| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 101,129 | 4,303,188 | +4,202,059 | 0.00 | 0.02 | +0.02 | buy |
| Two Seas Capital LP | 745,185 | 1,959,178 | +1,213,993 | 1.85 | 6.51 | +4.66 | buy |
| BVF INC/IL | 1,559,595 | 2,559,595 | +1,000,000 | 2.22 | 5.87 | +3.65 | buy |
| TWO SIGMA INVESTMENTS, LP | 473,014 | 930,741 | +457,727 | 0.03 | 0.06 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 0 | 405,080 | +405,080 | 0.00 | 0.10 | +0.10 | buy |
| Woodline Partners LP | 104,000 | 415,335 | +311,335 | 0.02 | 0.11 | +0.10 | buy |
| Vestal Point Capital, LP | 0 | 285,000 | +285,000 | 0.00 | 0.57 | +0.57 | buy |
| ORBIMED ADVISORS LLC | 0 | 275,000 | +275,000 | 0.00 | 0.43 | +0.43 | buy |
| BRAIDWELL LP | 0 | 222,701 | +222,701 | 0.00 | 0.53 | +0.53 | buy |
| Patient Square Capital LP | 0 | 210,000 | +210,000 | 0.00 | 2.68 | +2.68 | buy |
| CITADEL ADVISORS LLC | 309,777 | 513,531 | +203,754 | 0.01 | 0.03 | +0.02 | buy |
| Nearwater Capital Markets, Ltd | 61,500 | 261,500 | +200,000 | 0.04 | 0.44 | +0.40 | buy |
| Bronte Capital Management Pty Ltd. | 0 | 198,256 | +198,256 | 0.00 | 1.52 | +1.52 | buy |
| Prosight Management, LP | 554,633 | 735,000 | +180,367 | 4.85 | 8.67 | +3.83 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 136,730 | +136,730 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.60 | +0.60 | buy |
| MARSHALL WACE, LLP | 24,023 | 140,588 | +116,565 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 210,732 | 316,453 | +105,721 | 2.89 | 5.58 | +2.69 | buy |
| Invesco Ltd. | 468,159 | 567,458 | +99,299 | 0.00 | 0.01 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 85,868 | 179,247 | +93,379 | 0.16 | 0.68 | +0.52 | buy |
| MORGAN STANLEY | 566,421 | 659,387 | +92,966 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 254,361 | 346,795 | +92,434 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 74,998 | 165,178 | +90,180 | 0.74 | 2.70 | +1.97 | buy |
| JPMORGAN CHASE & CO | 150,804 | 240,102 | +89,298 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 72,031 | 161,252 | +89,221 | 0.23 | 0.70 | +0.47 | buy |
| Squarepoint Ops LLC | 20,257 | 107,385 | +87,128 | 0.00 | 0.02 | +0.01 | buy |
| Sofinnova Investments, Inc. | 438,630 | 509,546 | +70,916 | 0.80 | 1.84 | +1.04 | buy |
| Qube Research & Technologies Ltd | 323,915 | 390,675 | +66,760 | 0.02 | 0.04 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 208,302 | 271,758 | +63,456 | 0.09 | 0.23 | +0.14 | buy |
| Rhenman & Partners Asset Management AB | 0 | 59,000 | +59,000 | 0.00 | 0.52 | +0.52 | buy |
| Alyeska Investment Group, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 195,656 | 244,727 | +49,071 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 48,474 | +48,474 | 0.00 | 0.03 | +0.03 | buy |
| LMR Partners LLP | 0 | 48,294 | +48,294 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,380 | 168,007 | +47,627 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 645,607 | 692,650 | +47,043 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 43,227 | +43,227 | 0.00 | 0.22 | +0.22 | buy |
| Trexquant Investment LP | 18,821 | 55,476 | +36,655 | 0.01 | 0.03 | +0.02 | buy |
| TFG Asset Management GP Ltd | 69,287 | 103,037 | +33,750 | 0.62 | 1.46 | +0.84 | buy |
| MOODY ALDRICH PARTNERS LLC | 56,023 | 89,527 | +33,504 | 0.44 | 1.16 | +0.72 | buy |
| BANK OF AMERICA CORP /DE/ | 26,092 | 58,958 | +32,866 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 287,561 | 320,172 | +32,611 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 53,212 | 77,402 | +24,190 | 0.03 | 0.08 | +0.05 | buy |
| Informed Momentum Co LLC | 12,972 | 36,126 | +23,154 | 0.06 | 0.30 | +0.24 | buy |
| NORTHERN TRUST CORP | 56,076 | 78,598 | +22,522 | 0.00 | 0.00 | +0.00 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 9,728 | 31,320 | +21,592 | 0.15 | 0.91 | +0.76 | buy |
| Russell Investments Group, Ltd. | 85,666 | 106,248 | +20,582 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 20,457 | +20,457 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 15,310 | 34,782 | +19,472 | 0.01 | 0.04 | +0.03 | buy |
| Man Group plc | 0 | 19,446 | +19,446 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 17,299 | 36,181 | +18,882 | 0.01 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 16,057 | 34,527 | +18,470 | 0.01 | 0.04 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 16,184 | 34,025 | +17,841 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 15,444 | 32,356 | +16,912 | 0.00 | 0.00 | +0.00 | buy |
| IMC-Chicago, LLC | 0 | 16,361 | +16,361 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 31,900 | 47,900 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 15,813 | +15,813 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 10,862 | 26,545 | +15,683 | 0.01 | 0.04 | +0.03 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 14,564 | 30,141 | +15,577 | 0.00 | 0.01 | +0.01 | buy |
| Steward Partners Investment Advisory, LLC | 213 | 15,526 | +15,313 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 14,984 | +14,984 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,520 | 28,682 | +14,162 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 12,878 | +12,878 | 0.00 | 0.01 | +0.01 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 12,000 | +12,000 | 0.00 | 1.05 | +1.05 | buy |
| SummitTX Capital, L.P. | 31,353 | 42,624 | +11,271 | 0.04 | 0.10 | +0.06 | buy |
| Scientech Research LLC | 0 | 11,032 | +11,032 | 0.00 | 0.66 | +0.66 | buy |
| EMERALD ADVISERS, LLC | 384,342 | 394,604 | +10,262 | 0.50 | 0.90 | +0.40 | buy |
| ALLSTATE CORP | 0 | 9,837 | +9,837 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 7,005 | 16,181 | +9,176 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 7,765 | 16,910 | +9,145 | 0.01 | 0.04 | +0.03 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 8,948 | +8,948 | 0.00 | 0.04 | +0.04 | buy |
| State of New Jersey Common Pension Fund D | 0 | 8,288 | +8,288 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 8,063 | +8,063 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 7,411 | +7,411 | 0.00 | 0.14 | +0.14 | buy |
| CenterBook Partners LP | 0 | 7,407 | +7,407 | 0.00 | 0.03 | +0.03 | buy |
| PEAK6 LLC | 0 | 7,000 | +7,000 | 0.00 | 0.01 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 6,700 | +6,700 | 0.00 | 0.08 | +0.08 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 6,695 | +6,695 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 6,661 | +6,661 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 6,597 | +6,597 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 6,439 | +6,439 | 0.00 | 0.12 | +0.12 | buy |
| Monashee Investment Management LLC | 94,134 | 100,000 | +5,866 | 2.24 | 3.91 | +1.67 | buy |
| Persistent Asset Partners Ltd | 0 | 5,820 | +5,820 | 0.00 | 0.16 | +0.16 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 5,384 | 10,883 | +5,499 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,629 | 13,670 | +5,041 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 4,591 | +4,591 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 0 | 4,550 | +4,550 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 1,448 | 5,949 | +4,501 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 12,413 | 16,658 | +4,245 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 4,000 | +4,000 | 0.00 | 0.02 | +0.02 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 3,741 | +3,741 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 3,718 | +3,718 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 3,685 | +3,685 | 0.00 | 0.00 | +0.00 | buy |
| Orion Porfolio Solutions, LLC | 0 | 3,543 | +3,543 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 3,159 | +3,159 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 3,127 | +3,127 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 3,098 | +3,098 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 3,057 | +3,057 | 0.00 | 0.02 | +0.02 | buy |
| LVW Advisors, LLC | 0 | 3,022 | +3,022 | 0.00 | 0.02 | +0.02 | buy |