| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 14,256,048 | 14,782,722 | +526,674 | 0.03 | 0.04 | +0.01 | buy |
| VANGUARD GROUP INC | 9,996,960 | 10,119,641 | +122,681 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 5,148,293 | 4,891,137 | -257,156 | 0.02 | 0.03 | +0.00 | sell |
| DODGE & COX | 1,287,820 | 3,016,425 | +1,728,605 | 0.08 | 0.24 | +0.16 | buy |
| CITADEL ADVISORS LLC | 1,764,590 | 2,538,109 | +773,519 | 0.21 | 0.32 | +0.11 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,574,546 | 2,489,397 | -85,149 | 0.45 | 0.50 | +0.06 | sell |
| AQR CAPITAL MANAGEMENT LLC | 1,843,281 | 1,896,891 | +53,610 | 0.29 | 0.33 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,859,232 | 1,875,062 | +15,830 | 0.02 | 0.02 | +0.00 | buy |
| Bellevue Group AG | 1,863,800 | 1,820,000 | -43,800 | 3.48 | 4.78 | +1.30 | sell |
| MORGAN STANLEY | 1,349,381 | 1,573,297 | +223,916 | 0.01 | 0.02 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,675,176 | 1,490,513 | -184,663 | 0.02 | 0.02 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 718,226 | 1,457,425 | +739,199 | 0.01 | 0.04 | +0.02 | buy |
| JPMORGAN CHASE & CO | 1,497,931 | 1,371,186 | -126,745 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 894,217 | 1,070,096 | +175,879 | 0.03 | 0.03 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,017,154 | 983,799 | -33,355 | 0.02 | 0.03 | +0.00 | sell |
| NORTHERN TRUST CORP | 771,624 | 981,939 | +210,315 | 0.01 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 874,665 | 949,512 | +74,847 | 0.02 | 0.02 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 819,968 | 944,738 | +124,770 | 0.23 | 0.32 | +0.09 | buy |
| ORBIMED ADVISORS LLC | 302,220 | 938,120 | +635,900 | 0.64 | 2.66 | +2.02 | buy |
| DSM CAPITAL PARTNERS LLC | 944,154 | 932,595 | -11,559 | 1.66 | 1.97 | +0.31 | sell |
| BRAIDWELL LP | 917,674 | 901,790 | -15,884 | 3.00 | 3.65 | +0.65 | sell |
| BROWN ADVISORY INC | 942,147 | 898,293 | -43,854 | 0.14 | 0.16 | +0.02 | sell |
| ARMISTICE CAPITAL, LLC | 181,381 | 892,000 | +710,619 | 0.55 | 2.83 | +2.28 | buy |
| Bank of New York Mellon Corp | 858,250 | 870,290 | +12,040 | 0.02 | 0.02 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,316,590 | 862,000 | -454,590 | 2.27 | 2.24 | -0.03 | sell |
| JENNISON ASSOCIATES LLC | 334,800 | 820,694 | +485,894 | 0.02 | 0.07 | +0.04 | buy |
| JANUS HENDERSON GROUP PLC | 792,196 | 794,118 | +1,922 | 0.05 | 0.06 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 747,291 | 762,557 | +15,266 | 0.02 | 0.02 | +0.00 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 736,910 | 748,359 | +11,449 | 0.17 | 0.21 | +0.04 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 25,802 | 737,772 | +711,970 | 0.01 | 0.20 | +0.19 | buy |
| Rock Springs Capital Management LP | 939,000 | 720,500 | -218,500 | 3.52 | 3.74 | +0.22 | sell |
| Pictet Asset Management Holding SA | 842,197 | 611,119 | -231,078 | 0.11 | 0.09 | -0.02 | sell |
| FRANKLIN RESOURCES INC | 664,336 | 608,935 | -55,401 | 0.02 | 0.02 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 636,914 | 577,616 | -59,298 | 0.02 | 0.03 | +0.00 | sell |
| IEQ CAPITAL, LLC | 512,480 | 557,904 | +45,424 | 0.72 | 0.74 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 523,632 | 550,157 | +26,525 | 0.01 | 0.02 | +0.00 | buy |
| GW&K Investment Management, LLC | 510,089 | 514,082 | +3,993 | 0.50 | 0.60 | +0.09 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 420,748 | 512,820 | +92,072 | 0.20 | 0.28 | +0.09 | buy |
| Fiera Capital Corp | 516,801 | 499,109 | -17,692 | 0.18 | 0.21 | +0.04 | sell |
| BANK OF AMERICA CORP /DE/ | 623,588 | 484,034 | -139,554 | 0.01 | 0.01 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 689,986 | 480,565 | -209,421 | 0.12 | 0.11 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 437,831 | 461,782 | +23,951 | 0.02 | 0.02 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 462,147 | 453,091 | -9,056 | 0.04 | 0.04 | +0.00 | sell |
| UBS Group AG | 359,569 | 419,428 | +59,859 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 312,767 | 418,712 | +105,945 | 0.03 | 0.05 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 496,094 | 413,479 | -82,615 | 0.01 | 0.01 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 544,321 | 394,652 | -149,669 | 0.06 | 0.05 | -0.01 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 404,000 | 393,710 | -10,290 | 0.03 | 0.04 | +0.01 | sell |
| Hood River Capital Management LLC | 263,210 | 355,058 | +91,848 | 0.49 | 0.72 | +0.23 | buy |
