| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 1,276,595 | 1,559,595 | +283,000 | 2.94 | 2.22 | -0.72 | buy |
| VANGUARD GROUP INC | 948,647 | 1,027,089 | +78,442 | 0.00 | 0.00 | -0.00 | buy |
| Two Seas Capital LP | 0 | 745,185 | +745,185 | 0.00 | 1.85 | +1.85 | buy |
| BlackRock, Inc. | 609,114 | 645,607 | +36,493 | 0.00 | 0.00 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 268,000 | 596,000 | +328,000 | 0.48 | 0.62 | +0.14 | buy |
| MORGAN STANLEY | 929,151 | 566,421 | -362,730 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 0 | 554,633 | +554,633 | 0.00 | 4.85 | +4.85 | buy |
| TWO SIGMA INVESTMENTS, LP | 434,237 | 473,014 | +38,777 | 0.04 | 0.03 | -0.01 | buy |
| Invesco Ltd. | 226,897 | 468,159 | +241,262 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 545,994 | 454,075 | -91,919 | 0.02 | 0.01 | -0.01 | sell |
| Sofinnova Investments, Inc. | 118,419 | 438,630 | +320,211 | 0.41 | 0.80 | +0.39 | buy |
| Point72 Asset Management, L.P. | 123,658 | 433,419 | +309,761 | 0.02 | 0.03 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 323,246 | 384,342 | +61,096 | 0.59 | 0.50 | -0.09 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 924,896 | 383,310 | -541,586 | 0.08 | 0.02 | -0.05 | sell |
| 22NW, LP | 331,115 | 331,115 | 0 | 8.88 | 5.89 | -2.98 | hold |
| Qube Research & Technologies Ltd | 3,974 | 323,915 | +319,941 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 361,073 | 309,777 | -51,296 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 178,908 | 308,414 | +129,506 | 0.02 | 0.03 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 171,776 | 295,716 | +123,940 | 0.03 | 0.04 | +0.01 | buy |
| UBS Group AG | 90,822 | 287,561 | +196,739 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 182,814 | 282,021 | +99,207 | 0.02 | 0.02 | +0.00 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 289,050 | 280,150 | -8,900 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 225,236 | 254,361 | +29,125 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 233,205 | 253,125 | +19,920 | 0.69 | 0.52 | -0.16 | buy |
| JANE STREET GROUP, LLC | 0 | 218,337 | +218,337 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 300,000 | 210,732 | -89,268 | 7.13 | 2.89 | -4.24 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 434 | 210,298 | +209,864 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 224,828 | 208,302 | -16,526 | 0.13 | 0.09 | -0.04 | sell |
| STATE STREET CORP | 128,999 | 195,656 | +66,657 | 0.00 | 0.00 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 153,846 | 188,112 | +34,266 | 0.68 | 0.71 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 53,201 | 178,274 | +125,073 | 0.61 | 1.29 | +0.68 | buy |
| HRT FINANCIAL LP | 13,158 | 173,443 | +160,285 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 278,541 | 172,881 | -105,660 | 0.02 | 0.01 | -0.01 | sell |
| JPMORGAN CHASE & CO | 0 | 150,804 | +150,804 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 77,055 | 147,793 | +70,738 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 114,664 | 120,380 | +5,716 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 418,522 | 112,946 | -305,576 | 1.47 | 0.28 | -1.19 | sell |
| Jefferies Financial Group Inc. | 303,200 | 111,900 | -191,300 | 0.16 | 0.04 | -0.12 | sell |
| Woodline Partners LP | 233,059 | 104,000 | -129,059 | 0.06 | 0.02 | -0.05 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 48,617 | 101,166 | +52,549 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 39,967 | 101,129 | +61,162 | 0.00 | 0.00 | +0.00 | buy |
| ING GROEP NV | 0 | 100,000 | +100,000 | 0.00 | 0.03 | +0.03 | buy |
| Monashee Investment Management LLC | 0 | 94,134 | +94,134 | 0.00 | 2.24 | +2.24 | buy |
| DEUTSCHE BANK AG\ | 90,000 | 90,743 | +743 | 0.00 | 0.00 | -0.00 | buy |
| Quinn Opportunity Partners LLC | 109,868 | 85,868 | -24,000 | 0.46 | 0.16 | -0.30 | sell |
| Russell Investments Group, Ltd. | 17,049 | 85,666 | +68,617 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 85,000 | 85,000 | 0 | 3.93 | 2.84 | -1.09 | hold |
| Propel Bio Management, LLC | 49,000 | 82,822 | +33,822 | 2.79 | 2.99 | +0.20 | buy |
