| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 101,129 | 4,303,188 | +4,202,059 | 0.00 | 0.02 | +0.02 | buy |
| BVF INC/IL | 1,559,595 | 2,559,595 | +1,000,000 | 2.22 | 5.87 | +3.65 | buy |
| Two Seas Capital LP | 745,185 | 1,959,178 | +1,213,993 | 1.85 | 6.51 | +4.66 | buy |
| TWO SIGMA INVESTMENTS, LP | 473,014 | 930,741 | +457,727 | 0.03 | 0.06 | +0.03 | buy |
| Prosight Management, LP | 554,633 | 735,000 | +180,367 | 4.85 | 8.67 | +3.83 | buy |
| BlackRock, Inc. | 645,607 | 692,650 | +47,043 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 566,421 | 659,387 | +92,966 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 596,000 | 578,000 | -18,000 | 0.62 | 1.37 | +0.76 | sell |
| Invesco Ltd. | 468,159 | 567,458 | +99,299 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 309,777 | 513,531 | +203,754 | 0.01 | 0.03 | +0.02 | buy |
| Sofinnova Investments, Inc. | 438,630 | 509,546 | +70,916 | 0.80 | 1.84 | +1.04 | buy |
| Woodline Partners LP | 104,000 | 415,335 | +311,335 | 0.02 | 0.11 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 0 | 405,080 | +405,080 | 0.00 | 0.10 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 454,075 | 404,277 | -49,798 | 0.01 | 0.02 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 384,342 | 394,604 | +10,262 | 0.50 | 0.90 | +0.40 | buy |
| Qube Research & Technologies Ltd | 323,915 | 390,675 | +66,760 | 0.02 | 0.04 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 254,361 | 346,795 | +92,434 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 287,561 | 320,172 | +32,611 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 210,732 | 316,453 | +105,721 | 2.89 | 5.58 | +2.69 | buy |
| Vestal Point Capital, LP | 0 | 285,000 | +285,000 | 0.00 | 0.57 | +0.57 | buy |
| 22NW, LP | 331,115 | 281,115 | -50,000 | 5.89 | 13.86 | +7.97 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 280,150 | 279,150 | -1,000 | 0.01 | 0.02 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 0 | 275,000 | +275,000 | 0.00 | 0.43 | +0.43 | buy |
| GILDER GAGNON HOWE & CO LLC | 208,302 | 271,758 | +63,456 | 0.09 | 0.23 | +0.14 | buy |
| Nearwater Capital Markets, Ltd | 61,500 | 261,500 | +200,000 | 0.04 | 0.44 | +0.40 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 253,125 | 256,106 | +2,981 | 0.52 | 0.89 | +0.37 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 383,310 | 249,090 | -134,220 | 0.02 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 195,656 | 244,727 | +49,071 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 150,804 | 240,102 | +89,298 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 222,701 | +222,701 | 0.00 | 0.53 | +0.53 | buy |
| Patient Square Capital LP | 0 | 210,000 | +210,000 | 0.00 | 2.68 | +2.68 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 198,256 | +198,256 | 0.00 | 1.52 | +1.52 | buy |
| Quinn Opportunity Partners LLC | 85,868 | 179,247 | +93,379 | 0.16 | 0.68 | +0.52 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,380 | 168,007 | +47,627 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 74,998 | 165,178 | +90,180 | 0.74 | 2.70 | +1.97 | buy |
| ADAR1 Capital Management, LLC | 72,031 | 161,252 | +89,221 | 0.23 | 0.70 | +0.47 | buy |
| MARSHALL WACE, LLP | 24,023 | 140,588 | +116,565 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 136,730 | +136,730 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 147,793 | 126,942 | -20,851 | 0.00 | 0.00 | +0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.60 | +0.60 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 188,112 | 122,326 | -65,786 | 0.71 | 0.75 | +0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 210,298 | 121,539 | -88,759 | 0.01 | 0.01 | +0.00 | sell |
| JANE STREET GROUP, LLC | 218,337 | 112,652 | -105,685 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 20,257 | 107,385 | +87,128 | 0.00 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 85,666 | 106,248 | +20,582 | 0.00 | 0.01 | +0.00 | buy |
| TFG Asset Management GP Ltd | 69,287 | 103,037 | +33,750 | 0.62 | 1.46 | +0.84 | buy |
| ING GROEP NV | 100,000 | 100,000 | 0 | 0.03 | 0.04 | +0.02 | hold |
| Monashee Investment Management LLC | 94,134 | 100,000 | +5,866 | 2.24 | 3.91 | +1.67 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 101,166 | 98,745 | -2,421 | 0.01 | 0.02 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 90,743 | 91,671 | +928 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 56,023 | 89,527 | +33,504 | 0.44 | 1.16 | +0.72 | buy |
| Stonepine Capital Management, LLC | 85,000 | 85,000 | 0 | 2.84 | 5.38 | +2.54 | hold |
| NORTHERN TRUST CORP | 56,076 | 78,598 | +22,522 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 53,212 | 77,402 | +24,190 | 0.03 | 0.08 | +0.05 | buy |
| HRT FINANCIAL LP | 173,443 | 70,667 | -102,776 | 0.02 | 0.01 | -0.01 | sell |
| Voleon Capital Management LP | 68,335 | 65,063 | -3,272 | 0.06 | 0.10 | +0.04 | sell |
| F/m Investments LLC | 58,123 | 61,104 | +2,981 | 0.09 | 0.29 | +0.20 | buy |
| Rhenman & Partners Asset Management AB | 0 | 59,000 | +59,000 | 0.00 | 0.52 | +0.52 | buy |
| BANK OF AMERICA CORP /DE/ | 26,092 | 58,958 | +32,866 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 55,240 | 57,014 | +1,774 | 0.07 | 0.12 | +0.05 | buy |
| Cambridge Investment Research Advisors, Inc. | 53,713 | 56,055 | +2,342 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 18,821 | 55,476 | +36,655 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 54,020 | 53,172 | -848 | 0.01 | 0.02 | +0.01 | sell |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 48,474 | +48,474 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 48,294 | +48,294 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 31,900 | 47,900 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 43,227 | +43,227 | 0.00 | 0.22 | +0.22 | buy |
| SummitTX Capital, L.P. | 31,353 | 42,624 | +11,271 | 0.04 | 0.10 | +0.06 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 172,881 | 41,781 | -131,100 | 0.01 | 0.00 | -0.01 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 60,431 | 36,907 | -23,524 | 0.17 | 0.17 | -0.00 | sell |
| Jain Global LLC | 17,299 | 36,181 | +18,882 | 0.01 | 0.03 | +0.03 | buy |
| Informed Momentum Co LLC | 12,972 | 36,126 | +23,154 | 0.06 | 0.30 | +0.24 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 282,021 | 35,851 | -246,170 | 0.02 | 0.01 | -0.02 | sell |
| ALGERT GLOBAL LLC | 15,310 | 34,782 | +19,472 | 0.01 | 0.04 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 16,057 | 34,527 | +18,470 | 0.01 | 0.04 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 16,184 | 34,025 | +17,841 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,444 | 32,356 | +16,912 | 0.00 | 0.00 | +0.00 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 9,728 | 31,320 | +21,592 | 0.15 | 0.91 | +0.76 | buy |
| Birchview Capital, LP | 31,000 | 31,000 | 0 | 0.77 | 1.27 | +0.50 | hold |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 14,564 | 30,141 | +15,577 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,520 | 28,682 | +14,162 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 41,201 | 28,244 | -12,957 | 0.15 | 0.23 | +0.09 | sell |
| Erste Asset Management GmbH | 28,000 | 28,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Y-Intercept (Hong Kong) Ltd | 10,862 | 26,545 | +15,683 | 0.01 | 0.04 | +0.03 | buy |
| CITIGROUP INC | 35,777 | 25,048 | -10,729 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 23,114 | 21,331 | -1,783 | 0.08 | 0.10 | +0.01 | sell |
| BIT Capital GmbH | 21,100 | 21,100 | 0 | 0.04 | 0.08 | +0.05 | hold |
| ExodusPoint Capital Management, LP | 0 | 20,457 | +20,457 | 0.00 | 0.01 | +0.01 | buy |
| AWM Investment Company, Inc. | 40,000 | 20,000 | -20,000 | 0.16 | 0.16 | -0.00 | sell |
| Man Group plc | 0 | 19,446 | +19,446 | 0.00 | 0.00 | +0.00 | buy |
| Deuterium Capital Management, LLC | 37,349 | 18,000 | -19,349 | 2.29 | 1.51 | -0.78 | sell |
| WINTON GROUP Ltd | 7,765 | 16,910 | +9,145 | 0.01 | 0.04 | +0.03 | buy |
| Legal & General Group Plc | 12,413 | 16,658 | +4,245 | 0.00 | 0.00 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 16,361 | +16,361 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 7,005 | 16,181 | +9,176 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 15,813 | +15,813 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 213 | 15,526 | +15,313 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 14,984 | +14,984 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 11,749 | 14,555 | +2,806 | 0.13 | 0.29 | +0.16 | buy |