| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 28,710,136 | 28,949,515 | +239,379 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 17,630,583 | 17,880,873 | +250,290 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 10,740,198 | 14,623,269 | +3,883,071 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 11,414,671 | 7,476,495 | -3,938,176 | 0.82 | 0.51 | -0.32 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 7,385,513 | 7,374,138 | -11,375 | 0.00 | 0.00 | +0.00 | sell |
| Nitorum Capital, L.P. | 6,561,465 | 5,325,823 | -1,235,642 | 6.19 | 6.68 | +0.49 | sell |
| UBS Group AG | 5,194,739 | 5,103,097 | -91,642 | 0.01 | 0.01 | +0.00 | sell |
| Avoro Capital Advisors LLC | 4,468,877 | 4,444,444 | -24,433 | 0.31 | 0.25 | -0.06 | sell |
| MORGAN STANLEY | 3,850,451 | 4,443,922 | +593,471 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 4,016,682 | 4,443,603 | +426,921 | 0.00 | 0.01 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 4,225,000 | +4,225,000 | 0.00 | 0.64 | +0.64 | buy |
| FMR LLC | 3,318,761 | 3,577,534 | +258,773 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,300,557 | 3,571,955 | +2,271,398 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,467,721 | 3,305,012 | -162,709 | 0.00 | 0.00 | +0.00 | sell |
| 180 WEALTH ADVISORS, LLC | 2,872,286 | 2,958,944 | +86,658 | 1.88 | 1.91 | +0.03 | buy |
| NORTHERN TRUST CORP | 2,774,913 | 2,629,888 | -145,025 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,578,322 | 2,564,526 | -13,796 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 2,947,539 | 2,362,221 | -585,318 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 2,631,816 | 2,162,242 | -469,574 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,949,909 | 1,921,967 | -27,942 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,694,000 | 1,894,000 | +200,000 | 0.01 | 0.02 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,205,450 | 1,882,234 | +676,784 | 0.01 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,234,168 | 1,861,046 | +626,878 | 0.02 | 0.04 | +0.01 | buy |
| Eversept Partners, LP | 2,042,727 | 1,852,563 | -190,164 | 0.84 | 0.59 | -0.25 | sell |
| Qube Research & Technologies Ltd | 2,600,130 | 1,831,136 | -768,994 | 0.02 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 850,797 | 1,757,487 | +906,690 | 0.01 | 0.02 | +0.01 | buy |
| EcoR1 Capital, LLC | 0 | 1,660,000 | +1,660,000 | 0.00 | 0.43 | +0.43 | buy |
| Invesco Ltd. | 1,635,980 | 1,580,796 | -55,184 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 1,539,665 | 1,248,545 | -291,120 | 0.00 | 0.00 | -0.00 | sell |
| APIS CAPITAL ADVISORS, LLC | 0 | 1,200,100 | +1,200,100 | 0.00 | 1.19 | +1.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 2,010,237 | 1,188,438 | -821,799 | 0.02 | 0.01 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 501,891 | 1,089,059 | +587,168 | 0.00 | 0.00 | +0.00 | buy |
| AXIOM INVESTORS LLC /DE | 899,400 | 1,037,704 | +138,304 | 0.04 | 0.05 | +0.02 | buy |
| BARCLAYS PLC | 846,056 | 1,025,437 | +179,381 | 0.00 | 0.00 | +0.00 | buy |
| DELTEC ASSET MANAGEMENT LLC | 723,500 | 974,700 | +251,200 | 0.64 | 0.92 | +0.27 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,597,677 | 894,204 | -703,473 | 0.03 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 894,313 | 873,493 | -20,820 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 477,207 | 843,026 | +365,819 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 485,094 | 827,853 | +342,759 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 707,140 | +707,140 | 0.00 | 0.01 | +0.01 | buy |
| SCOPIA CAPITAL MANAGEMENT LP | 694,961 | 694,961 | 0 | 0.52 | 0.83 | +0.31 | hold |
| Apollo Management Holdings, L.P. | 664,113 | 664,113 | 0 | 0.05 | 0.04 | -0.02 | hold |
| Parkman Healthcare Partners LLC | 656,084 | 640,356 | -15,728 | 0.39 | 0.35 | -0.04 | sell |
| AQR CAPITAL MANAGEMENT LLC | 736,679 | 639,249 | -97,430 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 587,186 | +587,186 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 433,846 | 578,402 | +144,556 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 559,900 | 574,700 | +14,800 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 856,946 | 553,759 | -303,187 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 375,228 | 548,257 | +173,029 | 0.00 | 0.00 | +0.00 | buy |
| 1492 Capital Management LLC | 504,244 | 535,270 | +31,026 | 1.10 | 1.16 | +0.07 | buy |
| JPMORGAN CHASE & CO | 2,047,869 | 522,190 | -1,525,679 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 586,539 | 512,740 | -73,799 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,831,327 | 510,964 | -1,320,363 | 0.02 | 0.01 | -0.01 | sell |
| Schonfeld Strategic Advisors LLC | 173,268 | 484,162 | +310,894 | 0.01 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 102,309 | 472,859 | +370,550 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 209,432 | 452,470 | +243,038 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 446,930 | +446,930 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 558,261 | 432,785 | -125,476 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 1,715,637 | 427,058 | -1,288,579 | 0.02 | 0.00 | -0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 412,388 | 405,660 | -6,728 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 441,775 | 381,423 | -60,352 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 599,126 | 375,561 | -223,565 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 230,911 | 370,718 | +139,807 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 232,708 | 333,829 | +101,121 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 267,940 | 307,158 | +39,218 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 212,475 | 302,000 | +89,525 | 0.79 | 1.02 | +0.22 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 300,504 | +300,504 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 319,185 | 294,003 | -25,182 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 279,091 | 278,850 | -241 | 0.00 | 0.00 | +0.00 | sell |
| Voleon Capital Management LP | 237,242 | 269,796 | +32,554 | 0.03 | 0.03 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 264,293 | +264,293 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 256,741 | 255,615 | -1,126 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 245,279 | +245,279 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 238,681 | +238,681 | 0.00 | 0.03 | +0.03 | buy |
| Aquatic Capital Management LLC | 55,040 | 222,163 | +167,123 | 0.01 | 0.04 | +0.03 | buy |
| Mariner, LLC | 206,702 | 209,479 | +2,777 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 202,412 | 206,612 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 187,720 | 204,121 | +16,401 | 0.00 | 0.00 | +0.00 | buy |
| Aaron Wealth Advisors LLC | 198,408 | 200,763 | +2,355 | 0.06 | 0.06 | -0.00 | buy |
| Bruce & Co., Inc. | 195,073 | 195,073 | 0 | 0.32 | 0.34 | +0.02 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 112,516 | 194,978 | +82,462 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 98,651 | 178,494 | +79,843 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 179,537 | 171,757 | -7,780 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 48,778 | 169,001 | +120,223 | 0.01 | 0.03 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 162,217 | 163,280 | +1,063 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 171,791 | 161,951 | -9,840 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 161,300 | 161,300 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MetLife Investment Management, LLC | 171,010 | 154,254 | -16,756 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 79,935 | 143,592 | +63,657 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 149,194 | 140,440 | -8,754 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 127,763 | 127,763 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 127,363 | 127,363 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Brevan Howard Capital Management LP | 0 | 122,610 | +122,610 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 121,148 | +121,148 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 116,975 | +116,975 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 113,137 | 115,191 | +2,054 | 0.01 | 0.02 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 168,730 | 106,440 | -62,290 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 102,118 | 105,945 | +3,827 | 0.00 | 0.00 | +0.00 | buy |
| HUB Investment Partners, LLC | 103,972 | 104,429 | +457 | 0.02 | 0.02 | -0.00 | buy |
| KING LUTHER CAPITAL MANAGEMENT CORP | 0 | 102,995 | +102,995 | 0.00 | 0.00 | +0.00 | buy |