| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,261,384 | 7,431,403 | +170,019 | 0.01 | 0.02 | +0.01 | buy |
| VR Adviser, LLC | 4,148,428 | 4,148,428 | 0 | 6.21 | 7.60 | +1.38 | hold |
| Fairmount Funds Management LLC | 3,705,262 | 3,705,262 | 0 | 8.55 | 13.13 | +4.58 | hold |
| BlackRock, Inc. | 3,539,415 | 3,527,087 | -12,328 | 0.00 | 0.00 | +0.00 | sell |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | 2,666,690 | 0 | 0.21 | 0.37 | +0.15 | hold |
| Paradigm Biocapital Advisors LP | 1,710,316 | 2,320,316 | +610,000 | 1.39 | 2.33 | +0.94 | buy |
| RTW INVESTMENTS, LP | 2,058,148 | 2,058,148 | 0 | 0.62 | 1.00 | +0.38 | hold |
| Deep Track Capital, LP | 2,161,510 | 2,034,203 | -127,307 | 1.49 | 2.06 | +0.56 | sell |
| STATE STREET CORP | 1,383,847 | 1,613,461 | +229,614 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,476,501 | 1,395,501 | -81,000 | 0.82 | 1.35 | +0.53 | sell |
| Polar Capital Holdings Plc | 978,288 | 1,047,693 | +69,405 | 0.14 | 0.22 | +0.09 | buy |
| CITADEL ADVISORS LLC | 726,118 | 1,007,537 | +281,419 | 0.01 | 0.04 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 938,421 | 1,004,056 | +65,635 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 942,507 | 954,867 | +12,360 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 745,277 | 802,470 | +57,193 | 0.03 | 0.06 | +0.02 | buy |
| Avidity Partners Management LP | 660,424 | 760,424 | +100,000 | 5.77 | 7.55 | +1.78 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 649,346 | 727,449 | +78,103 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 574,553 | 574,882 | +329 | 0.07 | 0.11 | +0.04 | buy |
| Cormorant Asset Management, LP | 533,340 | 533,340 | 0 | 0.92 | 1.32 | +0.40 | hold |
| Bellevue Group AG | 0 | 507,008 | +507,008 | 0.00 | 0.59 | +0.59 | buy |
| Affinity Asset Advisors, LLC | 802,342 | 499,673 | -302,669 | 1.75 | 1.44 | -0.31 | sell |
| Synergy Asset Management, LLC | 458,946 | 476,196 | +17,250 | 1.45 | 2.48 | +1.03 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | 430,330 | 0 | 1.85 | 2.31 | +0.46 | hold |
| Candriam S.C.A. | 400,509 | 411,006 | +10,497 | 0.06 | 0.10 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 329,496 | 321,949 | -7,547 | 0.00 | 0.00 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 313,130 | +313,130 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 280,904 | 299,044 | +18,140 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 92,995 | 246,711 | +153,716 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 242,021 | +242,021 | 0.00 | 1.70 | +1.70 | buy |
| Atika Capital Management LLC | 0 | 229,900 | +229,900 | 0.00 | 1.78 | +1.78 | buy |
| UBS Group AG | 271,013 | 212,271 | -58,742 | 0.00 | 0.00 | +0.00 | sell |
| Cable Car Capital, LP | 400,000 | 200,000 | -200,000 | 0.75 | 3.39 | +2.64 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 190,030 | +190,030 | 0.00 | 0.01 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 185,513 | +185,513 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 184,863 | +84,863 | 0.01 | 0.03 | +0.02 | buy |
| GREAT POINT PARTNERS LLC | 183,330 | 183,330 | 0 | 1.80 | 2.20 | +0.40 | hold |
| JENNISON ASSOCIATES LLC | 0 | 176,680 | +176,680 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 122,198 | 175,454 | +53,256 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 174,052 | +174,052 | 0.00 | 0.90 | +0.90 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 150,908 | +150,908 | 0.00 | 0.87 | +0.87 | buy |
| DEUTSCHE BANK AG\ | 119,329 | 140,789 | +21,460 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 128,110 | 136,884 | +8,774 | 0.46 | 0.32 | -0.14 | buy |
| MOODY ALDRICH PARTNERS LLC | 126,812 | 135,061 | +8,249 | 0.72 | 1.19 | +0.48 | buy |
