| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 9,710,328 | 9,930,926 | +220,598 | 0.03 | 0.03 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 12,295,000 | 6,681,000 | -5,614,000 | 0.07 | 0.04 | -0.04 | sell |
| STATE STREET CORP | 4,063,336 | 3,989,961 | -73,375 | 0.03 | 0.02 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,735,543 | 2,295,108 | +559,565 | 0.02 | 0.03 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,988,546 | 2,251,646 | +263,100 | 0.41 | 0.49 | +0.08 | buy |
| MORGAN STANLEY | 2,326,294 | 2,065,636 | -260,658 | 0.03 | 0.02 | -0.00 | sell |
| Bellevue Group AG | 2,430,500 | 2,055,874 | -374,626 | 4.90 | 4.32 | -0.57 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,476,949 | 1,820,796 | +343,847 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,623,124 | 1,713,714 | +90,590 | 0.02 | 0.02 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,600,000 | 1,600,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 1,551,367 | 1,378,513 | -172,854 | 0.12 | 0.10 | -0.02 | sell |
| DODGE & COX | 1,259,744 | 1,265,244 | +5,500 | 0.11 | 0.10 | -0.00 | buy |
| Invesco Ltd. | 673,808 | 1,136,942 | +463,134 | 0.02 | 0.03 | +0.01 | buy |
| DSM CAPITAL PARTNERS LLC | 1,222,009 | 1,136,002 | -86,007 | 2.46 | 2.14 | -0.32 | sell |
| BROWN ADVISORY INC | 1,113,413 | 1,088,333 | -25,080 | 0.21 | 0.20 | -0.01 | sell |
| Pictet Asset Management Holding SA | 1,213,313 | 1,081,449 | -131,864 | 0.18 | 0.16 | -0.01 | sell |
| Rock Springs Capital Management LP | 1,196,000 | 1,054,900 | -141,100 | 3.89 | 3.70 | -0.19 | sell |
| ARMISTICE CAPITAL, LLC | 1,048,000 | 1,023,739 | -24,261 | 3.67 | 3.76 | +0.09 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,199,542 | 1,003,750 | -195,792 | 0.03 | 0.02 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 738,852 | 994,611 | +255,759 | 0.18 | 0.23 | +0.05 | buy |
| Bank of New York Mellon Corp | 979,060 | 921,335 | -57,725 | 0.03 | 0.02 | -0.00 | sell |
| CITADEL ADVISORS LLC | 112,000 | 841,318 | +729,318 | 0.01 | 0.11 | +0.10 | buy |
| Point72 Asset Management, L.P. | 1,391,970 | 837,426 | -554,544 | 0.56 | 0.34 | -0.22 | sell |
| PERCEPTIVE ADVISORS LLC | 270,794 | 804,409 | +533,615 | 0.80 | 1.96 | +1.16 | buy |
| FRANKLIN RESOURCES INC | 772,310 | 793,825 | +21,515 | 0.05 | 0.03 | -0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 720,593 | 790,193 | +69,600 | 0.26 | 0.29 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 691,632 | 775,727 | +84,095 | 0.02 | 0.02 | +0.00 | buy |
| Polar Capital Holdings Plc | 835,833 | 775,556 | -60,277 | 0.68 | 0.56 | -0.12 | sell |
| BRAIDWELL LP | 715,209 | 730,209 | +15,000 | 3.46 | 3.25 | -0.22 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 686,835 | 725,178 | +38,343 | 0.02 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 807,281 | 715,068 | -92,213 | 0.02 | 0.02 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 752,865 | 712,798 | -40,067 | 0.50 | 0.44 | -0.06 | sell |
| Vestal Point Capital, LP | 800,000 | 710,000 | -90,000 | 11.17 | 8.10 | -3.07 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 896,719 | 691,004 | -205,715 | 2.18 | 1.66 | -0.52 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 617,453 | 599,424 | -18,029 | 0.03 | 0.03 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 586,950 | 580,617 | -6,333 | 0.06 | 0.06 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 472,979 | 566,713 | +93,734 | 0.01 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 658,000 | 536,500 | -121,500 | 3.32 | 2.63 | -0.69 | sell |
| GW&K Investment Management, LLC | 535,962 | 527,874 | -8,088 | 0.66 | 0.64 | -0.02 | sell |
| FIRST TRUST ADVISORS LP | 590,725 | 526,582 | -64,143 | 0.08 | 0.07 | -0.01 | sell |
| Fiera Capital Corp | 516,865 | 511,542 | -5,323 | 0.21 | 0.21 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 410,103 | 506,666 | +96,563 | 0.09 | 0.11 | +0.02 | buy |
| IEQ CAPITAL, LLC | 482,826 | 506,113 | +23,287 | 1.06 | 1.00 | -0.06 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 594,437 | 503,193 | -91,244 | 0.46 | 0.36 | -0.09 | sell |
| MILLENNIUM MANAGEMENT LLC | 688,956 | 455,220 | -233,736 | 0.09 | 0.05 | -0.03 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 307,630 | 431,982 | +124,352 | 0.07 | 0.07 | -0.00 | buy |
| NORGES BANK | 271,182 | 425,216 | +154,034 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 519,279 | 423,100 | -96,179 | 1.37 | 1.07 | -0.30 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 418,245 | 418,675 | +430 | 0.04 | 0.03 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 425,747 | 405,347 | -20,400 | 0.02 | 0.02 | -0.00 | sell |
| Legal & General Group Plc | 441,507 | 402,616 | -38,891 | 0.02 | 0.02 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 398,323 | 399,380 | +1,057 | 0.04 | 0.04 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 46,981 | 391,244 | +344,263 | 0.02 | 0.17 | +0.15 | buy |
| APG Asset Management N.V. | 382,544 | 377,118 | -5,426 | 0.09 | 0.08 | -0.00 | sell |
| Amundi | 340,214 | 361,672 | +21,458 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 337,076 | 359,856 | +22,780 | 0.02 | 0.02 | +0.00 | buy |
| Russell Investments Group, Ltd. | 405,279 | 349,317 | -55,962 | 0.10 | 0.08 | -0.02 | sell |
| Sarissa Capital Management LP | 470,000 | 346,426 | -123,574 | 9.54 | 8.36 | -1.19 | sell |
| JENNISON ASSOCIATES LLC | 451,462 | 345,446 | -106,016 | 0.04 | 0.03 | -0.01 | sell |
| Clearbridge Investments, LLC | 340,802 | 340,802 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Assenagon Asset Management S.A. | 315,560 | 337,737 | +22,177 | 0.13 | 0.12 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 336,536 | 325,022 | -11,514 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 318,920 | 322,107 | +3,187 | 0.04 | 0.04 | -0.00 | buy |
| Candriam S.C.A. | 369,899 | 315,684 | -54,215 | 0.34 | 0.28 | -0.06 | sell |
| Robeco Institutional Asset Management B.V. | 177,699 | 310,225 | +132,526 | 0.06 | 0.09 | +0.04 | buy |
| Swiss National Bank | 305,300 | 294,200 | -11,100 | 0.03 | 0.03 | -0.00 | sell |
| Man Group plc | 318,434 | 289,761 | -28,673 | 0.12 | 0.11 | -0.01 | sell |
| MACQUARIE GROUP LTD | 328,129 | 276,010 | -52,119 | 0.05 | 0.04 | -0.01 | sell |
| PANAGORA ASSET MANAGEMENT INC | 70,348 | 267,597 | +197,249 | 0.05 | 0.19 | +0.14 | buy |
| BARCLAYS PLC | 232,168 | 257,239 | +25,071 | 0.02 | 0.02 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 255,869 | 254,933 | -936 | 0.05 | 0.05 | -0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 243,935 | 252,565 | +8,630 | 0.02 | 0.02 | +0.00 | buy |
| JANE STREET GROUP, LLC | 13,880 | 252,004 | +238,124 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 169,610 | 251,831 | +82,221 | 0.05 | 0.06 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 918,391 | 245,381 | -673,010 | 0.45 | 0.12 | -0.34 | sell |
| AXA S.A. | 116,211 | 243,689 | +127,478 | 0.05 | 0.10 | +0.05 | buy |
| UBS Group AG | 143,894 | 235,626 | +91,732 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 264,552 | 232,519 | -32,033 | 0.00 | 0.00 | -0.00 | sell |
| Hood River Capital Management LLC | 212,390 | 227,998 | +15,608 | 0.77 | 0.70 | -0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 782,044 | 227,019 | -555,025 | 0.07 | 0.02 | -0.05 | sell |
| WELLS FARGO & COMPANY/MN | 103,028 | 221,814 | +118,786 | 0.00 | 0.01 | +0.00 | buy |
| Iron Triangle Partners LP | 0 | 220,000 | +220,000 | 0.00 | 3.14 | +3.14 | buy |
| JUPITER ASSET MANAGEMENT LTD | 210,091 | 218,466 | +8,375 | 0.27 | 0.29 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 214,396 | 206,368 | -8,028 | 0.04 | 0.04 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 199,586 | 199,397 | -189 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 210,473 | 195,273 | -15,200 | 0.06 | 0.06 | -0.00 | sell |
| JANE STREET GROUP, LLC | 213,000 | 195,000 | -18,000 | 0.00 | 0.00 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 65,900 | 188,549 | +122,649 | 0.01 | 0.03 | +0.02 | buy |
| TOBAM | 226,841 | 178,253 | -48,588 | 2.61 | 2.20 | -0.41 | sell |
| National Pension Service | 180 | 174,330 | +174,150 | 0.00 | 0.03 | +0.03 | buy |
| ROYAL BANK OF CANADA | 122,547 | 162,534 | +39,987 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 173,628 | 160,223 | -13,405 | 0.01 | 0.01 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 185,000 | 159,776 | -25,224 | 0.46 | 0.51 | +0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 224,907 | 157,780 | -67,127 | 0.07 | 0.05 | -0.02 | sell |
| CITIGROUP INC | 171,933 | 155,078 | -16,855 | 0.03 | 0.02 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 72,608 | 154,711 | +82,103 | 0.02 | 0.04 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 175,777 | 151,873 | -23,904 | 0.01 | 0.01 | -0.00 | sell |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 74,745 | 151,683 | +76,938 | 0.03 | 0.05 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 75,535 | 150,127 | +74,592 | 0.01 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 90,000 | 150,000 | +60,000 | 1.71 | 2.03 | +0.32 | buy |