| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,303,188 | 5,067,920 | +764,732 | 0.02 | 0.02 | -0.00 | buy |
| Two Seas Capital LP | 1,959,178 | 3,092,234 | +1,133,056 | 6.51 | 8.24 | +1.73 | buy |
| BlackRock, Inc. | 692,650 | 2,941,851 | +2,249,201 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 2,559,595 | 2,391,075 | -168,520 | 5.87 | 4.27 | -1.60 | sell |
| TWO SIGMA INVESTMENTS, LP | 930,741 | 1,202,004 | +271,263 | 0.06 | 0.06 | +0.01 | buy |
| Vestal Point Capital, LP | 285,000 | 1,000,000 | +715,000 | 0.57 | 1.63 | +1.06 | buy |
| MORGAN STANLEY | 659,387 | 936,560 | +277,173 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 244,727 | 909,679 | +664,952 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 346,795 | 881,306 | +534,511 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 735,000 | 810,000 | +75,000 | 8.67 | 9.74 | +1.07 | buy |
| ARMISTICE CAPITAL, LLC | 578,000 | 724,000 | +146,000 | 1.37 | 1.40 | +0.03 | buy |
| GILDER GAGNON HOWE & CO LLC | 271,758 | 600,873 | +329,115 | 0.23 | 0.43 | +0.20 | buy |
| MILLENNIUM MANAGEMENT LLC | 404,277 | 478,120 | +73,843 | 0.02 | 0.02 | +0.00 | buy |
| BRAIDWELL LP | 222,701 | 473,617 | +250,916 | 0.53 | 1.22 | +0.69 | buy |
| Sofinnova Investments, Inc. | 509,546 | 471,763 | -37,783 | 1.84 | 1.76 | -0.08 | sell |
| Woodline Partners LP | 415,335 | 470,875 | +55,540 | 0.11 | 0.10 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 275,000 | 465,346 | +190,346 | 0.43 | 0.62 | +0.18 | buy |
| UBS Group AG | 320,172 | 428,400 | +108,228 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 394,604 | 390,158 | -4,446 | 0.90 | 0.64 | -0.26 | sell |
| LORD, ABBETT & CO. LLC | 405,080 | 381,624 | -23,456 | 0.10 | 0.08 | -0.02 | sell |
| DAFNA Capital Management LLC | 165,178 | 318,380 | +153,202 | 2.70 | 4.24 | +1.54 | buy |
| NORTHERN TRUST CORP | 78,598 | 308,531 | +229,933 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.31 | +0.31 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 284,971 | +284,971 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 168,007 | 284,971 | +116,964 | 0.00 | 0.00 | +0.00 | buy |
| 22NW, LP | 281,115 | 281,115 | 0 | 13.86 | 18.75 | +4.88 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 249,090 | 278,977 | +29,887 | 0.02 | 0.02 | -0.01 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 279,150 | 272,850 | -6,300 | 0.02 | 0.01 | -0.00 | sell |
| BARCLAYS PLC | 32,356 | 262,362 | +230,006 | 0.00 | 0.01 | +0.00 | buy |
| Nearwater Capital Markets, Ltd | 261,500 | 261,500 | 0 | 0.44 | 0.31 | -0.13 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 256,106 | 255,587 | -519 | 0.89 | 0.63 | -0.27 | sell |
| ADAR1 Capital Management, LLC | 161,252 | 244,184 | +82,932 | 0.70 | 0.80 | +0.10 | buy |
| SEVEN GRAND MANAGERS, LLC | 125,000 | 240,000 | +115,000 | 0.60 | 0.67 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 91,671 | 239,831 | +148,160 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 126,942 | 228,490 | +101,548 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 215,300 | +215,300 | 0.00 | 0.00 | +0.00 | buy |
| Bronte Capital Management Pty Ltd. | 198,256 | 198,434 | +178 | 1.52 | 1.56 | +0.04 | buy |
| GREAT POINT PARTNERS LLC | 316,453 | 175,000 | -141,453 | 5.58 | 2.88 | -2.70 | sell |
| AMERIPRISE FINANCIAL INC | 136,730 | 165,941 | +29,211 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 513,531 | 159,747 | -353,784 | 0.03 | 0.01 | -0.02 | sell |
| Quinn Opportunity Partners LLC | 179,247 | 153,076 | -26,171 | 0.68 | 0.50 | -0.18 | sell |
| Rhenman & Partners Asset Management AB | 59,000 | 141,250 | +82,250 | 0.52 | 0.93 | +0.41 | buy |
| Qube Research & Technologies Ltd | 390,675 | 130,521 | -260,154 | 0.04 | 0.01 | -0.03 | sell |
| Soleus Capital Management, L.P. | 0 | 128,362 | +128,362 | 0.00 | 0.31 | +0.31 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 122,326 | 122,767 | +441 | 0.75 | 0.47 | -0.28 | buy |
| Stonepine Capital Management, LLC | 85,000 | 120,654 | +35,654 | 5.38 | 6.41 | +1.03 | buy |
| SummitTX Capital, L.P. | 42,624 | 112,934 | +70,310 | 0.10 | 0.21 | +0.11 | buy |
| Jump Financial, LLC | 77,402 | 107,351 | +29,949 | 0.08 | 0.07 | -0.02 | buy |
| APEIRON CAPITAL Ltd | 0 | 106,431 | +106,431 | 0.00 | 4.77 | +4.77 | buy |
| CITIGROUP INC | 25,048 | 102,760 | +77,712 | 0.00 | 0.00 | +0.00 | buy |
| ING GROEP NV | 100,000 | 100,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| LMR Partners LLP | 48,294 | 100,000 | +51,706 | 0.03 | 0.05 | +0.02 | buy |
| Nuveen, LLC | 0 | 96,636 | +96,636 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 6,597 | 96,061 | +89,464 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 34,527 | 95,770 | +61,243 | 0.04 | 0.11 | +0.07 | buy |
| Russell Investments Group, Ltd. | 106,248 | 89,092 | -17,156 | 0.01 | 0.01 | -0.00 | sell |
| TFG Asset Management GP Ltd | 103,037 | 86,996 | -16,041 | 1.46 | 0.99 | -0.47 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 85,110 | +85,110 | 0.00 | 0.24 | +0.24 | buy |
| Birchview Capital, LP | 31,000 | 81,000 | +50,000 | 1.27 | 2.64 | +1.37 | buy |
| Invesco Ltd. | 567,458 | 79,856 | -487,602 | 0.01 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 5,949 | 70,371 | +64,422 | 0.01 | 0.14 | +0.13 | buy |
| ALGERT GLOBAL LLC | 34,782 | 67,130 | +32,348 | 0.04 | 0.06 | +0.02 | buy |
| MOODY ALDRICH PARTNERS LLC | 89,527 | 64,135 | -25,392 | 1.16 | 0.80 | -0.36 | sell |
| Swiss National Bank | 47,900 | 61,600 | +13,700 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 61,104 | 60,585 | -519 | 0.29 | 0.21 | -0.08 | sell |
| BANK OF AMERICA CORP /DE/ | 58,958 | 60,561 | +1,603 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 20,457 | 58,507 | +38,050 | 0.01 | 0.04 | +0.02 | buy |
| Trexquant Investment LP | 55,476 | 56,680 | +1,204 | 0.03 | 0.02 | -0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 56,055 | 56,186 | +131 | 0.01 | 0.01 | -0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 0 | 50,465 | +50,465 | 0.00 | 0.32 | +0.32 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,025 | 47,072 | +13,047 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,276 | 45,680 | +34,404 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 44,600 | +44,600 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 600 | 43,094 | +42,494 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 36,907 | 41,902 | +4,995 | 0.17 | 0.19 | +0.02 | buy |
| Voleon Capital Management LP | 65,063 | 40,838 | -24,225 | 0.10 | 0.05 | -0.05 | sell |
| Anson Funds Management LP | 0 | 40,535 | +40,535 | 0.00 | 0.26 | +0.26 | buy |
| Atom Investors LP | 43,227 | 40,519 | -2,708 | 0.22 | 0.25 | +0.03 | sell |
| Burkehill Global Management, LP | 0 | 40,000 | +40,000 | 0.00 | 0.10 | +0.10 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 31,320 | 38,802 | +7,482 | 0.91 | 0.93 | +0.02 | buy |
| NOMURA HOLDINGS INC | 0 | 38,657 | +38,657 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 38,165 | +38,165 | 0.00 | 0.02 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 98,745 | 36,897 | -61,848 | 0.02 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 0 | 36,000 | +36,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,682 | 34,820 | +6,138 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 34,188 | +34,188 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 53,172 | 33,673 | -19,499 | 0.02 | 0.01 | -0.01 | sell |
| Ghisallo Capital Management LLC | 0 | 32,000 | +32,000 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 31,586 | +31,586 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 28,678 | +28,678 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 28,000 | 28,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| WINTON GROUP Ltd | 16,910 | 25,900 | +8,990 | 0.04 | 0.06 | +0.02 | buy |
| Legal & General Group Plc | 16,658 | 23,780 | +7,122 | 0.00 | 0.00 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 23,441 | +23,441 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 22,542 | +22,542 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 22,417 | +22,417 | 0.00 | 0.97 | +0.97 | buy |
| IMC-Chicago, LLC | 16,361 | 22,412 | +6,051 | 0.02 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 240,102 | 22,138 | -217,964 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 48,474 | 21,918 | -26,556 | 0.03 | 0.02 | -0.01 | sell |
| BIT Capital GmbH | 21,100 | 21,100 | 0 | 0.08 | 0.05 | -0.03 | hold |