| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 60,379,366 | 63,771,366 | +3,392,000 | 1.02 | 0.86 | -0.16 | buy |
| BlackRock, Inc. | 46,605,750 | 45,913,344 | -692,406 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 34,423,125 | 35,660,969 | +1,237,844 | 0.00 | 0.00 | -0.00 | buy |
| Deep Track Capital, LP | 41,096,522 | 32,511,271 | -8,585,251 | 1.57 | 0.98 | -0.59 | sell |
| Vivo Capital, LLC | 27,225,292 | 27,225,292 | 0 | 3.00 | 2.32 | -0.68 | hold |
| STATE STREET CORP | 26,618,814 | 26,867,322 | +248,508 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 17,290,000 | 23,290,000 | +6,000,000 | 1.27 | 1.30 | +0.04 | buy |
| Eversept Partners, LP | 12,599,002 | 17,659,983 | +5,060,981 | 1.32 | 1.31 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 21,307,395 | 16,174,398 | -5,132,997 | 0.00 | 0.00 | -0.00 | sell |
| Clearbridge Investments, LLC | 14,224,978 | 14,242,953 | +17,975 | 0.01 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,123,540 | 13,027,335 | -96,205 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 10,698,356 | 12,603,418 | +1,905,062 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 17,225,000 | 11,320,000 | -5,905,000 | 1.07 | 0.55 | -0.52 | sell |
| CITADEL ADVISORS LLC | 15,705,068 | 9,925,786 | -5,779,282 | 0.02 | 0.01 | -0.01 | sell |
| Aberdeen Group plc | 5,970,923 | 9,527,083 | +3,556,160 | 0.01 | 0.02 | +0.01 | buy |
| Nantahala Capital Management, LLC | 9,025,000 | 9,025,000 | 0 | 0.76 | 0.71 | -0.05 | hold |
| FMR LLC | 7,701,070 | 8,076,965 | +375,895 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 5,883,792 | 7,504,094 | +1,620,302 | 0.04 | 0.04 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 5,130,262 | 5,140,809 | +10,547 | 0.00 | 0.00 | -0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 5,335,216 | 5,048,936 | -286,280 | 0.10 | 0.09 | -0.01 | sell |
| Pale Fire Capital SE | 2,281,754 | 4,788,594 | +2,506,840 | 0.34 | 0.81 | +0.47 | buy |
| NORTHERN TRUST CORP | 4,862,558 | 4,726,605 | -135,953 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 11,367,989 | 4,603,876 | -6,764,113 | 0.01 | 0.00 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,509,465 | 4,514,063 | +4,598 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 4,527,741 | 3,499,747 | -1,027,994 | 0.10 | 0.07 | -0.03 | sell |
| Kynam Capital Management, LP | 3,456,318 | 3,456,318 | 0 | 0.35 | 0.30 | -0.06 | hold |
| UBS Group AG | 7,721,107 | 3,273,705 | -4,447,402 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 4,722,818 | 3,107,529 | -1,615,289 | 0.01 | 0.01 | -0.00 | sell |
| Candriam S.C.A. | 3,253,960 | 2,839,484 | -414,476 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,852,018 | 2,801,468 | +949,450 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 3,494,346 | 2,698,010 | -796,336 | 0.00 | 0.00 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,330,000 | 2,330,000 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Nuveen, LLC | 1,974,779 | 1,999,843 | +25,064 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 1,935,606 | 1,575,429 | -360,177 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 1,574,744 | 1,573,836 | -908 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 1,500,000 | 1,500,000 | 0 | 0.19 | 0.14 | -0.05 | hold |
| NAN FUNG TRINITY (HK) Ltd | 1,373,550 | 1,373,550 | 0 | 0.19 | 0.14 | -0.04 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,240,671 | 1,296,163 | +55,492 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,312,867 | 1,232,288 | -80,579 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 960,461 | 1,225,658 | +265,197 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 901,874 | 1,200,225 | +298,351 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 3,288,707 | 1,130,076 | -2,158,631 | 0.01 | 0.00 | -0.01 | sell |
| World Investment Advisors | 1,039,779 | 1,033,779 | -6,000 | 0.03 | 0.02 | -0.01 | sell |
| JANE STREET GROUP, LLC | 2,122,338 | 1,013,003 | -1,109,335 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 926,100 | 926,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Almitas Capital LLC | 946,323 | 896,323 | -50,000 | 0.30 | 0.26 | -0.04 | sell |
