| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 37,798 | 1,610,651 | +1,572,853 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 279,648 | 1,326,893 | +1,047,245 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,682,300 | 5,512,300 | +830,000 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 21,567 | 751,431 | +729,864 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 515,726 | 1,147,676 | +631,950 | 0.36 | 0.80 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 236,116 | 849,410 | +613,294 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 0 | 550,000 | +550,000 | 0.00 | 0.06 | +0.06 | buy |
| Jefferies Financial Group Inc. | 0 | 350,029 | +350,029 | 0.00 | 0.08 | +0.08 | buy |
| MORGAN STANLEY | 68,133 | 405,998 | +337,865 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 13,984 | 342,418 | +328,434 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 240,174 | +240,174 | 0.00 | 0.02 | +0.02 | buy |
| VR Adviser, LLC | 3,085,620 | 3,285,620 | +200,000 | 3.96 | 4.37 | +0.41 | buy |
| Fairmount Funds Management LLC | 3,211,922 | 3,371,922 | +160,000 | 6.38 | 6.50 | +0.12 | buy |
| Qube Research & Technologies Ltd | 41,360 | 152,082 | +110,722 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 477,327 | 583,327 | +106,000 | 0.47 | 0.47 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 719,660 | 819,660 | +100,000 | 0.62 | 0.55 | -0.06 | buy |
| RTW INVESTMENTS, LP | 1,850,648 | 1,945,649 | +95,001 | 0.66 | 0.57 | -0.09 | buy |
| BARCLAYS PLC | 0 | 74,583 | +74,583 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 64,044 | +64,044 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 60,494 | +60,494 | 0.00 | 0.03 | +0.03 | buy |
| TORONTO DOMINION BANK | 0 | 58,332 | +58,332 | 0.00 | 0.00 | +0.00 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 375,330 | 430,330 | +55,000 | 1.84 | 2.03 | +0.19 | buy |
| Commodore Capital LP | 1,369,714 | 1,419,714 | +50,000 | 2.10 | 2.02 | -0.08 | buy |
| Weiss Asset Management LP | 0 | 40,000 | +40,000 | 0.00 | 0.02 | +0.02 | buy |
| 683 Capital Management, LLC | 0 | 33,875 | +33,875 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 30,305 | +30,305 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 25,162 | +25,162 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 25,023 | +25,023 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,800 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 349,836 | 368,698 | +18,862 | 1.33 | 1.12 | -0.21 | buy |
| JANE STREET GROUP, LLC | 0 | 17,706 | +17,706 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 15,608 | +15,608 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 82,137 | 95,089 | +12,952 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 12,175 | +12,175 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 7,421 | +7,421 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 0 | 2,800 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,166 | +1,166 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 468 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 390,795 | 390,969 | +174 | 0.08 | 0.05 | -0.03 | buy |
| Daiwa Securities Group Inc. | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 95,076 | 95,076 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redmile Group, LLC | 411,728 | 411,728 | 0 | 0.59 | 0.56 | -0.04 | hold |
| Ensign Peak Advisors, Inc | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cable Car Capital, LP | 333,371 | 333,371 | 0 | 8.81 | 0.49 | -8.31 | hold |
| Activest Wealth Management | 166 | 166 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 720,547 | 720,547 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 42,298 | 42,298 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 308,795 | 308,795 | 0 | 0.06 | 0.05 | -0.02 | hold |
| New England Capital Financial Advisors LLC | 41 | 0 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 965 | 584 | -381 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 11,187 | 0 | -11,187 | 0.05 | 0.00 | -0.05 | sell |
| CITIGROUP INC | 26,720 | 8,028 | -18,692 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 482,330 | 360,732 | -121,598 | 0.04 | 0.02 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 69,200 | -130,800 | 0.01 | 0.00 | -0.01 | sell |
| Logos Global Management LP | 257,330 | 0 | -257,330 | 0.71 | 0.00 | -0.71 | sell |
| GREAT POINT PARTNERS LLC | 514,659 | 228,803 | -285,856 | 3.81 | 2.09 | -1.72 | sell |
| PERCEPTIVE ADVISORS LLC | 1,235,187 | 845,567 | -389,620 | 0.65 | 0.46 | -0.19 | sell |
| Avidity Partners Management LP | 790,926 | 352,124 | -438,802 | 0.99 | 0.68 | -0.31 | sell |
| Deep Track Capital, LP | 1,235,187 | 750,000 | -485,187 | 0.97 | 0.55 | -0.42 | sell |