| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VR Adviser, LLC | 3,285,620 | 4,148,428 | +862,808 | 4.37 | 3.62 | -0.75 | buy |
| Deep Track Capital, LP | 750,000 | 1,444,709 | +694,709 | 0.55 | 0.48 | -0.07 | buy |
| Blackstone Inc. | 240,174 | 783,653 | +543,479 | 0.02 | 0.04 | +0.01 | buy |
| Polar Capital Holdings Plc | 550,000 | 1,050,000 | +500,000 | 0.06 | 0.07 | +0.01 | buy |
| BRAIDWELL LP | 1,147,676 | 1,572,426 | +424,750 | 0.80 | 0.57 | -0.24 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 350,036 | +350,036 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 244,199 | +244,199 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 368,698 | 545,362 | +176,664 | 1.12 | 0.88 | -0.24 | buy |
| Ikarian Capital, LLC | 0 | 175,000 | +175,000 | 0.00 | 0.58 | +0.58 | buy |
| ADAR1 Capital Management, LLC | 0 | 132,780 | +132,780 | 0.00 | 0.26 | +0.26 | buy |
| MORGAN STANLEY | 405,998 | 527,791 | +121,793 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 0 | 116,698 | +116,698 | 0.00 | 0.01 | +0.01 | buy |
| Cable Car Capital, LP | 333,371 | 450,000 | +116,629 | 0.49 | 5.24 | +4.75 | buy |
| STATE STREET CORP | 25,023 | 86,681 | +61,658 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 350,029 | 405,029 | +55,000 | 0.08 | 0.07 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 53,615 | +53,615 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 5,512,300 | 5,561,808 | +49,508 | 0.01 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 46,511 | +46,511 | 0.00 | 0.00 | +0.00 | buy |
| B Group, Inc. | 20,000 | 58,215 | +38,215 | 0.24 | 0.52 | +0.28 | buy |
| ExodusPoint Capital Management, LP | 0 | 35,912 | +35,912 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 35,800 | +35,800 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 29,365 | +29,365 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,610,651 | 1,637,433 | +26,782 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 19,800 | 44,900 | +25,100 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 24,804 | +24,804 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 30,305 | 54,126 | +23,821 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 21,831 | +21,831 | 0.00 | 0.00 | +0.00 | buy |
| Cannon Global Investment Management, LLC | 0 | 19,000 | +19,000 | 0.00 | 0.54 | +0.54 | buy |
| AlphaQuest LLC | 0 | 16,335 | +16,335 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 342,418 | 352,585 | +10,167 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 12,175 | 22,022 | +9,847 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 25,162 | 33,883 | +8,721 | 0.00 | 0.00 | -0.00 | buy |
| Artia Global Partners LP | 0 | 7,380 | +7,380 | 0.00 | 0.02 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 60,494 | 65,749 | +5,255 | 0.03 | 0.02 | -0.01 | buy |
| GROUP ONE TRADING LLC | 23 | 2,108 | +2,085 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 74,583 | 75,333 | +750 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,298 | 42,919 | +621 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 584 | 754 | +170 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 735 | 896 | +161 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,421 | 7,509 | +88 | 0.01 | 0.01 | -0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,166 | 1,253 | +87 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 468 | 497 | +29 | 0.00 | 0.00 | -0.00 | buy |
| Weiss Asset Management LP | 40,000 | 40,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Daiwa Securities Group Inc. | 116 | 116 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 1,945,649 | 1,945,649 | 0 | 0.57 | 0.31 | -0.27 | hold |
| Parallel Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avidity Partners Management LP | 352,124 | 352,124 | 0 | 0.68 | 0.75 | +0.06 | hold |
| Fairmount Funds Management LLC | 3,371,922 | 3,371,922 | 0 | 6.50 | 5.37 | -1.13 | hold |
| Commodore Capital LP | 1,419,714 | 1,419,714 | 0 | 2.02 | 1.07 | -0.94 | hold |
| Activest Wealth Management | 166 | 166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Frazier Life Sciences Management, L.P. | 583,327 | 583,327 | 0 | 0.47 | 0.27 | -0.20 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | 430,330 | 0 | 2.03 | 1.13 | -0.90 | hold |
| Allostery Investments LP | 20,000 | 20,000 | 0 | 0.76 | 0.30 | -0.47 | hold |
| FRANKLIN RESOURCES INC | 720,547 | 720,547 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 15,608 | 15,608 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TORONTO DOMINION BANK | 58,332 | 58,332 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aster Capital Management (DIFC) Ltd | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 390,969 | 390,804 | -165 | 0.05 | 0.03 | -0.03 | sell |
| JPMORGAN CHASE & CO | 2,800 | 0 | -2,800 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 751,431 | 747,674 | -3,757 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 64,044 | 59,585 | -4,459 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 8,028 | 1,554 | -6,474 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 95,089 | 87,501 | -7,588 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 17,706 | 0 | -17,706 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 360,732 | 342,399 | -18,333 | 0.02 | 0.01 | -0.01 | sell |
| Redmile Group, LLC | 411,728 | 386,963 | -24,765 | 0.56 | 0.38 | -0.18 | sell |
| Ensign Peak Advisors, Inc | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 33,875 | 0 | -33,875 | 0.06 | 0.00 | -0.06 | sell |
| TD ASSET MANAGEMENT INC | 95,076 | 45,876 | -49,200 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 69,200 | 0 | -69,200 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 152,082 | 52,026 | -100,056 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 228,803 | 0 | -228,803 | 2.09 | 0.00 | -2.09 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 308,795 | 0 | -308,795 | 0.05 | 0.00 | -0.05 | sell |
| Paradigm Biocapital Advisors LP | 819,660 | 0 | -819,660 | 0.55 | 0.00 | -0.55 | sell |
| PERCEPTIVE ADVISORS LLC | 845,567 | 0 | -845,567 | 0.46 | 0.00 | -0.46 | sell |
| JANUS HENDERSON GROUP PLC | 849,410 | 0 | -849,410 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,326,893 | 411,602 | -915,291 | 0.00 | 0.00 | -0.00 | sell |