| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 1,365,032 | 10,564,267 | +9,199,235 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 16,524,634 | 24,143,681 | +7,619,047 | 3.84 | 4.17 | +0.33 | buy |
| DEUTSCHE BANK AG\ | 246,833 | 7,068,004 | +6,821,171 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 3,702,546 | 8,814,497 | +5,111,951 | 0.55 | 1.04 | +0.50 | buy |
| Deep Track Capital, LP | 25,700,000 | 29,583,449 | +3,883,449 | 2.11 | 2.19 | +0.07 | buy |
| VANGUARD GROUP INC | 26,650,246 | 28,564,574 | +1,914,328 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 1,135,195 | +1,135,195 | 0.00 | 0.05 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,012,902 | 10,943,649 | +930,747 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 651,180 | 1,441,603 | +790,423 | 0.00 | 0.00 | +0.00 | buy |
| Ally Bridge Group (NY) LLC | 2,221,639 | 2,971,639 | +750,000 | 5.53 | 3.74 | -1.79 | buy |
| ORBIMED ADVISORS LLC | 0 | 485,000 | +485,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 466,674 | +466,674 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 437,027 | +437,027 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 188,352 | 613,415 | +425,063 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 311,500 | +311,500 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 255,019 | +255,019 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 25,371,385 | 25,625,606 | +254,221 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 391,709 | 643,164 | +251,455 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 471,809 | 699,443 | +227,634 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,634,330 | 3,842,500 | +208,170 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 1,032,469 | 1,237,234 | +204,765 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 55,844 | 253,796 | +197,952 | 0.02 | 0.12 | +0.10 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 517,684 | 714,012 | +196,328 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 19,075 | 192,445 | +173,370 | 0.00 | 0.00 | +0.00 | buy |
| Nan Fung Group Holdings Ltd | 753,550 | 913,550 | +160,000 | 1.29 | 1.20 | -0.09 | buy |
| Bank of New York Mellon Corp | 1,613,253 | 1,771,145 | +157,892 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 242,666 | 392,197 | +149,531 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 144,800 | +144,800 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 1,629,186 | 1,738,574 | +109,388 | 0.00 | 0.00 | -0.00 | buy |
| Crestline Management, LP | 585,151 | 687,378 | +102,227 | 0.15 | 0.13 | -0.01 | buy |
| ROYAL BANK OF CANADA | 68,143 | 149,418 | +81,275 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 11,015 | 89,722 | +78,707 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 113,829 | 170,420 | +56,591 | 0.02 | 0.03 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 12,769 | 68,749 | +55,980 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 52,165 | +52,165 | 0.00 | 0.03 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 13,426 | 62,820 | +49,394 | 0.01 | 0.03 | +0.02 | buy |
| HighVista Strategies LLC | 200,893 | 240,234 | +39,341 | 0.20 | 0.18 | -0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 35,675 | +35,675 | 0.00 | 0.00 | +0.00 | buy |
| Inspire Investing, LLC | 145,785 | 181,369 | +35,584 | 0.04 | 0.04 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 11,844 | 42,724 | +30,880 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 184,931 | 210,890 | +25,959 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 98,913 | 119,503 | +20,590 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 171,278 | 187,779 | +16,501 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 12,397 | 28,817 | +16,420 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 47,351 | 63,437 | +16,086 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 105,942 | 121,561 | +15,619 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 48,313 | 61,909 | +13,596 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 604,101 | 617,363 | +13,262 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 78,197 | 90,193 | +11,996 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 218,297 | 230,264 | +11,967 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,777 | +11,777 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,564,349 | 1,575,585 | +11,236 | 0.00 | 0.00 | -0.00 | buy |
| Platform Technology Partners | 0 | 10,100 | +10,100 | 0.00 | 0.01 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 32,005 | 41,892 | +9,887 | 0.04 | 0.06 | +0.01 | buy |
| SEI INVESTMENTS CO | 94,310 | 102,375 | +8,065 | 0.00 | 0.00 | -0.00 | buy |
| WEDBUSH SECURITIES INC | 91,555 | 99,557 | +8,002 | 0.01 | 0.01 | -0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 248,540 | 254,663 | +6,123 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 48,854 | 54,300 | +5,446 | 0.00 | 0.00 | -0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 126,974 | 132,053 | +5,079 | 0.02 | 0.02 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 25,973 | 30,282 | +4,309 | 0.01 | 0.01 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 29,866 | 34,118 | +4,252 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 200,244 | 204,125 | +3,881 | 0.00 | 0.00 | -0.00 | buy |
| Private Advisor Group, LLC | 347,586 | 351,144 | +3,558 | 0.01 | 0.01 | -0.00 | buy |
| Summit X, LLC | 358,458 | 361,961 | +3,503 | 0.24 | 0.22 | -0.02 | buy |
| Cresset Asset Management, LLC | 157,244 | 160,634 | +3,390 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 705,986 | 709,143 | +3,157 | 0.00 | 0.00 | -0.00 | buy |
| MPM BioImpact LLC | 10,712,481 | 10,715,620 | +3,139 | 6.06 | 5.29 | -0.77 | buy |
| Allspring Global Investments Holdings, LLC | 347,932 | 351,022 | +3,090 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 4,807 | 7,512 | +2,705 | 0.00 | 0.00 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 20,623 | 23,093 | +2,470 | 0.00 | 0.00 | -0.00 | buy |
| Tennessee Valley Asset Management Partners | 12,650 | 15,000 | +2,350 | 0.01 | 0.01 | -0.00 | buy |
| XPONANCE, INC. | 29,332 | 31,032 | +1,700 | 0.00 | 0.00 | -0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 35,197 | 36,817 | +1,620 | 0.00 | 0.00 | +0.00 | buy |
| GTS SECURITIES LLC | 85,154 | 86,764 | +1,610 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Investment Solutions, Inc. /IL | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 259,526 | 260,827 | +1,301 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 10,000 | 10,996 | +996 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 67,785 | 68,467 | +682 | 0.00 | 0.00 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 129,105 | 129,639 | +534 | 0.00 | 0.00 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 514 | +514 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 410,104 | 410,422 | +318 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 2,000 | 2,265 | +265 | 0.00 | 0.00 | -0.00 | buy |
| Plante Moran Financial Advisors, LLC | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| Kozak & Associates, Inc. | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 11,633 | 11,633 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 49,479 | 49,479 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HANTZ FINANCIAL SERVICES, INC. | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 512,741 | 512,741 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 335 | 335 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 46,202,425 | 46,202,425 | 0 | 1.93 | 1.52 | -0.41 | hold |
| Indiana Trust & Investment Management Co | 1,736 | 1,736 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WealthTrust Axiom LLC | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 1,441 | 1,441 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 1,407 | 1,407 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Savant Capital, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 22,776,409 | 22,776,409 | 0 | 3.73 | 3.20 | -0.53 | hold |
| MetLife Investment Management, LLC | 262,662 | 262,662 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Focused Wealth Management, Inc | 288 | 288 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pinnacle Wealth Management Advisory Group, LLC | 50,505 | 50,505 | 0 | 0.01 | 0.01 | -0.00 | hold |