| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,954,765 | 12,706,230 | -248,535 | 0.03 | 0.03 | +0.00 | sell |
| VANGUARD GROUP INC | 9,807,066 | 9,706,559 | -100,507 | 0.02 | 0.02 | +0.00 | sell |
| DODGE & COX | 5,566,814 | 5,556,618 | -10,196 | 0.39 | 0.42 | +0.03 | sell |
| JPMORGAN CHASE & CO | 4,261,747 | 4,730,152 | +468,405 | 0.04 | 0.04 | +0.01 | buy |
| STATE STREET CORP | 4,468,266 | 4,346,479 | -121,787 | 0.02 | 0.02 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,086,457 | 2,866,731 | -219,726 | 0.04 | 0.04 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,510,015 | 2,773,648 | +1,263,633 | 0.16 | 0.25 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,366,397 | 2,418,297 | +51,900 | 0.40 | 0.45 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,959,265 | 2,024,825 | +65,560 | 0.02 | 0.02 | +0.00 | buy |
| MORGAN STANLEY | 1,819,745 | 1,826,937 | +7,192 | 0.01 | 0.02 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,028,858 | 1,811,762 | -217,096 | 0.05 | 0.04 | -0.00 | sell |
| Bellevue Group AG | 1,820,000 | 1,763,105 | -56,895 | 5.04 | 5.14 | +0.10 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 744,650 | 1,202,756 | +458,106 | 0.35 | 0.57 | +0.22 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,167,802 | 1,184,345 | +16,543 | 2.66 | 2.55 | -0.12 | buy |
| RTW INVESTMENTS, LP | 1,062,072 | 1,062,072 | 0 | 1.90 | 1.84 | -0.06 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,194,219 | 977,210 | -217,009 | 0.13 | 0.11 | -0.03 | sell |
| BNP Paribas Asset Management Holding S.A. | 1,032,296 | 948,033 | -84,263 | 0.32 | 0.34 | +0.03 | sell |
| NORTHERN TRUST CORP | 929,058 | 925,714 | -3,344 | 0.02 | 0.02 | +0.00 | sell |
| BRAIDWELL LP | 1,160,425 | 880,282 | -280,143 | 4.99 | 3.67 | -1.32 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 789,715 | 829,547 | +39,832 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 2,049,075 | 793,239 | -1,255,836 | 0.22 | 0.09 | -0.13 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,387,635 | 765,237 | -622,398 | 0.04 | 0.02 | -0.01 | sell |
| Bank of New York Mellon Corp | 778,630 | 761,396 | -17,234 | 0.02 | 0.02 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 684,439 | 710,122 | +25,683 | 0.02 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 653,011 | 704,254 | +51,243 | 0.01 | 0.01 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 676,024 | 697,022 | +20,998 | 3.22 | 3.07 | -0.15 | buy |
| Pictet Asset Management Holding SA | 696,122 | 693,446 | -2,676 | 0.09 | 0.09 | +0.00 | sell |
| IEQ CAPITAL, LLC | 572,973 | 692,601 | +119,628 | 0.44 | 0.30 | -0.15 | buy |
| FRANKLIN RESOURCES INC | 703,521 | 634,965 | -68,556 | 0.02 | 0.02 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 584,431 | 618,129 | +33,698 | 0.02 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 443,245 | 614,577 | +171,332 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 685,865 | 609,613 | -76,252 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 776,070 | 595,170 | -180,900 | 0.05 | 0.04 | -0.01 | sell |
| GW&K Investment Management, LLC | 612,365 | 594,385 | -17,980 | 0.69 | 0.74 | +0.05 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 787,299 | 571,785 | -215,514 | 0.22 | 0.16 | -0.06 | sell |
| RAYMOND JAMES FINANCIAL INC | 791,526 | 566,937 | -224,589 | 0.03 | 0.03 | -0.01 | sell |
| Swedbank AB | 503,502 | 547,329 | +43,827 | 0.07 | 0.08 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 570,868 | 519,953 | -50,915 | 0.04 | 0.04 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 524,040 | 512,260 | -11,780 | 0.05 | 0.06 | +0.00 | sell |
| Hood River Capital Management LLC | 257,538 | 501,491 | +243,953 | 0.45 | 0.83 | +0.38 | buy |
| Fiera Capital Corp | 490,594 | 479,676 | -10,918 | 0.21 | 0.22 | +0.01 | sell |
| BROWN ADVISORY INC | 599,219 | 468,547 | -130,672 | 0.10 | 0.09 | -0.01 | sell |
| DEUTSCHE BANK AG\ | 409,978 | 450,804 | +40,826 | 0.02 | 0.02 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 255,050 | 450,050 | +195,000 | 1.20 | 1.83 | +0.62 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 125,162 | 411,660 | +286,498 | 0.01 | 0.04 | +0.03 | buy |
| Legal & General Group Plc | 399,426 | 400,170 | +744 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 447,900 | 382,441 | -65,459 | 0.10 | 0.08 | -0.01 | sell |
| UBS Group AG | 602,125 | 364,572 | -237,553 | 0.02 | 0.01 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 423,471 | 363,113 | -60,358 | 0.04 | 0.04 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 438,540 | 353,640 | -84,900 | 1.39 | 1.19 | -0.20 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 347,565 | +347,565 | 0.00 | 0.07 | +0.07 | buy |
| Clearbridge Investments, LLC | 342,302 | 336,936 | -5,366 | 0.03 | 0.04 | +0.00 | sell |
| Invesco Ltd. | 289,245 | 323,611 | +34,366 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 270,502 | 315,462 | +44,960 | 0.04 | 0.05 | +0.01 | buy |
| BARCLAYS PLC | 271,390 | 303,978 | +32,588 | 0.01 | 0.02 | +0.00 | buy |
| RHUMBLINE ADVISERS | 309,190 | 303,510 | -5,680 | 0.03 | 0.03 | +0.00 | sell |
| Sarissa Capital Management LP | 303,151 | 303,151 | 0 | 24.68 | 23.59 | -1.09 | hold |
| SEI INVESTMENTS CO | 220,759 | 300,195 | +79,436 | 0.03 | 0.05 | +0.01 | buy |
| Candriam S.C.A. | 298,551 | 287,645 | -10,906 | 0.22 | 0.21 | -0.00 | sell |
| Swiss National Bank | 299,400 | 285,300 | -14,100 | 0.02 | 0.02 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 248,633 | 281,113 | +32,480 | 0.11 | 0.12 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 284,338 | 258,346 | -25,992 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE GROUP LLC | 251,732 | 251,628 | -104 | 1.23 | 1.33 | +0.10 | sell |
| Nuveen, LLC | 228,862 | 244,966 | +16,104 | 0.01 | 0.01 | +0.00 | buy |
| ROYAL BANK OF CANADA | 121,152 | 244,676 | +123,524 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 322,064 | 237,082 | -84,982 | 0.03 | 0.02 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 243,730 | 231,763 | -11,967 | 0.02 | 0.02 | +0.00 | sell |
| Amundi | 219,195 | 230,263 | +11,068 | 0.01 | 0.01 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 235,488 | 221,290 | -14,198 | 0.02 | 0.02 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 203,407 | +203,407 | 0.00 | 0.06 | +0.06 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 198,039 | 202,846 | +4,807 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 7,082 | 199,220 | +192,138 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 173,369 | 194,157 | +20,788 | 0.01 | 0.02 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 113,229 | 193,948 | +80,719 | 0.03 | 0.05 | +0.02 | buy |
| Susquehanna Portfolio Strategies, LLC | 184,035 | 184,035 | 0 | 0.51 | 0.41 | -0.10 | hold |
| HSBC HOLDINGS PLC | 189,237 | 183,657 | -5,580 | 0.02 | 0.02 | -0.00 | sell |
| BRAUN STACEY ASSOCIATES INC | 170,370 | 183,027 | +12,657 | 0.77 | 0.84 | +0.07 | buy |
| First Turn Management, LLC | 0 | 181,897 | +181,897 | 0.00 | 3.83 | +3.83 | buy |
| Ensign Peak Advisors, Inc | 170,783 | 180,431 | +9,648 | 0.04 | 0.04 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 174,774 | 175,574 | +800 | 0.03 | 0.03 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 180,338 | 166,414 | -13,924 | 9.72 | 7.66 | -2.06 | sell |
| Eagle Health Investments LP | 217,200 | 162,800 | -54,400 | 6.74 | 6.00 | -0.74 | sell |
| LOOMIS SAYLES & CO L P | 140,484 | 160,816 | +20,332 | 0.02 | 0.03 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 0.95 | 0.81 | -0.14 | hold |
| Integral Health Asset Management, LLC | 150,000 | 150,000 | 0 | 1.76 | 1.53 | -0.23 | hold |
| TWO SIGMA ADVISERS, LP | 0 | 148,773 | +148,773 | 0.00 | 0.04 | +0.04 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 147,880 | 147,789 | -91 | 0.17 | 0.16 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 166,010 | 141,822 | -24,188 | 2.41 | 2.19 | -0.23 | sell |
| AMERICAN CENTURY COMPANIES INC | 191,262 | 138,913 | -52,349 | 0.01 | 0.01 | -0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 138,000 | +138,000 | 0.00 | 1.04 | +1.04 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 135,314 | 136,950 | +1,636 | 0.02 | 0.02 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 180,259 | 136,756 | -43,503 | 0.01 | 0.01 | -0.00 | sell |
| Gotham Asset Management, LLC | 91,129 | 136,354 | +45,225 | 0.07 | 0.08 | +0.01 | buy |
| Freestone Grove Partners LP | 168,133 | 132,338 | -35,795 | 0.16 | 0.14 | -0.02 | sell |
| Iron Triangle Partners LP | 0 | 131,390 | +131,390 | 0.00 | 2.62 | +2.62 | buy |
| C WorldWide Group Holding A/S | 135,000 | 125,000 | -10,000 | 0.23 | 0.27 | +0.04 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 92,864 | 124,845 | +31,981 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 114,940 | 124,108 | +9,168 | 0.06 | 0.07 | +0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 203,628 | 123,704 | -79,924 | 0.28 | 0.17 | -0.11 | sell |
| Retirement Systems of Alabama | 120,958 | 119,917 | -1,041 | 0.05 | 0.06 | +0.00 | sell |