| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 1,276,595 | +1,276,595 | 0.00 | 2.94 | +2.94 | buy |
| VANGUARD GROUP INC | 729,492 | 948,647 | +219,155 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 72,139 | 929,151 | +857,012 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 221,891 | 924,896 | +703,005 | 0.01 | 0.08 | +0.07 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 791,000 | +791,000 | 0.00 | 0.25 | +0.25 | buy |
| BlackRock, Inc. | 415,226 | 609,114 | +193,888 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 649,033 | 545,994 | -103,039 | 0.02 | 0.02 | +0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 79,395 | 434,237 | +354,842 | 0.00 | 0.04 | +0.03 | buy |
| Nantahala Capital Management, LLC | 709,761 | 418,522 | -291,239 | 1.30 | 1.47 | +0.17 | sell |
| CITADEL ADVISORS LLC | 0 | 361,073 | +361,073 | 0.00 | 0.02 | +0.02 | buy |
| 22NW, LP | 146,115 | 331,115 | +185,000 | 2.38 | 8.88 | +6.50 | buy |
| EMERALD ADVISERS, LLC | 0 | 323,246 | +323,246 | 0.00 | 0.59 | +0.59 | buy |
| Jefferies Financial Group Inc. | 0 | 303,200 | +303,200 | 0.00 | 0.16 | +0.16 | buy |
| GREAT POINT PARTNERS LLC | 0 | 300,000 | +300,000 | 0.00 | 7.13 | +7.13 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 299,718 | 289,050 | -10,668 | 0.01 | 0.01 | +0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 247,060 | 278,541 | +31,481 | 0.01 | 0.02 | +0.01 | buy |
| ARMISTICE CAPITAL, LLC | 124,000 | 268,000 | +144,000 | 0.12 | 0.48 | +0.36 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 233,205 | +233,205 | 0.00 | 0.69 | +0.69 | buy |
| Woodline Partners LP | 246,145 | 233,059 | -13,086 | 0.03 | 0.06 | +0.03 | sell |
| Invesco Ltd. | 32,032 | 226,897 | +194,865 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 132,373 | 225,236 | +92,863 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 28,902 | 224,828 | +195,926 | 0.01 | 0.13 | +0.12 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 386,290 | 182,814 | -203,476 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 178,908 | +178,908 | 0.00 | 0.02 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 171,776 | +171,776 | 0.00 | 0.03 | +0.03 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 153,846 | +153,846 | 0.00 | 0.68 | +0.68 | buy |
| STATE STREET CORP | 50,105 | 128,999 | +78,894 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 125,000 | 125,000 | 0 | 1.63 | 2.27 | +0.64 | hold |
| Point72 Asset Management, L.P. | 0 | 123,658 | +123,658 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 0 | 118,419 | +118,419 | 0.00 | 0.41 | +0.41 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 65,929 | 114,664 | +48,735 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 109,868 | +109,868 | 0.00 | 0.46 | +0.46 | buy |
| Hudson Bay Capital Management LP | 0 | 107,678 | +107,678 | 0.00 | 0.04 | +0.04 | buy |
| FRED ALGER MANAGEMENT, LLC | 52,711 | 91,807 | +39,096 | 0.01 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 0 | 91,480 | +91,480 | 0.00 | 0.05 | +0.05 | buy |
| UBS Group AG | 201,371 | 90,822 | -110,549 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 0 | 90,000 | +90,000 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 51,998 | 87,174 | +35,176 | 0.08 | 0.10 | +0.02 | buy |
| Stonepine Capital Management, LLC | 50,200 | 85,000 | +34,800 | 1.28 | 3.93 | +2.65 | buy |
| Informed Momentum Co LLC | 24,156 | 78,209 | +54,053 | 0.09 | 0.50 | +0.41 | buy |
| GOLDMAN SACHS GROUP INC | 62,450 | 77,055 | +14,605 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 46,953 | 76,450 | +29,497 | 0.03 | 0.10 | +0.06 | buy |
| DIADEMA PARTNERS LP | 0 | 75,000 | +75,000 | 0.00 | 2.97 | +2.97 | buy |
| MOODY ALDRICH PARTNERS LLC | 45,412 | 73,716 | +28,304 | 0.23 | 0.80 | +0.57 | buy |
| ADAR1 Capital Management, LLC | 15,796 | 72,007 | +56,211 | 0.07 | 0.41 | +0.34 | buy |
| Longaeva Partners L.P. | 0 | 62,729 | +62,729 | 0.00 | 0.76 | +0.76 | buy |
| Artia Global Partners LP | 0 | 57,999 | +57,999 | 0.00 | 0.58 | +0.58 | buy |
| WOLVERINE TRADING, LLC | 15,072 | 57,758 | +42,686 | 0.01 | 0.07 | +0.06 | buy |
