| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 44,111,916 | +44,111,916 | 0.00 | 2.90 | +2.90 | buy |
| VANGUARD GROUP INC | 31,933,299 | 32,449,910 | +516,611 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 46,202,425 | 32,285,755 | -13,916,670 | 2.59 | 1.69 | -0.90 | sell |
| STATE STREET CORP | 22,548,467 | 28,961,671 | +6,413,204 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 19,725,000 | 28,875,000 | +9,150,000 | 0.15 | 0.23 | +0.08 | buy |
| Vivo Capital, LLC | 27,225,292 | 27,225,292 | 0 | 10.66 | 10.23 | -0.43 | hold |
| JANUS HENDERSON GROUP PLC | 9,401,957 | 22,565,846 | +13,163,889 | 0.02 | 0.05 | +0.03 | buy |
| Darwin Global Management, Ltd. | 23,915,480 | 22,038,773 | -1,876,707 | 12.35 | 8.14 | -4.22 | sell |
| Holocene Advisors, LP | 0 | 18,171,350 | +18,171,350 | 0.00 | 0.33 | +0.33 | buy |
| GOLDMAN SACHS GROUP INC | 11,297,679 | 17,940,973 | +6,643,294 | 0.01 | 0.02 | +0.01 | buy |
| FMR LLC | 15,355,776 | 14,979,056 | -376,720 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 12,836,821 | 13,067,999 | +231,178 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 12,091,824 | 12,662,404 | +570,580 | 0.01 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 20,030,000 | 9,696,535 | -10,333,465 | 1.67 | 0.72 | -0.95 | sell |
| Deep Track Capital, LP | 13,000,000 | 7,575,049 | -5,424,951 | 1.65 | 1.10 | -0.55 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 6,356,182 | 7,072,000 | +715,818 | 0.46 | 0.55 | +0.09 | buy |
| Woodline Partners LP | 16,951,016 | 7,038,313 | -9,912,703 | 0.69 | 0.27 | -0.42 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,277,923 | 7,036,618 | -4,241,305 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 4,740,272 | 5,134,403 | +394,131 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,266,903 | 4,684,332 | +2,417,429 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,339,021 | 4,450,382 | +111,361 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 7,650,414 | 4,120,205 | -3,530,209 | 0.03 | 0.02 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 4,117,336 | 4,077,079 | -40,257 | 0.31 | 0.25 | -0.06 | sell |
| Iron Triangle Partners LP | 0 | 3,351,000 | +3,351,000 | 0.00 | 2.14 | +2.14 | buy |
| UBS Group AG | 2,317,361 | 3,222,476 | +905,115 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 3,124,967 | +3,124,967 | 0.00 | 2.25 | +2.25 | buy |
| AMERIPRISE FINANCIAL INC | 1,743,472 | 2,817,440 | +1,073,968 | 0.00 | 0.00 | +0.00 | buy |
| NEA Management Company, LLC | 2,776,409 | 2,776,409 | 0 | 0.89 | 0.69 | -0.20 | hold |
| BANK OF AMERICA CORP /DE/ | 2,278,262 | 2,638,555 | +360,293 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,593,168 | 2,595,177 | +1,002,009 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,142,919 | 2,489,261 | +346,342 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 3,625,709 | 2,463,527 | -1,162,182 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 999,270 | 1,801,561 | +802,291 | 1.05 | 1.84 | +0.80 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 0 | 1,700,000 | +1,700,000 | 0.00 | 0.12 | +0.12 | buy |
| Bank of New York Mellon Corp | 2,016,622 | 1,659,043 | -357,579 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 1,656,629 | +1,656,629 | 0.00 | 0.08 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,500,000 | 0 | 1.00 | 1.06 | +0.05 | hold |
| Aberdeen Group plc | 0 | 1,487,258 | +1,487,258 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 967,446 | 1,424,004 | +456,558 | 0.02 | 0.02 | +0.01 | buy |
| Nan Fung Group Holdings Ltd | 1,373,550 | 1,373,550 | 0 | 6.21 | 5.37 | -0.84 | hold |
| BRIDGER MANAGEMENT, LLC | 1,338,084 | 1,338,084 | 0 | 2.92 | 3.04 | +0.12 | hold |
| Ally Bridge Group (NY) LLC | 2,736,663 | 1,331,053 | -1,405,610 | 6.91 | 3.23 | -3.68 | sell |
| BARCLAYS PLC | 604,981 | 1,299,912 | +694,931 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 1,272,583 | +1,272,583 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 599,291 | 1,229,782 | +630,491 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 692,863 | 1,128,073 | +435,210 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.38 | +0.38 | buy |
| World Investment Advisors | 10,043 | 1,029,553 | +1,019,510 | 0.00 | 0.15 | +0.14 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 902,055 | 1,020,743 | +118,688 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.37 | +0.37 | buy |
