| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 14,682,394 | 12,954,765 | -1,727,629 | 0.03 | 0.03 | -0.00 | sell |
| VANGUARD GROUP INC | 9,941,887 | 9,807,066 | -134,821 | 0.02 | 0.02 | +0.00 | sell |
| DODGE & COX | 5,534,624 | 5,566,814 | +32,190 | 0.35 | 0.39 | +0.04 | buy |
| STATE STREET CORP | 4,862,116 | 4,468,266 | -393,850 | 0.02 | 0.02 | -0.00 | sell |
| JPMORGAN CHASE & CO | 2,670,998 | 4,261,747 | +1,590,749 | 0.02 | 0.04 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,539,601 | 3,086,457 | +1,546,856 | 0.02 | 0.04 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,502,697 | 2,366,397 | -136,300 | 0.42 | 0.40 | -0.02 | sell |
| CITADEL ADVISORS LLC | 889,028 | 2,049,075 | +1,160,047 | 0.10 | 0.22 | +0.13 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,097,981 | 2,028,858 | -69,123 | 0.04 | 0.05 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,969,754 | 1,959,265 | -10,489 | 0.02 | 0.02 | +0.00 | sell |
| Bellevue Group AG | 1,820,000 | 1,820,000 | 0 | 4.51 | 5.04 | +0.53 | hold |
| MORGAN STANLEY | 1,518,237 | 1,819,745 | +301,508 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,074,630 | 1,510,015 | +435,385 | 0.12 | 0.16 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,159,367 | 1,387,635 | +228,268 | 0.03 | 0.04 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 576,590 | 1,194,219 | +617,629 | 0.06 | 0.13 | +0.07 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,489,000 | 1,167,802 | -321,198 | 3.26 | 2.66 | -0.60 | sell |
| BRAIDWELL LP | 1,191,925 | 1,160,425 | -31,500 | 4.63 | 4.99 | +0.35 | sell |
| RTW INVESTMENTS, LP | 0 | 1,062,072 | +1,062,072 | 0.00 | 1.90 | +1.90 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,255,106 | 1,032,296 | -222,810 | 0.37 | 0.32 | -0.06 | sell |
| NORGES BANK | 999,821 | 972,856 | -26,965 | 0.02 | 0.02 | -0.00 | sell |
| NORTHERN TRUST CORP | 957,280 | 929,058 | -28,222 | 0.02 | 0.02 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 792,482 | 791,526 | -956 | 0.03 | 0.03 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 775,773 | 789,715 | +13,942 | 0.02 | 0.02 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 878,815 | 787,299 | -91,516 | 0.21 | 0.22 | +0.00 | sell |
| Bank of New York Mellon Corp | 828,682 | 778,630 | -50,052 | 0.02 | 0.02 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 783,966 | 776,070 | -7,896 | 0.05 | 0.05 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 3,808 | 744,650 | +740,842 | 0.00 | 0.35 | +0.35 | buy |
| FRANKLIN RESOURCES INC | 579,429 | 703,521 | +124,092 | 0.02 | 0.02 | +0.00 | buy |
| Pictet Asset Management Holding SA | 387,574 | 696,122 | +308,548 | 0.05 | 0.09 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 737,437 | 685,865 | -51,572 | 0.02 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 615,636 | 684,439 | +68,803 | 0.02 | 0.02 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,000,190 | 676,024 | -324,166 | 2.96 | 3.22 | +0.26 | sell |
| BANK OF AMERICA CORP /DE/ | 561,069 | 653,011 | +91,942 | 0.01 | 0.01 | +0.00 | buy |
| GW&K Investment Management, LLC | 511,356 | 612,365 | +101,009 | 0.52 | 0.69 | +0.17 | buy |
| UBS Group AG | 785,501 | 602,125 | -183,376 | 0.02 | 0.02 | -0.00 | sell |
| BROWN ADVISORY INC | 895,542 | 599,219 | -296,323 | 0.14 | 0.10 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 576,172 | 584,431 | +8,259 | 0.02 | 0.02 | +0.00 | buy |
| IEQ CAPITAL, LLC | 537,017 | 572,973 | +35,956 | 0.47 | 0.44 | -0.03 | buy |
| JENNISON ASSOCIATES LLC | 804,466 | 570,868 | -233,598 | 0.06 | 0.04 | -0.02 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 382,440 | 524,040 | +141,600 | 0.03 | 0.05 | +0.02 | buy |
| Swedbank AB | 429,697 | 503,502 | +73,805 | 0.06 | 0.07 | +0.01 | buy |
| Fiera Capital Corp | 494,475 | 490,594 | -3,881 | 0.20 | 0.21 | +0.01 | sell |
| Allspring Global Investments Holdings, LLC | 387,806 | 447,900 | +60,094 | 0.07 | 0.10 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 315,710 | 443,245 | +127,535 | 0.01 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 934,640 | 438,540 | -496,100 | 2.48 | 1.39 | -1.10 | sell |
| FIRST TRUST ADVISORS LP | 593,355 | 423,471 | -169,884 | 0.06 | 0.04 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 426,934 | 409,978 | -16,956 | 0.02 | 0.02 | +0.00 | sell |
| Legal & General Group Plc | 382,927 | 399,426 | +16,499 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 342,302 | 342,302 | 0 | 0.03 | 0.03 | +0.00 | hold |