| Sio Capital Management, LLC | 118,126 | 132,496 | +14,370 | 0.59 | 0.94 | +0.34 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 48,686 | 126,366 | +77,680 | 0.03 | 0.13 | +0.10 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 84,716 | 121,225 | +36,509 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 113,009 | +113,009 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 114,173 | 106,883 | -7,290 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 101,354 | +101,354 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 139,272 | 100,091 | -39,181 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 143,121 | 97,042 | -46,079 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 86,347 | 86,938 | +591 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 173,329 | 85,737 | -87,592 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 0 | 79,380 | +79,380 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 0 | 78,911 | +78,911 | 0.00 | 1.07 | +1.07 | buy |
| TD ASSET MANAGEMENT INC | 79,896 | 75,696 | -4,200 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 75,680 | 75,680 | 0 | 0.00 | 0.01 | +0.00 | hold |
| B Group, Inc. | 75,000 | 75,000 | 0 | 1.68 | 2.73 | +1.04 | hold |
| AMERICAN CENTURY COMPANIES INC | 57,080 | 74,386 | +17,306 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,358 | 72,563 | +11,205 | 0.00 | 0.00 | +0.00 | buy |
| Secure Asset Management, LLC | 81,664 | 72,422 | -9,242 | 0.39 | 0.56 | +0.17 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 67,481 | +67,481 | 0.00 | 0.08 | +0.08 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 42,503 | 66,600 | +24,097 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 63,591 | +63,591 | 0.00 | 2.23 | +2.23 | buy |
| Palo Alto Investors LP | 59,985 | 59,985 | 0 | 0.25 | 0.45 | +0.20 | hold |
| Informed Momentum Co LLC | 0 | 59,946 | +59,946 | 0.00 | 0.34 | +0.34 | buy |
| RHUMBLINE ADVISERS | 41,017 | 46,356 | +5,339 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 3,041 | 45,459 | +42,418 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 43,841 | +43,841 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 43,000 | 43,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 42,732 | +42,732 | 0.00 | 0.05 | +0.05 | buy |
| Voleon Capital Management LP | 23,548 | 40,539 | +16,991 | 0.02 | 0.04 | +0.03 | buy |
| Rafferty Asset Management, LLC | 38,485 | 40,487 | +2,002 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,800 | 40,400 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 39,751 | 39,404 | -347 | 0.01 | 0.01 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 36,912 | +36,912 | 0.00 | 0.03 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,184 | 29,184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 27,671 | 24,463 | -3,208 | 0.00 | 0.00 | +0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 15,247 | 23,667 | +8,420 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 9,676 | 22,840 | +13,164 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 20,417 | 22,620 | +2,203 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,658 | 21,370 | -288 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 21,362 | 21,363 | +1 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,665 | 20,984 | +12,319 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,152 | 20,964 | +812 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,840 | 20,840 | 0 | 0.05 | 0.06 | +0.01 | hold |
| XTX Topco Ltd | 0 | 20,180 | +20,180 | 0.00 | 0.02 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,566 | 19,364 | -9,202 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 14,623 | 18,336 | +3,713 | 0.01 | 0.03 | +0.02 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 15,406 | 18,229 | +2,823 | 0.01 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 22,968 | 18,099 | -4,869 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 14,244 | 16,902 | +2,658 | 0.00 | 0.00 | +0.00 | buy |
| Brookwood Investment Group LLC | 16,569 | 15,993 | -576 | 0.06 | 0.10 | +0.04 | sell |
| Legal & General Group Plc | 18,744 | 15,918 | -2,826 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 43,261 | 14,831 | -28,430 | 0.00 | 0.00 | -0.00 | sell |
| Optimize Financial Inc | 0 | 13,442 | +13,442 | 0.00 | 0.32 | +0.32 | buy |
| Creative Planning | 7,696 | 12,736 | +5,040 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 12,500 | 12,500 | 0 | 0.18 | 0.32 | +0.14 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,600 | 12,200 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 12,100 | 12,100 | 0 | 0.00 | 0.00 | +0.00 | hold |