| DAFNA Capital Management LLC | 54,998 | 74,998 | +20,000 | 0.77 | 0.74 | -0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 27,335 | 72,241 | +44,906 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 72,007 | 72,031 | +24 | 0.41 | 0.23 | -0.18 | buy |
| TFG Asset Management GP Ltd | 0 | 69,287 | +69,287 | 0.00 | 0.62 | +0.62 | buy |
| Voleon Capital Management LP | 0 | 68,335 | +68,335 | 0.00 | 0.06 | +0.06 | buy |
| Nearwater Capital Markets, Ltd | 0 | 61,500 | +61,500 | 0.00 | 0.04 | +0.04 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 60,431 | +60,431 | 0.00 | 0.17 | +0.17 | buy |
| Hudson Bay Capital Management LP | 107,678 | 59,691 | -47,987 | 0.04 | 0.01 | -0.02 | sell |
| F/m Investments LLC | 53,088 | 58,123 | +5,035 | 0.12 | 0.09 | -0.02 | buy |
| NORTHERN TRUST CORP | 38,490 | 56,076 | +17,586 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 73,716 | 56,023 | -17,693 | 0.80 | 0.44 | -0.35 | sell |
| Aquatic Capital Management LLC | 0 | 55,240 | +55,240 | 0.00 | 0.07 | +0.07 | buy |
| FRED ALGER MANAGEMENT, LLC | 91,807 | 54,020 | -37,787 | 0.02 | 0.01 | -0.01 | sell |
| Cambridge Investment Research Advisors, Inc. | 46,636 | 53,713 | +7,077 | 0.01 | 0.01 | -0.00 | buy |
| Jump Financial, LLC | 0 | 53,212 | +53,212 | 0.00 | 0.03 | +0.03 | buy |
| NORGES BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 9,185 | 42,277 | +33,092 | 0.01 | 0.08 | +0.07 | buy |
| Headlands Technologies LLC | 29,830 | 41,201 | +11,371 | 0.14 | 0.15 | +0.01 | buy |
| AWM Investment Company, Inc. | 40,000 | 40,000 | 0 | 0.21 | 0.16 | -0.05 | hold |
| Deuterium Capital Management, LLC | 37,349 | 37,349 | 0 | 3.08 | 2.29 | -0.79 | hold |
| Engineers Gate Manager LP | 17,630 | 37,284 | +19,654 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 3,047 | 35,777 | +32,730 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.07 | +0.07 | buy |
| Swiss National Bank | 0 | 31,900 | +31,900 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 6,798 | 31,353 | +24,555 | 0.02 | 0.04 | +0.02 | buy |
| Birchview Capital, LP | 4,021 | 31,000 | +26,979 | 0.17 | 0.77 | +0.59 | buy |
| Simplify Asset Management Inc. | 87,174 | 28,000 | -59,174 | 0.10 | 0.02 | -0.08 | sell |
| Erste Asset Management GmbH | 17,000 | 28,000 | +11,000 | 0.01 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 26,522 | +26,522 | 0.00 | 0.17 | +0.17 | buy |
| BANK OF AMERICA CORP /DE/ | 47,959 | 26,092 | -21,867 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 6,900 | 24,700 | +17,800 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 24,023 | +24,023 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 23,114 | +23,114 | 0.00 | 0.08 | +0.08 | buy |
| SIMPLEX TRADING, LLC | 76,450 | 21,936 | -54,514 | 0.10 | 0.03 | -0.07 | sell |
| BIT Capital GmbH | 0 | 21,100 | +21,100 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 34,500 | 20,257 | -14,243 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 91,480 | 18,821 | -72,659 | 0.05 | 0.01 | -0.05 | sell |
| J. Goldman & Co LP | 0 | 18,352 | +18,352 | 0.00 | 0.03 | +0.03 | buy |
| Jain Global LLC | 32,787 | 17,299 | -15,488 | 0.02 | 0.01 | -0.02 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 16,184 | +16,184 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 16,057 | 16,057 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Knott David M Jr | 0 | 15,500 | +15,500 | 0.00 | 0.30 | +0.30 | buy |
| BARCLAYS PLC | 16,679 | 15,444 | -1,235 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 15,310 | +15,310 | 0.00 | 0.01 | +0.01 | buy |
| Palumbo Wealth Management LLC | 26,154 | 14,714 | -11,440 | 0.48 | 0.15 | -0.32 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 14,946 | 14,564 | -382 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 14,520 | +14,520 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 13,811 | +13,811 | 0.00 | 0.02 | +0.02 | buy |
| Gainplan LLC | 5,035 | 13,500 | +8,465 | 0.12 | 0.21 | +0.09 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 13,485 | +13,485 | 0.00 | 0.46 | +0.46 | buy |
| CIBC WORLD MARKET INC. | 0 | 13,282 | +13,282 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 78,209 | 12,972 | -65,237 | 0.50 | 0.06 | -0.44 | sell |