| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 165,178 | 318,380 | +153,202 | 2.70 | 4.24 | +1.54 | buy |
| ARMISTICE CAPITAL, LLC | 578,000 | 724,000 | +146,000 | 0.74 | 0.62 | -0.12 | buy |
| Rhenman & Partners Asset Management AB | 59,000 | 141,250 | +82,250 | 0.52 | 0.93 | +0.41 | buy |
| Prosight Management, LP | 735,000 | 810,000 | +75,000 | 8.67 | 9.74 | +1.07 | buy |
| SummitTX Capital, L.P. | 42,624 | 112,934 | +70,310 | 0.10 | 0.20 | +0.11 | buy |
| Birchview Capital, LP | 31,000 | 81,000 | +50,000 | 1.27 | 2.64 | +1.37 | buy |
| Stonepine Capital Management, LLC | 85,000 | 120,654 | +35,654 | 2.45 | 3.94 | +1.49 | buy |
| Gainplan LLC | 5,000 | 14,962 | +9,962 | 0.27 | 0.41 | +0.14 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36,907 | 41,902 | +4,995 | 0.17 | 0.19 | +0.02 | buy |
| AWM Investment Company, Inc. | 20,000 | 20,925 | +925 | 0.16 | 0.13 | -0.03 | buy |
| FNY Investment Advisers, LLC | 4,750 | 5,500 | +750 | 0.15 | 0.14 | -0.01 | buy |
| Bronte Capital Management Pty Ltd. | 198,256 | 198,434 | +178 | 1.41 | 1.49 | +0.08 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 256,106 | 255,587 | -519 | 0.89 | 0.63 | -0.27 | sell |
| GREAT LAKES ADVISORS, LLC | 3,741 | 2,946 | -795 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 4,000 | 1,600 | -2,400 | 0.02 | 0.01 | -0.02 | sell |
| HighVista Strategies LLC | 14,555 | 8,708 | -5,847 | 0.29 | 0.14 | -0.15 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 279,150 | 272,850 | -6,300 | 0.02 | 0.01 | -0.00 | sell |
| TFG Asset Management GP Ltd | 103,037 | 86,996 | -16,041 | 1.44 | 0.96 | -0.48 | sell |
| Voleon Capital Management LP | 65,063 | 40,838 | -24,225 | 0.10 | 0.05 | -0.05 | sell |
| MOODY ALDRICH PARTNERS LLC | 89,527 | 64,135 | -25,392 | 1.16 | 0.80 | -0.36 | sell |
| Quinn Opportunity Partners LLC | 179,247 | 153,076 | -26,171 | 0.67 | 0.50 | -0.18 | sell |
| Sofinnova Investments, Inc. | 509,546 | 471,763 | -37,783 | 1.39 | 1.70 | +0.31 | sell |
| GREAT POINT PARTNERS LLC | 316,453 | 175,000 | -141,453 | 5.23 | 2.31 | -2.92 | sell |
| BVF INC/IL | 2,559,595 | 2,391,075 | -168,520 | 5.87 | 4.27 | -1.60 | sell |