| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 0 | 2,666,690 | +2,666,690 | 0.00 | 0.13 | +0.13 | buy |
| FMR LLC | 5,616,471 | 7,257,621 | +1,641,150 | 0.00 | 0.01 | +0.00 | buy |
| Avoro Capital Advisors LLC | 0 | 1,333,340 | +1,333,340 | 0.00 | 0.33 | +0.33 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,268,021 | +1,268,021 | 0.00 | 0.70 | +0.70 | buy |
| Deep Track Capital, LP | 1,918,798 | 2,654,781 | +735,983 | 0.69 | 1.42 | +0.73 | buy |
| Point72 Asset Management, L.P. | 330,000 | 1,037,002 | +707,002 | 0.01 | 0.04 | +0.03 | buy |
| Cormorant Asset Management, LP | 0 | 533,340 | +533,340 | 0.00 | 0.71 | +0.71 | buy |
| Affinity Asset Advisors, LLC | 603,479 | 959,180 | +355,701 | 1.00 | 1.72 | +0.72 | buy |
| Fairmount Funds Management LLC | 3,371,922 | 3,705,262 | +333,340 | 4.90 | 6.41 | +1.51 | buy |
| Commodore Capital LP | 1,419,714 | 1,753,054 | +333,340 | 1.12 | 1.65 | +0.52 | buy |
| CITADEL ADVISORS LLC | 0 | 316,886 | +316,886 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 352,124 | 660,424 | +308,300 | 0.79 | 2.89 | +2.10 | buy |
| STATE STREET CORP | 372,806 | 652,028 | +279,222 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 116,698 | 366,994 | +250,296 | 0.01 | 0.04 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 410,881 | 626,806 | +215,925 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,988,880 | 2,204,551 | +215,671 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 390,904 | 574,330 | +183,426 | 0.02 | 0.05 | +0.03 | buy |
| GREAT POINT PARTNERS LLC | 0 | 183,330 | +183,330 | 0.00 | 1.47 | +1.47 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 84,002 | 246,926 | +162,924 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 91,094 | +91,094 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 78,995 | +78,995 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 0 | 75,000 | +75,000 | 0.00 | 0.75 | +0.75 | buy |
| Palo Alto Investors LP | 0 | 59,985 | +59,985 | 0.00 | 0.15 | +0.15 | buy |
| Polar Capital Holdings Plc | 975,000 | 1,032,307 | +57,307 | 0.06 | 0.10 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 1,012,968 | 1,065,782 | +52,814 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 34,111 | +34,111 | 0.00 | 0.00 | +0.00 | buy |
| Financial Enhancement Group LLC | 0 | 32,819 | +32,819 | 0.00 | 0.10 | +0.10 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 29,184 | +29,184 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 67,645 | 95,417 | +27,772 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 826,724 | 850,400 | +23,676 | 0.04 | 0.07 | +0.03 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 15,406 | +15,406 | 0.00 | 0.01 | +0.01 | buy |
| ALTFEST L J & CO INC | 0 | 13,297 | +13,297 | 0.00 | 0.03 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 12,787 | +12,787 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 63,509 | 70,632 | +7,123 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 91,164 | 95,330 | +4,166 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,455 | 20,856 | +3,401 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,803 | 5,747 | +2,944 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,361 | 22,119 | +2,758 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 2,253 | +2,253 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 2,014 | +2,014 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 28,570 | 30,327 | +1,757 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 6,108 | 7,358 | +1,250 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 734 | 1,877 | +1,143 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,310 | 16,318 | +1,008 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 729 | +729 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 394 | +394 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 852,338 | 852,411 | +73 | 0.02 | 0.03 | +0.01 | buy |
| Arax Advisory Partners | 0 | 72 | +72 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 2 | 6 | +4 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,446 | 1,448 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,697 | 1,698 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,777 | 2,777 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 45,876 | 45,876 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 116 | 116 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 1,945,649 | 1,945,649 | 0 | 0.31 | 0.46 | +0.15 | hold |
| MetLife Investment Management, LLC | 16,513 | 16,513 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J.Safra Asset Management Corp | 24 | 24 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 4,148,428 | 4,148,428 | 0 | 3.48 | 4.49 | +1.01 | hold |
| Parallel Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nuveen, LLC | 35,313 | 35,313 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 166 | 166 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | 430,330 | 0 | 1.05 | 1.20 | +0.15 | hold |
| B Group, Inc. | 75,000 | 75,000 | 0 | 0.73 | 1.38 | +0.65 | hold |
| Legal & General Group Plc | 2,477 | 2,477 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,600 | 8,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 929 | 929 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 58,332 | 58,332 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 64,991 | 64,991 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Caitong International Asset Management Co., Ltd | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 896 | 806 | -90 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,349 | 2,218 | -131 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 52,747 | 51,908 | -839 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 15,425 | 14,479 | -946 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,520 | 6,565 | -955 | 0.01 | 0.01 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,892 | 13,143 | -1,749 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 222,178 | 219,709 | -2,469 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 15,025 | 12,506 | -2,519 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 78,380 | 75,680 | -2,700 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 32,342 | 28,566 | -3,776 | 0.00 | 0.00 | +0.00 | sell |
| AlphaQuest LLC | 16,064 | 10,761 | -5,303 | 0.02 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 9,840 | 3,371 | -6,469 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 12,326 | 0 | -12,326 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,900 | 0 | -13,900 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 64,926 | 48,266 | -16,660 | 0.02 | 0.02 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 707,406 | 689,972 | -17,434 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 19,003 | 0 | -19,003 | 0.01 | 0.00 | -0.01 | sell |
| UBS Group AG | 110,646 | 86,560 | -24,086 | 0.00 | 0.00 | +0.00 | sell |