| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 44,111,916 | +44,111,916 | 0.00 | 2.90 | +2.90 | buy |
| Holocene Advisors, LP | 0 | 18,171,350 | +18,171,350 | 0.00 | 0.33 | +0.33 | buy |
| JANUS HENDERSON GROUP PLC | 9,401,957 | 22,565,846 | +13,163,889 | 0.02 | 0.05 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 19,725,000 | 28,875,000 | +9,150,000 | 0.15 | 0.23 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 11,297,679 | 17,940,973 | +6,643,294 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 22,548,467 | 28,961,671 | +6,413,204 | 0.00 | 0.01 | +0.00 | buy |
| Iron Triangle Partners LP | 0 | 3,351,000 | +3,351,000 | 0.00 | 2.14 | +2.14 | buy |
| First Turn Management, LLC | 0 | 3,124,967 | +3,124,967 | 0.00 | 2.25 | +2.25 | buy |
| CITADEL ADVISORS LLC | 2,266,903 | 4,684,332 | +2,417,429 | 0.01 | 0.02 | +0.01 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 0 | 1,700,000 | +1,700,000 | 0.00 | 0.12 | +0.12 | buy |
| Walleye Capital LLC | 0 | 1,656,629 | +1,656,629 | 0.00 | 0.08 | +0.08 | buy |
| Aberdeen Group plc | 0 | 1,487,258 | +1,487,258 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 1,272,583 | +1,272,583 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 1,743,472 | 2,817,440 | +1,073,968 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 0.38 | +0.38 | buy |
| World Investment Advisors | 10,043 | 1,029,553 | +1,019,510 | 0.00 | 0.15 | +0.14 | buy |
| MORGAN STANLEY | 1,593,168 | 2,595,177 | +1,002,009 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.37 | +0.37 | buy |
| Exome Asset Management LLC | 0 | 905,126 | +905,126 | 0.00 | 2.78 | +2.78 | buy |
| UBS Group AG | 2,317,361 | 3,222,476 | +905,115 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 999,270 | 1,801,561 | +802,291 | 1.05 | 1.84 | +0.80 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 6,356,182 | 7,072,000 | +715,818 | 0.46 | 0.55 | +0.09 | buy |
| BARCLAYS PLC | 604,981 | 1,299,912 | +694,931 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 636,000 | +636,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 599,291 | 1,229,782 | +630,491 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 155,432 | 782,372 | +626,940 | 0.01 | 0.03 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 12,091,824 | 12,662,404 | +570,580 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 31,933,299 | 32,449,910 | +516,611 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 494,016 | +494,016 | 0.00 | 0.21 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 90,000 | 557,159 | +467,159 | 0.08 | 0.42 | +0.35 | buy |
| Rafferty Asset Management, LLC | 967,446 | 1,424,004 | +456,558 | 0.02 | 0.02 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 692,863 | 1,128,073 | +435,210 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 4,740,272 | 5,134,403 | +394,131 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 383,732 | 775,219 | +391,487 | 0.00 | 0.01 | +0.00 | buy |
| COOKSON PEIRCE & CO INC | 0 | 379,533 | +379,533 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 2,278,262 | 2,638,555 | +360,293 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,142,919 | 2,489,261 | +346,342 | 0.01 | 0.02 | +0.00 | buy |
| ALGERT GLOBAL LLC | 127,071 | 395,071 | +268,000 | 0.02 | 0.05 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 82,862 | 348,062 | +265,200 | 0.03 | 0.12 | +0.09 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 242,819 | +242,819 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 12,836,821 | 13,067,999 | +231,178 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 229,020 | 433,547 | +204,527 | 0.00 | 0.00 | +0.00 | buy |
| Main Management ETF Advisors, LLC | 0 | 197,104 | +197,104 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 41,245 | 226,742 | +185,497 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 33,172 | 205,332 | +172,160 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 154,900 | +154,900 | 0.00 | 0.57 | +0.57 | buy |
| J. Goldman & Co LP | 40,500 | 176,239 | +135,739 | 0.01 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 902,055 | 1,020,743 | +118,688 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,339,021 | 4,450,382 | +111,361 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 183,256 | 281,519 | +98,263 | 0.03 | 0.05 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 253,857 | 341,884 | +88,027 | 0.06 | 0.07 | +0.02 | buy |
| DnB Asset Management AS | 0 | 78,649 | +78,649 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 82,660 | 159,754 | +77,094 | 0.04 | 0.07 | +0.03 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 296,743 | 372,759 | +76,016 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 0 | 71,998 | +71,998 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 14,236 | 79,923 | +65,687 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 810,800 | 871,400 | +60,600 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 49,263 | +49,263 | 0.00 | 0.13 | +0.13 | buy |
| China Universal Asset Management Co., Ltd. | 69,683 | 115,937 | +46,254 | 0.04 | 0.06 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 46,000 | +46,000 | 0.00 | 0.12 | +0.12 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 44,394 | +44,394 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 406,655 | 450,826 | +44,171 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 185,406 | 228,426 | +43,020 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 105,240 | 145,592 | +40,352 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 39,199 | +39,199 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 13,309 | 47,455 | +34,146 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 250,327 | 284,058 | +33,731 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 58,754 | 91,488 | +32,734 | 0.01 | 0.02 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 31,991 | +31,991 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 289,394 | 320,999 | +31,605 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 27,318 | +27,318 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 153,678 | 177,587 | +23,909 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 22,065 | +22,065 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 90,507 | 111,954 | +21,447 | 0.00 | 0.00 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 131,045 | 151,555 | +20,510 | 0.04 | 0.07 | +0.03 | buy |
| Focus Partners Wealth | 0 | 20,280 | +20,280 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 240,453 | 258,894 | +18,441 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 74,947 | 92,784 | +17,837 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 414,472 | 432,116 | +17,644 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 15,885 | +15,885 | 0.00 | 0.01 | +0.01 | buy |
| Inspire Advisors, LLC | 0 | 14,902 | +14,902 | 0.00 | 0.01 | +0.01 | buy |
| WOLVERINE TRADING, LLC | 0 | 14,819 | +14,819 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 14,727 | +14,727 | 0.00 | 0.00 | +0.00 | buy |
| ROVIN CAPITAL /UT/ /ADV | 0 | 13,610 | +13,610 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 115,400 | 128,527 | +13,127 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 100 | 13,165 | +13,065 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 13,064 | +13,064 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 12,804 | +12,804 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 24,142 | 35,888 | +11,746 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 36,328 | 47,477 | +11,149 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 262,324 | 270,670 | +8,346 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 10,867 | 18,296 | +7,429 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 147,280 | 154,423 | +7,143 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 17,071 | 22,630 | +5,559 | 0.00 | 0.00 | -0.00 | buy |
| WEDBUSH SECURITIES INC | 90,120 | 94,771 | +4,651 | 0.01 | 0.02 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 17,708 | 21,802 | +4,094 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 27,006 | 30,674 | +3,668 | 0.07 | 0.08 | +0.01 | buy |
| COMERICA BANK | 0 | 2,755 | +2,755 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 166,502 | 169,200 | +2,698 | 0.00 | 0.00 | -0.00 | buy |
| Alternative Investment Advisors, LLC. | 19,597 | 22,209 | +2,612 | 0.05 | 0.05 | +0.01 | buy |