| WELLS FARGO & COMPANY/MN | 769,258 | 855,141 | +85,883 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 551,115 | 834,115 | +283,000 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 986,354 | 821,890 | -164,464 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 1,600,000 | 805,800 | -794,200 | 1.78 | 0.84 | -0.94 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,364,280 | 737,166 | -1,627,114 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 837,653 | 727,512 | -110,141 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 0 | 686,538 | +686,538 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 697,055 | 651,571 | -45,484 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 1,392,980 | 627,297 | -765,683 | 0.03 | 0.02 | -0.00 | sell |
| Lion Point Capital, LP | 500,000 | 578,000 | +78,000 | 3.89 | 3.95 | +0.06 | buy |
| ALPS ADVISORS INC | 302,509 | 524,159 | +221,650 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 284,868 | 502,509 | +217,641 | 0.11 | 0.18 | +0.07 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 479,430 | 475,257 | -4,173 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 507,900 | 443,328 | -64,572 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 364,400 | 421,458 | +57,058 | 0.02 | 0.02 | +0.00 | buy |
| Private Advisor Group, LLC | 418,877 | 420,332 | +1,455 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 625,291 | 386,341 | -238,950 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 385,546 | 365,046 | -20,500 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 376,272 | 364,212 | -12,060 | 0.00 | 0.00 | -0.00 | sell |
| Inspire Investing, LLC | 329,051 | 354,150 | +25,099 | 0.04 | 0.04 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 456,176 | 336,176 | -120,000 | 0.06 | 0.03 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 288,838 | 312,027 | +23,189 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 213,466 | 306,913 | +93,447 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 304,213 | 301,593 | -2,620 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 266,749 | 297,062 | +30,313 | 0.00 | 0.00 | +0.00 | buy |
| MOODY NATIONAL BANK TRUST DIVISION | 296,379 | 295,425 | -954 | 0.03 | 0.04 | +0.00 | sell |
| JPMORGAN CHASE & CO | 487,249 | 264,478 | -222,771 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 165,516 | 258,397 | +92,881 | 0.01 | 0.01 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 239,357 | 239,357 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 233,992 | 233,992 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Nvest Financial, LLC | 313,726 | 228,791 | -84,935 | 0.25 | 0.13 | -0.12 | sell |
| Scientech Research LLC | 0 | 227,472 | +227,472 | 0.00 | 0.19 | +0.19 | buy |
| Russell Investments Group, Ltd. | 230,334 | 225,046 | -5,288 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 220,623 | 205,691 | -14,932 | 0.01 | 0.01 | -0.00 | sell |
| Creative Planning | 348,589 | 203,847 | -144,742 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 219,398 | 202,520 | -16,878 | 0.00 | 0.00 | -0.00 | sell |
| Cresset Asset Management, LLC | 182,844 | 188,546 | +5,702 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 214,422 | 183,366 | -31,056 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 261,865 | 178,497 | -83,368 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | 171,453 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 180,450 | 166,844 | -13,606 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 113,333 | 158,787 | +45,454 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 153,371 | 153,371 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EntryPoint Capital, LLC | 0 | 151,909 | +151,909 | 0.00 | 0.08 | +0.08 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 142,122 | 142,122 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CITIGROUP INC | 76,312 | 139,391 | +63,079 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 140,855 | 134,936 | -5,919 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 129,333 | +129,333 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 116,136 | 128,026 | +11,890 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 57,011 | 123,848 | +66,837 | 0.00 | 0.00 | +0.00 | buy |
| Mason & Associates Inc | 0 | 120,700 | +120,700 | 0.00 | 0.03 | +0.03 | buy |
| HighTower Advisors, LLC | 119,219 | 117,204 | -2,015 | 0.00 | 0.00 | -0.00 | sell |
| Dynamic Technology Lab Private Ltd | 31,918 | 111,281 | +79,363 | 0.01 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 106,133 | 106,133 | 0 | 0.00 | 0.00 | -0.00 | hold |