| AXA S.A. | 333,699 | 341,734 | +8,035 | 0.12 | 0.12 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 341,578 | +341,578 | 0.00 | 0.07 | +0.07 | buy |
| CITIGROUP INC | 466,189 | 322,064 | -144,125 | 0.04 | 0.03 | -0.01 | sell |
| RHUMBLINE ADVISERS | 314,486 | 309,190 | -5,296 | 0.03 | 0.03 | +0.00 | sell |
| Sarissa Capital Management LP | 309,116 | 303,151 | -5,965 | 22.10 | 24.68 | +2.58 | sell |
| Swiss National Bank | 285,500 | 299,400 | +13,900 | 0.02 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 330,840 | 298,551 | -32,289 | 0.23 | 0.22 | -0.01 | sell |
| Invesco Ltd. | 567,320 | 289,245 | -278,075 | 0.01 | 0.01 | -0.01 | sell |
| WELLS FARGO & COMPANY/MN | 255,391 | 284,338 | +28,947 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 200,218 | 271,390 | +71,172 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 231,348 | 270,502 | +39,154 | 0.03 | 0.04 | +0.01 | buy |
| Hood River Capital Management LLC | 337,164 | 257,538 | -79,626 | 0.64 | 0.45 | -0.18 | sell |
| PERCEPTIVE ADVISORS LLC | 100,050 | 255,050 | +155,000 | 0.39 | 1.20 | +0.81 | buy |
| FMR LLC | 95,918 | 254,844 | +158,926 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE GROUP LLC | 212,100 | 251,732 | +39,632 | 1.03 | 1.23 | +0.20 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 55,865 | 248,633 | +192,768 | 0.03 | 0.11 | +0.08 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 248,420 | 243,730 | -4,690 | 0.02 | 0.02 | +0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 231,458 | 235,488 | +4,030 | 0.02 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 286,496 | 228,862 | -57,634 | 0.01 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 141,425 | 220,759 | +79,334 | 0.02 | 0.03 | +0.01 | buy |
| Amundi | 231,187 | 219,195 | -11,992 | 0.01 | 0.01 | +0.00 | sell |
| Eagle Health Investments LP | 225,100 | 217,200 | -7,900 | 6.46 | 6.74 | +0.27 | sell |
| Zurich Insurance Group Ltd/FI | 0 | 211,911 | +211,911 | 0.00 | 0.21 | +0.21 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 175,641 | 203,628 | +27,987 | 0.25 | 0.28 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 122,306 | 198,039 | +75,733 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 191,182 | 191,262 | +80 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 243,035 | 189,237 | -53,798 | 0.02 | 0.02 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 184,035 | +184,035 | 0.00 | 0.51 | +0.51 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 180,338 | +180,338 | 0.00 | 9.72 | +9.72 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 150,661 | 180,259 | +29,598 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 174,774 | 174,774 | 0 | 0.03 | 0.03 | +0.00 | hold |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 166,865 | 173,369 | +6,504 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 194,744 | 170,783 | -23,961 | 0.04 | 0.04 | -0.00 | sell |
| BRAUN STACEY ASSOCIATES INC | 0 | 170,370 | +170,370 | 0.00 | 0.77 | +0.77 | buy |
| Freestone Grove Partners LP | 5,209 | 168,133 | +162,924 | 0.01 | 0.16 | +0.15 | buy |
| Squarepoint Ops LLC | 0 | 166,602 | +166,602 | 0.00 | 0.05 | +0.05 | buy |
| Parkman Healthcare Partners LLC | 168,382 | 166,010 | -2,372 | 2.21 | 2.41 | +0.21 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 72,583 | 162,969 | +90,386 | 1.68 | 4.19 | +2.52 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 0.92 | 0.95 | +0.04 | hold |
| Integral Health Asset Management, LLC | 150,000 | 150,000 | 0 | 1.84 | 1.76 | -0.08 | hold |
| Logos Global Management LP | 0 | 150,000 | +150,000 | 0.00 | 2.52 | +2.52 | buy |
| Rhenman & Partners Asset Management AB | 89,817 | 149,217 | +59,400 | 1.14 | 2.37 | +1.23 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 143,369 | 147,880 | +4,511 | 0.16 | 0.17 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 119,300 | 145,330 | +26,030 | 0.02 | 0.02 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 140,484 | +140,484 | 0.00 | 0.02 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,944 | 135,314 | -1,630 | 0.02 | 0.02 | +0.00 | sell |
| C WorldWide Group Holding A/S | 115,000 | 135,000 | +20,000 | 0.16 | 0.23 | +0.07 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 66,600 | 125,162 | +58,562 | 0.01 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 123,183 | 123,323 | +140 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 148,845 | 121,740 | -27,105 | 0.02 | 0.02 | -0.00 | sell |
| Distillate Capital Partners LLC | 129,789 | 121,614 | -8,175 | 0.74 | 0.82 | +0.08 | sell |