| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Two Seas Capital LP | 0 | 745,185 | +745,185 | 0.00 | 1.85 | +1.85 | buy |
| Prosight Management, LP | 0 | 554,633 | +554,633 | 0.00 | 4.85 | +4.85 | buy |
| ARMISTICE CAPITAL, LLC | 268,000 | 596,000 | +328,000 | 0.48 | 0.62 | +0.14 | buy |
| Sofinnova Investments, Inc. | 118,419 | 438,630 | +320,211 | 0.41 | 0.80 | +0.39 | buy |
| Qube Research & Technologies Ltd | 3,974 | 323,915 | +319,941 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 123,658 | 433,419 | +309,761 | 0.02 | 0.03 | +0.01 | buy |
| BVF INC/IL | 1,276,595 | 1,559,595 | +283,000 | 2.94 | 2.22 | -0.72 | buy |
| Invesco Ltd. | 226,897 | 468,159 | +241,262 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 218,337 | +218,337 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 434 | 210,298 | +209,864 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 90,822 | 287,561 | +196,739 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 13,158 | 173,443 | +160,285 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 150,804 | +150,804 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 178,908 | 308,414 | +129,506 | 0.02 | 0.03 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 53,201 | 178,274 | +125,073 | 0.61 | 1.29 | +0.68 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 171,776 | 295,716 | +123,940 | 0.03 | 0.04 | +0.01 | buy |
| ING GROEP NV | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 182,814 | 282,021 | +99,207 | 0.02 | 0.02 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 94,134 | +94,134 | 0.00 | 2.24 | +2.24 | buy |
| VANGUARD GROUP INC | 948,647 | 1,027,089 | +78,442 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 77,055 | 147,793 | +70,738 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 69,287 | +69,287 | 0.00 | 0.62 | +0.62 | buy |
| Russell Investments Group, Ltd. | 17,049 | 85,666 | +68,617 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 68,335 | +68,335 | 0.00 | 0.06 | +0.06 | buy |
| STATE STREET CORP | 128,999 | 195,656 | +66,657 | 0.00 | 0.00 | +0.00 | buy |
| Nearwater Capital Markets, Ltd | 0 | 61,500 | +61,500 | 0.00 | 0.04 | +0.04 | buy |
| FMR LLC | 39,967 | 101,129 | +61,162 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 323,246 | 384,342 | +61,096 | 0.59 | 0.50 | -0.09 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 60,431 | +60,431 | 0.00 | 0.17 | +0.17 | buy |
| Aquatic Capital Management LLC | 0 | 55,240 | +55,240 | 0.00 | 0.07 | +0.07 | buy |
| Jump Financial, LLC | 0 | 53,212 | +53,212 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 48,617 | 101,166 | +52,549 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 27,335 | 72,241 | +44,906 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 434,237 | 473,014 | +38,777 | 0.04 | 0.03 | -0.01 | buy |
| BlackRock, Inc. | 609,114 | 645,607 | +36,493 | 0.00 | 0.00 | -0.00 | buy |
| Caption Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.07 | +0.07 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 153,846 | 188,112 | +34,266 | 0.68 | 0.71 | +0.03 | buy |
| Propel Bio Management, LLC | 49,000 | 82,822 | +33,822 | 2.79 | 2.99 | +0.20 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 9,185 | 42,277 | +33,092 | 0.01 | 0.08 | +0.07 | buy |
| CITIGROUP INC | 3,047 | 35,777 | +32,730 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 31,900 | +31,900 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 225,236 | 254,361 | +29,125 | 0.00 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 4,021 | 31,000 | +26,979 | 0.17 | 0.77 | +0.59 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 26,522 | +26,522 | 0.00 | 0.17 | +0.17 | buy |
| SummitTX Capital, L.P. | 6,798 | 31,353 | +24,555 | 0.02 | 0.04 | +0.02 | buy |
| MARSHALL WACE, LLP | 0 | 24,023 | +24,023 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 23,114 | +23,114 | 0.00 | 0.08 | +0.08 | buy |
| BIT Capital GmbH | 0 | 21,100 | +21,100 | 0.00 | 0.04 | +0.04 | buy |
| DAFNA Capital Management LLC | 54,998 | 74,998 | +20,000 | 0.77 | 0.74 | -0.04 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 233,205 | 253,125 | +19,920 | 0.69 | 0.52 | -0.16 | buy |
| Engineers Gate Manager LP | 17,630 | 37,284 | +19,654 | 0.01 | 0.02 | +0.01 | buy |
| J. Goldman & Co LP | 0 | 18,352 | +18,352 | 0.00 | 0.03 | +0.03 | buy |
| HRT FINANCIAL LP | 6,900 | 24,700 | +17,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 38,490 | 56,076 | +17,586 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 16,184 | +16,184 | 0.00 | 0.00 | +0.00 | buy |
| Knott David M Jr | 0 | 15,500 | +15,500 | 0.00 | 0.30 | +0.30 | buy |
| ALGERT GLOBAL LLC | 0 | 15,310 | +15,310 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 14,520 | +14,520 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 13,811 | +13,811 | 0.00 | 0.02 | +0.02 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 13,485 | +13,485 | 0.00 | 0.46 | +0.46 | buy |
| CIBC WORLD MARKET INC. | 0 | 13,282 | +13,282 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 12,413 | +12,413 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 11,749 | +11,749 | 0.00 | 0.13 | +0.13 | buy |
| Headlands Technologies LLC | 29,830 | 41,201 | +11,371 | 0.14 | 0.15 | +0.01 | buy |
| Erste Asset Management GmbH | 17,000 | 28,000 | +11,000 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 10,954 | +10,954 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 10,862 | +10,862 | 0.00 | 0.01 | +0.01 | buy |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 0 | 9,728 | +9,728 | 0.00 | 0.15 | +0.15 | buy |
| Sigma Planning Corp | 0 | 9,000 | +9,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 8,629 | +8,629 | 0.00 | 0.00 | +0.00 | buy |
| Gainplan LLC | 5,035 | 13,500 | +8,465 | 0.12 | 0.21 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 8,100 | +8,100 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 7,765 | +7,765 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 7,200 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 46,636 | 53,713 | +7,077 | 0.01 | 0.01 | -0.00 | buy |
| FORA Capital, LLC | 0 | 5,761 | +5,761 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,664 | 120,380 | +5,716 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 475 | 5,561 | +5,086 | 0.00 | 0.01 | +0.00 | buy |
| F/m Investments LLC | 53,088 | 58,123 | +5,035 | 0.12 | 0.09 | -0.02 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 4,927 | +4,927 | 0.00 | 0.03 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 0 | 4,863 | +4,863 | 0.00 | 0.06 | +0.06 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 2,602 | 5,200 | +2,598 | 0.05 | 0.06 | +0.01 | buy |
| FLAGSHIP HARBOR ADVISORS, LLC | 0 | 2,179 | +2,179 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 5,897 | 7,196 | +1,299 | 0.02 | 0.01 | -0.01 | buy |
| Bayforest Capital Ltd | 1,679 | 2,541 | +862 | 0.05 | 0.08 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 90,000 | 90,743 | +743 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 0 | 685 | +685 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Founders Capital Management | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 141 | +141 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 127 | +127 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 58 | +58 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 72,007 | 72,031 | +24 | 0.41 | 0.23 | -0.18 | buy |
| Nova Wealth Management, Inc. | 16 | 40 | +24 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 1,565 | 1,580 | +15 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |