| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,050,000 | 11,000,000 | +9,950,000 | 0.38 | 2.31 | +1.93 | buy |
| Woodline Partners LP | 7,038,313 | 11,587,344 | +4,549,031 | 0.27 | 0.28 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 22,565,846 | 27,082,461 | +4,516,615 | 0.05 | 0.05 | 0.00 | buy |
| Holocene Advisors, LP | 18,171,350 | 22,195,909 | +4,024,559 | 0.33 | 0.25 | -0.08 | buy |
| SEGALL BRYANT & HAMILL, LLC | 4,077,079 | 7,446,275 | +3,369,196 | 0.25 | 0.36 | +0.11 | buy |
| J. Goldman & Co LP | 176,239 | 1,669,684 | +1,493,445 | 0.02 | 0.15 | +0.13 | buy |
| First Turn Management, LLC | 3,124,967 | 3,893,327 | +768,360 | 2.25 | 2.47 | +0.22 | buy |
| Affinity Asset Advisors, LLC | 1,500,000 | 2,250,000 | +750,000 | 1.06 | 1.24 | +0.19 | buy |
| Exome Asset Management LLC | 905,126 | 1,561,152 | +656,026 | 2.78 | 4.23 | +1.45 | buy |
| Aberdeen Group plc | 1,487,258 | 1,847,285 | +360,027 | 0.01 | 0.01 | -0.00 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 1,700,000 | 1,850,000 | +150,000 | 0.12 | 0.11 | -0.01 | buy |
| ALGERT GLOBAL LLC | 395,071 | 528,686 | +133,615 | 0.05 | 0.04 | 0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 348,062 | 476,994 | +128,932 | 0.12 | 0.14 | +0.02 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 151,555 | 267,629 | +116,074 | 0.07 | 0.10 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 242,819 | 351,724 | +108,905 | 0.01 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 250,711 | 330,911 | +80,200 | 0.02 | 0.01 | -0.01 | buy |
| Dynamic Technology Lab Private Ltd | 42,421 | 109,651 | +67,230 | 0.02 | 0.06 | +0.04 | buy |
| Hennion & Walsh Asset Management, Inc. | 341,884 | 403,703 | +61,819 | 0.07 | 0.06 | -0.01 | buy |
| PROFUND ADVISORS LLC | 281,519 | 234,210 | +47,309 | 0.05 | 0.03 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 67,490 | 89,198 | +21,708 | 0.14 | 0.13 | -0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 46,000 | 63,500 | +17,500 | 0.12 | 0.15 | +0.03 | buy |
| DnB Asset Management AS | 78,649 | 92,243 | +13,594 | 0.00 | 0.00 | -0.00 | buy |
| WEDBUSH SECURITIES INC | 94,771 | 81,959 | +12,812 | 0.02 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 115,937 | 128,176 | +12,239 | 0.06 | 0.04 | -0.02 | buy |
| Alternative Investment Advisors, LLC. | 22,209 | 32,578 | +10,369 | 0.05 | 0.06 | +0.01 | buy |
| LAZARI CAPITAL MANAGEMENT, INC. | 68,424 | 76,424 | +8,000 | 0.13 | 0.11 | -0.03 | buy |
| ROVIN CAPITAL /UT/ /ADV | 13,610 | 17,270 | +3,660 | 0.02 | 0.02 | -0.00 | buy |
| PINNACLE ASSOCIATES LTD | 50,505 | 52,505 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New Hampshire | 1,000 | 2,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 3,852 | 4,507 | +655 | 0.00 | 0.00 | 0.00 | buy |
| Forefront Analytics, LLC | 18,491 | 19,023 | +532 | 0.04 | 0.03 | -0.01 | buy |
| Inspire Advisors, LLC | 14,902 | 15,360 | +458 | 0.01 | 0.01 | -0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 27,122 | 27,295 | +173 | 0.01 | 0.01 | -0.00 | buy |
| Crewe Advisors LLC | 8,300 | 7,900 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Summit X, LLC | 385,056 | 382,972 | -2,084 | 0.40 | 0.30 | -0.10 | sell |
| HighMark Wealth Management LLC | 5,325 | 1,775 | -3,550 | 0.01 | 0.00 | -0.01 | sell |
| E Fund Management Co., Ltd. | 91,488 | 85,539 | -5,949 | 0.02 | 0.02 | -0.01 | sell |
| Chicago Partners Investment Group LLC | 24,815 | 17,059 | -7,756 | 0.00 | 0.00 | -0.00 | sell |
| AXIOM INVESTORS LLC /DE | 322,745 | 308,438 | -14,307 | 0.01 | 0.01 | -0.00 | sell |
| Main Management ETF Advisors, LLC | 197,104 | 180,848 | -16,256 | 0.04 | 0.03 | -0.01 | sell |
| Inspire Investing, LLC | 159,754 | 116,860 | -42,894 | 0.07 | 0.05 | -0.03 | sell |
| Lion Point Capital, LP | 630,000 | 500,000 | -130,000 | 6.37 | 9.27 | +2.90 | sell |
| ADAR1 Capital Management, LLC | 557,159 | 337,676 | -219,483 | 0.42 | 0.25 | -0.18 | sell |
| Rafferty Asset Management, LLC | 1,424,004 | 1,203,583 | -220,421 | 0.02 | 0.02 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 1,331,053 | 1,074,824 | -256,229 | 3.23 | 3.26 | +0.03 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,801,561 | 920,022 | -881,539 | 1.84 | 0.73 | -1.11 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 32,285,755 | 30,009,536 | -2,276,219 | 1.69 | 1.41 | -0.28 | sell |
| Deep Track Capital, LP | 7,575,049 | 4,011,287 | -3,563,762 | 1.10 | 0.53 | -0.57 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 28,875,000 | 21,800,000 | -7,075,000 | 0.23 | 0.13 | -0.10 | sell |
| Darwin Global Management, Ltd. | 22,038,773 | 9,569,835 | -12,468,938 | 8.14 | 3.21 | -4.93 | sell |