| Legal & General Group Plc | 390,585 | 345,690 | -44,895 | 0.01 | 0.01 | +0.00 | sell |
| Bridgewater Associates, LP | 135,186 | 332,598 | +197,412 | 0.09 | 0.21 | +0.12 | buy |
| NORGES BANK | 351,064 | 325,295 | -25,769 | 0.01 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 321,747 | 320,478 | -1,269 | 0.03 | 0.04 | +0.01 | sell |
| Clearbridge Investments, LLC | 319,299 | 319,299 | 0 | 0.03 | 0.04 | +0.01 | hold |
| Iron Triangle Partners LP | 0 | 318,195 | +318,195 | 0.00 | 5.06 | +5.06 | buy |
| Sarissa Capital Management LP | 410,483 | 309,116 | -101,367 | 11.76 | 13.07 | +1.31 | sell |
| Candriam S.C.A. | 483,241 | 303,972 | -179,269 | 0.32 | 0.24 | -0.08 | sell |
| AXA S.A. | 269,172 | 297,704 | +28,532 | 0.09 | 0.12 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 533,324 | 289,840 | -243,484 | 0.06 | 0.03 | -0.03 | sell |
| Swiss National Bank | 298,700 | 285,300 | -13,400 | 0.02 | 0.03 | +0.00 | sell |
| MACQUARIE GROUP LTD | 492,190 | 274,126 | -218,064 | 0.06 | 0.05 | -0.02 | sell |
| Amundi | 656,695 | 261,860 | -394,835 | 0.03 | 0.01 | -0.01 | sell |
| Impax Asset Management Group plc | 85,000 | 261,599 | +176,599 | 0.04 | 0.16 | +0.12 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 253,186 | 252,469 | -717 | 0.02 | 0.02 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 248,928 | +248,928 | 0.00 | 0.13 | +0.13 | buy |
| WELLS FARGO & COMPANY/MN | 260,415 | 246,579 | -13,836 | 0.01 | 0.01 | +0.00 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 231,941 | 232,857 | +916 | 0.02 | 0.02 | +0.00 | buy |
| Avidity Partners Management LP | 460,000 | 220,400 | -239,600 | 2.70 | 3.00 | +0.30 | sell |
| RENAISSANCE GROUP LLC | 204,140 | 217,572 | +13,432 | 0.97 | 1.23 | +0.26 | buy |
| HSBC HOLDINGS PLC | 223,258 | 212,354 | -10,904 | 0.02 | 0.02 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 176,725 | 210,175 | +33,450 | 0.03 | 0.03 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 233,540 | 203,210 | -30,330 | 0.01 | 0.01 | +0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 150,000 | 200,000 | +50,000 | 0.34 | 0.48 | +0.13 | buy |
| Logos Global Management LP | 0 | 200,000 | +200,000 | 0.00 | 3.19 | +3.19 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 194,728 | +194,728 | 0.00 | 0.06 | +0.06 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 204,205 | 189,896 | -14,309 | 0.02 | 0.03 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 303,842 | 180,406 | -123,436 | 0.16 | 0.11 | -0.05 | sell |
| BARCLAYS PLC | 181,591 | 178,368 | -3,223 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 179,774 | 177,774 | -2,000 | 0.03 | 0.03 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 174,835 | 173,694 | -1,141 | 0.04 | 0.04 | +0.01 | sell |
| Neuberger Berman Group LLC | 159,543 | 168,176 | +8,633 | 0.01 | 0.02 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 166,803 | +166,803 | 0.00 | 1.73 | +1.73 | buy |
| CITIGROUP INC | 200,519 | 165,180 | -35,339 | 0.02 | 0.02 | +0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 160,000 | +160,000 | 0.00 | 1.93 | +1.93 | buy |
| Aberdeen Group plc | 136,424 | 156,574 | +20,150 | 0.03 | 0.04 | +0.01 | buy |
| Eagle Health Investments LP | 128,600 | 155,000 | +26,400 | 2.86 | 5.19 | +2.33 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 107,482 | 154,852 | +47,370 | 0.09 | 0.14 | +0.05 | buy |
| SEI INVESTMENTS CO | 155,119 | 150,424 | -4,695 | 0.02 | 0.03 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 163,054 | 150,331 | -12,723 | 0.01 | 0.01 | +0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 1.23 | 1.35 | +0.12 | hold |
| Man Group plc | 296,179 | 145,164 | -151,015 | 0.10 | 0.06 | -0.04 | sell |
| Qube Research & Technologies Ltd | 763,355 | 145,111 | -618,244 | 0.16 | 0.03 | -0.13 | sell |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 138,755 | 139,670 | +915 | 0.16 | 0.20 | +0.04 | buy |
| FMR LLC | 246,106 | 139,662 | -106,444 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 123,068 | 139,441 | +16,373 | 0.01 | 0.02 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 134,160 | 136,549 | +2,389 | 0.02 | 0.02 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 211,274 | 126,735 | -84,539 | 0.02 | 0.02 | -0.01 | sell |
| Russell Investments Group, Ltd. | 210,777 | 126,217 | -84,560 | 0.04 | 0.02 | -0.01 | sell |
| Retirement Systems of Alabama | 122,661 | 123,107 | +446 | 0.05 | 0.06 | +0.01 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 125,720 | 121,142 | -4,578 | 0.03 | 0.04 | +0.01 | sell |