| DAFNA Capital Management LLC | 10,000 | 54,998 | +44,998 | 0.07 | 0.77 | +0.70 | buy |
| STEMPOINT CAPITAL LP | 0 | 53,201 | +53,201 | 0.00 | 0.61 | +0.61 | buy |
| F/m Investments LLC | 0 | 53,088 | +53,088 | 0.00 | 0.12 | +0.12 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 51,270 | +51,270 | 0.00 | 2.87 | +2.87 | buy |
| Eversept Partners, LP | 115,000 | 49,890 | -65,110 | 0.30 | 0.22 | -0.08 | sell |
| Propel Bio Management, LLC | 0 | 49,000 | +49,000 | 0.00 | 2.79 | +2.79 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 21,335 | 48,617 | +27,282 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 67,561 | 47,959 | -19,602 | 0.00 | 0.00 | +0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 12,082 | 46,636 | +34,554 | 0.00 | 0.01 | +0.01 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 45,042 | +45,042 | 0.00 | 0.12 | +0.12 | buy |
| AWM Investment Company, Inc. | 0 | 40,000 | +40,000 | 0.00 | 0.21 | +0.21 | buy |
| FMR LLC | 15,276 | 39,967 | +24,691 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 17,777 | 39,321 | +21,544 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 24,144 | 38,490 | +14,346 | 0.00 | 0.00 | +0.00 | buy |
| Deuterium Capital Management, LLC | 37,349 | 37,349 | 0 | 1.81 | 3.08 | +1.26 | hold |
| Walleye Capital LLC | 0 | 36,107 | +36,107 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 34,500 | +34,500 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 128,818 | 32,787 | -96,031 | 0.05 | 0.02 | -0.03 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 66,140 | 30,140 | -36,000 | 0.04 | 0.04 | -0.00 | sell |
| Headlands Technologies LLC | 2,522 | 29,830 | +27,308 | 0.01 | 0.14 | +0.13 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 420,958 | 27,335 | -393,623 | 0.02 | 0.00 | -0.02 | sell |
| Palumbo Wealth Management LLC | 23,772 | 26,154 | +2,382 | 0.19 | 0.48 | +0.29 | buy |
| Verition Fund Management LLC | 0 | 24,415 | +24,415 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 17,630 | +17,630 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 0 | 17,270 | +17,270 | 0.00 | 0.71 | +0.71 | buy |
| Russell Investments Group, Ltd. | 5,038 | 17,049 | +12,011 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 17,000 | +17,000 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 9,009 | 16,679 | +7,670 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 16,057 | +16,057 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 148,240 | 14,946 | -133,294 | 0.02 | 0.00 | -0.01 | sell |
| CAXTON ASSOCIATES LLP | 0 | 13,977 | +13,977 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 13,744 | +13,744 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 13,158 | +13,158 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 12,400 | +12,400 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,798 | 11,976 | -5,822 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 10,086 | +10,086 | 0.00 | 0.00 | +0.00 | buy |
| HB Wealth Management, LLC | 0 | 9,244 | +9,244 | 0.00 | 0.00 | +0.00 | buy |
| Glenmede Investment Management, LP | 0 | 9,200 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 9,185 | +9,185 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 93,181 | 8,529 | -84,652 | 0.08 | 0.01 | -0.06 | sell |
| Kestra Advisory Services, LLC | 0 | 7,650 | +7,650 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 6,900 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 12,426 | 6,798 | -5,628 | 0.01 | 0.02 | +0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 0 | 5,981 | +5,981 | 0.00 | 0.03 | +0.03 | buy |
| XTX Topco Ltd | 0 | 5,897 | +5,897 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 5,435 | +5,435 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 5,388 | 5,426 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Gainplan LLC | 15,000 | 5,035 | -9,965 | 0.18 | 0.12 | -0.05 | sell |
| Rangeley Capital, LLC | 0 | 4,895 | +4,895 | 0.00 | 0.26 | +0.26 | buy |
| LPL Financial LLC | 0 | 4,754 | +4,754 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH LANE CAPITAL, LP | 0 | 4,500 | +4,500 | 0.00 | 0.26 | +0.26 | buy |
| Bank of New York Mellon Corp | 0 | 4,327 | +4,327 | 0.00 | 0.00 | +0.00 | buy |