.00 | -0.00 | buy |
| TIAA TRUST, NATIONAL ASSOCIATION | 58,250 | 58,310 | +60 | 0.00 | 0.00 | +0.00 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 69,424 | 68,424 | -1,000 | 0.13 | 0.13 | +0.00 | sell |
| Crewe Advisors LLC | 9,700 | 8,300 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 19,906 | 18,491 | -1,415 | 0.04 | 0.04 | -0.00 | sell |
| Optiver Holding B.V. | 5,829 | 3,852 | -1,977 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 45,346 | 42,421 | -2,925 | 0.02 | 0.02 | -0.00 | sell |
| ALPS ADVISORS INC | 462,671 | 455,654 | -7,017 | 0.01 | 0.01 | +0.00 | sell |
| Summit X, LLC | 405,638 | 385,056 | -20,582 | 0.39 | 0.40 | +0.01 | sell |
| AXIOM INVESTORS LLC /DE | 351,850 | 322,745 | -29,105 | 0.01 | 0.01 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 4,117,336 | 4,077,079 | -40,257 | 0.31 | 0.25 | -0.06 | sell |
| HighVista Strategies LLC | 179,799 | 127,284 | -52,515 | 0.28 | 0.20 | -0.08 | sell |
| Polar Asset Management Partners Inc. | 370,311 | 250,711 | -119,600 | 0.03 | 0.02 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 1,201,200 | 606,214 | -594,986 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 2,736,663 | 1,331,053 | -1,405,610 | 6.91 | 3.23 | -3.68 | sell |
| Darwin Global Management, Ltd. | 23,915,480 | 22,038,773 | -1,876,707 | 12.35 | 8.14 | -4.22 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,277,923 | 7,036,618 | -4,241,305 | 0.01 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 13,000,000 | 7,575,049 | -5,424,951 | 1.65 | 1.10 | -0.55 | sell |
| Woodline Partners LP | 16,951,016 | 7,038,313 | -9,912,703 | 0.69 | 0.27 | -0.42 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 46,202,425 | 32,285,755 | -13,916,670 | 2.59 | 1.69 | -0.90 | sell |