| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 4,682,300 | +4,682,300 | 0.00 | 0.01 | +0.01 | buy |
| Fairmount Funds Management LLC | 0 | 3,211,922 | +3,211,922 | 0.00 | 6.38 | +6.38 | buy |
| VR Adviser, LLC | 0 | 3,085,620 | +3,085,620 | 0.00 | 3.96 | +3.96 | buy |
| RTW INVESTMENTS, LP | 0 | 1,850,648 | +1,850,648 | 0.00 | 0.66 | +0.66 | buy |
| Commodore Capital LP | 0 | 1,369,714 | +1,369,714 | 0.00 | 2.10 | +2.10 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,235,187 | +1,235,187 | 0.00 | 0.65 | +0.65 | buy |
| Deep Track Capital, LP | 0 | 1,235,187 | +1,235,187 | 0.00 | 0.97 | +0.97 | buy |
| Avidity Partners Management LP | 0 | 790,926 | +790,926 | 0.00 | 0.99 | +0.99 | buy |
| FRANKLIN RESOURCES INC | 0 | 720,547 | +720,547 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 719,660 | +719,660 | 0.00 | 0.62 | +0.62 | buy |
| BRAIDWELL LP | 0 | 515,726 | +515,726 | 0.00 | 0.36 | +0.36 | buy |
| GREAT POINT PARTNERS LLC | 0 | 514,659 | +514,659 | 0.00 | 3.81 | +3.81 | buy |
| Point72 Asset Management, L.P. | 0 | 482,330 | +482,330 | 0.00 | 0.04 | +0.04 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 477,327 | +477,327 | 0.00 | 0.47 | +0.47 | buy |
| Redmile Group, LLC | 0 | 411,728 | +411,728 | 0.00 | 0.59 | +0.59 | buy |
| Woodline Partners LP | 0 | 390,795 | +390,795 | 0.00 | 0.08 | +0.08 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 0 | 375,330 | +375,330 | 0.00 | 1.84 | +1.84 | buy |
| Affinity Asset Advisors, LLC | 0 | 349,836 | +349,836 | 0.00 | 1.33 | +1.33 | buy |
| Cable Car Capital, LP | 0 | 333,371 | +333,371 | 0.00 | 8.81 | +8.81 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 308,795 | +308,795 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 279,648 | +279,648 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 257,330 | +257,330 | 0.00 | 0.71 | +0.71 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 236,116 | +236,116 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 95,076 | +95,076 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 82,137 | +82,137 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 68,133 | +68,133 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 42,298 | +42,298 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 41,360 | +41,360 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 37,798 | +37,798 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 26,720 | +26,720 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 13,984 | +13,984 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 11,187 | +11,187 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 0 | 965 | +965 | 0.00 | 0.00 | +0.00 | buy |
| Activest Wealth Management | 0 | 166 | +166 | 0.00 | 0.00 | +0.00 | buy |
| New England Capital Financial Advisors LLC | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |