| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,706,230 | 12,830,597 | +124,367 | 0.03 | 0.03 | -0.00 | buy |
| VANGUARD GROUP INC | 9,706,559 | 9,700,301 | -6,258 | 0.02 | 0.02 | -0.00 | sell |
| DODGE & COX | 5,556,618 | 5,508,042 | -48,576 | 0.42 | 0.42 | +0.00 | sell |
| JPMORGAN CHASE & CO | 4,730,152 | 5,200,356 | +470,204 | 0.04 | 0.05 | +0.01 | buy |
| STATE STREET CORP | 4,346,479 | 4,242,681 | -103,798 | 0.02 | 0.02 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 2,773,648 | 3,271,706 | +498,058 | 0.25 | 0.24 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,418,297 | 2,238,797 | -179,500 | 0.45 | 0.49 | +0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,024,825 | 2,059,282 | +34,457 | 0.02 | 0.02 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,866,731 | 1,872,240 | -994,491 | 0.04 | 0.03 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,811,762 | 1,744,560 | -67,202 | 0.04 | 0.04 | -0.00 | sell |
| Bellevue Group AG | 1,763,105 | 1,703,304 | -59,801 | 5.14 | 4.58 | -0.56 | sell |
| BNP Paribas Asset Management Holding S.A. | 948,033 | 1,395,902 | +447,869 | 0.34 | 0.23 | -0.12 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 1,202,756 | 1,291,278 | +88,522 | 0.57 | 0.61 | +0.03 | buy |
| NORTHERN TRUST CORP | 925,714 | 1,221,184 | +295,470 | 0.02 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 1,826,937 | 1,209,378 | -617,559 | 0.02 | 0.01 | -0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,184,345 | 1,184,345 | 0 | 2.55 | 2.15 | -0.39 | hold |
| NORGES BANK | 0 | 1,146,896 | +1,146,896 | 0.00 | 0.02 | +0.02 | buy |
| RTW INVESTMENTS, LP | 1,062,072 | 1,062,072 | 0 | 1.84 | 1.51 | -0.33 | hold |
| TWO SIGMA INVESTMENTS, LP | 347,565 | 984,811 | +637,246 | 0.07 | 0.21 | +0.13 | buy |
| UBS Group AG | 364,572 | 983,528 | +618,956 | 0.01 | 0.03 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 829,547 | 850,632 | +21,085 | 0.02 | 0.02 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 148,773 | 842,592 | +693,819 | 0.04 | 0.23 | +0.19 | buy |
| ARMISTICE CAPITAL, LLC | 697,022 | 820,240 | +123,218 | 3.07 | 2.85 | -0.22 | buy |
| Pictet Asset Management Holding SA | 693,446 | 776,934 | +83,488 | 0.09 | 0.11 | +0.01 | buy |
| BRAIDWELL LP | 880,282 | 751,534 | -128,748 | 3.67 | 3.41 | -0.26 | sell |
| IEQ CAPITAL, LLC | 692,601 | 745,113 | +52,512 | 0.30 | 0.32 | +0.02 | buy |
| Bank of New York Mellon Corp | 761,396 | 738,676 | -22,720 | 0.02 | 0.02 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 765,237 | 722,476 | -42,761 | 0.02 | 0.02 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 710,122 | 716,475 | +6,353 | 0.02 | 0.02 | -0.00 | buy |
| Fiera Capital Corp | 479,676 | 637,408 | +157,732 | 0.22 | 0.29 | +0.07 | buy |
| RAYMOND JAMES FINANCIAL INC | 566,937 | 631,422 | +64,485 | 0.03 | 0.03 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 614,577 | 585,677 | -28,900 | 0.02 | 0.02 | -0.00 | sell |
| Swedbank AB | 547,329 | 584,129 | +36,800 | 0.08 | 0.08 | +0.00 | buy |
| GW&K Investment Management, LLC | 594,385 | 576,648 | -17,737 | 0.74 | 0.71 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 618,129 | 555,494 | -62,635 | 0.03 | 0.02 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 634,965 | 532,759 | -102,206 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 704,254 | 528,104 | -176,150 | 0.01 | 0.01 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 512,260 | 507,740 | -4,520 | 0.06 | 0.05 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 363,113 | 486,809 | +123,696 | 0.04 | 0.05 | +0.01 | buy |
| Zurich Insurance Group Ltd/FI | 0 | 459,437 | +459,437 | 0.00 | 0.45 | +0.45 | buy |
| JANUS HENDERSON GROUP PLC | 595,170 | 459,176 | -135,994 | 0.04 | 0.03 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 977,210 | 442,866 | -534,344 | 0.11 | 0.05 | -0.06 | sell |
| Hood River Capital Management LLC | 501,491 | 389,297 | -112,194 | 0.83 | 0.61 | -0.23 | sell |
| DEUTSCHE BANK AG\ | 450,804 | 367,944 | -82,860 | 0.02 | 0.02 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 609,613 | 364,535 | -245,078 | 0.01 | 0.01 | -0.01 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 411,660 | 360,711 | -50,949 | 0.04 | 0.03 | -0.01 | sell |
| MARSHALL WACE, LLP | 97,289 | 348,843 | +251,554 | 0.02 | 0.05 | +0.03 | buy |
| Invesco Ltd. | 323,611 | 343,421 | +19,810 | 0.01 | 0.01 | -0.00 | buy |
| Allspring Global Investments Holdings, LLC | 382,441 | 339,432 | -43,009 | 0.08 | 0.08 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 450,050 | 331,050 | -119,000 | 1.83 | 0.86 | -0.97 | sell |
