| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 17,290,000 | 23,290,000 | +6,000,000 | 1.27 | 1.30 | +0.04 | buy |
| Eversept Partners, LP | 12,599,002 | 17,659,983 | +5,060,981 | 1.32 | 1.31 | -0.01 | buy |
| Aberdeen Group plc | 5,970,923 | 9,527,083 | +3,556,160 | 0.01 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 60,379,366 | 63,771,366 | +3,392,000 | 1.02 | 0.86 | -0.16 | buy |
| Pale Fire Capital SE | 2,281,754 | 4,788,594 | +2,506,840 | 0.34 | 0.81 | +0.47 | buy |
| MORGAN STANLEY | 10,698,356 | 12,603,418 | +1,905,062 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 5,883,792 | 7,504,094 | +1,620,302 | 0.04 | 0.04 | +0.00 | buy |
| VANGUARD GROUP INC | 34,423,125 | 35,660,969 | +1,237,844 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,852,018 | 2,801,468 | +949,450 | 0.00 | 0.01 | +0.00 | buy |
| Centiva Capital, LP | 0 | 686,538 | +686,538 | 0.00 | 0.05 | +0.05 | buy |
| FMR LLC | 7,701,070 | 8,076,965 | +375,895 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 901,874 | 1,200,225 | +298,351 | 0.00 | 0.00 | +0.00 | buy |
| MML INVESTORS SERVICES, LLC | 551,115 | 834,115 | +283,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 960,461 | 1,225,658 | +265,197 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 26,618,814 | 26,867,322 | +248,508 | 0.00 | 0.00 | -0.00 | buy |
| Scientech Research LLC | 0 | 227,472 | +227,472 | 0.00 | 0.19 | +0.19 | buy |
| ALPS ADVISORS INC | 302,509 | 524,159 | +221,650 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 284,868 | 502,509 | +217,641 | 0.11 | 0.18 | +0.07 | buy |
| EntryPoint Capital, LLC | 0 | 151,909 | +151,909 | 0.00 | 0.08 | +0.08 | buy |
| Virtu Financial LLC | 0 | 129,333 | +129,333 | 0.00 | 0.01 | +0.01 | buy |
| Mason & Associates Inc | 0 | 120,700 | +120,700 | 0.00 | 0.03 | +0.03 | buy |
| PROFUND ADVISORS LLC | 213,466 | 306,913 | +93,447 | 0.01 | 0.01 | +0.00 | buy |
| XTX Topco Ltd | 165,516 | 258,397 | +92,881 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 769,258 | 855,141 | +85,883 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 31,918 | 111,281 | +79,363 | 0.01 | 0.03 | +0.03 | buy |
| Lion Point Capital, LP | 500,000 | 578,000 | +78,000 | 3.89 | 3.95 | +0.06 | buy |
| Man Group plc | 57,011 | 123,848 | +66,837 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 76,312 | 139,391 | +63,079 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 364,400 | 421,458 | +57,058 | 0.02 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,240,671 | 1,296,163 | +55,492 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 44,818 | 91,619 | +46,801 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 113,333 | 158,787 | +45,454 | 0.00 | 0.00 | -0.00 | buy |
| Abel Hall, LLC | 0 | 43,627 | +43,627 | 0.00 | 0.01 | +0.01 | buy |
| Global Retirement Partners, LLC | 60,000 | 100,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 738 | 38,319 | +37,581 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 36,196 | +36,196 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 266,749 | 297,062 | +30,313 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 29,590 | +29,590 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 28,423 | +28,423 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 28,000 | +28,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtue Capital Management, LLC | 10,000 | 36,302 | +26,302 | 0.00 | 0.13 | +0.13 | buy |
| Inspire Investing, LLC | 329,051 | 354,150 | +25,099 | 0.04 | 0.04 | -0.00 | buy |
| Nuveen, LLC | 1,974,779 | 1,999,843 | +25,064 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 288,838 | 312,027 | +23,189 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 15,753 | 37,341 | +21,588 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 14,224,978 | 14,242,953 | +17,975 | 0.01 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 15,428 | +15,428 | 0.00 | 0.00 | +0.00 | buy |
| Blueshift Asset Management, LLC | 0 | 15,308 | +15,308 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 14,385 | +14,385 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 116,136 | 128,026 | +11,890 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 11,436 | +11,436 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 11,319 | +11,319 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 11,112 | +11,112 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 5,130,262 | 5,140,809 | +10,547 | 0.00 | 0.00 | -0.00 | buy |
| Fort Sheridan Advisors LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NWAM LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| LCM Capital Management Inc | 12,400 | 22,400 | +10,000 | 0.01 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 24,666 | 31,020 | +6,354 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 182,844 | 188,546 | +5,702 | 0.00 | 0.00 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 31,659 | 37,355 | +5,696 | 0.01 | 0.01 | +0.00 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 33,725 | 39,405 | +5,680 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,509,465 | 4,514,063 | +4,598 | 0.00 | 0.00 | -0.00 | buy |
| Cetera Investment Advisers | 54,421 | 57,782 | +3,361 | 0.00 | 0.00 | -0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 6,582 | 9,838 | +3,256 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 6,380 | 9,169 | +2,789 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 14,254 | 17,002 | +2,748 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,323 | 3,670 | +2,347 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 418,877 | 420,332 | +1,455 | 0.00 | 0.00 | -0.00 | buy |
| Chicago Partners Investment Group LLC | 20,524 | 21,760 | +1,236 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 13,165 | 14,247 | +1,082 | 0.00 | 0.00 | -0.00 | buy |
| Rockefeller Capital Management L.P. | 9,500 | 10,572 | +1,072 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 77 | 1,127 | +1,050 | 0.00 | 0.00 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Key FInancial Inc | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1,582 | 2,403 | +821 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 449 | +449 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 42,545 | 42,921 | +376 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 36 | 403 | +367 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 69,624 | 69,926 | +302 | 0.00 | 0.00 | -0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 36,737 | 36,981 | +244 | 0.00 | 0.00 | -0.00 | buy |
| Corient Private Wealth LLC | 35,405 | 35,617 | +212 | 0.00 | 0.00 | -0.00 | buy |
| Kilter Group LLC | 0 | 154 | +154 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 1,000 | 1,120 | +120 | 0.00 | 0.00 | -0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 400 | 470 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Sowell Financial Services LLC | 27,000 | 27,039 | +39 | 0.00 | 0.00 | -0.00 | buy |
| FIDUCIARY ADVISORS, INC. | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 17,209 | 17,209 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 45,637 | 45,637 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROVIN CAPITAL /UT/ /ADV | 17,270 | 17,270 | 0 | 0.01 | 0.01 | -0.00 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 106,133 | 106,133 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HANTZ FINANCIAL SERVICES, INC. | 100 | 100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 233,992 | 233,992 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 64,879 | 64,879 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COUNTRY TRUST BANK | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 239,357 | 239,357 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 335 | 335 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Indiana Trust & Investment Management Co | 1,736 | 1,736 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 103,230 | 103,230 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 1,441 | 1,441 | 0 | 0.00 | 0.00 | -0.00 | hold |