| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 515,726 | 1,147,676 | +631,950 | 0.36 | 0.80 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 236,116 | 849,410 | +613,294 | 0.00 | 0.01 | 0.00 | buy |
| VR Adviser, LLC | 3,085,620 | 3,285,620 | +200,000 | 3.96 | 4.37 | +0.41 | buy |
| Fairmount Funds Management LLC | 3,211,922 | 3,371,922 | +160,000 | 6.38 | 6.50 | +0.12 | buy |
| Frazier Life Sciences Management, L.P. | 477,327 | 583,327 | +106,000 | 0.47 | 0.47 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 719,660 | 819,660 | +100,000 | 0.62 | 0.55 | -0.06 | buy |
| RTW INVESTMENTS, LP | 1,850,648 | 1,945,649 | +95,001 | 0.66 | 0.57 | -0.09 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 375,330 | 430,330 | +55,000 | 1.84 | 2.03 | +0.19 | buy |
| Commodore Capital LP | 1,369,714 | 1,419,714 | +50,000 | 2.10 | 2.02 | -0.08 | buy |
| Affinity Asset Advisors, LLC | 349,836 | 368,698 | +18,862 | 1.17 | 0.96 | -0.21 | buy |
| Woodline Partners LP | 390,795 | 390,969 | +174 | 0.08 | 0.05 | -0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 69,200 | -130,800 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 514,659 | 228,803 | -285,856 | 3.71 | 2.09 | -1.62 | sell |
| PERCEPTIVE ADVISORS LLC | 1,235,187 | 845,567 | -389,620 | 0.64 | 0.45 | -0.19 | sell |
| Avidity Partners Management LP | 790,926 | 352,124 | -438,802 | 0.99 | 0.68 | -0.31 | sell |
| Deep Track Capital, LP | 1,235,187 | 750,000 | -485,187 | 0.97 | 0.55 | -0.42 | sell |