| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 10,056,446 | 9,996,960 | -59,486 | 0.03 | 0.02 | -0.01 | sell |
| STATE STREET CORP | 4,608,357 | 5,148,293 | +539,936 | 0.03 | 0.02 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,468,146 | 2,574,546 | +106,400 | 0.58 | 0.45 | -0.13 | buy |
| Bellevue Group AG | 1,898,640 | 1,863,800 | -34,840 | 4.25 | 3.48 | -0.77 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,819,622 | 1,859,232 | +39,610 | 0.02 | 0.02 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 1,223,055 | 1,843,281 | +620,226 | 0.26 | 0.29 | +0.04 | buy |
| CITADEL ADVISORS LLC | 740,939 | 1,764,590 | +1,023,651 | 0.10 | 0.21 | +0.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,798,848 | 1,675,176 | -123,672 | 0.03 | 0.02 | -0.01 | sell |
| JPMORGAN CHASE & CO | 2,362,735 | 1,497,931 | -864,804 | 0.03 | 0.01 | -0.01 | sell |
| MORGAN STANLEY | 1,544,869 | 1,349,381 | -195,488 | 0.02 | 0.01 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 691,004 | 1,316,590 | +625,586 | 1.58 | 2.27 | +0.68 | buy |
| DODGE & COX | 1,280,820 | 1,287,820 | +7,000 | 0.11 | 0.08 | -0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,132,589 | 1,017,154 | -115,435 | 0.03 | 0.02 | -0.01 | sell |
| DSM CAPITAL PARTNERS LLC | 997,784 | 944,154 | -53,630 | 1.99 | 1.66 | -0.33 | sell |
| BROWN ADVISORY INC | 995,214 | 942,147 | -53,067 | 0.18 | 0.14 | -0.04 | sell |
| Rock Springs Capital Management LP | 940,000 | 939,000 | -1,000 | 3.91 | 3.52 | -0.39 | sell |
| BRAIDWELL LP | 759,009 | 917,674 | +158,665 | 3.28 | 3.00 | -0.28 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 912,064 | 894,217 | -17,847 | 0.04 | 0.03 | -0.01 | sell |
| Invesco Ltd. | 1,258,104 | 874,665 | -383,439 | 0.04 | 0.02 | -0.02 | sell |
| Bank of New York Mellon Corp | 934,404 | 858,250 | -76,154 | 0.02 | 0.02 | -0.01 | sell |
| Pictet Asset Management Holding SA | 871,324 | 842,197 | -29,127 | 0.14 | 0.11 | -0.03 | sell |
| BNP Paribas Asset Management Holding S.A. | 782,870 | 819,968 | +37,098 | 0.28 | 0.23 | -0.04 | buy |
| JANUS HENDERSON GROUP PLC | 971,203 | 792,196 | -179,007 | 0.07 | 0.05 | -0.02 | sell |
| NORTHERN TRUST CORP | 810,620 | 771,624 | -38,996 | 0.02 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 601,720 | 763,355 | +161,635 | 0.15 | 0.16 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 752,501 | 747,291 | -5,210 | 0.02 | 0.02 | -0.00 | sell |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 656,118 | 736,910 | +80,792 | 0.22 | 0.17 | -0.05 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 899,493 | 718,226 | -181,267 | 0.02 | 0.01 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 710,600 | 689,986 | -20,614 | 0.16 | 0.12 | -0.04 | sell |
| FRANKLIN RESOURCES INC | 808,450 | 664,336 | -144,114 | 0.03 | 0.02 | -0.01 | sell |
| Amundi | 391,313 | 656,695 | +265,382 | 0.02 | 0.03 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 621,865 | 636,914 | +15,049 | 0.03 | 0.02 | -0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 618,931 | 623,588 | +4,657 | 0.01 | 0.01 | -0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 307,100 | 582,789 | +275,689 | 0.40 | 0.59 | +0.19 | buy |
| FIRST TRUST ADVISORS LP | 433,537 | 544,321 | +110,784 | 0.06 | 0.06 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 430,609 | 533,324 | +102,715 | 0.06 | 0.06 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 721,087 | 524,168 | -196,919 | 0.41 | 0.23 | -0.18 | sell |
| DIMENSIONAL FUND ADVISORS LP | 472,929 | 523,632 | +50,703 | 0.02 | 0.01 | -0.00 | buy |
| Fiera Capital Corp | 527,902 | 516,801 | -11,101 | 0.23 | 0.18 | -0.05 | sell |
| IEQ CAPITAL, LLC | 506,086 | 512,480 | +6,394 | 0.94 | 0.72 | -0.21 | buy |
| GW&K Investment Management, LLC | 546,068 | 510,089 | -35,979 | 0.69 | 0.50 | -0.18 | sell |
| AMERIPRISE FINANCIAL INC | 413,172 | 496,094 | +82,922 | 0.02 | 0.01 | -0.00 | buy |
| MACQUARIE GROUP LTD | 270,977 | 492,190 | +221,213 | 0.04 | 0.06 | +0.02 | buy |
| Candriam S.C.A. | 465,467 | 483,241 | +17,774 | 0.39 | 0.32 | -0.07 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 485,020 | 462,147 | -22,873 | 0.05 | 0.04 | -0.01 | sell |
| Avidity Partners Management LP | 491,000 | 460,000 | -31,000 | 2.87 | 2.70 | -0.17 | sell |
| DEUTSCHE BANK AG\ | 433,107 | 437,831 | +4,724 | 0.03 | 0.02 | -0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 56,885 | 420,748 | +363,863 | 0.03 | 0.20 | +0.17 | buy |
| Sarissa Capital Management LP | 410,483 | 410,483 | 0 | 9.54 | 11.76 | +2.22 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 409,290 | 404,000 | -5,290 | 0.04 | 0.03 | -0.01 | sell |
| Legal & General Group Plc | 402,499 | 390,585 | -11,914 | 0.02 | 0.01 | -0.00 | sell |
| Robeco Institutional Asset Management B.V. | 333,981 | 387,282 | +53,301 | 0.10 | 0.09 | -0.01 | buy |
| UBS Group AG | 316,927 | 359,569 | +42,642 | 0.01 | 0.01 | -0.00 | buy |
| NORGES BANK | 449,565 | 351,064 | -98,501 | 0.01 | 0.01 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 499,323 | 334,800 | -164,523 | 0.04 | 0.02 | -0.02 | sell |
| RHUMBLINE ADVISERS | 324,288 | 321,747 | -2,541 | 0.04 | 0.03 | -0.01 | sell |
| Clearbridge Investments, LLC | 340,802 | 319,299 | -21,503 | 0.04 | 0.03 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 187,483 | 312,767 | +125,284 | 0.02 | 0.03 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 119,837 | 303,842 | +184,005 | 0.08 | 0.16 | +0.08 | buy |
| ORBIMED ADVISORS LLC | 448,200 | 302,220 | -145,980 | 1.23 | 0.64 | -0.59 | sell |
| Swiss National Bank | 294,600 | 298,700 | +4,100 | 0.03 | 0.02 | -0.01 | buy |
| Man Group plc | 233,225 | 296,179 | +62,954 | 0.08 | 0.10 | +0.01 | buy |
| AXA S.A. | 284,022 | 269,172 | -14,850 | 0.12 | 0.09 | -0.02 | sell |
| Hood River Capital Management LLC | 243,897 | 263,210 | +19,313 | 0.70 | 0.49 | -0.21 | buy |
| WELLS FARGO & COMPANY/MN | 234,969 | 260,415 | +25,446 | 0.01 | 0.01 | -0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 373,762 | 253,186 | -120,576 | 0.03 | 0.02 | -0.01 | sell |
| ROYAL BANK OF CANADA | 167,427 | 252,910 | +85,483 | 0.01 | 0.01 | +0.00 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 59,425 | 247,043 | +187,618 | 1.33 | 3.95 | +2.62 | buy |
| FMR LLC | 341,829 | 246,106 | -95,723 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 202,793 | 233,540 | +30,747 | 0.01 | 0.01 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 243,443 | 231,941 | -11,502 | 0.02 | 0.02 | -0.01 | sell |
| HSBC HOLDINGS PLC | 113,073 | 223,258 | +110,185 | 0.01 | 0.02 | +0.01 | buy |
| TRUIST FINANCIAL CORP | 31,546 | 214,283 | +182,737 | 0.01 | 0.04 | +0.03 | buy |
| PERCEPTIVE ADVISORS LLC | 649,909 | 212,228 | -437,681 | 2.16 | 0.52 | -1.63 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 185,384 | 211,274 | +25,890 | 0.03 | 0.02 | -0.00 | buy |
| Russell Investments Group, Ltd. | 288,761 | 210,777 | -77,984 | 0.06 | 0.04 | -0.03 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 137,543 | 204,205 | +66,662 | 0.02 | 0.02 | +0.00 | buy |
| RENAISSANCE GROUP LLC | 0 | 204,140 | +204,140 | 0.00 | 0.97 | +0.97 | buy |
| CITIGROUP INC | 116,289 | 200,519 | +84,230 | 0.02 | 0.02 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 51,200 | 182,147 | +130,947 | 0.14 | 0.40 | +0.26 | buy |
| BARCLAYS PLC | 162,389 | 181,591 | +19,202 | 0.01 | 0.01 | -0.00 | buy |
| ARMISTICE CAPITAL, LLC | 978,488 | 181,381 | -797,107 | 3.52 | 0.55 | -2.98 | sell |
| AMERICAN CENTURY COMPANIES INC | 198,536 | 181,250 | -17,286 | 0.02 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 208,407 | 179,774 | -28,633 | 0.04 | 0.03 | -0.01 | sell |
| Andra AP-fonden | 161,300 | 177,900 | +16,600 | 0.37 | 0.30 | -0.07 | buy |
| PRUDENTIAL FINANCIAL INC | 194,254 | 176,725 | -17,529 | 0.04 | 0.03 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 272,613 | 174,835 | -97,778 | 0.07 | 0.04 | -0.03 | sell |
| D. E. Shaw & Co., Inc. | 108,378 | 169,454 | +61,076 | 0.02 | 0.03 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 155,985 | 163,054 | +7,069 | 0.01 | 0.01 | -0.00 | buy |
| Neuberger Berman Group LLC | 123,741 | 159,543 | +35,802 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 128,016 | 155,119 | +27,103 | 0.02 | 0.02 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 160,270 | 150,337 | -9,933 | 0.03 | 0.02 | -0.01 | sell |
| SOROS FUND MANAGEMENT LLC | 194,776 | 150,000 | -44,776 | 0.60 | 0.34 | -0.26 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 1.23 | +1.23 | buy |
| Rafferty Asset Management, LLC | 122,998 | 140,835 | +17,837 | 0.06 | 0.06 | -0.01 | buy |
| Federation des caisses Desjardins du Quebec | 109,735 | 139,503 | +29,768 | 0.08 | 0.08 | -0.00 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 138,755 | 138,755 | 0 | 0.20 | 0.16 | -0.04 | hold |
| Aberdeen Group plc | 161,147 | 136,424 | -24,723 | 0.04 | 0.03 | -0.01 | sell |
| Bridgewater Associates, LP | 87,548 | 135,186 | +47,638 | 0.06 | 0.09 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 137,805 | 134,160 | -3,645 | 0.02 | 0.02 | -0.01 | sell |