| Legal & General Group Plc | 400,170 | 330,606 | -69,564 | 0.01 | 0.01 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 353,640 | 314,240 | -39,400 | 1.19 | 0.91 | -0.28 | sell |
| ROYAL BANK OF CANADA | 244,676 | 311,012 | +66,336 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 336,936 | 310,077 | -26,859 | 0.04 | 0.04 | -0.00 | sell |
| Hudson Bay Capital Management LP | 40,510 | 305,000 | +264,490 | 0.03 | 0.25 | +0.21 | buy |
| Sarissa Capital Management LP | 303,151 | 303,151 | 0 | 23.59 | 19.29 | -4.30 | hold |
| RHUMBLINE ADVISERS | 303,510 | 297,444 | -6,066 | 0.03 | 0.03 | -0.00 | sell |
| Candriam S.C.A. | 287,645 | 293,096 | +5,451 | 0.21 | 0.21 | -0.00 | buy |
| Nuveen, LLC | 244,966 | 286,785 | +41,819 | 0.01 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 193,948 | 281,320 | +87,372 | 0.05 | 0.07 | +0.02 | buy |
| Swiss National Bank | 285,300 | 271,800 | -13,500 | 0.02 | 0.02 | -0.00 | sell |
| RENAISSANCE GROUP LLC | 251,628 | 252,293 | +665 | 1.33 | 1.44 | +0.10 | buy |
| BARCLAYS PLC | 303,978 | 252,241 | -51,737 | 0.02 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 39,470 | 249,154 | +209,684 | 0.01 | 0.06 | +0.05 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 281,113 | 246,289 | -34,824 | 0.12 | 0.09 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 258,346 | 242,111 | -16,235 | 0.01 | 0.01 | -0.00 | sell |
| Man Group plc | 80,832 | 231,210 | +150,378 | 0.02 | 0.06 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 231,763 | 226,377 | -5,386 | 0.02 | 0.02 | -0.00 | sell |
| BROWN ADVISORY INC | 468,547 | 225,288 | -243,259 | 0.09 | 0.04 | -0.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 100,975 | 213,992 | +113,017 | 0.01 | 0.02 | +0.01 | buy |
| Squarepoint Ops LLC | 40,481 | 209,706 | +169,225 | 0.01 | 0.06 | +0.05 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 202,846 | 206,731 | +3,885 | 0.01 | 0.01 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 221,290 | 202,666 | -18,624 | 0.02 | 0.02 | -0.00 | sell |
| Handelsbanken Fonder AB | 109,467 | 200,867 | +91,400 | 0.05 | 0.09 | +0.04 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 194,157 | 196,821 | +2,664 | 0.02 | 0.02 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 184,035 | 184,035 | 0 | 0.41 | 0.40 | -0.01 | hold |
| BRAUN STACEY ASSOCIATES INC | 183,027 | 182,262 | -765 | 0.84 | 0.84 | -0.00 | sell |
| SEI INVESTMENTS CO | 300,195 | 179,397 | -120,798 | 0.05 | 0.03 | -0.02 | sell |
| Soleus Capital Management, L.P. | 138,000 | 175,982 | +37,982 | 1.04 | 1.06 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 175,574 | 174,774 | -800 | 0.03 | 0.03 | +0.00 | sell |
| LOOMIS SAYLES & CO L P | 160,816 | 169,220 | +8,404 | 0.03 | 0.03 | +0.00 | buy |
| Gotham Asset Management, LLC | 136,354 | 168,572 | +32,218 | 0.08 | 0.09 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 180,431 | 167,307 | -13,124 | 0.04 | 0.04 | +0.00 | sell |
| Amundi | 230,263 | 166,350 | -63,913 | 0.01 | 0.01 | -0.00 | sell |
| PFM Health Sciences, LP | 57,246 | 163,197 | +105,951 | 0.69 | 2.34 | +1.66 | buy |
| Eagle Health Investments LP | 162,800 | 162,800 | 0 | 6.00 | 5.07 | -0.93 | hold |
| AMERICAN CENTURY COMPANIES INC | 138,913 | 158,485 | +19,572 | 0.01 | 0.01 | +0.00 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 166,414 | 151,815 | -14,599 | 7.66 | 6.76 | -0.90 | sell |
| Integral Health Asset Management, LLC | 150,000 | 150,000 | 0 | 1.53 | 1.08 | -0.46 | hold |
| Bridgewater Associates, LP | 23,038 | 149,990 | +126,952 | 0.01 | 0.08 | +0.06 | buy |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | 147,789 | 149,156 | +1,367 | 0.16 | 0.15 | -0.01 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 98,423 | 147,623 | +49,200 | 0.09 | 0.12 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 104,962 | 145,561 | +40,599 | 0.11 | 0.14 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 203,407 | 141,101 | -62,306 | 0.06 | 0.04 | -0.02 | sell |
| Freestone Grove Partners LP | 132,338 | 140,529 | +8,191 | 0.14 | 0.14 | +0.01 | buy |
| DnB Asset Management AS | 124,108 | 139,457 | +15,349 | 0.07 | 0.07 | +0.00 | buy |
| Trexquant Investment LP | 31,745 | 137,186 | +105,441 | 0.05 | 0.17 | +0.13 | buy |
| SG Americas Securities, LLC | 15,191 | 134,530 | +119,339 | 0.01 | 0.03 | +0.02 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,950 | 134,172 | -2,778 | 0.02 | 0.02 | -0.00 | sell |
| Cerity Partners LLC | 103,626 | 133,759 | +30,133 | 0.02 | 0.03 | +0.00 | buy |