| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,257,621 | 7,261,384 | +3,763 | 0.01 | 0.01 | +0.00 | buy |
| VR Adviser, LLC | 4,148,428 | 4,148,428 | 0 | 4.49 | 6.21 | +1.72 | hold |
| Fairmount Funds Management LLC | 3,705,262 | 3,705,262 | 0 | 6.41 | 8.55 | +2.14 | hold |
| BlackRock, Inc. | 2,204,551 | 3,539,415 | +1,334,864 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 2,666,690 | 2,666,690 | 0 | 0.13 | 0.21 | +0.08 | hold |
| VANGUARD GROUP INC | 1,776,665 | 2,453,530 | +676,865 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 2,654,781 | 2,161,510 | -493,271 | 1.42 | 1.49 | +0.07 | sell |
| RTW INVESTMENTS, LP | 1,945,649 | 2,058,148 | +112,499 | 0.46 | 0.62 | +0.16 | buy |
| Commodore Capital LP | 1,753,054 | 1,753,054 | 0 | 1.65 | 3.54 | +1.89 | hold |
| Paradigm Biocapital Advisors LP | 0 | 1,710,316 | +1,710,316 | 0.00 | 1.39 | +1.39 | buy |
| PERCEPTIVE ADVISORS LLC | 1,268,021 | 1,476,501 | +208,480 | 0.70 | 0.82 | +0.12 | buy |
| STATE STREET CORP | 652,028 | 1,383,847 | +731,819 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 1,333,340 | 1,333,340 | 0 | 0.33 | 0.40 | +0.07 | hold |
| Blackstone Inc. | 850,400 | 1,165,408 | +315,008 | 0.07 | 0.15 | +0.08 | buy |
| Polar Capital Holdings Plc | 1,032,307 | 978,288 | -54,019 | 0.10 | 0.14 | +0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 689,972 | 942,507 | +252,535 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,065,782 | 938,421 | -127,361 | 0.01 | 0.01 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 959,180 | 802,342 | -156,838 | 1.72 | 1.75 | +0.03 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 852,411 | 745,277 | -107,134 | 0.03 | 0.03 | +0.01 | sell |
| CITADEL ADVISORS LLC | 316,886 | 726,118 | +409,232 | 0.00 | 0.01 | +0.01 | buy |
| Avidity Partners Management LP | 660,424 | 660,424 | 0 | 2.89 | 5.77 | +2.88 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 626,806 | 649,346 | +22,540 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,037,002 | 600,000 | -437,002 | 0.04 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 574,330 | 574,553 | +223 | 0.05 | 0.07 | +0.02 | buy |
| Cormorant Asset Management, LP | 533,340 | 533,340 | 0 | 0.71 | 0.92 | +0.21 | hold |
| Synergy Asset Management, LLC | 0 | 458,946 | +458,946 | 0.00 | 1.45 | +1.45 | buy |
| SR ONE CAPITAL MANAGEMENT, LP | 430,330 | 430,330 | 0 | 1.20 | 1.85 | +0.65 | hold |
| Candriam S.C.A. | 366,994 | 400,509 | +33,515 | 0.04 | 0.06 | +0.02 | buy |
| Cable Car Capital, LP | 500,000 | 400,000 | -100,000 | 4.12 | 0.75 | -3.37 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 246,926 | 329,496 | +82,570 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 219,709 | 280,904 | +61,195 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 86,560 | 271,013 | +184,453 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 190,000 | +190,000 | 0.00 | 0.24 | +0.24 | buy |
| GREAT POINT PARTNERS LLC | 183,330 | 183,330 | 0 | 1.47 | 1.80 | +0.33 | hold |
| BARCLAYS PLC | 95,330 | 173,329 | +77,999 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,318 | 143,121 | +126,803 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 78,995 | 139,272 | +60,277 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 128,110 | +128,110 | 0.00 | 0.46 | +0.46 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 126,812 | +126,812 | 0.00 | 0.72 | +0.72 | buy |
| MORGAN STANLEY | 134,833 | 122,198 | -12,635 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 22,119 | 119,329 | +97,210 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 118,126 | +118,126 | 0.00 | 0.59 | +0.59 | buy |
| Bank of New York Mellon Corp | 70,632 | 114,173 | +43,541 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 19,775 | 92,995 | +73,220 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 35,313 | 86,347 | +51,034 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,382,350 | 84,795 | -1,297,555 | 0.79 | 0.08 | -0.71 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 91,094 | 84,716 | -6,378 | 0.00 | 0.00 | +0.00 | sell |
| Secure Asset Management, LLC | 0 | 81,664 | +81,664 | 0.00 | 0.39 | +0.39 | buy |
| TD ASSET MANAGEMENT INC | 45,876 | 79,896 | +34,020 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 95,417 | 76,415 | -19,002 | 0.00 | 0.00 | +0.00 | sell |
| Aberdeen Group plc | 75,680 | 75,680 | 0 | 0.00 | 0.00 | +0.00 | hold |
| B Group, Inc. | 75,000 | 75,000 | 0 | 1.38 | 1.68 | +0.31 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 51,908 | 61,358 | +9,450 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 59,985 | 59,985 | 0 | 0.15 | 0.25 | +0.11 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 58,723 | +58,723 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 34,111 | 57,080 | +22,969 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 48,266 | 48,686 | +420 | 0.02 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 20,856 | 43,261 | +22,405 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 43,000 | +43,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 42,503 | +42,503 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 30,327 | 41,017 | +10,690 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 39,751 | +39,751 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 12,787 | 38,485 | +25,698 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 37,800 | +37,800 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 35,710 | +35,710 | 0.00 | 0.01 | +0.01 | buy |
| Financial Enhancement Group LLC | 32,819 | 31,293 | -1,526 | 0.10 | 0.14 | +0.04 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 29,184 | 29,184 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 28,566 | 28,566 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 27,671 | +27,671 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 23,548 | +23,548 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 22,968 | +22,968 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,698 | 21,658 | +19,960 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,513 | 21,362 | +4,849 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 20,840 | 20,840 | 0 | 0.04 | 0.05 | +0.01 | hold |
| JPMORGAN CHASE & CO | 14,479 | 20,417 | +5,938 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,143 | 20,152 | +7,009 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,477 | 18,744 | +16,267 | 0.00 | 0.00 | +0.00 | buy |
| Brookwood Investment Group LLC | 0 | 16,569 | +16,569 | 0.00 | 0.06 | +0.06 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 15,406 | 15,406 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 15,247 | +15,247 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 10,761 | 14,901 | +4,140 | 0.01 | 0.03 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 12,506 | 14,813 | +2,307 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 14,623 | +14,623 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 14,244 | +14,244 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 75,000 | 12,500 | -62,500 | 0.75 | 0.18 | -0.57 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 12,100 | +12,100 | 0.00 | 0.00 | +0.00 | buy |
| ALTFEST L J & CO INC | 13,297 | 10,857 | -2,440 | 0.03 | 0.04 | +0.01 | sell |
| Allianz Asset Management GmbH | 0 | 10,300 | +10,300 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,358 | 10,207 | +2,849 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,371 | 9,828 | +6,457 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 9,676 | +9,676 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 9,416 | +9,416 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 9,189 | +9,189 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 8,814 | +8,814 | 0.00 | 0.07 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 8,665 | +8,665 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,600 | 8,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 8,275 | +8,275 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |