| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,431,403 | 9,057,645 | +1,626,242 | 0.02 | 0.04 | +0.02 | buy |
| BlackRock, Inc. | 3,527,087 | 4,990,181 | +1,463,094 | 0.00 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 4,148,428 | 4,148,428 | 0 | 7.60 | 11.97 | +4.38 | hold |
| Fairmount Funds Management LLC | 3,705,262 | 3,705,262 | 0 | 13.13 | 23.31 | +10.18 | hold |
| Capital World Investors | 0 | 3,401,639 | +3,401,639 | 0.00 | 0.04 | +0.04 | buy |
| RTW INVESTMENTS, LP | 2,058,148 | 3,139,030 | +1,080,882 | 1.00 | 2.55 | +1.55 | buy |
| STATE STREET CORP | 1,613,461 | 2,673,090 | +1,059,629 | 0.00 | 0.01 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 2,320,316 | 2,144,526 | -175,790 | 2.33 | 3.82 | +1.50 | sell |
| Deep Track Capital, LP | 2,034,203 | 1,926,000 | -108,203 | 2.06 | 2.70 | +0.64 | sell |
| Bellevue Group AG | 507,008 | 1,657,190 | +1,150,182 | 0.59 | 3.32 | +2.73 | buy |
| FRANKLIN RESOURCES INC | 1,004,056 | 1,621,451 | +617,395 | 0.01 | 0.03 | +0.02 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,554,597 | +1,554,597 | 0.00 | 1.29 | +1.29 | buy |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | 1,503,478 | -1,163,212 | 0.37 | 0.41 | +0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 954,867 | 1,429,954 | +475,087 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,395,501 | 1,345,063 | -50,438 | 1.35 | 1.99 | +0.64 | sell |
| Polar Capital Holdings Plc | 1,047,693 | 1,228,609 | +180,916 | 0.22 | 0.33 | +0.11 | buy |
| CITADEL ADVISORS LLC | 1,007,537 | 1,119,011 | +111,474 | 0.04 | 0.06 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,103,743 | +1,103,743 | 0.00 | 0.07 | +0.07 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,928 | 1,079,015 | +1,068,087 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 727,449 | 838,603 | +111,154 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 760,424 | 760,424 | 0 | 7.55 | 11.59 | +4.04 | hold |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 658,301 | +658,301 | 0.00 | 1.63 | +1.63 | buy |
| JPMORGAN CHASE & CO | 22,620 | 655,027 | +632,407 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 75,680 | 646,943 | +571,263 | 0.01 | 0.09 | +0.08 | buy |
| UBS Group AG | 212,271 | 639,363 | +427,092 | 0.00 | 0.01 | +0.01 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 313,130 | 631,433 | +318,303 | 0.06 | 0.20 | +0.13 | buy |
| Pictet Asset Management Holding SA | 0 | 619,076 | +619,076 | 0.00 | 0.06 | +0.06 | buy |
| Affinity Asset Advisors, LLC | 499,673 | 590,000 | +90,327 | 1.44 | 2.75 | +1.31 | buy |
| Cormorant Asset Management, LP | 533,340 | 533,340 | 0 | 1.32 | 2.60 | +1.28 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 433,405 | +433,405 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 321,949 | 433,405 | +111,456 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 299,044 | 428,891 | +129,847 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 66,600 | 401,149 | +334,549 | 0.00 | 0.03 | +0.03 | buy |
| LORD, ABBETT & CO. LLC | 0 | 390,064 | +390,064 | 0.00 | 0.11 | +0.11 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 364,102 | +364,102 | 0.00 | 0.01 | +0.01 | buy |
| Synergy Asset Management, LLC | 476,196 | 356,301 | -119,895 | 2.48 | 3.20 | +0.72 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 190,030 | 355,003 | +164,973 | 0.01 | 0.05 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 100,091 | 352,824 | +252,733 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 150,908 | 352,802 | +201,894 | 0.87 | 3.74 | +2.86 | buy |
| Candriam S.C.A. | 411,006 | 352,716 | -58,290 | 0.10 | 0.15 | +0.05 | sell |
| Holocene Advisors, LP | 185,513 | 305,951 | +120,438 | 0.02 | 0.07 | +0.04 | buy |
| JENNISON ASSOCIATES LLC | 176,680 | 299,257 | +122,577 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 574,882 | 285,247 | -289,635 | 0.11 | 0.08 | -0.02 | sell |
| BRAIDWELL LP | 0 | 278,164 | +278,164 | 0.00 | 0.98 | +0.98 | buy |
| Siren, L.L.C. | 0 | 250,000 | +250,000 | 0.00 | 0.48 | +0.48 | buy |
| Nuveen, LLC | 86,938 | 249,267 | +162,329 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 240,000 | +240,000 | 0.00 | 0.31 | +0.31 | buy |
| Blackstone Inc. | 0 | 237,108 | +237,108 | 0.00 | 0.07 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 140,789 | 195,204 | +54,415 | 0.00 | 0.01 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 183,330 | 183,330 | 0 | 2.20 | 4.11 | +1.91 | hold |
| GOLDMAN SACHS GROUP INC | 246,711 | 179,439 | -67,272 | 0.00 | 0.00 | +0.00 | sell |
| Sio Capital Management, LLC | 132,496 | 177,118 | +44,622 | 0.94 | 2.89 | +1.95 | buy |
| Handelsbanken Fonder AB | 0 | 160,900 | +160,900 | 0.00 | 0.04 | +0.04 | buy |
| PFM Health Sciences, LP | 174,052 | 158,825 | -15,227 | 0.90 | 1.31 | +0.41 | sell |
| First Turn Management, LLC | 0 | 155,343 | +155,343 | 0.00 | 1.58 | +1.58 | buy |
| ExodusPoint Capital Management, LP | 101,354 | 148,212 | +46,858 | 0.05 | 0.13 | +0.08 | buy |
| Bank of New York Mellon Corp | 106,883 | 140,870 | +33,987 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 97,042 | 124,658 | +27,616 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 4,678 | 124,278 | +119,600 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 121,225 | 119,601 | -1,624 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 116,461 | +116,461 | 0.00 | 1.92 | +1.92 | buy |
| Parkman Healthcare Partners LLC | 0 | 113,188 | +113,188 | 0.00 | 1.11 | +1.11 | buy |
| DIMENSIONAL FUND ADVISORS LP | 113,009 | 113,176 | +167 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 45,459 | 112,876 | +67,417 | 0.00 | 0.01 | +0.01 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 112,000 | +112,000 | 0.00 | 1.04 | +1.04 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 110,000 | +110,000 | 0.00 | 0.42 | +0.42 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 126,366 | 106,863 | -19,503 | 0.13 | 0.18 | +0.05 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 16,902 | 104,310 | +87,408 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 75,696 | 102,944 | +27,248 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 135,061 | 101,411 | -33,650 | 1.19 | 1.73 | +0.54 | sell |
| Atika Capital Management LLC | 229,900 | 100,000 | -129,900 | 1.78 | 0.94 | -0.84 | sell |
| TORONTO DOMINION BANK | 0 | 89,837 | +89,837 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 184,863 | 87,744 | -97,119 | 0.03 | 0.02 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 6,040 | 85,895 | +79,855 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 0 | 80,000 | +80,000 | 0.00 | 0.72 | +0.72 | buy |
| MORGAN STANLEY | 175,454 | 76,360 | -99,094 | 0.00 | 0.00 | -0.00 | sell |
| B Group, Inc. | 75,000 | 75,000 | 0 | 2.73 | 4.05 | +1.32 | hold |
| BARCLAYS PLC | 85,737 | 74,762 | -10,975 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 72,734 | +72,734 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,563 | 68,421 | -4,142 | 0.00 | 0.01 | +0.00 | sell |
| Fisher Asset Management, LLC | 0 | 67,874 | +67,874 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 79,380 | 67,668 | -11,712 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 10,387 | 67,101 | +56,714 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,400 | 66,080 | +25,680 | 0.00 | 0.00 | +0.00 | buy |
| Secure Asset Management, LLC | 72,422 | 65,899 | -6,523 | 0.56 | 0.88 | +0.32 | sell |
| Swiss National Bank | 43,000 | 63,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 39,404 | 61,014 | +21,610 | 0.01 | 0.03 | +0.02 | buy |
| RHUMBLINE ADVISERS | 46,356 | 60,784 | +14,428 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 59,946 | 59,014 | -932 | 0.34 | 0.50 | +0.16 | sell |
| Atle Fund Management AB | 0 | 54,886 | +54,886 | 0.00 | 1.41 | +1.41 | buy |
| WELLS FARGO & COMPANY/MN | 14,831 | 51,924 | +37,093 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 0 | 51,038 | +51,038 | 0.00 | 0.17 | +0.17 | buy |
| Ghisallo Capital Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.09 | +0.09 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.17 | +0.17 | buy |
| Trexquant Investment LP | 0 | 49,616 | +49,616 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 40,487 | 43,110 | +2,623 | 0.01 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 41,987 | +41,987 | 0.00 | 2.79 | +2.79 | buy |
| HighVista Strategies LLC | 78,911 | 41,902 | -37,009 | 1.07 | 0.91 | -0.16 | sell |
| XTX Topco Ltd | 20,180 | 40,506 | +20,326 | 0.02 | 0.05 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 39,776 | +39,776 | 0.00 | 0.00 | +0.00 | buy |