| JANE STREET GROUP, LLC | 1,483,880 | 950,666 | -533,214 | 0.01 | 0.01 | +0.00 | sell |
| Exome Asset Management LLC | 0 | 905,126 | +905,126 | 0.00 | 2.78 | +2.78 | buy |
| Swiss National Bank | 810,800 | 871,400 | +60,600 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 846,768 | 822,774 | -23,994 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 155,432 | 782,372 | +626,940 | 0.01 | 0.03 | +0.02 | buy |
| Artisan Partners Limited Partnership | 383,732 | 775,219 | +391,487 | 0.00 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 744,270 | 745,614 | +1,344 | 0.51 | 0.51 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 1,344,128 | 718,754 | -625,374 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 915,949 | 695,535 | -220,414 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 636,000 | +636,000 | 0.00 | 0.00 | +0.00 | buy |
| Lion Point Capital, LP | 630,000 | 630,000 | 0 | 8.36 | 11.47 | +3.11 | hold |
| TD ASSET MANAGEMENT INC | 1,201,200 | 606,214 | -594,986 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 90,000 | 557,159 | +467,159 | 0.08 | 0.42 | +0.35 | buy |
| MML INVESTORS SERVICES, LLC | 851,228 | 551,168 | -300,060 | 0.01 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 866,690 | 519,674 | -347,016 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 494,016 | +494,016 | 0.00 | 0.21 | +0.21 | buy |
| ALPS ADVISORS INC | 462,671 | 455,654 | -7,017 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 406,655 | 450,826 | +44,171 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 229,020 | 433,547 | +204,527 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 414,472 | 432,116 | +17,644 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 127,071 | 395,071 | +268,000 | 0.02 | 0.05 | +0.03 | buy |
| Summit X, LLC | 405,638 | 385,056 | -20,582 | 0.39 | 0.40 | +0.01 | sell |
| COOKSON PEIRCE & CO INC | 0 | 379,533 | +379,533 | 0.00 | 0.08 | +0.08 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 296,743 | 372,759 | +76,016 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,862 | 348,062 | +265,200 | 0.03 | 0.12 | +0.09 | buy |
| Hennion & Walsh Asset Management, Inc. | 253,857 | 341,884 | +88,027 | 0.06 | 0.07 | +0.02 | buy |
| MetLife Investment Management, LLC | 332,762 | 323,659 | -9,103 | 0.01 | 0.01 | +0.00 | sell |
| AXIOM INVESTORS LLC /DE | 351,850 | 322,745 | -29,105 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 289,394 | 320,999 | +31,605 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 363,157 | 318,526 | -44,631 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 309,802 | 311,166 | +1,364 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 305,347 | 305,347 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LPL Financial LLC | 250,327 | 284,058 | +33,731 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 183,256 | 281,519 | +98,263 | 0.03 | 0.05 | +0.02 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 262,324 | 270,670 | +8,346 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 240,453 | 258,894 | +18,441 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 370,311 | 250,711 | -119,600 | 0.04 | 0.03 | -0.01 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 242,819 | +242,819 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,406 | 228,426 | +43,020 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 41,245 | 226,742 | +185,497 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 33,172 | 205,332 | +172,160 | 0.00 | 0.00 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 0 | 197,104 | +197,104 | 0.00 | 0.04 | +0.04 | buy |
| OSAIC HOLDINGS, INC. | 189,548 | 191,817 | +2,269 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 192,213 | 188,248 | -3,965 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 153,678 | 177,587 | +23,909 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 40,500 | 176,239 | +135,739 | 0.01 | 0.03 | +0.03 | buy |
| Cresset Asset Management, LLC | 166,502 | 169,200 | +2,698 | 0.00 | 0.00 | -0.00 | buy |
| Private Advisor Group, LLC | 179,168 | 168,173 | -10,995 | 0.01 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 189,225 | 162,440 | -26,785 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 82,660 | 159,754 | +77,094 | 0.04 | 0.07 | +0.03 | buy |