| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 16,524,634 | 24,143,681 | +7,619,047 | 3.84 | 4.17 | +0.33 | buy |
| Sofinnova Investments, Inc. | 3,702,546 | 8,814,497 | +5,111,951 | 0.50 | 1.04 | +0.55 | buy |
| Deep Track Capital, LP | 25,700,000 | 29,583,449 | +3,883,449 | 2.11 | 2.19 | +0.07 | buy |
| Ally Bridge Group (NY) LLC | 2,221,639 | 2,971,639 | +750,000 | 5.53 | 3.74 | -1.79 | buy |
| Nan Fung Group Holdings Ltd | 753,550 | 913,550 | +160,000 | 1.29 | 1.20 | -0.09 | buy |
| Crestline Management, LP | 585,151 | 687,378 | +102,227 | 0.14 | 0.12 | -0.02 | buy |
| China Universal Asset Management Co., Ltd. | 13,426 | 62,820 | +49,394 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 322,857 | 275,823 | +47,034 | 0.04 | 0.03 | 0.00 | sell |
| HighVista Strategies LLC | 200,893 | 240,234 | +39,341 | 0.20 | 0.18 | -0.01 | buy |
| Inspire Investing, LLC | 145,785 | 181,369 | +35,584 | 0.04 | 0.04 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 32,005 | 41,892 | +9,887 | 0.04 | 0.06 | +0.01 | buy |
| WEDBUSH SECURITIES INC | 91,555 | 99,557 | +8,002 | 0.01 | 0.01 | 0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 126,974 | 132,053 | +5,079 | 0.02 | 0.02 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 25,973 | 30,282 | +4,309 | 0.01 | 0.01 | +0.00 | buy |
| Chicago Partners Investment Group LLC | 29,866 | 34,118 | +4,252 | 0.00 | 0.00 | +0.00 | buy |
| Summit X, LLC | 358,458 | 361,961 | +3,503 | 0.24 | 0.22 | -0.02 | buy |
| MPM BioImpact LLC | 10,712,481 | 10,715,620 | +3,139 | 6.06 | 5.29 | -0.77 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 20,623 | 23,093 | +2,470 | 0.00 | 0.00 | -0.00 | buy |
| Tennessee Valley Asset Management Partners | 12,650 | 15,000 | +2,350 | 0.01 | 0.01 | +0.00 | buy |
| Forefront Analytics, LLC | 29,116 | 28,316 | -800 | 0.04 | 0.03 | -0.01 | sell |
| Crewe Advisors LLC | 2,000 | 1,000 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| IHT Wealth Management, LLC | 34,350 | 31,350 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 97,708 | 89,633 | -8,075 | 0.02 | 0.01 | -0.00 | sell |
| LAZARI CAPITAL MANAGEMENT, INC. | 127,924 | 114,424 | -13,500 | 0.16 | 0.14 | -0.02 | sell |
| ALPS ADVISORS INC | 386,300 | 358,782 | -27,518 | 0.01 | 0.01 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 133,145 | 22,058 | -111,087 | 0.05 | 0.01 | -0.04 | sell |
| Rafferty Asset Management, LLC | 1,902,266 | 1,669,087 | -233,179 | 0.02 | 0.01 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 3,624,000 | 3,296,000 | -328,000 | 0.12 | 0.09 | -0.02 | sell |
| SEGALL BRYANT & HAMILL, LLC | 4,990,499 | 4,419,820 | -570,679 | 0.12 | 0.18 | +0.06 | sell |