| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 60,379,366 | 60,379,366 | 0 | 1.43 | 1.02 | -0.42 | hold |
| BlackRock, Inc. | 50,023,485 | 46,605,750 | -3,417,735 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 43,000,000 | 41,096,522 | -1,903,478 | 1.95 | 1.57 | -0.38 | sell |
| VANGUARD GROUP INC | 35,614,200 | 34,423,125 | -1,191,075 | 0.00 | 0.00 | -0.00 | sell |
| Vivo Capital, LLC | 27,225,292 | 27,225,292 | 0 | 3.93 | 3.00 | -0.93 | hold |
| STATE STREET CORP | 23,631,876 | 26,618,814 | +2,986,938 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 9,815,660 | 21,307,395 | +11,491,735 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 16,140,000 | 17,290,000 | +1,150,000 | 1.57 | 1.27 | -0.31 | buy |
| Vestal Point Capital, LP | 23,775,000 | 17,225,000 | -6,550,000 | 1.76 | 1.07 | -0.69 | sell |
| CITADEL ADVISORS LLC | 12,035,901 | 15,705,068 | +3,669,167 | 0.01 | 0.02 | +0.00 | buy |
| Clearbridge Investments, LLC | 14,376,311 | 14,224,978 | -151,333 | 0.02 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 14,152,038 | 13,123,540 | -1,028,498 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 7,320,174 | 12,599,002 | +5,278,828 | 1.04 | 1.32 | +0.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 6,047,354 | 11,367,989 | +5,320,635 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 13,295,442 | 10,698,356 | -2,597,086 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 0 | 9,025,000 | +9,025,000 | 0.00 | 0.76 | +0.76 | buy |
| UBS Group AG | 11,745,012 | 7,721,107 | -4,023,905 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 4,837,625 | 7,701,070 | +2,863,445 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 6,985,932 | 5,970,923 | -1,015,009 | 0.02 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 7,998,188 | 5,883,792 | -2,114,396 | 0.06 | 0.04 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 7,192,184 | 5,335,216 | -1,856,968 | 0.14 | 0.10 | -0.05 | sell |
| DEUTSCHE BANK AG\ | 3,718,003 | 5,130,262 | +1,412,259 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 5,254,214 | 4,862,558 | -391,656 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 4,981,598 | 4,722,818 | -258,780 | 0.01 | 0.01 | -0.00 | sell |
| ALGERT GLOBAL LLC | 4,448,600 | 4,527,741 | +79,141 | 0.13 | 0.10 | -0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,689,314 | 4,509,465 | -179,849 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 6,389,739 | 3,494,346 | -2,895,393 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 3,456,318 | 3,456,318 | 0 | 0.52 | 0.35 | -0.17 | hold |
| Squarepoint Ops LLC | 3,599,221 | 3,288,707 | -310,514 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 1,895,892 | 3,253,960 | +1,358,068 | 0.02 | 0.02 | +0.01 | buy |
| 683 Capital Management, LLC | 3,100,000 | 3,010,000 | -90,000 | 0.44 | 0.37 | -0.07 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 4,999,100 | 2,364,280 | -2,634,820 | 0.01 | 0.00 | -0.01 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,330,000 | 2,330,000 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Pale Fire Capital SE | 0 | 2,281,754 | +2,281,754 | 0.00 | 0.34 | +0.34 | buy |
| JANE STREET GROUP, LLC | 0 | 2,122,338 | +2,122,338 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 2,114,479 | 1,974,779 | -139,700 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 2,152,825 | 1,935,606 | -217,219 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 3,414,377 | 1,858,354 | -1,556,023 | 3.97 | 1.68 | -2.29 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 1,852,018 | +1,852,018 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,000,000 | 1,600,000 | +600,000 | 1.39 | 1.78 | +0.39 | buy |
| Bank of New York Mellon Corp | 1,634,410 | 1,574,744 | -59,666 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,500,000 | 0 | 0.31 | 0.19 | -0.12 | hold |
| Arax Advisory Partners | 0 | 1,392,980 | +1,392,980 | 0.00 | 0.03 | +0.03 | buy |
| NAN FUNG TRINITY (HK) Ltd | 1,373,550 | 1,373,550 | 0 | 0.23 | 0.19 | -0.04 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 2,078,625 | 1,312,867 | -765,758 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,603,685 | 1,240,671 | -363,014 | 0.00 | 0.00 | -0.00 | sell |
| World Investment Advisors | 1,032,403 | 1,039,779 | +7,376 | 0.03 | 0.03 | -0.00 | buy |
| Rafferty Asset Management, LLC | 828,509 | 986,354 | +157,845 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 790,447 | 960,461 | +170,014 | 0.00 | 0.00 | +0.00 | buy |
| Almitas Capital LLC | 0 | 946,323 | +946,323 | 0.00 | 0.30 | +0.30 | buy |
| Swiss National Bank | 973,500 | 926,100 | -47,400 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 497,407 | 901,874 | +404,467 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 716,000 | 845,000 | +129,000 | 0.36 | 0.31 | -0.05 | buy |
| RHUMBLINE ADVISERS | 873,893 | 837,653 | -36,240 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 581,942 | 769,258 | +187,316 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 437,795 | 763,511 | +325,716 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 696,781 | 697,055 | +274 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 625,291 | 625,291 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MML INVESTORS SERVICES, LLC | 551,915 | 551,115 | -800 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 1,085,427 | 537,927 | -547,500 | 0.15 | 0.06 | -0.09 | sell |
| Legal & General Group Plc | 550,871 | 507,900 | -42,971 | 0.00 | 0.00 | -0.00 | sell |
| Lion Point Capital, LP | 500,000 | 500,000 | 0 | 4.79 | 3.89 | -0.89 | hold |
| JPMORGAN CHASE & CO | 540,088 | 487,249 | -52,839 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 479,503 | 479,430 | -73 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 441,176 | 456,176 | +15,000 | 0.10 | 0.06 | -0.04 | buy |
| Aquatic Capital Management LLC | 0 | 437,875 | +437,875 | 0.00 | 0.01 | +0.01 | buy |
| Private Advisor Group, LLC | 347,488 | 418,877 | +71,389 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 207,992 | 417,896 | +209,904 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 385,546 | +385,546 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 34,174 | 376,272 | +342,098 | 0.00 | 0.00 | +0.00 | buy |
| Empire Financial Management Company, LLC | 0 | 370,000 | +370,000 | 0.00 | 0.12 | +0.12 | buy |
| Hennion & Walsh Asset Management, Inc. | 371,035 | 364,400 | -6,635 | 0.02 | 0.02 | -0.00 | sell |
| Creative Planning | 357,427 | 348,589 | -8,838 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 284,724 | 329,051 | +44,327 | 0.04 | 0.04 | +0.00 | buy |
| Nvest Financial, LLC | 322,125 | 313,726 | -8,399 | 0.24 | 0.25 | +0.01 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 372,513 | 304,213 | -68,300 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 343,560 | 302,509 | -41,051 | 0.00 | 0.00 | -0.00 | sell |
| MOODY NATIONAL BANK TRUST DIVISION | 299,819 | 296,379 | -3,440 | 0.04 | 0.03 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 498,445 | 288,838 | -209,607 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 284,868 | 284,868 | 0 | 0.14 | 0.11 | -0.02 | hold |
| Brevan Howard Capital Management LP | 35,617 | 269,528 | +233,911 | 0.00 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 363,137 | 266,749 | -96,388 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 150,706 | 261,865 | +111,159 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 226,579 | 251,081 | +24,502 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 239,357 | 239,357 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 354,715 | 233,992 | -120,723 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 224,100 | 230,334 | +6,234 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 190,763 | 226,508 | +35,745 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 352,342 | 220,623 | -131,719 | 0.02 | 0.01 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 227,282 | 219,398 | -7,884 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 214,771 | 214,422 | -349 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 175,931 | 213,466 | +37,535 | 0.01 | 0.01 | +0.00 | buy |
| Cresset Asset Management, LLC | 177,304 | 182,844 | +5,540 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 316,622 | 180,450 | -136,172 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | 171,453 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 124,522 | 165,516 | +40,994 | 0.01 | 0.01 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 152,451 | 154,992 | +2,541 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 143,832 | 153,371 | +9,539 | 0.00 | 0.00 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 142,122 | 142,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arizona State Retirement System | 148,233 | 140,855 | -7,378 | 0.00 | 0.00 | -0.00 | sell |